INTERLEUKIN-6 PROFILE IN EARLY POSTOPERATIVE PERIOD AFTER KIDNEY TRANSPLANTATION
https://doi.org/10.15825/1995-1191-2013-1-51-59
Abstract
Aim. To study the profile of IL-6 in the early postoperative period after kidney transplantation and the factors that affect concentration of this cytokine.
Methods and results. 28 kidney recipients were included in the study. It has been found that in most patients after surgery IL-6 was released, and the absence of such a reaction was a poor prognostic sign. Rate of increasing of the concentration and form of its curve within the first postoperative day depended on the length of preservation, warm ischemia time, type of donor, and differed in recipients with normal and delayed initial graft function. Conclusion. Further study of the role of circulating factors in kidney transplantation would improve patient outcomes.
About the Authors
A. V. Vatazin
Moscow Regional Research Clinical Institute named after M.F. Vladimirsky
A. B. Zulkarnaev
Moscow Regional Research Clinical Institute named after M.F. Vladimirsky
E. E. Kruglov
Moscow Regional Research Clinical Institute named after M.F. Vladimirsky
P. V. Astakhov
Moscow Regional Research Clinical Institute named after M.F. Vladimirsky
M. Krstic
Moscow Regional Research Clinical Institute named after M.F. Vladimirsky
K. K. Gubarev
Moscow Regional Research Clinical Institute named after M.F. Vladimirsky
I. A. Vasilenko
Moscow Regional Research Clinical Institute named after M.F. Vladimirsky
D. V. Artemov
Moscow Regional Research Clinical Institute named after M.F. Vladimirsky
References
1. Траилин А.В., Никоненко Т.Н., Никоненко А.С. Ис- ходное состояние донорской почки и риск развития отсроченной и замедленной функции почечного ал- лотрансплантата // Вестник трансплантологии и ис- кусственных органов. 2008. Т. 10 (3). С. 13–18.
2. Boros P.J., Bromberg S. New cellular and molecular im- mune pathways in ischemia/reperfusion injury // Am. J. Transplant. 2006. Vol. 6 (4). P. 652–658.
3. Caban A., Budziński G., Oczkowicz G. et al. Factors de- termining changes in concentrations of pro-inflammato- ry markers in blood serum in the initial period afterkid- ney transplantation from dead donor // Ann Transplant. 2009. Vol. 14 (4). P. 10–13.
4. Camporeale A., Poli V. IL-6., IL-17 and STAT3: a holy trinity in auto-immunity? // Front Biosci. 2012. Vol. 17. P. 2306–2326.
5. de Vries D.K., Lindeman J.H., Ringers J. et al. Donor brain death predisposes human kidney grafts to a proin- flammatory reaction after transplantation // Am. J. Trans- plant. 2011. Vol. 11 (5). P. 1064–1070.
6. de Vries D.K., Lindeman J.H., Tsikas D. et al. Early renal ischemia-reperfusion injury in humans is dominated by IL-6 release from the allograft // Am. J. Transplant. 2009. Vol. 9 (7). P. 1574–1584.
7. Domanski L., Pawlik A., Safranow K et al. Purine and cytokine concentrations in the renal vein of the allograft during reperfusion // Transplant. Proc. 2007. Vol. 39 (5). P. 1319–1322.
8. Hosgood S.A., Hunter J.P., Nicholson M.L. Early urinary biomarkers of warm and cold ischemic injury in an experimentalkidney model // J. Surg. Res. 2012. Vol. 174
9. (2). P. 85–90.
10. Kaminska D., Tyran B., Mazanowska O. et al. Cytokine
11. gene expression in kidney allograft biopsies after donor brain death and ischemia-reperfusion injury using in situ reverse-transcription polymerase chain reaction analy- sis // Transplantation. 2007. Vol. 84 (9). P. 1118–1124.
12. Kielar M.L., John R., Bennett M. et al. Maladaptive role of IL-6 in ischemic acute renal failure // J. Am. Soc. Nephrol. 2005. Vol. 16 (11). P. 3315–3325.
13. KosieradzkiM.,RowińskiW.Ischemia/reperfusioninjury in kidney transplantation: mechanisms and prevention // Transplant. Proc. 2008. Vol. 40 (10). P. 3279–3288.
14. Nechemia-Arbely Y., Barkan D., Pizov G. et al. IL-6/IL- 6R axis plays a critical role in acute kidney injury // J. Am. Soc. Nephrol. 2008. 19 (6). P. 1106–1115.
15. PatelN.S.,ChatterjeeP.K.,DiPaolaR.etal.Endogenous interleukin-6 enhances the renal injury, dysfunction, and inflammation caused by ischemia/reperfusion // J. Phar- macol. Exp. Ther. 2005. Vol. 312 (3). P. 1170–1178.
Review
For citations:
Vatazin A.V., Zulkarnaev A.B., Kruglov E.E., Astakhov P.V., Krstic M., Gubarev K.K., Vasilenko I.A., Artemov D.V. INTERLEUKIN-6 PROFILE IN EARLY POSTOPERATIVE PERIOD AFTER KIDNEY TRANSPLANTATION. Russian Journal of Transplantology and Artificial Organs. 2013;15(1):51-59. (In Russ.) https://doi.org/10.15825/1995-1191-2013-1-51-59
Views:
1387
Email this article 