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THE INFLUENCE OF POSTTRANSPLANT FACTORS ON THE LONG-TERM SURVIVAL AFTER HEART TRANSPLANTATION

https://doi.org/10.15825/1995-1191-2009-2-6-15

Abstract

In this study 71 patients (61 male and 10 female) were included, who have been operated in our institute from 1987 to 2006. All of them were undergoing orthotopic heart transplantation. The age of patients was from 14 to 57 years (the mean age 34,5). Only patients who were discharged from the hospital were included in the study. For statistical analysis Kaplan-Mayer survival analysis, relative risks (RR) and ODDR, proportional hazard risks regression of Cox were used. Coronary arteries disease was identifi ed as risk factor for long-term survival prognosis. Types B1, B2 and C arteriopathy are very unfavorable for long-term survival prognosis.

Percutaneus coronary intervention for type A improves long-term survival prognosis in comparison with types B and C.

About the Author

V.M. Zakharevich
Academician V.I. Shumakov Federal Research Center of Transplantology and Artifi cial Organs, Moscow
Russian Federation


References

1. Болезнь коронарных артерий пересаженного сердца / Под ред. В.И. Шумакова. М.: ООО «МИА», 2008. 160 с.

2. Трансплантация сердца: Руководство для врачей /Под ред. В.И. Шумакова. М.: ООО «МИА», 2006. 400 с.

3. Трансплантология: Руководство для врачей / Под ред. В.И. Шумакова. М.: ООО «МИА», 2006. 540 с.

4. Шумаков В.И., Хубутия М.Ш., Шевченко О.П. Отторжение пересаженного сердца. М.: Реафарм, 2005. 240 с.

5. Agel R.A., Wells B.J., Hage F.G., Tallaj J. et al. Re-stenosis after drug-eluting stents in cardiac allograft vasculopathy // J Heart Lung Transplant. 2008. V. 27 (6). P. 610–615.

6. Aranda J.M., Pauly D.F., Kerensky R.A. et al. Percutaneous coronary intervention versus medical therapy for coronary allograft vasculopathy. One centers experience // J Heart Lung Transplant. 2002. V. 21 (8). P. 860–866.

7. Avedissian M.G., Bush H.S., Leachman D.R. et al. Percutaneous transluminal coronary angioplasty after cardiac transplantation // Texas Heart Institute J. 1989. V. 16. P. 288–291.

8. Baumgartner W.A. Heart and lung transplantation. Saunders, 2nd edition. 2002. 597 p.

9. Crespo-Leiro M.G., Alonso-Pulpon L., Vazquez de Prada J.A. et al. Malignancy after heart transplantation: incidence, prognosis and risk factors // Am J Transplant. 2008. V. 8 (5). P. 1031–1039.

10. Gao S.Z., Alderman E.L., Schroeder J.S., Silverman J.F., Hunt S.A. Accelerated coronary vascular disease in the heart transplant patient: coronary arteriographic fi ndings // J Am Coll Cardiol. 1988. V. 12 (3). P. 334–340. 15

11. Hoffmeier A., Wagner T., Nashan D., Rukosujew A., Erren M., Schmid C., Wirtz S.P., Scheld H.H. Malignomas following heart transplantation. Z Kardiol. 2002. V. 91 (12). P. 1013–1023.

12. Kirklin J.K., Yong J.B., McGiffi n J.B. Heart transplantation. Churchill Livingstone, 1st edition. 2002. 883 p.

13. Lones M.A., Czer L.S., Trento A., Harasty D., Miller J.M., Fishbein M.C. Clinical-pathologic features of humoral rejection in cardiac allografts: a study in 81 consecutive patients // J Heart Lung Transplant. 1995. V. 14 (1 Pt 1). P. 151–162.

14. Lunel F., Cadranel J.F., Rosenheim M. et al. Hepatitis virus infections in heart transplant recipients: epidemiology, natural history, characteristics, and impact on survival. Gastroenterology. 2000. V. 119 (4). P. 1064–1074.

15. Marcus G.M., Hoang K.L., Hunt S.A., Chun S.H., Lee B.K. Prevalence, patterns of development, and prognosis of right bundle branch block in heart transplant recipients // Am J Cardiol. 2006. V. 98 (9). P. 1288–1290.

16. Mills R.M., Naftel D.C., Kirklin J.K. et al. Heart transplant rejection with hemodynamic compromise: a multiinstitutional study of the role of endomyocardial cellular infi ltrate. Cardiac Transplant Research Database //J Heart Lung Transplant. 1997. V. 16 (8). P. 813–821.

17. Ong J.P., Barnes D.S., Younossi Z.M. et al. Outcome of de novo hepatitis C virus infection in heart transplant recipients // Hepatology. 1999. V. 30 (5). P. 1293–1298.

18. Potena L., Holweg C.T., Chin C. et al. Acute rejection and cardiac allograft vascular disease is reduced busuppression of subclinical cytomegalovirus infection //Transplantation. 2006. V. 82 (3). P. 398–405.

19. Syeda B., Roedler S., Schukro C. et al. Transplant coronary artery disease: Incidence, progression and interventional revascularization // Int J Cardiol. 2005. V. 104 (3). P. 269–274.

20. Tanaka K., Li H., Curran P.J. et al. Usefulness and safety of percutaneous coronary interventions for cardiac transplant vasculopathy // Am J Cardiol. 2006. V. 97 (8). P. 1192–1197.

21. Tarantini G., Favaretto E., Gardin A. et al. Drug-eluting stents for the treatment of coronary lesions in cardiac transplant vasculopathy: acute and mid-term clinical and angiographic outcomes // J Cardiovasc Med (Hagerstown). 2008. V. 9 (4). P. 396–402.

22. Taylor D.O., Edwards L.B., Boucek M.M. et al. The registry of international Society for Heart and Lung Transplantation: Twenty-first offi cial adult heart transplant report – 2004 // J art Lung Transplant. 2004. V. 23 (7). P. 796–803.

23. Valantine H.A. The role of viruses in cardiac allograft vasculopathy // Am J Transplant. 2004. V. 4 (2). P. 169–177.

24. Wedemeyer H., Pethig K., Manns M.P., Boker K.H. Hepatitis B infection in heart transplant patients // Gastroenterology. 2001. V. 120 (5). P. 1311–1313.

25. Wellnhofer E., Hiemann N.E., Hug J. et al. A decade of percutaneous coronary interventions in cardiac transplant recipients: a monocentric study in 160 patients // J.Heart Lung Transplant. 2008. V. 27 (1). P. 17–25.

26. Woo G.W., Schofi eld R.S., Pauly D.F. et al. Incidence, predictors and outcomes of cardiac pacing after cardiac transplantation: an 11-year retrospective analysis // Transplantation, 2008. V. 85 (8). P. 1216–1218.


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For citations:


Zakharevich V. THE INFLUENCE OF POSTTRANSPLANT FACTORS ON THE LONG-TERM SURVIVAL AFTER HEART TRANSPLANTATION. Russian Journal of Transplantology and Artificial Organs. 2009;11(2):6-15. (In Russ.) https://doi.org/10.15825/1995-1191-2009-2-6-15

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ISSN 1995-1191 (Print)