NON-LIPID MECHANISMS OF STATINS ACTION FOR HEART TRANSPLANT RECIPIENTS
https://doi.org/10.15825/1995-1191-2013-2-142-147
Abstract
Statins are widely used in the treatment of heart transplant recipients. It is assumed that the effectiveness of statins after heart transplantation is due not only to hypolipidemic effects, but also to non-lipid effects, including anti-inflammato- ry. In the review are presented the recently published results of the pro-and retrospective studies on the role of statins in the treatment of post-heart transplant recipients. Also there were analyzed the immunomodulatory and anti-in- flammatory mechanisms based on reduced levels of C-reactive protein, decreased concentration of cytokines (TNF-α, IL-6, IL-2R), suppression of tissue factor expression by monocytes etc. Another important factor is the role of statins in reducing the risk of cancer for transplant recipients. The use of statins in the treatment with immunosuppressive agents is an important factor in optimizing the long-term outcomes, reduction in the incidence of acute rejection and coronary artery disease of transplanted heart, increasing the duration and quality of life for heart transplant recipients.
About the Authors
А. О. Shevchenko
Department of cardiology (FPU) (Head – Prof. O.P. Shevchenko) Pirogov Russian National Research Medical University (Rector – Prof. A.G. Kamkin), Moscow, Russian Federation
Academician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation (Head – academician of RAMSci, prof. S.V. Gautier) Moscow, Russian Federation
T. A. Khalilulin
Academician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation (Head – academician of RAMSci, prof. S.V. Gautier) Moscow, Russian Federation
Department of Transplantation and Artificial Organs (Head – academician of RAMSci,
prof. S.V. Gauthier) First Moscow State Medical University named after I.M. Sechenov (Rector – corresponding member of RAMSci, prof. P.V. Glybochko), Moscow, Russian Federation
O. P. Shevchenko
Academician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation (Head – academician of RAMSci, prof. S.V. Gautier) Moscow, Russian Federation
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Review
For citations:
Shevchenko А.О., Khalilulin T.A., Shevchenko O.P. NON-LIPID MECHANISMS OF STATINS ACTION FOR HEART TRANSPLANT RECIPIENTS. Russian Journal of Transplantology and Artificial Organs. 2013;15(2):142-147. (In Russ.) https://doi.org/10.15825/1995-1191-2013-2-142-147
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