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Вестник трансплантологии и искусственных органов

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Антителоопосредованное отторжение трансплантата сердца

https://doi.org/10.15825/1995-1191-2021-4-47-61

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Аннотация

Роль антителоопосредованного отторжения в прогнозе выживаемости реципиентов сердца изучается в клинической трансплантологии более 20 лет. Данный патологический процесс выступает значимым фактором риска развития сердечной недостаточности и васкулопатии трансплантата. Антителоопосредованное отторжение является результатом активации гуморального иммунного звена и выработки донорспецифических антител, которые вызывают повреждение миокарда за счет системы комплемента. Наличие донор-специфических антител связано с более низкой выживаемостью аллотрансплантата. Лечение антителоопосредованного отторжения должно проводиться с учетом степени отторжения и наличия или отсутствия дисфункции трансплантата. Основной принцип лечения заключается в ингибировании системы гуморального иммунитета на разных уровнях. В настоящее время в мировой клинической практике достигнуты значительные успехи в изучении данного вопроса, однако требуются дальнейшие исследования для определения и разработки оптимальных схем лечения пациентов с гуморальным отторжением трансплантата сердца.

Об авторах

В. С. Кван
ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России
Россия

Кван Вера Сергеевна

123182, ул. Щукинская, д. 1

Тел. (966) 326-28-24



Н. Н. Колоскова
ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России
Россия

Москва



Ю. А. Качанова
ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России
Россия

Москва



Н. Н. Сайфуллина
ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России
Россия

Москва



А. Ю. Гончарова
ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России
Россия

Москва



Л. Б. Круглый
ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России
Россия

Москва



А. О. Шевченко
ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России; ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Минздрава России (Сеченовский университет); ФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздрава России
Россия

Москва



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Рецензия

Для цитирования:


Кван В.С., Колоскова Н.Н., Качанова Ю.А., Сайфуллина Н.Н., Гончарова А.Ю., Круглый Л.Б., Шевченко А.О. Антителоопосредованное отторжение трансплантата сердца. Вестник трансплантологии и искусственных органов. 2021;23(4):47-61. https://doi.org/10.15825/1995-1191-2021-4-47-61

For citation:


Kvan V.S., Koloskova N.N., Kachanova Yu.A., Sayfullina N.N., Goncharova A.Yu., Krugly L.B., Shevchenko A.O. Antibody-mediated rejection in heart transplantation. Russian Journal of Transplantology and Artificial Organs. 2021;23(4):47-61. https://doi.org/10.15825/1995-1191-2021-4-47-61

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ISSN 1995-1191 (Print)
ISSN 2412-6160 (Online)