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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vtio</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник трансплантологии и искусственных органов</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Transplantology and Artificial Organs</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-1191</issn><publisher><publisher-name>Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15825/1995-1191-2019-1-71-76</article-id><article-id custom-type="elpub" pub-id-type="custom">vtio-991</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Трансплантация сердца и вспомогательное кровообращение</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Heart Transplantation and Assisted Circulation</subject></subj-group></article-categories><title-group><article-title>Оценка биоэнергетики сокращения миокарда в условиях механической поддержки кровообращения</article-title><trans-title-group xml:lang="en"><trans-title>The assessment bioenergy of cardiac contraction in the conditions of mechanical support circulation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иткин</surname><given-names>Г. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Itkin</surname><given-names>G. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>123182, Москва, ул. Щукинская, д. 1.Тел. (916) 129-78-33. </p></bio><bio xml:lang="en"><p>1, Shchukinskaya str., Moscow, 123182. Tel. (916) 129-78-33.</p></bio><email xlink:type="simple">georgeitkin@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бучнев</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Buchnev</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кулешов</surname><given-names>А. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuleshov</surname><given-names>A. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сырбу</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Syrbu</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра физики живых систем</p><p>Москва</p></bio><bio xml:lang="en"><p>Department of physics of living systems</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России; Московский физико-технический институт (Государственный университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation; Moscow Institute of Physics and Technology (State University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>17</day><month>05</month><year>2019</year></pub-date><volume>21</volume><issue>1</issue><fpage>71</fpage><lpage>76</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Иткин Г.П., Бучнев А.С., Кулешов А.П., Сырбу А.И., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Иткин Г.П., Бучнев А.С., Кулешов А.П., Сырбу А.И.</copyright-holder><copyright-holder xml:lang="en">Itkin G.P., Buchnev A.S., Kuleshov A.P., Syrbu A.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.transpl.ru/vtio/article/view/991">https://journal.transpl.ru/vtio/article/view/991</self-uri><abstract><p>Цель: разработать новый модифицированный индекс для оценки биоэнергетики сокращения сердца в условиях сердечной недостаточности при механической поддержке кровообращения. Провести оценку биоэнергетики сердца при использовании систем обхода левого желудочка сердца с использованием насосов непульсирующего потока. Рассмотреть принципиальное преимущество насосов непульсирующего потока с генерацией пульсирующего потока в режиме кардиосинхронизированной сопульсации перед режимом контрпульсации.</p></abstract><trans-abstract xml:lang="en"><p>Aim: to develop a new modified index for the assessment of bioenergy heart in conditions of heart failure. To assess the energy of the heart when using systems to bypass the left ventricle of the heart using non-pulsed flow pumps. To consider the fundamental advantage of non-pulsating flow pumps with the generation of a pulsating flow in the cardio-synchronized copulsation mode over the counterpulsation mode.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сердечная недостаточность</kwd><kwd>работа сердца</kwd><kwd>потребление O2 миокардом</kwd><kwd>механическая поддержка кровообращения</kwd><kwd>насосы непульсирующнго потока</kwd><kwd>внутрижелудочковаядиаграмма давление–объем</kwd><kwd>сопульсация</kwd><kwd>контрпульсация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cardiac failure</kwd><kwd>heart work</kwd><kwd>consume O2 by myocardium</kwd><kwd>mechanical support circulation</kwd><kwd>nonpulsatile pump</kwd><kwd>diagram pressure–volume</kwd><kwd>copulsation</kwd><kwd>counterpulsation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Uriel N, Sayer G, Annamalai S, Kapur NK, Burkhoff D. Mechanical Unloading in Heart Failure. J Am Coll Cardiol. 2018 Jul; 31 (72): 569–580. doi: 10.1016/j.jacc.2018.05.038.</mixed-citation><mixed-citation xml:lang="en">Uriel N, Sayer G, Annamalai S, Kapur NK, Burkhoff D. Mechanical Unloading in Heart Failure. J Am Coll Cardiol. 2018 Jul; 31 (72): 569–580. doi: 10.1016/j.jacc.2018.05.038.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Kirklin JK, Naftel DC, Pagani FD, Kormos RL, Stevenson LW, Blume ED et al. Seventh INTERMACS annual report: 15,000 patients and counting. J. Heart Lung Transplant. 2015; 34 (12): 1495–1504. doi: 10.1016/j.healun.2015.10.003.</mixed-citation><mixed-citation xml:lang="en">Kirklin JK, Naftel DC, Pagani FD, Kormos RL, Stevenson LW, Blume ED et al. Seventh INTERMACS annual report: 15,000 patients and counting. J. Heart Lung Transplant. 2015; 34 (12): 1495–1504. doi: 10.1016/j.healun.2015.10.003.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Slaughter MS, Rogers JG, Milano CA, Russell SD, Conte JV, Feldman D et al. Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med. 2009; 361: 2241–2251. doi: 10.1056/NEJMoa0909938.</mixed-citation><mixed-citation xml:lang="en">Slaughter MS, Rogers JG, Milano CA, Russell SD, Conte JV, Feldman D et al. Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med. 2009; 361: 2241–2251. doi: 10.1056/NEJMoa0909938.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Crow S, John R, Boyle A, Shumway S, Liao K, ColvinAdams M et al. Gastrointestinal bleeding rates in recipients of nonpulsatile and pulsatile left ventricular assist devices. J Thorac Cardiovasc Surg. 2009; 137: 208–215. doi: 10.1016/j.jtcvs.2008.07.032.</mixed-citation><mixed-citation xml:lang="en">Crow S, John R, Boyle A, Shumway S, Liao K, ColvinAdams M et al. Gastrointestinal bleeding rates in recipients of nonpulsatile and pulsatile left ventricular assist devices. J Thorac Cardiovasc Surg. 2009; 137: 208–215. doi: 10.1016/j.jtcvs.2008.07.032.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Zamarripa Garcia MA, Enriquez LA, Dembitsky W, MayNewman K. The Effect of Aortic Valve Incompetence on the Hemodynamics of a Continuous Flow Ventricular Assist Device in a Mock Circulation. ASAIO Journal. 2008; 54: 237–244. doi: 10.1097/MAT.0b013e31816a309b.</mixed-citation><mixed-citation xml:lang="en">Zamarripa Garcia MA, Enriquez LA, Dembitsky W, MayNewman K. The Effect of Aortic Valve Incompetence on the Hemodynamics of a Continuous Flow Ventricular Assist Device in a Mock Circulation. ASAIO Journal. 2008; 54: 237–244. doi: 10.1097/MAT.0b013e31816a309b.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Soucy KG, Koenig SC, Giridharan GA, Sobieski MA, Slaughter MS. Defining pulsatility during continuous-flow ventricular assist device support. J Heart Lung Transplant. 2013; 32: 581–587. doi: 10.1097/MAT.0b013e31816a309b.</mixed-citation><mixed-citation xml:lang="en">Soucy KG, Koenig SC, Giridharan GA, Sobieski MA, Slaughter MS. Defining pulsatility during continuous-flow ventricular assist device support. J Heart Lung Transplant. 2013; 32: 581–587. doi: 10.1097/MAT.0b013e31816a309b.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ising MS, Sobieski MA, Slaughter MS, Koenig SC, Giridharan GA. Feasibility of Pump Speed Modulation for Restoring Vascular Pulsatility with Rotary Blood Pumps. ASAIO J. 2015 Sep-Oct; 61 (5): 526–532. doi: 10.1097/MAT.0000000000000262.</mixed-citation><mixed-citation xml:lang="en">Ising MS, Sobieski MA, Slaughter MS, Koenig SC, Giridharan GA. Feasibility of Pump Speed Modulation for Restoring Vascular Pulsatility with Rotary Blood Pumps. ASAIO J. 2015 Sep-Oct; 61 (5): 526–532. doi: 10.1097/MAT.0000000000000262.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Pirbodaghi T, Axiak S, Weber A, Gempp T, Vandenberghe S. Pulsatile control of rotary blood pumps: does the modulation waveform matter? J Thorac Cardiovasc Surg. 2012; 144: 970–977. doi: 10.1016/j.jtcvs.2012.02.015.</mixed-citation><mixed-citation xml:lang="en">Pirbodaghi T, Axiak S, Weber A, Gempp T, Vandenberghe S. Pulsatile control of rotary blood pumps: does the modulation waveform matter? J Thorac Cardiovasc Surg. 2012; 144: 970–977. doi: 10.1016/j.jtcvs.2012.02.015.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Suga H, Sagawa K, Shoukas AA. Load independence of the instantaneous pressure-volume ratio of the canine left ventricle and effects of epinephrine and heart rate on the ratio. Circ Res. 1973 Mar; 32 (3): 314–322. doi: 10.1161/01.res.32.3.314.</mixed-citation><mixed-citation xml:lang="en">Suga H, Sagawa K, Shoukas AA. Load independence of the instantaneous pressure-volume ratio of the canine left ventricle and effects of epinephrine and heart rate on the ratio. Circ Res. 1973 Mar; 32 (3): 314–322. doi: 10.1161/01.res.32.3.314.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Kishimoto S, Date K, Arakawa M, Takewa Y, Nishimura T, Tsukiya T et al. Influence of a novel electrocardiogram-synchronized rotational-speed-change system of an implantable continuous-flow left ventricular assist device (EVAHEART) on hemolytic performance. J Artif Organs. 2014; 17: 373–377. doi: 10.1007/s10047-014-0787-8.</mixed-citation><mixed-citation xml:lang="en">Kishimoto S, Date K, Arakawa M, Takewa Y, Nishimura T, Tsukiya T et al. Influence of a novel electrocardiogram-synchronized rotational-speed-change system of an implantable continuous-flow left ventricular assist device (EVAHEART) on hemolytic performance. J Artif Organs. 2014; 17: 373–377. doi: 10.1007/s10047-014-0787-8.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Bartoli CR, Sherwood LC, Giridharan GA, Litwak KN, Sobieski M, Prabhu SD et al. Hemodynamic Responses to Continuous versus Pulsatile Mechanical Unloading of the Failing Left Ventricle. ASAIO Journal. 2010; 56: 410–416. doi: 10.1097/mat.0b013e3181e7bf3c.</mixed-citation><mixed-citation xml:lang="en">Bartoli CR, Sherwood LC, Giridharan GA, Litwak KN, Sobieski M, Prabhu SD et al. Hemodynamic Responses to Continuous versus Pulsatile Mechanical Unloading of the Failing Left Ventricle. ASAIO Journal. 2010; 56: 410–416. doi: 10.1097/mat.0b013e3181e7bf3c.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Guan Y, Karkhanis T, Wang S, Rider A, Koenig SC, Slaughter MS et al. Physiologic benefits of pulsatile perfusion during mechanical circulatory support for the treatment of acute and chronic heart failure in adults. Artificial Organs. 2010; 34: 529–536. doi: 10.1111/j.1525-1594.2010.00996.x.</mixed-citation><mixed-citation xml:lang="en">Guan Y, Karkhanis T, Wang S, Rider A, Koenig SC, Slaughter MS et al. Physiologic benefits of pulsatile perfusion during mechanical circulatory support for the treatment of acute and chronic heart failure in adults. Artificial Organs. 2010; 34: 529–536. doi: 10.1111/j.1525-1594.2010.00996.x.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Evans CL, Matsuoka Y. Effect of various mechanical conditionsbof gaseous metabolism and efficiency of mammalian heart. J Physiol. 1915; 49: 378–405. doi: 10.1113/jphysiol.1915.sp001716.</mixed-citation><mixed-citation xml:lang="en">Evans CL, Matsuoka Y. Effect of various mechanical conditionsbof gaseous metabolism and efficiency of mammalian heart. J Physiol. 1915; 49: 378–405. doi: 10.1113/jphysiol.1915.sp001716.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Monroe RG, French GN. Left ventricular pressurevolume relationship and myocardial oxygen consuvption in isolated heart. Circ Res. 1961; 9: 362–374. doi: 10.1161/01.res.9.2.362.</mixed-citation><mixed-citation xml:lang="en">Monroe RG, French GN. Left ventricular pressurevolume relationship and myocardial oxygen consuvption in isolated heart. Circ Res. 1961; 9: 362–374. doi: 10.1161/01.res.9.2.362.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Parissis HL, Graham V, Lampridis S, Lau M, Hooks G. IABP: history-evolution-pathophysiology-indications: what we need to know. J Cardiothorac Surg. 2016; 11: 122–127. doi: 10.1186/s13019-016-0513-0.</mixed-citation><mixed-citation xml:lang="en">Parissis HL, Graham V, Lampridis S, Lau M, Hooks G. IABP: history-evolution-pathophysiology-indications: what we need to know. J Cardiothorac Surg. 2016; 11: 122–127. doi: 10.1186/s13019-016-0513-0.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Lewartowski B, Michałowski J, Sedek G, Kryńska E, Wasilewska-Dziubińska E. Directly measured tensiontime index as a correlate of myocardial oxygen consumption. Eur J Cardiol. 1980; 11: 61–70. PMID: 7363921.</mixed-citation><mixed-citation xml:lang="en">Lewartowski B, Michałowski J, Sedek G, Kryńska E, Wasilewska-Dziubińska E. Directly measured tensiontime index as a correlate of myocardial oxygen consumption. Eur J Cardiol. 1980; 11: 61–70. PMID: 7363921.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Gordon DG. The physics of left ventricular ejection and its implications for muscle mechanics. Eur J Cardiol. 1976; 4: 87–95. PMID: 1278222.</mixed-citation><mixed-citation xml:lang="en">Gordon DG. The physics of left ventricular ejection and its implications for muscle mechanics. Eur J Cardiol. 1976; 4: 87–95. PMID: 1278222.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Kern MJ, Aguirre FV, Caraccido EA et al. Hemodynamic effects of new intra-aortic balloon counterpulsation timing methods in patients: a multicenter evaluation. Am Heart J. 1999; 137: 1129–1136.</mixed-citation><mixed-citation xml:lang="en">Kern MJ, Aguirre FV, Caraccido EA et al. Hemodynamic effects of new intra-aortic balloon counterpulsation timing methods in patients: a multicenter evaluation. Am Heart J. 1999; 137: 1129–1136.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
