Post-transplant malignancies in solid organ recipients: development mechanisms and risk factors
https://doi.org/10.15825/1995-1191-2021-3-192-197
Abstract
According to the International Agency for Research on Cancer, there were an estimated 19,292,789 new cancer cases in various localizations and 9,958,133 cancer deaths worldwide in 2020. These frightening figures clearly show that malignancies among the population is a pressing matter. The risk of post-transplant malignancy in solid organ recipients is 2–6-times higher than in the general population. Given the steadily increasing number of solid organ transplants worldwide and the gradual increase in life expectancy among organ recipients, studying the issues concerning risk factors and development mechanisms becomes a crucial task.
About the Authors
A. V. Nikulin
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Russian Federation
Andrey V. Nikulin
1, Shchukinskaya str., Moscow, 123182
I. V. Pashkov
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Moscow
Y. S. Yakunin
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Moscow
References
1. Katabathina V.S. et al. Malignancy after solid organ transplantation: Comprehensive imaging review. Radiographics. 2016; 36: 1390–1407. https://doi.org/10.1148/rg.2016150175
2. González-Cruz C., Ferrándiz-Pulido C., García-Patos Briones V. Melanoma in Solid Organ Transplant Recipients. Actas Dermosifiliogr. 2020. https://doi.org/10.1016/j.adengl.2021.01.011
3. Rousseau-Gazaniol C. et al. Lung cancer in renal transplant recipients: A case-control study. Lung Cancer. Elsevier Ireland Ltd. 2017; 111: 96–100. https://doi.org/10.1016/j.lungcan.2017.07.011
4. Acuna S.A. Etiology of increased cancer incidence after solid organ transplantation. Transplant. Rev. Elsevier Inc. 2018; 32: 218–224. https://doi.org/10.1016/j.trre.2018.07.001
5. Vajdic C.M., Van Leeuwen M.T. Cancer incidence and risk factors after solid organ transplantation. Int. J. Cancer. 2009; 125: 1747–1754. https://doi.org/10.1002/ijc.24439
6. Asch W.S., Perazella M.A. Cancer and Mortality in Solid-Organ Transplantation: Preventable or Inevitable? Am. J. Kidney Dis. 2016; 68: 839–842. https://doi.org/10.1053/j.ajkd.2016.06.009
7. Huo Z. et al. Cancer Risks in Solid Organ Transplant Recipients: Results from a Comprehensive Analysis of 72 Cohort Studies. Oncoimmunology. Taylor & Francis. 2020; 9. https://doi.org/10.1080/2162402X.2020.1848068
8. Brennan D.C. et al. Development of malignancy following solid organ transplantation. UpToDate. 2016; 10: 1–20.
9. Noone A.M. et al. Cancer-attributable mortality among solid organ transplant recipients in the United States: 1987 through 2014. Cancer. 2019; 125: 2647–2655.
10. Endén K. et al. Cancer morbidity and mortality after pediatric solid organ transplantation—a nationwide register study. Pediatr. Nephrol. Pediatric Nephrology. 2020; 35: 1719–1728. https://doi.org/10.1007/s00467-020-04546-y
11. Fogel A.L., Miyar M., Teng J.M.C. Cutaneous Malignancies in Pediatric Solid Organ Transplant Recipients. Pediatr. Dermatol. 2016; 33: 585–593.
12. Rademacher S. et al. The 28-year incidence of de novo malignancies after liver transplantation: A single-center analysis of risk factors and mortality in 1616 patients. Liver Transplant. 2017; 23: 1404–1414. https://doi.org/10.1002/lt.24795
13. Engels E.A. Cancer in Solid Organ Transplant Recipients: There Is Still Much to Learn and Do. Am. J. Transplant. 2017; 17: 1967–1969. https://doi.org/10.1111/ajt.14140
14. Legendre C. et al. Long-term challenges after solid organ transplantation: Summary of expert presentations from the Sandoz 5th standalone transplantation meeting, 2017. Transplantation. 2018; 102: 1–14. DOI: 10.1097/TP.0000000000002316
15. Wang X., Dong M. Malignancy After Lung Transplantation: How to Manage Immunosuppression? Transplant. Proc. Elsevier Inc. 2020; 52: 315–320. https://doi.org/10.1016/j.transproceed.2019.09.012
16. Yanik E.L. et al. Comparison of cancer diagnoses between the US solid organ transplant registry and linked central cancer registries. Am. J. Transplant. 2016; 16: 2986–2993. https://doi.org/10.1111/ajt.13818
17. Liao J.B., Fisher C.E., Madeleine M.M. Gynecologic cancers and solid organ transplantation. Am. J. Transplant. 2019; 19: 1266–1277. https://doi.org/10.1111/ajt.15292
18. Hall E.C. et al. Cumulative incidence of cancer after solid organ transplantation. Cancer. 2013; 119: 2300–2308. https://doi.org/10.1002/cncr.28043
19. Hellström V.C. et al. Malignancies in transplanted patients: Multidisciplinary evaluation and switch to mTOR inhibitors after kidney transplantation – experiences from a prospective, clinical, observational study. Acta Oncol. (Madr). 2016; 55: 774–781. https://doi.org/10.3109/0284186X.2015.1130855
20. Guillemin A. et al. Cancers solides après transplantation d’organe : épidémiologie, pronostic et spécificités de prise en charge. Bull. Cancer. Société Française du Cancer. 2017; 104: 245–257. https://doi.org/10.1016/j.bulcan.2016.12.008
21. Shtraichman O., Ahya V.N. Malignancy after lung transplantation. Ann. Transl. Med. 2020; 8: 416–416. DOI: 10.21037/atm.2020.02.126
22. Ridker P.M. et al. Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial. Lancet. 2017; 390: 1833–1842. https://doi.org/10.1016/S0140-6736(17)32247-X
23. Wareham N.E. et al. Risk of de novo or secondary cancer after solid organ or allogeneic haematopoietic stem cell transplantation. J. Cancer Res. Clin. Oncol. Springer Berlin Heidelberg. 2019; 145: 3125–3135. https://doi.org/10.1007/s00432-019-03039-2
24. Acuna S.A. et al. Cancer recurrence after solid organ transplantation: A systematic review and meta-analysis. Transplant. Rev. Elsevier Inc. 2017; 31: 240–248. https://doi.org/10.1016/j.trre.2017.08.003
Supplementary files
Review
For citations:
Nikulin A.V., Pashkov I.V., Yakunin Y.S. Post-transplant malignancies in solid organ recipients: development mechanisms and risk factors. Russian Journal of Transplantology and Artificial Organs. 2021;23(3):192-197. https://doi.org/10.15825/1995-1191-2021-3-192-197
Views:
573
Email this article 