Biodegradable materials based on natural silk fabric as promising scaffolds for tissue engineering and regenerative medicine
https://doi.org/10.15825/1995-1191-2020-4-105-114
Abstract
Objective: to develop a method for obtaining scaffolds based on natural silk fabric and to study their biocompatibility in vitro.
Materials and methods. To obtain biodegradable scaffolds based on natural silk fabric, we propose treating natural silk fabric with a water-ethanol solution of calcium chloride. Differences in the structure of the resulting scaffolds were identified via scanning electron microscopy.
Conclusion. The resulting scaffolds are non-toxic to cells and support cell adhesion and proliferation. Our studies make it possible to consider the resulting biodegradable scaffolds as promising constructs for tissue engineering and regenerative medicine.
About the Authors
L. A. Safonova
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Moscow
Russian Federation
Moscow
M. M. Bobrova
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Moscow
Russian Federation
Moscow
A. E. Efimov
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Moscow
Russian Federation
Moscow
O. I. Agapova
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Moscow
Russian Federation
Moscow
I. I. Agapov
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Russian Federation
1, Schukinskaya str., Moscow, 123182, Russian Federation
Phone: (985) 231-60-42
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Review
For citations:
Safonova L.A., Bobrova M.M., Efimov A.E., Agapova O.I., Agapov I.I. Biodegradable materials based on natural silk fabric as promising scaffolds for tissue engineering and regenerative medicine. Russian Journal of Transplantology and Artificial Organs. 2020;22(4):105-114. https://doi.org/10.15825/1995-1191-2020-4-105-114
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