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INDIVIDUAL STABILITY OF STEREOTYPES OF IMMUNE REACTING AND MODERN POSSIBILITIES OF THEIR DIAGNOSTIC IN ORGAN TRANSPLANTATION (IMMUNE-PHYSIOLOGICAL ANALYSIS OF A PROBLEM)

https://doi.org/10.15825/1995-1191-2013-2-123-134

Abstract

The authors prove variants of immune reacting of an human organism in organ transplantation by existence of individual specific programs of reacting on alloantigens which, using natural activatory and inhibitory mecha- nisms, form various degree of stability of two physiological stereotypes of “behavior of immune system” – ef- fectoric and tolerogenic. For identification of an individual predominant stereotype of recipient immune reacting on a graft and for forecasting changes of an immunological homeostasis in a human organism, authors suggest to use indexes of reactance of immune system – conservatism and plasticity which can be taped by selection of the conforming biomarkers. Now the system of markers characterizing inflammatory reactions (infections/ inflammation) for recognition organ rejection and related complications, is widely used. For forecasting of an individual dominant stereotype of reacting in immunologically quiet post-transplant follow-up authors suggest to study a system of informative cellular markers of adaptive immunity and to use them for a formation of complex informative diagnostic immuno-cellular modules. 

About the Authors

N. A. Onischenko
Laboratory stem cells biotechnology (Head – prof. N.A. Onischenko) Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs (Head – academician of RAMSci, prof. S.V. Gautier), Moscow, Russian Federation


S. D. Artamonov
Laboratory stem cells biotechnology (Head – prof. N.A. Onischenko) Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs (Head – academician of RAMSci, prof. S.V. Gautier), Moscow, Russian Federation


M. E. Krasheninnikov
Laboratory stem cells biotechnology (Head – prof. N.A. Onischenko) Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs (Head – academician of RAMSci, prof. S.V. Gautier), Moscow, Russian Federation


L. V. Bashkina
Laboratory stem cells biotechnology (Head – prof. N.A. Onischenko) Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs (Head – academician of RAMSci, prof. S.V. Gautier), Moscow, Russian Federation


A. O. Nicolskaya
Laboratory stem cells biotechnology (Head – prof. N.A. Onischenko) Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs (Head – academician of RAMSci, prof. S.V. Gautier), Moscow, Russian Federation


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For citations:


Onischenko N.A., Artamonov S.D., Krasheninnikov M.E., Bashkina L.V., Nicolskaya A.O. INDIVIDUAL STABILITY OF STEREOTYPES OF IMMUNE REACTING AND MODERN POSSIBILITIES OF THEIR DIAGNOSTIC IN ORGAN TRANSPLANTATION (IMMUNE-PHYSIOLOGICAL ANALYSIS OF A PROBLEM). Russian Journal of Transplantology and Artificial Organs. 2013;15(2):123-134. (In Russ.) https://doi.org/10.15825/1995-1191-2013-2-123-134

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