COVID-19 in solid organ transplant recipients: initial report from national multicenter observational study «ROKKOR-recipient»
https://doi.org/10.15825/1995-1191-2020-3-8-17
Abstract
We herein present our initial report from «ROKKOR-recipient», a national multicenter observational study. The prevalence, risk factors, clinical manifestations and outcomes of the novel coronavirus disease 2019 (COVID-19) in solid organ transplant recipients receiving immunosuppressive therapy were investigated. The study enrolled 251 COVID-19 patients (220 kidney recipients, 7 liver recipients, 1 liver-kidney recipient, and 23 heart recipients). The subjects came from 20 regions in Russia. The symptoms, clinical presentation, imaging and lab test results, therapy and outcomes of COVID-19 were described. It was established that solid organ transplant recipients with COVID-19 have a higher risk of developing adverse events. Predictors of adverse events include associated cardiovascular diseases, pulmonary diseases, diabetes, and kidney failure. Symptoms of the disease include dyspnea, rash and catarrhal signs, as well as initial low blood oxygen saturation (SpO2 <92%), leukocytosis (white blood cell count >10 × 109/L), elevated creatinine levels (>130 μmol/L) and a marked decrease in glomerular filtration rate, requiring hemodialysis. Performing organ transplant surgery in COVID-19 does not increase the risk of adverse events but could save the lives of waitlisted terminally ill patients.
About the Authors
S. V. Gautier
Shumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov University
Russian Federation
Moscow
Russian Federation
Moscow
A. O. Shevchenko
Shumakov National Medical Research Center of Transplantology and Artificial Organs; Pirogov Medical University
Russian Federation
Russian Federation
Alexey Shevchenko.
Address: 1, Shchukinskaya str., Moscow, 123182, Russian Federation.
Phone: (495) 190-35-62.
O. M. Tsirulnikova
Sechenov University; Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Moscow
Russian Federation
Moscow
S. M. Khomyakov
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Moscow
Russian Federation
Moscow
O. N. Kotenko
Moscow City Scientific and Practical Center for Nephrology and Transplant Kidney Pathology, City Clinial Hospital No. 52
Russian Federation
Moscow
Russian Federation
Moscow
V. E. Vinogradov
Moscow City Scientific and Practical Center for Nephrology and Transplant Kidney Pathology, City Clinial Hospital No. 52; Research Institute of Health Care Organization and Medical Management
Russian Federation
Moscow
Russian Federation
Moscow
I. N. Abyzov
Republican Clinical Hospital
Russian Federation
Cheboksary
Russian Federation
Cheboksary
G. D. Avetisyan
Clinical Hospital No. 1
Russian Federation
Smolensk
Russian Federation
Smolensk
A. Yu. Anisimov
City Clinical Hospital No. 7
Russian Federation
Kazan
Russian Federation
Kazan
L. Yu. Artyukhina
Moscow City Scientific and Practical Center for Nephrology and Transplant Kidney Pathology, City Clinial Hospital No. 52
Russian Federation
Moscow
Russian Federation
Moscow
M. T. Bekov
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Moscow
Russian Federation
Moscow
V. A. Berdinsky
Moscow City Scientific and Practical Center for Nephrology and Transplant Kidney Pathology, City Clinial Hospital No. 52
Russian Federation
Moscow
Russian Federation
Moscow
V. S. Bogdanov
Moscow City Scientific and Practical Center for Nephrology and Transplant Kidney Pathology, City Clinial Hospital No. 52
Russian Federation
Moscow
Russian Federation
Moscow
A. Yu. Bykov
State Novosibirsk Regional Clinical Hospital
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
A. Yu. Vinokurov
Leningrad Regional Clinical Hospital
Russian Federation
St. Petersburg
Russian Federation
St. Petersburg
A. Yu. Goncharova
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Moscow
Russian Federation
Moscow
D. P. Evdokimov
Regional Clinical Hospital
Russian Federation
Krasnoyarsk
Russian Federation
Krasnoyarsk
D. V. Ezersky
Sergeev Regional Clinical Hospital No. 1
Russian Federation
Khabarovsk
Russian Federation
Khabarovsk
V. E. Zagainov
Volga Regional Medical Center
Russian Federation
Nizhny Novgorod
Russian Federation
Nizhny Novgorod
V. M. Zakharevich
Shumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov University
Russian Federation
Moscow
Russian Federation
Moscow
K. N. Zelenin
Ministry of Health of the Arkhangelsk Oblast
Russian Federation
Arkhangelsk
Russian Federation
Arkhangelsk
E. S. Ivanova
Moscow City Scientific and Practical Center for Nephrology and Transplant Kidney Pathology, City Clinial Hospital No. 52
Russian Federation
Moscow
Russian Federation
Moscow
A. A. Kartashev
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Moscow
Russian Federation
Moscow
N. G. Kvadratova
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Moscow
Russian Federation
Moscow
I. G. Kim
Moscow City Scientific and Practical Center for Nephrology and Transplant Kidney Pathology, City Clinial Hospital No. 52
Russian Federation
Moscow
Russian Federation
Moscow
N. N. Koloskova
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Moscow
Russian Federation
Moscow
V. L. Korobka
Rostov Regional Clinical Hospital
Russian Federation
Rostov-on-Don
Russian Federation
Rostov-on-Don
I. R. Kurbanuglov
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Moscow
Russian Federation
Moscow
M. A. Lysenko
Moscow City Scientific and Practical Center for Nephrology and Transplant Kidney Pathology, City Clinial Hospital No. 52
Russian Federation
Moscow
Russian Federation
Moscow
I. A. Miloserdov
Shumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov University
Russian Federation
Moscow
Russian Federation
Moscow
Ya. G. Moisyuk
Vladimirsky Moscow Regional Research Clinical Institute
Russian Federation
Moscow
Russian Federation
Moscow
G. V. Nikolaev
Almazov National Medical Research Centre
Russian Federation
St. Petersburg
Russian Federation
St. Petersburg
I. V. Ostrovskaya
Moscow City Scientific and Practical Center for Nephrology and Transplant Kidney Pathology, City Clinial Hospital No. 52
Russian Federation
Moscow
Russian Federation
Moscow
N. Yu. Petrova
Saratov Regional Clinical Hospital
Russian Federation
Saratov
Russian Federation
Saratov
A. V. Petryaev
Tula Regional Clinical Hospital
Russian Federation
Tula
Russian Federation
Tula
A. V. Pinchuk
Sklifosovsky Research Institute of Emergency Care
Russian Federation
Moscow
Russian Federation
Moscow
V. S. Platonov
District Clinical Hospital
Russian Federation
Khanty-Mansiysk
Russian Federation
Khanty-Mansiysk
V. N. Poptsov
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Moscow
Russian Federation
Moscow
Z. A. Porchkhidze
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Moscow
Russian Federation
Moscow
D. A. Saydulaev
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Moscow
Russian Federation
Moscow
A. D. Sapozhnikov
Shumakov National Medical Research Center of Transplantology and Artificial Organs in the City of Volzhsky
Russian Federation
Volzhsky
Russian Federation
Volzhsky
S. B. Semchenko
Center for Organ and Tissue Transplantation, Regional Clinical Hospital No. 1
Russian Federation
Tyumen
Russian Federation
Tyumen
M. M. Skorobogatov
District Clinical Hospital
Russian Federation
Khanty-Mansiysk
Russian Federation
Khanty-Mansiysk
V. Yu. Tereshchenko
Kabanov City Clinical Hospital No. 1
Russian Federation
Omsk
Russian Federation
Omsk
N. F. Frolova
Moscow City Scientific and Practical Center for Nephrology and Transplant Kidney Pathology, City Clinial Hospital No. 52
Russian Federation
Moscow
Russian Federation
Moscow
D. V. Khalikova
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Moscow
Russian Federation
Moscow
T. A. Khalilulin
Shumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov University
Russian Federation
Moscow
Russian Federation
Moscow
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Review
For citations:
Gautier S.V., Shevchenko A.O., Tsirulnikova O.M., Khomyakov S.M., Kotenko O.N., Vinogradov V.E., Abyzov I.N., Avetisyan G.D., Anisimov A.Yu., Artyukhina L.Yu., Bekov M.T., Berdinsky V.A., Bogdanov V.S., Bykov A.Yu., Vinokurov A.Yu., Goncharova A.Yu., Evdokimov D.P., Ezersky D.V., Zagainov V.E., Zakharevich V.M., Zelenin K.N., Ivanova E.S., Kartashev A.A., Kvadratova N.G., Kim I.G., Koloskova N.N., Korobka V.L., Kurbanuglov I.R., Lysenko M.A., Miloserdov I.A., Moisyuk Ya.G., Nikolaev G.V., Ostrovskaya I.V., Petrova N.Yu., Petryaev A.V., Pinchuk A.V., Platonov V.S., Poptsov V.N., Porchkhidze Z.A., Saydulaev D.A., Sapozhnikov A.D., Semchenko S.B., Skorobogatov M.M., Tereshchenko V.Yu., Frolova N.F., Khalikova D.V., Khalilulin T.A. COVID-19 in solid organ transplant recipients: initial report from national multicenter observational study «ROKKOR-recipient». Russian Journal of Transplantology and Artificial Organs. 2020;22(3):8-17. https://doi.org/10.15825/1995-1191-2020-3-8-17
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