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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vtio</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник трансплантологии и искусственных органов</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Transplantology and Artificial Organs</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-1191</issn><publisher><publisher-name>Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15825/1995-1191-2018-2-100-111</article-id><article-id custom-type="elpub" pub-id-type="custom">vtio-888</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Обзор литературы</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Literature Reviews</subject></subj-group></article-categories><title-group><article-title>ПОЛИМЕРНЫЕ ПРОТЕЗЫ КЛАПАНОВ СЕРДЦА: СОСТОЯНИЕ И ПЕРСПЕКТИВЫ</article-title><trans-title-group xml:lang="en"><trans-title>POLYMERIC HEART VALVE PROSTHESES: CONDITION AND PERSPECTIVES</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Резвова</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rezvova</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>650002, Кемерово, Сосновый бульвар, 6.</p></bio><bio xml:lang="en"><p>6, Sosnoviy blvd, 650002, Kemerovo.</p></bio><email xlink:type="simple">rezvovamaria@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Овчаренко</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ovcharenko</surname><given-names>E. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний».</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Scientiﬁ c Institution Research Institute for Complex Issues of Cardiovascular Diseases.</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>27</day><month>06</month><year>2018</year></pub-date><volume>20</volume><issue>2</issue><fpage>100</fpage><lpage>111</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Резвова М.А., Овчаренко Е.А., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Резвова М.А., Овчаренко Е.А.</copyright-holder><copyright-holder xml:lang="en">Rezvova M.A., Ovcharenko E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.transpl.ru/vtio/article/view/888">https://journal.transpl.ru/vtio/article/view/888</self-uri><abstract><p>Идея создания полимерного клапана сердца, обладающего высокой прочностью и биосовместимостью, берет свое начало в 60-х годах. С тех пор исследовано множество полимерных соединений, однако так и не было найдено решение данной проблемы. В последние годы в связи с развитием технологий синтеза высокомолекулярных соединений появились новые полимеры, обладающие потенциалом для решения данной проблемы, о чем свидетельствует ряд публикаций, описывающих экспериментальные и клинические данные. Тем не менее поиск полимера для основы створчатого аппарата протеза клапана сердца не теряет своей актуальности ввиду изученных недостатков и отсутствия доказательной базы, подтверждающей долгосрочную безопасность таких изделий. В настоящем обзоре представлены первые результаты исследования полимерных протезов клапанов сердца на основе нанокомпозитного полимера из полиэдрических олигомерных силсесквиоксановых наночастиц и поликарбонатномочевинного уретанового полимера POSS-PCU, поли(стирол-блок-изобутилен-блок-стирола) – SIBS, политетрафторэтилена PTFE и др., возможность получения новых сополимеров и композитов на базе полимеров олефинового ряда и полиэстеров, продемонстрирована идея создания материала с заданной трехмерной микроархитектурой, определяющей анизотропию и необходимые механические свойства.</p></abstract><trans-abstract xml:lang="en"><p>The idea of creating a polymer heart valve, which has high strength and biocompatibility, occurs in the 60’s. Since then, many polymer compounds have been investigated, but no solution has been found for this problem. In recent years, in connection with the development of technologies for the synthesis of high-molecular compounds, new polymers have appeared that can solve this problem, as evidenced by a number of publications describing experimental and clinical data. Nevertheless, the search for a polymer for the valve stem of the valvular valve body does not lose its relevance due to the deﬁ ciencies studied and the lack of evidence conﬁ rming the long-term safety of such products. This review presents the ﬁ rst results of a study of polymer heart valves prostheses based on a nanocomposite polymer from polyhedral oligomeric nanoparticles of silicosioxane and polycarbonate urethane polymer POSS-PCU, polystyrene block-isobutylene-block-styrene SIBS, PTFE polytetraﬂ uoroethylene, copolymers and composites based on oleﬁ n polymers series and polyesters, the idea of creating a material with a given three-dimensional microarchitecture that determines the anisotropy and the necessary mechanical properties.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>полимерный протез клапана сердца</kwd><kwd>поли(стирол-блок-изобутилен-блок-стирол)</kwd><kwd>полиэдральный олигомерный силсесквиоксан</kwd></kwd-group><kwd-group xml:lang="en"><kwd>heart valve prosthesis</kwd><kwd>poly(styrene-b-isobutylene-b-styrene)</kwd><kwd>polytetraﬂ uoroethylene</kwd><kwd>POSS-PCU polymer</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Chambers J. 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