vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2013-4-104-111vtio-87Research ArticleКлинические наблюденияClinical CasesТРАНСПЛАНТАЦИЯ ПЕЧЕНИ ПРИ ЭПИТЕЛИОИДНОЙ ГЕМАНГИОЭНДОТЕЛИОМЕ С КАНЦЕРОМАТОЗОМ БРЮШНОЙ ПОЛОСТИ: КЛИНИЧЕСКОЕ НАБЛЮДЕНИЕLIVER TRANSPLANTATION FOR EPITHELIOID HEMANGIOENDOTHELIOMA WITH DIFFUSE INTRAPERITONEAL METASTASES: A CASE REPORTПоршенниковИ. А.PorshennikovI. A.БыковА. Ю.BykovA. Yu.ПавликВ. Н.PavlikV. N.ЩекинаЕ. Е.ShchekinaE. E.БелобородовК. Ю.BeloborodovK. Yu.ГрязновК. А.GryaznovK. A.ЛащенковаЕ. В.LashchenkovaE. V.ПавловаТ. Н.PavlovaT. N.Отделение трансплантации органов (зав. – А.Ю. Быков) ГБУЗ НСО «Государственная Новосибирская областная клиническая больница» (гл. врач – Е.А. Комаровский), Новосибирск, Российская Федерация Кафедра госпитальной и детской хирургии (зав. – проф. Ю.В. Чикинев) ГБОУ ВПО «Новосибирский государственный медицинский университет» Минздрава РФ (ректор – проф. И.О. Маринкин), Новосибирск, Российская ФедерацияOrgan Transplantation Division (Head – A.Yu. Bykov), State Novosibirsk Regional Clinical Hospital (Head – E.A. Komarovsky), Novosibirsk, Russian Federation Chair of Hospital and Pediatric Surgery (Head – prof. Yu.V. Chikinev) Novosibirsk State Medical University (Rector – prof. I.O. Marinkin), Novosibirsk, Russian FederationОтделение трансплантации органов (зав. – А.Ю. Быков) ГБУЗ НСО «Государственная Новосибирская областная клиническая больница» (гл. врач – Е.А. Комаровский), Новосибирск, Российская ФедерацияOrgan Transplantation Division (Head – A.Yu. Bykov), State Novosibirsk Regional Clinical Hospital (Head – E.A. Komarovsky), Novosibirsk, Russian FederationОтделение анестезиологии и реанимации (зав. – А.Н. Колосов) ГБУЗ НСО «Государственная Новосибирская областная клиническая больница» (гл. врач – Е.А. Комаровский), Новосибирск, Российская ФедерацияAnaesthesiology & Resuscitation Division (Head – A.N. Kolosov), State Novosibirsk Regional Clinical Hospital (Head – E.A. Komarovsky), Novosibirsk, Russian FederationОтделение реанимации и интенсивной терапии хирургического профиля (зав. – Е.В. Лащенкова) ГБУЗ НСО «Государственная Новосибирская областная клиническая больница» (гл. врач – Е.А. Комаровский), Новосибирск, Российская ФедерацияChair of Hospital and Pediatric Surgery (Head – prof. Yu.V. Chikinev) Novosibirsk State Medical University (Rector – prof. I.O. Marinkin), Novosibirsk, Russian Federation201315052014154ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ том XV No 4–2013104111Copyright © Поршенников И.А., Быков А.Ю., Павлик В.Н., Щекина Е.Е., Белобородов К.Ю., Грязнов К.А., Лащенкова Е.В., Павлова Т.Н., 20142014Поршенников И.А., Быков А.Ю., Павлик В.Н., Щекина Е.Е., Белобородов К.Ю., Грязнов К.А., Лащенкова Е.В., Павлова Т.Н.Porshennikov I.A., Bykov A.Y., Pavlik V.N., Shchekina E.E., Beloborodov K.Y., Gryaznov K.A., Lashchenkova E.V., Pavlova T.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/87

В статье представлен клинической случай трансплантации печени у молодой пациентки со злокачественной эпителиоидной гемангиоэндотелиомой печени и канцероматозом брюшной полости. Мы наблюдаем 1-летнюю выживаемость без признаков опухолевой прогрессии на фоне иммуносупрессии эверолимусом. В кратком литературном обзоре рассмотрены лечебные опции и результаты операций при данном заболевании. 

We report the case of a young woman who underwent liver transplantation for epithelioid hemangioendothe- lioma with diffuse intraperitoneal metastases. We observe the 1-year survival without tumor progression on everolimus-based immunosuppression. The different therapies and the results of surgery for this disease are discussed in short literature review. 

эпителиоидная гемангиоэндотелиоматрансплантация печениэверолимусepithelioid hemangioendotheliomaliver transplantationeverolimusReferencesСПИСОК ЛИТЕРАТУРЫСПИСОК ЛИТЕРАТУРЫWeiss S.W., Enzinger F.M. Epithelioid hemangioendo- thelioma: a vascular tumor often mistaken for a carcino- ma. Cancer. 1982; 50: 970–981.Weiss S.W., Enzinger F.M. Epithelioid hemangioendo- thelioma: a vascular tumor often mistaken for a carcino- ma. Cancer. 1982; 50: 970–981.Grotz T.E., Nagorney D., Donohue J., Que F., Kendrick M., Farnell M., Harmsen S., Mulligan D., Nguyen J., Rosen C., Reid-Lombardo K.M. Hepatic epi- thelioid hemangioendothelioma: is transplantation the only treatment option? HPB. 2010; 12: 546–553.Grotz T.E., Nagorney D., Donohue J., Que F., Kendrick M., Farnell M., Harmsen S., Mulligan D., Nguyen J., Rosen C., Reid-Lombardo K.M. Hepatic epi- thelioid hemangioendothelioma: is transplantation the only treatment option? HPB. 2010; 12: 546–553.Makhlouf H.R., Ishak K.G., Goodman Z.D. Epithelioid hemangioendothelioma of the liver: a clinicopathologic study of 137 cases. Cancer. 1999; 85: 562–582.Makhlouf H.R., Ishak K.G., Goodman Z.D. Epithelioid hemangioendothelioma of the liver: a clinicopathologic study of 137 cases. Cancer. 1999; 85: 562–582.d’Annibale M., Piovanello P., Carlini P., Del Nonno F., Sciarretta F., Rossi M., Berloco P., Iappelli M., Lonar- do M.T., Perrone R., Donnorso R. Epithelioid hemangio- endothelioma of the liver: case report and review of the literature. Transplant. Proc. 2002; 34: 1248–1251.d’Annibale M., Piovanello P., Carlini P., Del Nonno F., Sciarretta F., Rossi M., Berloco P., Iappelli M., Lonar- do M.T., Perrone R., Donnorso R. Epithelioid hemangio- endothelioma of the liver: case report and review of the literature. Transplant. Proc. 2002; 34: 1248–1251.Mehrabi A., Kashfi A., Fonouni H., Schemmer P., Schmied B.M., Hallscheidt P., Schirmacher P., Weitz J., Friess H., Buchler M.W., Schmidt J. Primary malignant hepatic epithelioid hemangioendothelioma: a compre- hensive review of the literature with emphasis on the surgical therapy. Cancer. 2006; 107: 2108–2121.Mehrabi A., Kashfi A., Fonouni H., Schemmer P., Schmied B.M., Hallscheidt P., Schirmacher P., Weitz J., Friess H., Buchler M.W., Schmidt J. Primary malignant hepatic epithelioid hemangioendothelioma: a compre- hensive review of the literature with emphasis on the surgical therapy. Cancer. 2006; 107: 2108–2121.Sangro B., Iñarrairaegui M., Fernández-Ros N. Malig- nant epithelioid hemangioendothelioma of the liver suc- cessfully treated with Sorafenib. Rare Tumors. 2012; 4: 106–109.Sangro B., Iñarrairaegui M., Fernández-Ros N. Malig- nant epithelioid hemangioendothelioma of the liver suc- cessfully treated with Sorafenib. Rare Tumors. 2012; 4: 106–109.Gores G.J., Heimbach J.K., Rosen C.B. Liver transplan- tation for non-hepatocellular carcinoma malignancies. Liver Transpl. 2010; 16 (2): 22–25.Gores G.J., Heimbach J.K., Rosen C.B. Liver transplan- tation for non-hepatocellular carcinoma malignancies. Liver Transpl. 2010; 16 (2): 22–25.Grossman E.J., Millis J.M. Liver transplantation for non-hepatocellular carcinoma malignancy: indications, limitations, and analysis of the current literature. Liver Transpl. 2010; 16: 930–942.Grossman E.J., Millis J.M. Liver transplantation for non-hepatocellular carcinoma malignancy: indications, limitations, and analysis of the current literature. Liver Transpl. 2010; 16: 930–942.Niemi G., Breivik H. Epidural fentanyl markedly im- proves thoracic epidural analgesia in a low-dose infusion of bupivacaine, adrenaline and fentanyl. A randomized, double-blind crossover study with and without fentanyl. Acta Anaesthesiol. Scand. 2001; 45: 221–232.Niemi G., Breivik H. Epidural fentanyl markedly im- proves thoracic epidural analgesia in a low-dose infusion of bupivacaine, adrenaline and fentanyl. A randomized, double-blind crossover study with and without fentanyl. Acta Anaesthesiol. Scand. 2001; 45: 221–232.Hiatt J.R., Gabbay J., Busuttil R.W. Surgical anatomy of the hepatic arteries in 1000 cases. Ann. Surg. 1994; 220: 50–52.Hiatt J.R., Gabbay J., Busuttil R.W. Surgical anatomy of the hepatic arteries in 1000 cases. Ann. Surg. 1994; 220: 50–52.Olthoff K.M., Kulik L., Samstein B., Kaminski M., Abe- cassis M., Emond J., Shaked A., Christie J.D. Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors. Liver Transpl. 2010; 16: 943–949.Olthoff K.M., Kulik L., Samstein B., Kaminski M., Abe- cassis M., Emond J., Shaked A., Christie J.D. Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors. Liver Transpl. 2010; 16: 943–949.Lerut J.P., Orlando G., Adam R., Schiavo M., Klemp- nauer J., Mirza D., Boleslawski E., Burroughs A., Sel- lés C.F., Jaeck D., Pfitzmann R., Salizzoni M., Söder- dahl G., Steininger R., Wettergren A., Mazzaferro V., Le Treut Y.P., Karam V. The place of liver transplantation in the treatment of hepatic epithelioid hemangioendothe- lioma: report of the European Liver Transplant Registry. Ann. Surg. 2007; 246: 949–957.Lerut J.P., Orlando G., Adam R., Schiavo M., Klemp- nauer J., Mirza D., Boleslawski E., Burroughs A., Sel- lés C.F., Jaeck D., Pfitzmann R., Salizzoni M., Söder- dahl G., Steininger R., Wettergren A., Mazzaferro V., Le Treut Y.P., Karam V. The place of liver transplantation in the treatment of hepatic epithelioid hemangioendothe- lioma: report of the European Liver Transplant Registry. Ann. Surg. 2007; 246: 949–957.Rodriguez J.A., Becker N.S., O’Mahony C.A., Goss J.A., Aloia T.A. Long-term outcomes following liver trans- plantation for hepatic hemangioendothelioma: the UNOS experience from 1987 to 2005. J. Gastrointest. Surg. 2008; 12: 110–116.Rodriguez J.A., Becker N.S., O’Mahony C.A., Goss J.A., Aloia T.A. Long-term outcomes following liver trans- plantation for hepatic hemangioendothelioma: the UNOS experience from 1987 to 2005. J. Gastrointest. Surg. 2008; 12: 110–116.Zhang W., Jambulingam P.S., Silva M.A., Taniere P., Bramhall S.R., Mayer A.D., Buckels J.A., Mirza D.F. Or- thotopic liver transplantation for epithelioid haemangio- endothelioma. Eur. J. Surg. Oncol. 2007; 33: 898–901.Zhang W., Jambulingam P.S., Silva M.A., Taniere P., Bramhall S.R., Mayer A.D., Buckels J.A., Mirza D.F. Or- thotopic liver transplantation for epithelioid haemangio- endothelioma. Eur. J. Surg. Oncol. 2007; 33: 898–901.Seeliger H., Guba M., Kleespies A., Jauch K.W., Bruns C.J. Role of mTOR in solid tumor systems: a the- rapeutical target against primary tumor growth, metasta- ses, and angiogenesis. Cancer Metastasis Rev. 2007; 26: 611–621.Seeliger H., Guba M., Kleespies A., Jauch K.W., Bruns C.J. Role of mTOR in solid tumor systems: a the- rapeutical target against primary tumor growth, metasta- ses, and angiogenesis. Cancer Metastasis Rev. 2007; 26: 611–621.

The authors declare that there are no conflicts of interest present.