vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2013-4-112-125vtio-88Research ArticleОбзор литературыLiterature ReviewsИНФОРМАЦИОННАЯ ЗНАЧИМОСТЬ МОНИТОРИНГА ПОПУЛЯЦИЙ СD4+ Т-ЛИМФОЦИТОВ В ДИАГНОСТИКЕ И ПРОГНОЗИРОВАНИИ РЕАКЦИИ ОРГАНИЗМА НА ТРАНСПЛАНТАТSIGNIFICANCE OF СD4+ Т-LYMPHOCYTE POPULATIONS MONITORING FOR DIAGNOSING AND FORECASTING OF ORGANISM REACTION ON TRANSPLANTОнищенкоН. А.OnishchenkoN. A.БашкинаЛ. В.BashkinaL. V.НикольскаяА. О.NicolskayaA.. O.АртамоновС. Д.ArtamonovS. D.Лаборатория клеточных технологий отдела биомедицинских технологий и тканевой инженерии (зав. – д. м. н., проф. Н.А. Онищенко) ФГБУ «ФНЦ трансплантологии и искусственных органов им. академика В.И. Шумакова» Минздрава России (директор – академик РАМН, профессор С.В. Готье), Москва, Российская ФедерацияLab of cellular technologies of department of biomedical technologies and tissue engineering (Head – doct. med. sci., prof. N.A. Onishchenko) Acad. V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs (Head – academician RAMSci, prof. S.V. Gautier), Moscow, Russian Federation201315052014154ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ том XV No 4–2013112125Copyright © Онищенко Н.А., Башкина Л.В., Никольская А.О., Артамонов С.Д., 20142014Онищенко Н.А., Башкина Л.В., Никольская А.О., Артамонов С.Д.Onishchenko N.A., Bashkina L.V., Nicolskaya A.O., Artamonov S.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/88

В обзоре обосновывается необходимость внедрения в клиническую практику комплексного мониторинга иммунных клеток крови и цитокинов у больных с пересаженными органами для выбора индивидуальной тактики иммуносупрессивной терапии, оценки ее эффективности и прогнозирования результатов. Подчеркивается, что с особым вниманием следует отнестись к характеристике CD4+ T-лимфоцитов и определению соотношения их отдельных популяций в периферической крови (Treg, Th17, Tact клетки памяти CD4+CD25hiCD127hiCD45RO), так как именно они являются основными участниками ответа иммунной системы организма на трансплантат. 

In this review article the necessity of adaptation and introduction into clinical practice of simultaneous monitoring of immune blood cells and cytokines in patients with grafted organs for a choice of individual tactic of immuno- suppressive therapy, determination of its efficiency and forecasting is proved. It is emphasized, that with the spe- cial attention it ought to concern to characteristic of CD4 + T-lymphocytes and to definition of an interrelation of their separate populations in peripheral blood (Treg, Th17, Tact memory cells – CD4+CD25hiCD127hiCD45RO) since they are the basic participants of immune system reaction on grafts. 

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The authors declare that there are no conflicts of interest present.