Silk-based scaffolds for tissue engineering and reconstructive surgery: mechanical and structural properties
https://doi.org/10.15825/1995-1191-2025-4-125-132
Abstract
Silk is a promising natural biomaterial that combines mechanical strength, biocompatibility, and controlled biodegradation, making it highly suitable for scaffold creation for clinical practice. This study investigates how different processing methods influence the morphological and mechanical characteristics of silk-based scaffolds. The fi ndings showed that varying the processing conditions facilitates the production of materials with tailored properties, ranging from dense, mechanically robust structures to porous, rapidly degradable scaffolds. Highdensity samples (Fibroplen-Atlas) exhibited substantial mechanical stability, making them promising candidates for surgical applications in mechanically demanding areas such as ligaments, fascia, and tendons. In contrast, more porous scaffolds (Fibroplen-Gas) demonstrated accelerated biodegradation, which is advantageous for soft tissue regeneration. These results highlight the potential of silk scaffolds for personalized applications, where the balance between mechanical stability and biodegradation rate can be adjusted according to specific clinical needs.
About the Authors
E. I. Podbolotova
Shumakov National Medical Research Center of Transplantology and Artificial Organs;
Moscow Institute of Physics and Technology
Russian Federation
Russian Federation
Moscow; Dolgoprudny
A. R. Pashutin
Shumakov National Medical Research Center of Transplantology and Artificial Organs;
Moscow Institute of Physics and Technology
Russian Federation
Russian Federation
Moscow; Dolgoprudny
N. V. Grudinin
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Russian Federation
Moscow
I. I. Agapov
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Russian Federation
Moscow
E. A. Volkova
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Russian Federation
Moscow
O. I. Agapova
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Russian Federation
Moscow
A. E. Efimov
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Russian Federation
Moscow
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Supplementary files
Review
For citations:
Podbolotova E.I., Pashutin A.R., Grudinin N.V., Agapov I.I., Volkova E.A., Agapova O.I., Efimov A.E. Silk-based scaffolds for tissue engineering and reconstructive surgery: mechanical and structural properties. Russian Journal of Transplantology and Artificial Organs. 2025;27(4):125-132. (In Russ.) https://doi.org/10.15825/1995-1191-2025-4-125-132
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