Lung cancer in solid organ transplant recipients
https://doi.org/10.15825/25/1995-1191-2021-4-19-25
Abstract
Lung cancer remains the leading cause of cancer mortality worldwide. Solid organ transplant recipients are at risk of developing malignant tumors, including lung cancer, due to long-term use of immunosuppressive drugs. Development of cancer, including lung cancer, in this patient cohort, has a number of peculiarities. Moreover, malignant tumors in these patients are difficult to treat and have a poorer prognosis. This review presents a study of the issues concerning the mechanisms of lung cancer development, screening methods and treatment in solid organ transplant recipients.
About the Authors
A. V. Nikulin
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Russian Federation
Andrey Nikulin
1, Shchukinskaya str., Moscow, 123182, Russian Federation
Phone: (495) 190-35-62
I. V. Pashkov
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Russian Federation
Moscow
Ya. S. Yakunin
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Russian Federation
Moscow
References
1. Bade BC, Dela Cruz CS. Lung Cancer 2020: Epidemiology, Etiology and Prevention. Clin Chest Med Elsevier Inc. 2020; 41 (1): 1–24. doi: 10.1016/j.ccm.2019.10.001.
2. Wareham NE et al. Risk of de novo or secondary cancer after solid organ or allogeneic haematopoietic stem cell transplantation. J Cancer Res Clin Oncol Springer Berlin Heidelberg. 2019; 145 (12): 3125–3135. doi: 10.1007/s00432-019-03039-2.
3. Shtraichman O, Ahya VN. Malignancy after lung transplantation. Ann Transl Med. 2020; 8 (6): 416–416. doi: 10.21037/atm.2020.02.126.
4. Rousseau-Gazaniol C et al. Lung cancer in renal transplant recipients: A case-control study. Lung Cancer Elsevier Ireland Ltd. 2017; 111: 96–100. doi: 10.1016/j.lungcan.2017.07.011.
5. Acuna SA. Etiology of increased cancer incidence after solid organ transplantation. Transplant Rev Elsevier Inc. 2018; 32 (4): 218–224. doi: 10.1016/j.trre.2018.07.001.
6. Katabathina VS et al. Malignancy after solid organ transplantation: Comprehensive imaging review. Radiographics. 2016; 36 (5): 1390–1407. doi: 10.1148/rg.2016150175.
7. Yanik EL et al. Cancer risk after pediatric solid organ transplantation. Pediatrics. 2017; 139 (5). doi: 10.1542/peds.2016-3893.
8. Potaris K et al. Lung cancer after heart transplantation: A 17-year experience. Ann Thorac Surg. 2005; 79 (3):980–983. doi: 10.1016/j.athoracsur.2004.05.021.
9. Drevet G et al. Lung cancer surgical treatment after solid organ transplantation: A single center 30-year experience. Lung Cancer Elsevier. 2020; 139: 55–59. doi: 10.1016/j.lungcan.2019.10.023.
10. Robbins HY, Arcasoy SM. Malignancies Following Lung Transplantation. Clin Chest Med. 2011; 32 (2): 343–355. doi: 10.1016/j.ccm.2011.02.011.
11. Olland ABM et al. Primary lung cancer in lung transplant recipients. Ann Thorac Surg Elsevier Inc. 2014; 98 (1):362–371. doi: 10.1016/j.athoracsur.2014.04.014.
12. Noone AM et al. Cancer-attributable mortality among solid organ transplant recipients in the United States: 1987 through 2014. Cancer. 2019; 125 (15): 2647–2655. doi: 10.1002/cncr.32136.
13. Yanik EL et al. Comparison of cancer diagnoses between the US solid organ transplant registry and linked central cancer registries. Am J Transplant. 2016; 16 (10):2986–2993. doi: 10.1111/ajt.13818.
14. Pérez-Callejo D et al. Lung cancer in lung transplantation: Incidence and outcome. Postgrad Med J. 2018; 94 (1107): 15–19. doi: 10.1136/postgradmedj-2017-134868.
15. Choi YJ et al. Incidental lung cancer of explanted lungs from lung transplant recipients: Incidence, characteristics, and 5-year survival. Yonsei Med J. 2020; 61 (11):958–964. doi: 10.3349/ymj.2020.61.11.958.
16. Sonbol MB et al. A Case of Donor-Transmitted Non- Small Cell Lung Cancer After Liver Transplantation: An Unwelcome Guest. Oncologist. 2019; 24 (6): 2018–2020. doi: 10.1634/theoncologist.2018-0517.
17. Chatron E et al. Lung cancer after lung transplantation: An analysis of 25 years of experience in a single institution. Clin Transplant. 2019; 33 (1): 0–2. doi: 10.1111/ctr.13446.
18. Ekström M, Riise GC, Tanash HA. Risk of cancer after lung transplantation for COPD. Int J COPD. 2017; 12:2841–2847. doi: 10.2147/COPD.S147065.
19. Verleden GM, Fisher AJ. Lung transplantation and lung cancer: Is there a link? Respiration. 2011; 81 (6): 441–445. doi: 10.1159/000326934.
20. Triplette M et al. HHS Public Access. 2020; 19 (5):1478–1490. doi: 10.1111/ajt.15181.
21. Gershman E et al. Characteristics of lung cancer in idiopathic pulmonary fibrosis with single lung transplant versus non-transplanted patients: A retrospective observational study. BMJ Open Respir Res. 2020; 7 (1): 1–6. doi: 10.1136/bmjresp-2020-000566.
22. Vajdic CM, Van Leeuwen MT. Cancer incidence and risk factors after solid organ transplantation. Int J Cancer. 2009; 125 (8): 1747–1754. doi: 10.1002/ijc.24439.
23. Asch WS, Perazella MA. Cancer and Mortality in Solid- Organ Transplantation: Preventable or Inevitable? Am J Kidney Dis. 2016; 68 (6): 839–842. doi: 10.1053/j.ajkd.2016.06.009.
24. Huo Z et al. Cancer Risks in Solid Organ Transplant Recipients: Results from a Comprehensive Analysis of 72 Cohort Studies. Oncoimmunology. Taylor & Francis. 2020; 9 (1). doi: 10.1080/2162402X.2020.1848068.
25. Brennan DC et al. Development of malignancy following solid organ transplantation. UpToDate. 2016; 10:1–20.
26. Endén K et al. Cancer morbidity and mortality after pediatric solid organ transplantation – a nationwide register study. Pediatric Nephrology. 2020; 35 (9): 1719–1728. doi: 10.1007/s00467-020-04546-y.
27. Fogel AL, Miyar M, Teng JMC. Cutaneous Malignancies in Pediatric Solid Organ Transplant Recipients. Pediatr Dermatol. 2016; 33 (6): 585–593. doi: 10.1111/pde.12941.
28. Belli EV et al. Lung cancer following lung transplant: Single institution 10 year experience. Lung Cancer. Elsevier Ireland Ltd. 2013; 81 (3): 451–454. doi: 10.1016/j.lungcan.2013.05.018.
29. Acuna SA et al. Cancer Screening Recommendations for Solid Organ Transplant Recipients: A Systematic Review of Clinical Practice Guidelines. Am J Transplant. 2017; 17 (1): 103–114. doi: 10.1111/ajt.13978.
30. Godoy MCB et al. Understanding Lung-RADS 1.0: A Case-Based Review. Semin Ultrasound, CT MRI Elsevier. 2018; 39 (3): 260–272. doi: 10.1053/j.sult.2018.03.001.
31. American College of Radiology. Lung-RADS® Version 1.1 Assessment Categories. 2019; 3.
32. Robinson C, Chanchlani R, Kitchlu A. Malignancies after pediatric solid organ transplantation. Pediatric Nephrology. 2020. doi: 10.1007/s00467-020-04790-2.
33. Wang X, Dong M. Malignancy After Lung Transplantation: How to Manage Immunosuppression? Transplant Proc Elsevier Inc. 2020; 52 (1): 315–320. doi: 10.1016/j.transproceed.2019.09.012.
34. Engels EA. Cancer in Solid Organ Transplant Recipients: There Is Still Much to Learn and Do. Am J Transplant. 2017; 17 (8): 1967–1969. doi: 10.1111/ajt.14140.
35. Wong K et al. Safety and Efficacy of Immune Checkpoint Inhibitors in Patients With Metastatic Cancer Post Solid Organ Transplantation: A Case Report and Review of the Literature. Transplant Proc Elsevier Inc. 2019; 51 (9):3053–3058. doi: 10.1016/j.transproceed.2019.08.002.
36. Acuna SA et al. Cancer recurrence after solid organ transplantation: A systematic review and meta-analysis. Transplant Rev Elsevier Inc. 2017; 31 (4): 240–248. doi: 10.1016/j.trre.2017.08.
37. Buxeda A et al. Gender differences in cancer risk after kidney transplantation. Oncotarget. 2019; 10 (33):3114–3128. doi: 10.18632/oncotarget.26859.
38. Chen H et al. Stereotactic ablative radiotherapy for earlystage lung cancer following double lung transplantation. Radiat Oncol Radiation Oncology. 2018; 13 (1): 10–14. doi: 10.1186/s13014-018-1089-8.
39. Drevet G et al. Lung cancer surgical treatment after solid organ transplantation: a single center 30-year experience. Lung Cancer. 2020; 145: 222–224. doi: 10.1016/j.lungcan.2019.10.023.
40. Falcoz PE et al. Video-assisted thoracoscopic surgery versus open lobectomy for primary non-small-cell lung cancer: A propensity-matched analysis of outcome from the European Society of Thoracic Surgeon database. Eur J Cardio-thoracic Surg. 2016; 49 (2): 602–609. doi: 10.1093/ejcts/ezv154.
41. Demmy T, Dexter E. Overview of minimally invasive thoracic surgery. UpToDate. 2019; 1–84.
42. Cheng X et al. Minimally Invasive Thoracic Surgery 3.0. Ann Surg. 2018; 267 (1): 37–38. doi: 10.1097/SLA.0000000000002.
43. Xia ZN et al. Laparoscopic-Assisted Resection for Advanced Colorectal Cancer in Solid Organ Transplant Recipients. J Investig Surg. Taylor & Francis. 2018; 31 (6):483–490. doi: 10.1080/08941939.2017.1359707.
44. Al-Ameri M et al. Uniportal versus multiportal videoassisted thoracic surgery for lung cancer. J Thorac Dis. 2019; 11 (12): 5152–5161. doi: 10.21037/jtd.2019.12.01.
45. Cao C et al. European questionnaire on the clinical use of video-assisted thoracoscopic surgery. Interact Cardiovasc Thorac Surg. 2018; 27 (3): 379–383. doi: 10.1093/icvts/ivy062.
46. Seitlinger J et al. Conversion from video-assisted thoracic surgery (VATS) to thoracotomy during major lung resection: how does it affect perioperative outcomes? Interact Cardiovasc Thorac Surg. 2021; 32 (1): 55–63. doi: 10.1093/icvts/ivaa220.
47. Maeda H et al. Video-assisted thoracoscopic surgery after renal transplantation: A single-institution experience. Asian J Endosc Surg. 2016; 9 (1): 37–43. doi: 10.1111/ases.12248.
48. Chen LN et al. Characteristics and outcomes of lung cancer in solid organ transplant recipients. Lung Cancer Elsevier. 2020; 146: 297–302. doi: 10.1016/j.lungcan.2020.06.018.
49. Zhang SX, Liu Y. Primary lung cancer in Chinese renal transplant recipients: a single-center analysis. Nan Fang Yi Ke Da Xue Xue Bao. 2017; 37 (6): 715–720. doi: 10.3969/j.issn.1673-4254.2017.06.01.
50. Sigel K et al. Lung cancer prognosis in elderly solid organ transplant recipients. Transplantation. 2015; 99 (10): 2181–2189. doi: 10.1097/TP.0000000000000715.
51. https://gco.iarc.fr [Internet]. International Agency for Research on Cancer. Available from: https://gco.iarc.fr.
52. http://www.transplant-observatory.org [Internet]. Global Observatory on Donation and Transplantation. Available from: http://www.transplant-observatory.org.
Review
For citations:
Nikulin A.V., Pashkov I.V., Yakunin Ya.S. Lung cancer in solid organ transplant recipients. Russian Journal of Transplantology and Artificial Organs. 2021;23(4):19-25. https://doi.org/10.15825/25/1995-1191-2021-4-19-25
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