Perioperative prophylaxis of renal ischemia‑reperfusion injury
https://doi.org/10.15825/1995-1191-2024-4-46-60
Abstract
This paper reviews the strategies for correcting ischemia-reperfusion injury (IRI) in kidneys during surgeries and transplantation, discussed and proposed in the current literature. The pathophysiological mechanisms of IRI and a wide range of proposed methods for reducing the severity of injury are considered. The use of such techniques as the combination of ischemic, pharmacological pre- and postconditioning is still being studied. It was observed that researchers were very interested in immunological and biological (stem cell) therapeutic strategies as a potential avenue to lessen the severity of IRI.
About the Authors
S. V. Popov
Almazov National Medical Research Centre
Russian Federation
Russian Federation
St. Petersburg
R. G. Guseinov
Almazov National Medical Research Centre
Russian Federation
Russian Federation
St. Petersburg
K. V. Sivak
Almazov National Medical Research Centre
Russian Federation
Russian Federation
St. Petersburg
V. V. Perepelitsa
Almazov National Medical Research Centre
Russian Federation
Russian Federation
St. Petersburg
A. Beshtoev
Almazov National Medical Research Centre
Russian Federation
Russian Federation
St. Petersburg
T. Lelyavina
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Tatiana Lelyavina
2, Akkuratova str., St. Petersburg, 197341
Phone: (981) 908-90-18
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For citations:
Popov S.V., Guseinov R.G., Sivak K.V., Perepelitsa V.V., Beshtoev A., Lelyavina T. Perioperative prophylaxis of renal ischemia‑reperfusion injury. Russian Journal of Transplantology and Artificial Organs. 2024;26(4):46-60. https://doi.org/10.15825/1995-1191-2024-4-46-60
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