References

vtio

Вестник трансплантологии и искусственных органов

Russian Journal of Transplantology and Artificial Organs

1995-1191

Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation

10.15825/1995-1191-2018-3-95-104

vtio-918

Research Article

Обзор литературы

Literature Reviews

Аутотрансплантация Т-лимфоцитов как инструмент для антиген-специфической иммунотерапии онкологических заболеваний

Autotransplantation of T-lymphocytes as a tool for antigen-specific immunotherapy of oncological diseases

Лупатов

А. Ю.

Lupatov

A. Yu.

Адрес: 119121, Москва, ул. Погодинская, д. 10, кор. 8. Тел. (916) 324-10-20

Address: 10-8, Pogodinskaya Str., Moscow, 123182, Russian Federation. Теl. (916) 324-10-20

alupatov@mail.ru

Каралкин

П. А.

Karalkin

P. A.

Бойко

А. А.

Boyko

A. A.

Ярыгин

К. Н.

Yarygin

K. N.

ФГБНУ «НИИ биомедицинской химии имени В.Н. Ореховича»РоссияInstitute of Biomedical Chemistry MoscowRussian Federation

МНИОИ имени П.А. Герцена – филиал ФГБУ «НМИЦ радиологии» Минздрава РоссииРоссияP. Hertsen Moscow Oncology Research Center- branch of National Medical Research Radiological Center of the Ministry of HealthRussian Federation

Институт биоорганической химии имени М.М. Шемякина и Ю.А. Овчинникова РАНРоссияShemyakin-Ovchinnikov Institute of Bioorganic Chemistry of RASRussian Federation

2018

17092018

20395104

2018

Лупатов А.Ю., Каралкин П.А., Бойко А.А., Ярыгин К.Н.

Lupatov A.Y., Karalkin P.A., Boyko A.A., Yarygin K.N.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.transpl.ru/vtio/article/view/918

Аутотрансплантация клеток иммунной системы с целью вызвать реакцию иммунологического отторжения опухоли может оказаться востребованным инструментом в руках врачей. Несмотря на невысокую эффективность, продемонстрированную в прошлом, активное развитие биомедицинских клеточных технологий и генной инженерии привело к значительному улучшению результатов, получаемых при клинической апробации этого подхода. Наибольших успехов удалось добиться в области адоптивной иммунотерапии с использованием Т-лимфоцитов, специфичных к опухолевым антигенам. В данном обзоре описывается клинический опыт применения различных вариантов антиген-специфической адоптивной иммунотерапии опухолей, включая использование опухоль-инфильтрирующих T-лимфоцитов, T-лимфоцитов с перенаправленными трансгенными антигенраспознающими рецепторами, в том числе химерными. В статье также анализируются возможности и ограничения этих биомедицинских технологий.

Autotransplantation of immune cells to induce immunological rejection of tumors can be a useful approach in tumor treatment. Despite the low efficiency of this approach demonstrated in the past, the active development of cell technologies and genetic engineering has led to the significant improvement in clinical outcomes. A great success was achieved in adoptive immunotherapy with the T-lymphocytes specific to tumor antigens. This review describes the clinical experience in application of various antigen-specific adoptive immunotherapy methods including tumor-infiltrating T-lymphocytes, T-lymphocytes with redirected transgenic T-cell and chimeric antigenrecognizing receptors. The possibilities and limitations of these biomedical technologies are also analyzed in the article.

Т-лимфоцитыклеточная трансплантацияадоптивная иммунотерапиязлокачественные новообразованияопухоль-инфильтрирующие лимфоцитытрансгенный антигенраспознающий рецепторхимерный антигенраспознающий рецептор

Т-lymphocytescellular transplantationadoptive immunotherapymalignant tumorstumorinfiltrating lymphocytestransgenic antigen-recognition receptorchimeric antigen-recognition receptor

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The authors declare that there are no conflicts of interest present.