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THE USE OF BIOLOGICAL PRODUCTS IN ABDOMINAL SURGERY AND LIVER TRANSPLANTATION

https://doi.org/10.15825/1995-1191-2013-2-148-155

Abstract

This article provides an overview of new approaches to the prevention of infectious complications of bacterial nature after the high-technology operations in the abdominal surgery, first of all, after liver transplantation. At- tention is drawn to the first positive results of randomized studies on the use of biological preparations - probi- otics, prebiotics and synbiotics in patients after liver transplantation. The authors prove the prospects of further development of this subject based on successful model experiments on animals and various operational interven- tions in abdominal surgery. 

About the Authors

N. I. Gabrielyan
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs (Head – academician of RAMSci S.V. Gautier), Moscow, Russian Federation


L. I. Arefieva
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs (Head – academician of RAMSci S.V. Gautier), Moscow, Russian Federation


E. M. Gorskaya
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs (Head – academician of RAMSci S.V. Gautier), Moscow, Russian Federation


M. N. Kornilov
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs (Head – academician of RAMSci S.V. Gautier), Moscow, Russian Federation


Y. G. Moysyuk
Department of Tansplantology and Artificial organs (Head – academician of RAMSci, prof. S.V. Gautier) I.M. Sechenov First Moscow State Medical University (Rector – corresponding member of RAMSci, prof. P.V. Glybochko), Moscow, Russian Federation


O. M. Tsirulnikova
Department of Tansplantology and Artificial organs (Head – academician of RAMSci, prof. S.V. Gautier) I.M. Sechenov First Moscow State Medical University (Rector – corresponding member of RAMSci, prof. P.V. Glybochko), Moscow, Russian Federation


References

1. Инфекции в трансплантологии / Под ред. С.В. Готье. М.: Триада, 2010. 382.

2. Infection in transplantation / Ed. S.V. Gautier M.: Triada, 2010. 382.

3. William N.T. Probiotics // Am. J. Health System – Phar- macy. 2010; 67 (6): 449–458.

4. Lata J., Jurankova J., Kopacova M. Probiotics in hepato- logy // World J. Gastroenterol. 2011; 17 (24): 2890.

5. Kinross J., von Roon A.C., Penney N. The gut microbiota

6. as a target for improved surgical outcome and improved

7. patient care // Curr. Pharm. Des. 2009. 15913: 1537–1545.

8. Хасанова Т.В. Использование бактиспорина и СПСА- вакцины для профилактики и лечения гнойно-септи- ческих осложнений в хирургии: Автореф. дис. ...

9. канд. мед. наук. Уфа, 2003.

10. Hasanova T.V. Using baktisporin and SPSA vaccine for the prevention and treatment of septic complications in surgery: Authoref. dis ... cand. med. nauk. Ufa, 2003.

11. Anderson A.D.G., McNaught C.E., Jain P.K., MacFie J. Randomised clinical trial of symbiotic therapy in electi- ve surgical patients // Gut. 2004; 53: 241–245.

12. Piselli P., Zanfi C., Corazza V. Incidence and timing of infections after liver transplant in Italy // Transplant. Proc. 2007; 39 (6): 1950–1952.

13. Saner F.H., Olde Damink S.W., Paviakovic G. Pulmona- ry and blood stream infections in adult living donor and cadaveric liver transplant patients // Ttransplantation. 2008; 85 (11): 1564–1568.

14. Jeong Eun Kim, Seak Hee Oh, Kyung Mo Kim Infec- tions after living donor liver transplantation in children // J. Korean Med. Sci. 2010; 25 (4): 527–531.

15. Jeppsson B., Mangell P., Thorlacius H. Use of probiotics as prophylaxis for postoperative infections // Nutrients. 2011; 3 (5): 604–612.

16. Wang H., Zhang W., Zuo L. Bifidobacteria may be bene- ficial to intestinal microbiota and reduction of bacterial translocation in mice following ischaemia and reperfusi- on injury // Br. J. Nutr. 2012; 5: 1–9.

17. Rayes N., Pilarski T., Stockmann M. Effect of pre- and probiotics on liver regeneration after resection: a ran- domized, double-blind pilot study // Benef. Microbes. 2012; 3 (3): 237–244.

18. Sahin I., Acar S., Ozaydin I. Investigation of the effects of probiotic bacteria on bacterial translocation that de- veloped during diagnostic laparoscopy: an experimental study // Microbiyol. Bul. 2012; 46 (4): 660–670.

19. Seehofer D., Rayes N., Schiller R. Probiotics partly re- verse increased bacterial translocation after simultane- ous liver resection and colonic anastomosis in rats // J.Surg. Res. 2004. 4. 117 (2): 262–271.

20. Zhou H.J, Yin L., Chen C.Q. Administration of probiotics reduces bacterial translocation after intestinal transplan- tation in rats // Transplant. Proc. 2010; 42 (10): 4643– 4647.

21. Jiang J.W., Ren Z.G., Chen L.Y. Enteral supplementation with glycyl-glutamine impoves intestinal barrier func- tion after liver transplantation in rats // Hepatobiliary Pancreat. Dis. Int. 2011; 10 (4): 380–385.

22. Reddy B.S., MacFie J., Gatt M. Randomized clinical trial of effect of synbiotics, neomycin and mechanical bowel preparation on intestinal barrier function in patients un- dergoing colectomy // Br. J. Surg. 2007; 94: 546–554.

23. Sugawara G., Nagino M., Nishio H. Perioperative syn- biotic treatment to prevent postoperative infectious com- plications in biliary cancer surgery: A randomized cont- rolled trial // Ann. Surg. 2006; 244: 706–714.

24. Hovart M., Krebs B., Potrč S. Preoperative synbiotic bo- wel conditioning for elective colorectal surgery // Wien. Klin. Wochenschr. 2010; 122: 26–30.

25. Rayes N., Hansen S., Seehofer D. Early enternal supply of fiber and Lactobacilli versus conventional nutrition: A controlled trial in patients with major abdominal sur- gery // Nutrition. 2002; 18: 609–615.

26. Rayes N., Seehofer D., Theruvath T. Supply of prend pro- biotics reduces bacterial infection rates after liver trans- plantation – a randomized, double-blind trial // Am. J. Transplant. 2005; 5 (1): 125–130.

27. Eguchi S., Takatsuki M., Hidaka M. Perioperative sym- biotic treatment to prevent infectious complications in patients after elective living donor liver transplantation: a prospective randomized study // Am. J. Surg. 2011; 201 (4): 498–502.

28. Malaguarnera M., Gargante M.P., Malaguarnera G. Bifidobacterium combined with fructo-oligosaccharie versus lactulose in the treatment of patients with hepatic encephalopathy // Eur. J. Gastroenterol. Hepatol. 2010. 22 (2): 199–206.

29. Sharma P., Sharma B.C., Puri V., Sarin S.K. An open-label randomized controlled trial of lactulose and probiotics in the treatment of minimal hepatic encephalopathy // Eur. J. Gastroenterol. Hepatol. 2008. 20 (6): 506–511.

30. Ren Z.G., Liu H., Jiang J.V.V. Protective effect of pro- biotics on intestinal brrier function in malnourished rats after liver transplantation // Hepatobilliary Pancreat Dis. Int. 2011. 10 (5): 489–496.

31. Uchida K., Takahashi T., Inoue M. Immunonutritional effects during synbiotics therapy in pediatric patients with short bowel syndrome // Pediatr. Surg. Int. 2007; 23 (3): 243–248.

32. Barnes J.L., Hartmann B., Holst J.J. Intestinal adaptati- on is stimulated by partial enteral nutrition supplemen- ted with the prebiotic short-chain fructooligosaccharide in neonatal intestinal piglet model // JPEN J. Parenter

33. Enteral Nutr. 2012; 36 (5): 524–537.

34. Осипова И.Г., Михайлова Н.А., Сорокулова И.Б., Ва-

35. сильева Е.А. Споровые пробиотики // Журн. микро- биол. 2003; 3: 113–119.

36. Osipova I.G., Mikhailova N.A., Sorokulova I.B., Vasilie- va E.A. Spore probiotics // Zhurn. mikrobiol. 2003; 3: 113–119.

37. Парахонский А.П. Роль бактериальной транслокации в развитии хирургического сепсиса // Успехи совре- менного естествознания. 2007; 7: 18–22. Parakhonskiy A.P. The role of bacterial translocation in the development of surgical sepsis // Success of modern science. 2007; 7: 18–22.

38. Пушкарев А.М. Эффективность пробиотика бак- тиспорина в терапии внутригоспитальных инфек- ций // Урология. 2005; 4: 48–53.

39. Pushkarev A.M. Efficiency of probiotic baktisporin in

40. hospital infections therapia // Urology. 2005; 4: 48–53. 31. Слепых Н.И., Третьяков А.А., Стадников А.А., Пет- ров С.В. Эффективность споробактерина в профи- лактике и лечении постоперационных раневых ин- фекций // Вестник хирургии им. Н.И. Грекова. 2003;

41. (1): 65–69.

42. Slepyh N.I., Tretyakov A.A., Stadnikov A.A., Petrov S.V.

43. Efficiency of sporobakterin in the prevention and treat- ment of post-operative wound infections // Vestnik sur- gery N.I. Grekova. 2003; 162 (1): 65–69.

44. Тарасенко В.С. Острый деструктивный панкреатит. Некоторые аспекты патогенеза и лечения: Автореф. дис. ... докт. мед. наук. Оренбург, 2000.

45. Tarasenko V.S. Acute destructive pancreatitis. Some as- pects of the pathogenesis and treatment: Aftoref. dis. ... doct. med. nauk. Orenburg, 2000.


For citation:


Gabrielyan N.I., Arefieva L.I., Gorskaya E.M., Kornilov M.N., Moysyuk Y.G., Tsirulnikova O.M. THE USE OF BIOLOGICAL PRODUCTS IN ABDOMINAL SURGERY AND LIVER TRANSPLANTATION. Russian Journal of Transplantology and Artificial Organs. 2013;15(2):148-155. (In Russ.) https://doi.org/10.15825/1995-1191-2013-2-148-155

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ISSN 1995-1191 (Print)
ISSN 2412-6160 (Online)