vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2018-4-30-37vtio-947Research ArticleКлиническая трансплантологияClinical TransplantologyТрансплантация легких при первичной легочной артериальной гипертензии: особенности периоперационного периодаLung transplantation for idiopathic pulmonary arterial hypertension: perioperational featuresПопцовВ. Н.PoptsovV. N.

123182, Москва, ул. Щукинская, д. 1.Тел. (963) 644-96-39. 

1, Shchukinskaya str., Moscow, 123182. Tel. (963) 644-96-39.

poptsov_vit@mail.ruСпиринаЕ. А.SpirinaE. A.

Москва

Moscow

ПашковИ. В.PashkovI. V.

Москва

Moscow

БеликоваА. В.BelikovaA. V.

Москва

Moscow

ОлешкевичД. О.OleshkevichD. O.

Москва

Moscow

ЛатыповР. А.LatipovR. A.

Москва

Moscow

ЦирульниковаО. М.TsirulnikovaO. M.

Москва

Moscow

ЕпремянА. С.EpremianA. C.

Москва

Moscow

ШигаевЕ. Ф.ShigaevE. F.

Москва

Moscow

ГотьеС. В.GautierS. V.

Москва

Moscow

ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава РоссииРоссияV.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian FederationRussian FederationФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России; ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский университет)РоссияV.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation; I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovsky University)Russian Federation2018300120192043037Copyright © Попцов В.Н., Спирина Е.А., Пашков И.В., Беликова А.В., Олешкевич Д.О., Латыпов Р.А., Цирульникова О.М., Епремян А.С., Шигаев Е.Ф., Готье С.В., 20192019Попцов В.Н., Спирина Е.А., Пашков И.В., Беликова А.В., Олешкевич Д.О., Латыпов Р.А., Цирульникова О.М., Епремян А.С., Шигаев Е.Ф., Готье С.В.Poptsov V.N., Spirina E.A., Pashkov I.V., Belikova A.V., Oleshkevich D.O., Latipov R.A., Tsirulnikova O.M., Epremian A.C., Shigaev E.F., Gautier S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/947

Первичная легочная артериальная гипертензия (ПЛАГ) – необратимое заболевание, единственным методом радикального лечения которого является трансплантация легких (ТЛ).

Цель исследования

Цель исследования: анализ собственного опыта выполнения ТЛ у пациентов с ПЛАГ.

Материалы и методы

Материалы и методы. В исследование включили 8 взрослых реципиентов, которым была выполнена ТЛ в период с 2014-го по октябрь 2018 г. Всем реципиентам была выполнена двусторонняя последовательная трансплантация легких. У 7 из 8 реципиентов ТЛ осуществляли в условиях периферической ВА ЭКМО.

Результаты

Результаты. В послеоперационном периоде первичная дисфункция 3-й степени по классификации ISHLT развилась у 2 (25,0%) из 8 реципиентов, которая проявилась невозможностью прекращения ВА ЭКМО. Общая продолжительность применения ЭКМО у этих пациентов (n = 2) составила 6 и 7 суток. У других 6 (75,0%) реципиентов проявления ранней дисфункции пересаженных легких не носили столь напряженного характера (2-я степень по классификации ISHLT), и продолжительность послеоперационной ВА ЭКМО составила 3 суток. Госпитальная летальность у реципиентов легких, оперированных по поводу ЛАГ, составила 1 наблюдение.

Заключение

Заключение. Собственный опыт демонстрирует, что ТЛ является эффективной лечебной мерой у пациентов с ПЛАГ с показателями госпитальной, 1- и 3-летней выживаемости соответственно 87,5; 75,0 и 75,0%.

Lung transplantation (LT) for idiopathic pulmonary arterial hypertension (IPAH) now is the only radical treatment of this disease.

Aim

Aim: to analyze own experience of performing LT in patients with IPAH.

Materials and methods

Materials and methods. 8 adult IPAH patients, who underwent LT between 2014 and october 2018, were included. In 7 of 8 patients undergoing bilateral lung transplantation on intraoperative venoarterial extracorporeal membrane oxygenation (VA ECMO) with prolongation into the postoperative period.

Results

Results. VA ECMO support was prolonged into postoperative period 6 and 7 days respectively in 2 (25,0%) patients and 3 days in 6 (75,0%) patients. Hospital mortality in IPAH patients was 1.

Conclusions

Conclusions. Own experience demonstrates that LT is an effective method of treatment in patients with IPAH. Hospital, 1- and 3-year survival rates for the patient collective were 87.5, 75.0 and 75.0% respectively.

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The authors declare that there are no conflicts of interest present.