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Фибрин – перспективный материал для тканевой сосудистой инженерии

https://doi.org/10.15825/1995-1191-2020-1-196-208

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Аннотация

В данном обзоре свойства фибрина рассматриваются с позиции возможности использования в тканевой сосудистой инженерии (ТСИ). Аутологичный фибрин является одним из самых доступных биополимеров, поскольку с помощью несложных методик может быть получен из периферической крови. В обзоре даны описание и сравнительная характеристика методов и подходов получения фибринового геля. Способности фибрина поддерживать адгезию и миграцию, служить биологической клеточной нишей, контролировать ангиогенез, накапливать и дозированно высвобождать факторы роста являются уникальными и крайне полезными в ТСИ. Огромный потенциал формования позволяет получать сложные трехмерные формы, использовать фибрин как самостоятельный каркас или в качестве модифицирующего покрытия/пропитки. Фибриновые гели способны к полной биодеградации с помощью фибринолиза, но этот процесс должен хорошо контролироваться и быть предсказуемым. В обзоре обсуждаются основные способы регуляции скорости фибринолиза, а также возможные побочные эффекты такого воздействия. Низкая механическая прочность является главным ограничением использования фибрина в качестве основного каркаса в сосудистых протезах. В работе представлены возможные варианты повышения прочностных свойств фибриновой матрицы и дана оценка их эффективности. С учетом всех уникальных свойств и особенностей фибрин вполне может стать основой для идеального полностью аутологичного тканеинженерного сосудистого протеза малого диаметра.

Об авторах

В. Г. Матвеева
ФГБУ «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»
Россия

Матвеева Вера Геннадьевна. 

650002, Кемерово, Сосновый бульвар, д. 6.



М. Ю. Ханова
ФГБУ «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»
Россия
Кемерово


Л. В. Антонова
ФГБУ «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»
Россия
Кемерово


Л. С. Барбараш
ФГБУ «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»
Россия
Кемерово


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Для цитирования:


Матвеева В.Г., Ханова М.Ю., Антонова Л.В., Барбараш Л.С. Фибрин – перспективный материал для тканевой сосудистой инженерии. Вестник трансплантологии и искусственных органов. 2020;22(1):196-208. https://doi.org/10.15825/1995-1191-2020-1-196-208

For citation:


Matveeva V.G., Khanova M.U., Antonova L.V., Barbarash L.S. Fibrin – a promising material for vascular tissue engineering. Russian Journal of Transplantology and Artificial Organs. 2020;22(1):196-208. (In Russ.) https://doi.org/10.15825/1995-1191-2020-1-196-208

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ISSN 1995-1191 (Print)
ISSN 2412-6160 (Online)