Therapeutic potential of stem cell and cell-free therapies for acute and chronic kidney failure

Despite the global increase in the number of patients requiring care for end-stage chronic kidney disease (CKD), the demand for renal replacement therapy continues to exceed healthcare capacity. This gap underscores the need for innovative strategies to prevent the progression of acute kidney injury (AKI) to CKD. One promising approach is stem cell (SC) therapy, involving cells derived from various tissues or their secretory products (SC secretome). This review examines current evidence on the potential of cell-based therapies to promote regeneration of damaged renal structures by enhancing adaptive and compensatory mechanisms and suppression of maladaptive responses in kidney injury. Experimental studies demonstrate that SC therapy significantly improves renal function, accelerates recovery in AKI, and reduces the risk of progression to CKD. Notably, SC secretome therapy appears to be comparably effective to the use of stem cells themselves. Factors limiting the efficacy of cell therapy and potential strategies to overcome these challenges are also discussed.

1. Ronco C, Bellomo R, Kellum JA. Acute kidney injury. Lancet. 2019; 394: 1949–1964.

2. Al‑Jaghbeer M, Dealmeida D, Bilderback A, Ambrosino R, Kellum JA. Clinical Decision Support for In-Hospital AKI. J Am Soc Nephrol. 2018; 29: 654–660.

3. Jager KJ, Kovesdy C, Langham R Rosenberg M, Jha V, Zoccali C. A single number for advocacy and communication-worldwide more than 850 million individuals have kidney diseases. Nephro Dia Transplant. 2019; 34 (11): 1803–1805.

4. Andrusev AM, Peregudova NG, Shinkarev MB, Tomilina NA. Kidney replacement therapy for end Stage Kidney disease in Russian Federation, 2016-2020 Russian National Kidney Replacement Therapy. Registry Report of Russian Public Organization of Nephrologists «Russian Dialysis Society». Nephrology and Dialysis. 2022; 24 (4): 555–565. [In Russ]. https://doi.org/10.28996/2618-9801-2022-4-555-565.

5. Gautier SV, Khomyakov SM. Organ donation and transplantation in the Russian Federation in 2024. 17th Report from the Registry of the Russian Transplant Society. Russian Journal of Transplantology and Artificial Organs. 2025; 27 (3): 8–32. [In Russ, English abstract]. https://doi.org/10.15825/1995-1191-2025-3-8-32.

6. Yang J, Endo Y, Munir MM, Woldesenbet S, Altaf A, Limkemannet A et al. Waitlist Time, Age, and Social Vulnerability: Impact on the Survival Benefit of Deceased Donor Kidney Transplantation Versus Long-term Dialysis Among Patients With End-stage Renal Disease. Transplantation. 2025; 109 (1): e64–e74. doi: 10.1097/TP.000000000000512.

7. Rota C, Morigi M, Imberti B. Stem cell therapies in kidney diseases: progress and challenges. Int J Mol Sci. 2019; 20: 2790. https://doi.org/10.3390/ijms20112790.

8. Wang Z, Zhang C. From AKI to CKD: maladaptive repair and the underlying mechanisms. Int J Mol Sci. 2022; 23 (18): 10880.

9. Kellum JA, Romagnani P, Ashuntantang G, Ronco C, Zarbock A, Anders HJ. Acute kidney injury. Nat Rev Dis Primers. 2021; 7: 52.

10. Puthumana J. Thiessen‑Philbrook H, Xu L, Coca SG, Garg AX, Himmelfarb J et al. Biomarkers of inflammation and repair in kidney disease progression. J Clinl Invest. 2021; 131 (3): e139927. doi: 10.1172/JCI139927.

11. Kim CS, Bae EH, Ma SK, Kweon SS, Kim SW. Impact of Transient and Persistent Acute Kidney Injury on Chronic Kidney Disease Progression and Mortality after Gastric Surgery for Gastric Cancer. PLoS One. 2016; 11: e0168119.

12. Kirpatovskiy VI, Sokolov MA, Rabinovich EZ, Sivkov AV. Cellular and humoral mechanisms of renal regeneration. Experimental & Clinical Urology. 2017; 2: 102–111. [In Russ, English abstract].

13. Huang J, Kong Y, Xie C, Zhou L. Stem/progenitor cell in kidney: characteristics, homing, coordination, and maintenance. Stem Cell Res Ther. 2021; 12 (1): 197. doi: 10.1186/s13287-021-02266-0.

14. Suzuki E, Fujita D, Takahashi M, Oba S, Nishimatsu H. Adult stem cells as a tool for kidney regeneration. World J Nephrol. 2016; 5 (1): 43–52. doi: 10.5527/wjn. v5.i1.43.

15. Shankland SJ, Pippin JW, Duffield JS. Progenitor cells and podocyte regeneration. Semin Nephrol. 2014; 34 (4): 418–428. doi: 10.1016/j.semnephrol.2014.06.008.

16. Angelotti ML, Ronconi E, Ballerini L, Peired A, Mazzinghi B, Sagrinati C et al. Characterization of renal progenitors committed toward tubular lineage and their regenerative potential in renal tubular injury. Stem Cells. 2012; 30 (8): 1714–1725. doi: 10.1002/stem.1130.

17. Rinkevich Y, Montoro DT, Contreras‑Trujillo H, Harari-Steinberg O, Newman AM, Tsai JM et al. In vivo clonal analysis reveals lineage-restricted progenitor characteristics in mammalian kidney development, maintenance, and regeneration. Cell Rep. 2014; 7: 1270–1283. doi: 10.1016/j.celrep.2014.04.018.

18. Kusaba T, Lalli M, Kramann R, Kobayashi A, Humphreys BD. Differentiated kidney epithelial cells repair injured proximal tubule. Proc Natl Acad Sci USA. 2014; 111 (4): 1527–1532. doi: 10.1073/pnas.1310653110.

19. Miya M, Maeshima A, Mishima K, Sakurai N, Ikeuchi H, Kuroiwa T et al. Age related decline in label-retaining tubular cells: implication for reduced regenerative capacity after injury in the aging kidney. Am J Physiol Renal Physiol. 2012302 (6): F694–F702. doi: 10.1152/ajprenal.00249.201.

20. Geng H, Lan R, Singha PK, Gilchrist A, Weinreb PH, Violette SM et al. Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Galphaq-mediated Rho and alphavbeta6 integrin-dependent activation of TGF-beta. Am J Pathol. 2012, 181, 1236–1249.

21. Vanden Berghe T, Linkermann A, Jouan‑Lanhouet S, Walczak H, Vandenabeele P. Regulated necrosis: The expanding network of non-apoptotic cell death pathways. Nat Rev Mol Cell Biol. 2014; 15: 135–147.

22. Zuk A, Bonventre JV. Acute Kidney Injury. Annu Rev Med. 2016; 67: 293–307.

23. Fligny C, Duffield JS. Activation of pericytes: recent insights into kidney fibrosis and microvascular rarefaction. Curr Opin Rheumatol. 2013; 25 (1): 78–86. doi: 10.1097/BOR.0b013e32835b656b.

24. Ullah MM, Basile DP. Role of renal hypoxia in the progression from acute kidney injury to chronic kidney disease. Seminars in nephrology. – WB Saunders. 2019; 39 (6): 567–580.

25. Xu Y, Zou P, Cao X. Advances in pharmacotherapy for acute kidney injury. Expert Opin Pharmacother. 2022; 23 (6): 713–726. doi: 10.1080/14656566.2022.2050214.

26. Ahmadi A, Rad NK, Ezzatizadeh V, Moghadasali R. Kidney regeneration: stem cells as a new trend. Curr Stem Cell Res Ther. 2020; 15 (3): 263–283.

27. Marcheque J, Bussolati B, Csete M, Perin L. Concise Reviews: Stem Cells and Kidney Regeneration: An Update. Stem Cells Transl Med. 2019; 8: 82–92.

28. Wong CY. Current advances of stem cell-based therapy for kidney diseases. World J Stem Cells. 2021; 13 (7): 914–933.

29. Liu D, Cheng F, Pan S, Liu Z. Stem cells: a potential treatment option for kidney diseases. Stem Cell Res Ther. 2020; 11 (1): 249. doi: 10.1186/s13287-020-01751-2.

30. Chen F, Chen N, Xia C, Wang H, Shao L, Zhou C, Wang J. Mesenchymal Stem Cell Therapy in Kidney Diseases: Potential and Challenges. Cell Transplant. 2023; 32: 1–23. doi: 10.1177/09636897231164.

31. Golle L, Gerth HU, Beul K, Heitplatz B, Barth P, Fobker M et al. Bone marrow-derived cells and their conditioned medium induce microvascular repair in uremic rats by stimulation of endogenous repair mechanisms. Sci Rep. 2017; 7: 9444.

32. Zhang JB, Wang X, Lu GL, Huang HS, Xu SY. Adipose-derived mesenchymal stem cells therapy for acute kidney injury induced by ischemia-reperfusion in a rat model. Clin Exp Pharmacol Physiol. 2017; 44 (12): 1232–1240. doi: 10.1111/1440-1681.12811.

33. Lee KH, Tseng WC, Yang CY, Tarng DC. The antiinflammatory, anti-oxidative, and anti-apoptotic benefits of stem cells in acute ischemic kidney injury. Int J Mol Sci. 2019; 20 (14): 3529.

34. Yun CW, Lee SH. Potential and therapeutic efficacy of cell-based therapy using mesenchymal stem cells for acute/chronic kidney disease. Int J Mol Sci. 2019; 20 (7): 1619. https://doi.org/10.3390/ijms20071619.

35. Sivanathan KN, Coates PT. Improving human kidney function in renovascular disease with mesenchymal stem cell therapy. Kidney Int. 2020; 97 (4): 655–656. doi: 10.1016/j.kint.2019.12.020.

36. Textor SC, Abumoawad A, Saad A, Ferguson C, Dietz A. Stem Cell Therapy for Microvascular Injury Associated with Ischemic Nephropathy. Cells. 2021; 10 (4): 765. doi: 10.3390/cells10040765.

37. Cianci R, Simeoni M, Cianci E, De Marco O, Pisani A, Ferri C et al. Stem Cells in Kidney Ischemia: From Inflammation and Fibrosis to Renal Tissue Regeneration. Int J Mol Sci. 2023; 24 (5): 4631. doi: 10.3390/ijms24054631.

38. Selamet U, Ahdoot RS, Salasnek R, Abdelnour L, Hanna RM. Onconephrology: mitigation of renal injury in chemotherapy administration. Curr Opin Nephrol Hypertens. 2024; 33 (2): 257–266. doi: 10.1097/MNH.0000000000000960.

39. Van der Vorst MJDL, Neefjes ECW, Toffoli EC, Oosterling‑Jansen JEW, Vergeer MR, Leemans CR et al. Incidence and risk factors for acute kidney injury in head and neck cancer patients treated with concurrent chemoradiation with high-dose cisplatin. BMC Cancer. 2019; 19 (1): 1066.

40. Missoum A. Recent Updates on Mesenchymal Stem Cell Based Therapy for Acute Renal Failure. Curr Urol. 2020; 13 (4): 189–199. doi: 10.1159/000499272.

41. Karimzadeh P, Foroutan T, Nafar M, Kalavati S. Impact of Nanographene Oxide on Cisplatin Induced Acute Kidney Injury Managed by Stem Cells Therapy. Iran J Kidney Dis. 2023; 17 (5): 271–280. doi: 10.52547/ijkd.7472.

42. Ranjbar E, Tavakol Afshari J, KhajaviRad A, Ebrahimzadeh‑Bideskan A, Shafieian R. Insights into the protective capacity of human dental pulp stem cells and its secretome in cisplatin-induced nephrotoxicity: effects on oxidative stress and histological changes. J Basic Clin Physiol Pharmacol. 2022; 34 (3): 349–356. doi: 10.1515/jbcpp-2022-0159.

43. Abdelrahman SA, Raafat N, Abdelaal GMM, Aal SMA. Electric field-directed migration of mesenchymal stem cells enhances their therapeutic potential on cisplatin-induced acute nephrotoxicity in rats. Naunyn Schmiedebergs Arch Pharmacol. 2023; 396 (6): 1077–1093. doi: 10.1007/s00210-022-02380-7.

44. Ganguly A, Chetty S, Primavera R, Levitte S, Regmi S, Dulken BW et al. Time-course analysis of cisplatin induced AKI in preclinical models: implications for testing different sources of MSCs. J Transl Med. 2024; 22: 789. https://doi.org/10.1186/s12967-024-05439-6.

45. Kou M, Huang L, Yang J, Chiang Z, Chen S, Liu J et al. Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool? Cell Death Dis. 2022; 13 (7): 580.

46. Xia J, Minamino S, Kuwabara K, Arai S. Stem cell secretome as a new booster for regenerative medicine. Biosci Trends. 2019; 13 (4): 299–307. https://doi.org/10.5582/bst.2019.01226.

47. Vizoso FJ, Eiro N, Cid S, Schneider, Perez‑Fernandez R. Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine. Int J Mol Sci. 2017 (18): 1852. https://doi.org/10.3390/ijms1809185.

48. Groth CG, Andersson A, Bjorken C, Gunnarsson R, Hellerström C, Lundgren G et al. Transplantation of fetal pancreatic microfragments via the portal vein to a diabetic patient. Diabetes. 1980; 29 (suppl 1): 80–83.

49. Zhu RP, Lin XY, Wang JT. Fetal hepatocellular suspension transfusion (FHST) in the treatment of chronic active hepatitis B. Chung Hua Nei Ko Tsa Chih. 1990; 29: 419–421.

50. Harousseau JL, Devergie A, Lawler S, Gluckman E, Schaison G. Implant of fetal liver in severe bone marrow aplasia. Nouv Rev Francaise D’Hematologie. 1980; 22 (Suppl.): 572.

51. Hitchcock ER, Clough CG, Hughes RC, Kenny BG. Transplantation in Parkinson’s disease: stereotactic implantation of adrenal medulla and foetal mesencephalon. Acta Neurochir Suppl (Wieni). 1988; 46: 48–50. https:// doi.org/10.1007/978-3-7091-9029-6_11.

52. Saveliev SV. Transplantation of the embryonic brain. Arkhiv Patologii = Archive of Pathology. 1992; 54 (11): 43–46. [In Russ].

53. Carroll J, Gosden RG. Transplantation of frozen-thawed mouse primordial follicles. Hum Reprod. 1993; 8 (8): 1163–1167. https://doi.org/10.1093/oxfordjournals.humrep.a138221.

54. Kirpatovskiy ID, Dendeberov ES. Sposob lechenija vtorichnogo gipogonadizma. Patent RUS № 2177735.2002. [In Russ].

55. Chouaib B, Haack‑Sørensen M, Chaubron F, Cuisinier F, Collart‑Dutilleul PY. Towards the standardization of mesenchymal stem cell secretome-derived product manufacturing for tissue regeneration. Int J Mol Sci. 2023; 24 (16): 12594. https://doi.org/10.3390/ijms241612594.

56. Pushkar DYu, Kupriyanov YA, Gamidov SI, Krivoborodov GG, Spivak LG, Al‑Shukri SKh et al. Safety and efficacy of Vesusten® for patients with overactive bladder. Urologia. 2022; (3): 42–51. [In Russ]. https://doi.org/10.18565/urology.2022.3.42-51.

57. Khavinson VKh. Peptide medicines: past, present, future. Clinical Medicine (Russian Journal). 2020; 98 (3): 165–177. [In Russ]. https://doi.org/10.30629/0023-2149-2020-98-3-165-177.

58. Tsukanov AYu, Baypakova MI, Dorofeeva VP, Leonov OV, Glatko SB, Novoselov AV et al. Use of cattle bladder peptides in radiation injury of the bladder in a chronic experiment. Experimental and Clinical Urology. 2025; 18 (1): 18–26. [In Russ, English abstract]. https://doi.org/10.29188/2222-8543-2025-18-1-18-26.

59. Khochenkova YuA, Machkova YuS, Khochenkov DA, Sidorova TA, Safarova ER, Bastrikova NA et al. A study of the mechanisms of action of Fertiwell in vivo. Urologiia. 2023; (1): 60–70. [In Russ, English abstract]. https://doi.org/10.18565/urology.2023.1.60-70.

60. Bogatcheva NV, Coleman ME. Conditioned medium of mesenchymal stromal cells: a new class of therapeutics. Biochemistry (Mosc). 2019; 84 (11): 1375–1389. https://doi.org/10.1134/S0006297919110129.

61. Wang SY, Hong Q, Zhang CY, Yang YJ, Cai GY, Chen XM. miRNAs in stem cell-derived extracellular vesicles for acute kidney injury treatment: comprehensive review of preclinical studies. Stem Cell Res Ther. 2019; 10 (1): 281. https://doi.org/10.1186/s13287-019-1371-1.

62. Pokul LV, Orazov MR, Lebedeva MG. Overactive bladder in patients after hysterectomy. Features of therapy with regulatory peptides. Zhenskaya klinika = Women’s clinic. 2024; (2–3): 35–43. [In Russ, English abstract].

63. Kamchatnov PR, Izmajlov IA, Sokolov MA. The results of the use of the drug Cellex in patients with cerebrovascular diseases. Nervnie bolezni. 2018; 1: 26–30. [In Russ].

64. Kirpatovskiy VI., Sivkov AV, Golovanov SA, Drozhzheva VV, Samoilova SI, Rabinovich EZ et al. Prevention of the development of acute post-ishemicrenal insufficiency using a protein-peptide complex of embryonal tissue. Experimental and clinical urology. 2019; (3): 32–39.

65. Kirpatovskiy VI, Sivkov AV, Nazirov MR, Efremov GD, Sokolov MA, Komarova ZhV et al. Therapy with a protein-peptide complex of embryonic stem cells as a method of reducing the nephrotoxic effect of the chemotherapy drug cisplatin. Onkourologiya – Cancer Urology. 2025; 21 (2): 198–210. [In Russ, English abstract]. https://doi.org/10.17650/1726-9776-2025-21-2-198-210.

66. Tsuji K, Kitamura S, Sang Y, Fukushima K, Wada J. Adult kidney stem/progenitor cells contribute to regeneration through the secretion of trophic factors. Stem Cell Res. 2020; 46: 101865. doi: 10.1016/j.scr.2020.101865.

67. Machiguchi T, Nakamura T. Nephron generation in kidney cortices through injection of pretreated mesenchymal stem cell-differentiated tubular epithelial cells. Biochem Biophys Res Commun. 2019; 518 (1): 141–147. doi: 10.1016/j.bbrc.2019.08.022.

68. Arifin A, Purwanto B, Indarto D, Wasita B, Sumanjar T, Pamungkasari EP, Soetrisno S. Improvement of renal functions in mice with septic acute kidney injury using secretome of mesenchymal stem cells. Saudi J Biol Sci. 2024; 31 (3): 103931. doi: 10.1016/j.sjbs.2024.103931.

69. Van Koppen A, Joles JA, van Balkom BW, Lim SK, de Kleijn D, Giles RH et al. Human embryonic mesenchymal stem cell-derived conditioned medium rescues kidney function in rats with established chronic kidney disease. PLoS One. 2012; 7: e38746.

70. Aghajani Nargesi A, Lerman LO, Eirin A. Mesenchymal stem cell-derived extracellular vesicles for kidney repair: current status and looming challenges. Stem Cell Res Ther. 2017; 8 (1): 273.

71. Quaglia M, Merlotti G, Colombatto A, Bruno S, Stasi A, Franzin R et al. Stem Cell-Derived Extracellular Vesicles as Potential Therapeutic Approach for Acute Kidney Injury. Front Immunol. 2022; 13: 849891. doi: 10.3389/fimmu.2022.849891.

72. Eirin A, Lerman LO. Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles for Chronic Kidney Disease: Are We There Yet? Hypertension. 2021; 78 (2): 261–269. doi: 10.1161/HYPERTENSIONAHA.121.14596.

73. Li L, Wang R, Jia Y, Rong R, Xu M, Zhu T. Exosomes derived from mesenchymal stem cells ameliorate renal ischemic-reperfusion injury through inhibiting inflammation and cell apoptosis. Front Med. 2019; 6: 269.

74. Birtwistle L, Chen XM, Pollock C. Mesenchymal stem cell derived extracellular vesicles to the rescue of renal injury. Int J Mol Sci. 2021; 22 (12): 6596.

75. Lim SW, Kim KW, Kim BM, Shin YJ, Luo K, Quan Y et al. Alleviation of renal ischemia/reperfusion injury by exosomes from induced pluripotent stem CW. cell-derived mesenchymal stem cells. Korean J Intern Med. 2022; 37 (2): 411–424. doi: 10.3904/kjim.2020.438.

76. Gao F, Zuo B, Wang Y, Li S, Yang J, Sun D. Protective function of exosomes from adipose tissue-derived mesenchymal stem cells in acute kidney injury through SIRT1 pathway. Life Sci. 2020; 255: 117719.

77. Song T, Eirin A, Zhu X, Zhao Y, Krier JD, Tang H et al.. Mesenchymal stem cell-derived extracellular vesicles induce regulatory T cells to ameliorate chronic kidney injury. Hypertension. 2020; 75 (5): 1223–1232.

78. Alasmari WA, El‑Shetry ES, Ibrahim D, El‑Sawy NA, Eldoumani H, Metwally AS et al. Mesenchymal stem-cells’ exosomes are renoprotective in postmenopausal chronic kidney injury via reducing inflammation and degeneration. Free Radic Biol Med. 2022; 182: 150–159.

79. Wechsler ME, Rao VV, Borelli AN, Anseth KS. Engineering the MSC secretome: a hydrogel focused approach. Adv Healthc Mater. 2021; 10 (7): e2001948.

80. Liu Y, Han J, Fang J, Li R. The Beneficial Effects of Mesenchymal Stem Cells in Acute Kidney Injury: A Narrative Review. Curr Stem Cell Res Ther. 2024; 19 (2): 200–209. doi: 10.2174/1574888X18666230206115046.

81. Schmuck EG, Koch JM, Centanni JM, Hacker TA, Braun RK, Eldridge M et al. Biodistribution and clearance of human mesenchymal stem cells by quantitative three-dimensional cryo-imaging after intravenous infusion in a rat lung injury model. Stem Cells Transl Med. 2016; 5 (12): 1668–1675.

82. Herberts CA, Kwa MS, Hermsen HP. Risk factors in the development of stem cell therapy. J Transl Med. 2011; 9: 29.

83. Bagno LL, Salerno AG, Balkan W, Hare JM. Mechanism of action of mesenchymal stem cells (MSCs): impact of delivery method. Expert Opin Biol Ther. 2022; 22 (4): 449–463.

84. Huang M, Li D, Chen J, Ji Y, Su T, Chen Y et al. Comparison of the treatment efficacy of umbilical mesenchymal stem cell transplantation via renal subcapsular and parenchymal routes in AKI-CKD mice. Stem Cell Res Ther. 2022; 13 (1): 128.

85. Yim HE, Kim DS, Chung HC, Shing B. Controlled Delivery of Stem Cell-Derived Trophic Factors Accelerates Kidney Repair After Renal Ischemia-Reperfusion Injury in Rats. Stem Cells Transl Med. 2019; 8: 959–970.

86. Tarng DC, Tseng WC, Lee PY, Chiou SH, Hsieh SL. Induced pluripotent stem cell-derived conditioned medium attenuates acute kidney injury by downregulating the oxidative stress-related pathway in ischemia-reperfusion rats. Cell Transplant. 2016; 25: 517–530.

87. Abedi A, Azarnia M, Jamali Zahvarehy M, Foroutan T, Golestani S. Effect of different times of intraperitoneal injections of human bone marrow mesenchymal stem cell conditioned medium on gentamicin-induced acute kidney injury. Urol J. 2016; 13: 2707–2716.

88. Burst VR, Gillis M, Pütsch F, Herzog R, Fischer JH, Heid P et al. Poor cell survival limits the beneficial impact of mesenchymal stem cell transplantation on acute kidney injury. Nephron Exp Nephrol. 2010; 114 (3): e107–e116.

89. Jiang Y, Wang Y, Li Q, Yu C, Chu W. Natural polymer-based stimuliresponsive hydrogels. Curr Med Chem. 2020; 27 (16): 2631–2657.

90. Unal AZ, West JL. Synthetic ECM: bioactive synthetic hydrogels for 3D tissue engineering. Bioconjug Chem. 2020; 31 (10): 2253–2271.

91. Wang H, Shang Y, Chen X, Wang Z, Zhu D, Liu Y et al. Delivery of MSCs with a hybrid beta-sheet peptide hydrogel consisting IGF-1C domain and D-form peptide for acute kidney injury therapy. Int J Nanomed. 2020; 15: 4311–4324.

92. Fu Z, Zhang Y, Geng X, Chi K, Liu C, Songet C al. Optimization strategies of mesenchymal stem cell-based therapy for acute kidney injury. Stem Cell Res Ther. 2023; 14: 116: 2–16. doi: 10.1186/s13287-023-03351-2.

93. Yap JX, Leo CP, Mohd Yasin NH, Show PL, Chu DT, Singh V et al. Recent advances of natural biopolymeric culture scaffold: synthesis and modification. Bioengineered. 2022; 13 (2): 2226–2247.

94. Jansen K, Schuurmans CCL, Jansen J, Masereeuw R, Vermonden T. Hydrogel-Based Cell Therapies for Kidney Regeneration: Current Trends in Biofabrication and In Vivo Repair. Curr Pharm Des. 2017; 23 (26): 3845–3857. doi: 10.2174/1381612823666170710155726.

95. Huang S, Li Y, Wang X, Ma X, Zhang X. Injectable cogels of collagen and decellularized vascular matrix improve MSC-based therapy for acute kidney injury. J Biomater Sci Polym Ed. 2017; 28 (18): 2186–2195.

96. Sevastianov VI, Perova NV. Biopolimerniy geterogenniy gydrogel SFERO®gel – in’ektsionniy biodegradiruemiy implantat dlia zamestitelnoy i regeneratsioonnoy meditsine. Prakticheskaja meditsina. 2014; 8 (84): 120–126. [In Russ].

97. Zhou Y, Xu H, Xu W, Wang B, Wu H, Tao Y et al. Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro. Stem Cell Res Ther. 2013; 4 (2): 34.

98. Jahandideh S, Khatami S, Eslami Far A, Kadivar M. Anti-inflammatory effects of human embryonic stem cell-derived mesenchymal stem cells secretome preconditioned with diazoxide, trimetazidine and MG-132 on LPS-induced systemic inflammation mouse model. Artif Cells Nanomed Biotechnol. 2018; 46 (sup2): 1178–1187. doi: 10.1080/21691401.2018.1481862.