<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vtio</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник трансплантологии и искусственных органов</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Transplantology and Artificial Organs</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-1191</issn><publisher><publisher-name>Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15825/1995-1191-2018-1-138-143</article-id><article-id custom-type="elpub" pub-id-type="custom">vtio-865</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Обзор литературы</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Literature Reviews</subject></subj-group></article-categories><title-group><article-title>ПРОБЛЕМЫ ПРИМЕНЕНИЯ И ПУТИ ОПТИМИЗАЦИИ НЕПУЛЬСИРУЮЩИХ (РОТОРНЫХ) НАСОСОВ МЕХАНИЧЕСКОЙ ПОДДЕРЖКИ КРОВООБРАЩЕНИЯ</article-title><trans-title-group xml:lang="en"><trans-title>THE PROBLEMS AND THE OPTIMIZATION OF NON-PULSATING PUMPS OF THE ASSISTED BLOOD CIRCULATION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иткин</surname><given-names>И. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Itkin</surname><given-names>G. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иткин Георгий Пинкусович, кафедра физики живых систем</p><p>123182, Москва, ул. Щукинская, д. 1</p></bio><bio xml:lang="en"><p>Itkin Georgiy Pinkusovich, Department of physics of living systems</p><p>1, Shchukinskaya st., Moscow, 123182</p></bio><email xlink:type="simple">georgeitkin@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Готье</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gautier</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра трансплантологии и искусственных органов</p><p>Москва</p></bio><bio xml:lang="en"/><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова»;&#13;
Московский физико-технический институт (Государственный университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.I. Shumakov National Medical Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian Federation;&#13;
Moscow Institute of Physics and Technology (State University)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова»;&#13;
ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.I. Shumakov National Medical Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian Federation;&#13;
I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovsky University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>24</day><month>04</month><year>2018</year></pub-date><volume>20</volume><issue>1</issue><fpage>138</fpage><lpage>143</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Иткин И.П., Готье С.В., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Иткин И.П., Готье С.В.</copyright-holder><copyright-holder xml:lang="en">Itkin G.P., Gautier S.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.transpl.ru/vtio/article/view/865">https://journal.transpl.ru/vtio/article/view/865</self-uri><abstract><p>Метод механической поддержки кровообращения с использованием насосов непульсирующего потока, построенных на принципе роторных (центробежных и осевых) насосов, занял ведущее направление (94%) в мировой клинической практике для лечения больных с терминальной сердечной недостаточностью. Несмотря на это, клиника применения данных насосов в ряде случаев столкнулась с проблемами, связанными с данной технологией. Все это стимулировало развитие нового направления по разработке новых принципов управления роторными насосами, основанных на модуляции скорости оборотов насосов. В статье проведен анализ негативных факторов клинического применения насосов непульсирующего потока и обзор методов оптимизации управления насосами, основанных на модуляции скорости выходного потока.</p></abstract><trans-abstract xml:lang="en"><p>The method of mechanical circulation support using non-pulsating fl ow pumps, built on the principle of rotary (centrifugal and axial) pumps, took the leading direction (94%) in the world clinical practice for the treatment of the patients with terminal heart failure. Despite this, the clinic application of these pumps in a number of cases faced with the numbers of negative problems associated with this technology. This is stimulated of a new direction of principles for a control of the rotary pumps, based on the modulation of the speed pumps. The article analyzes the negative factors of the clinical application of non-pulsating fl ow pumps and gives an overview of the methods the optimization of the control pump based on the modulation of the output fl ow.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>механическая поддержка кровообращения</kwd><kwd>терминальная сердечная недостаточность</kwd><kwd>роторные насосы</kwd><kwd>модуляция выходного потока</kwd><kwd>система управления насосами</kwd></kwd-group><kwd-group xml:lang="en"><kwd>mechanical support of circulation</kwd><kwd>terminal heart failure</kwd><kwd>rotary pumps</kwd><kwd>modulation of output fl ow</kwd><kwd>control system</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kirklin JK, Naftel DC, Pagani FD, Kormos RL, Stevenson LW, Blume ED et al. Seventh INTERMACS annual report: 15,000 patients and counting. J. Heart Lung Transplant. 2015; 34 (12): 1495–1504. DOI: 10.1016/j.healun.2015.10.003.</mixed-citation><mixed-citation xml:lang="en">Kirklin JK, Naftel DC, Pagani FD, Kormos RL, Stevenson LW, Blume ED et al. Seventh INTERMACS annual report: 15,000 patients and counting. J. Heart Lung Transplant. 2015; 34 (12): 1495–1504. DOI: 10.1016/j.healun.2015.10.003.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Slaughter MS, Rogers JG, Milano CA, Russell SD, Conte JV, Feldman D et al. Advanced heart failure treated with continuous-fl ow left ventricular assist device. N. Engl. J. Med. 2009; 361 (23): 2241–2251. DOI: 10.1056/NEJMoa0909938.</mixed-citation><mixed-citation xml:lang="en">Slaughter MS, Rogers JG, Milano CA, Russell SD, Conte JV, Feldman D et al. Advanced heart failure treated with continuous-fl ow left ventricular assist device. N. Engl. J. Med. 2009; 361 (23): 2241–2251. DOI: 10.1056/NEJMoa0909938.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Miller L, Pagani FD, Russell SD, John R, Boyle AJ, Aaron son KD. Use of a continuous-fl ow device in patients awaiting heart transplantation. N. Engl. J. Med. 2007; 357: 885–896. PMID: 17761592 DOI: 10.1056/NEJMoa067758.</mixed-citation><mixed-citation xml:lang="en">Miller L, Pagani FD, Russell SD, John R, Boyle AJ, Aaron son KD. Use of a continuous-fl ow device in patients awaiting heart transplantation. N. Engl. J. Med. 2007; 357: 885–896. PMID: 17761592 DOI: 10.1056/NEJMoa067758.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Birks EJ, George RS, Hedger M, Bahrami T, Wilton P, Bowles CT et al. Reversal of severe heart failure with a continuous-fl ow left ventricular assist device and pharmacological therapy: a prospective study. Circulation. 2011; 123 (4): 381–390. DOI: 10.1161/CIRCULATIONAHA. 109.933960.</mixed-citation><mixed-citation xml:lang="en">Birks EJ, George RS, Hedger M, Bahrami T, Wilton P, Bowles CT et al. Reversal of severe heart failure with a continuous-fl ow left ventricular assist device and pharmacological therapy: a prospective study. Circulation. 2011; 123 (4): 381–390. DOI: 10.1161/CIRCULATIONAHA. 109.933960.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Birks EJ, George RS, Firouzi A, Wright G, Bahrami T, Yacoub MH et al. Long-term outcomes of patients bridged to recovery versus patients bridged to transplantation. J. Thorac. Cardiovasc. Surg. 2012; 190–196. DOI: 10.1016/j.jtcvs.2012.03.021.</mixed-citation><mixed-citation xml:lang="en">Birks EJ, George RS, Firouzi A, Wright G, Bahrami T, Yacoub MH et al. Long-term outcomes of patients bridged to recovery versus patients bridged to transplantation. J. Thorac. Cardiovasc. Surg. 2012; 190–196. DOI: 10.1016/j.jtcvs.2012.03.021.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Simon MA, Kormos RL, Murali S, Nair P, Heffernan M, Gorcsan J et al. Myocardial recovery using ventricular assist devices: prevalence, clinical characteristics, and outcomes. Circulation. 2005; 112 (9 Suppl): I32–I36. DOI: 10.1161/CIRCULATIONAHA.104.524124.</mixed-citation><mixed-citation xml:lang="en">Simon MA, Kormos RL, Murali S, Nair P, Heffernan M, Gorcsan J et al. Myocardial recovery using ventricular assist devices: prevalence, clinical characteristics, and outcomes. Circulation. 2005; 112 (9 Suppl): I32–I36. DOI: 10.1161/CIRCULATIONAHA.104.524124.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Drakos SG, Pagani FD, Lundberg MS, Baldwin JT. Advancing the Science of Myocardial Recovery With Mechanical Circulatory Support: A Working Group of the National, Heart, Lung, and Blood Institute. JACC Basic. Transl. Sci. 2017 Jun; 2 (3): 335–340. doi: 10.1016/j.jacbts.2016.12.003.</mixed-citation><mixed-citation xml:lang="en">Drakos SG, Pagani FD, Lundberg MS, Baldwin JT. Advancing the Science of Myocardial Recovery With Mechanical Circulatory Support: A Working Group of the National, Heart, Lung, and Blood Institute. JACC Basic. Transl. Sci. 2017 Jun; 2 (3): 335–340. doi: 10.1016/j.jacbts.2016.12.003.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Rose EA, Moskowitz AJ, Packer M, Sollano JA, Wiliams DL, Tierney AR et al. The REMATCH trial: rationale, design, and end points. Ann. Thorac. Surg. 1999; 67 (3): 723–730. PMID: 10215217.</mixed-citation><mixed-citation xml:lang="en">Rose EA, Moskowitz AJ, Packer M, Sollano JA, Wiliams DL, Tierney AR et al. The REMATCH trial: rationale, design, and end points. Ann. Thorac. Surg. 1999; 67 (3): 723–730. PMID: 10215217.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kirklin JK, Naftel DC, Pagani FD, Kormos RL, Stevenson L, Miller M et al. Long-term mechanical circulatory support (destination therapy): on track to compete with heart transplantation? J. Thorac. Cardiovasc. Surg. 2012; 144 (3): 584–603. DOI: 10.1016/j.jtcvs.2012.05.044.</mixed-citation><mixed-citation xml:lang="en">Kirklin JK, Naftel DC, Pagani FD, Kormos RL, Stevenson L, Miller M et al. Long-term mechanical circulatory support (destination therapy): on track to compete with heart transplantation? J. Thorac. Cardiovasc. Surg. 2012; 144 (3): 584–603. DOI: 10.1016/j.jtcvs.2012.05.044.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Drews T, Stepanenko A, Dandel M, Buz S, Lehmkupl HB, Helzer R. Mechanical circulatory support in patient of advanced age. Eur. J. Heart. Fail. 2010; 12 (9): 990–994. DOI: 10.1093/eurjhf/hfq076. PMID:20495203.</mixed-citation><mixed-citation xml:lang="en">Drews T, Stepanenko A, Dandel M, Buz S, Lehmkupl HB, Helzer R. Mechanical circulatory support in patient of advanced age. Eur. J. Heart. Fail. 2010; 12 (9): 990–994. DOI: 10.1093/eurjhf/hfq076. PMID:20495203.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Salamonsen RF, Mason DG, Ayre PJ. Response of rotary blood pumps to changes in preload and afterload at a fi xed speed setting are unphysiological when compared with the natural heart. Artif Organs. 2011 Mar; 35 (3): E47-53. doi: 10.1111/j.1525-1594.2010.01168.x. Epub 2011 Mar 1.</mixed-citation><mixed-citation xml:lang="en">Salamonsen RF, Mason DG, Ayre PJ. Response of rotary blood pumps to changes in preload and afterload at a fi xed speed setting are unphysiological when compared with the natural heart. Artif Organs. 2011 Mar; 35 (3): E47-53. doi: 10.1111/j.1525-1594.2010.01168.x. Epub 2011 Mar 1.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Soucy KG, Koenig SC, Giridharan GA, Sobieski MA, Slaughter MS. Rotary pumps and diminished pulsatility: do we need a pulse? ASAIO J. 2013; 59 (4): 355–366. doi: 10.1097/MAT.0b013e31829f9bb3.</mixed-citation><mixed-citation xml:lang="en">Soucy KG, Koenig SC, Giridharan GA, Sobieski MA, Slaughter MS. Rotary pumps and diminished pulsatility: do we need a pulse? ASAIO J. 2013; 59 (4): 355–366. doi: 10.1097/MAT.0b013e31829f9bb3.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Moazami N, Dembitsky WP, Adamson R, Steffen RJ, Soltesz EG, Starling RC, Fukamachi K. Does pulsatility matter in the era of continuous-fl ow blood pumps? J. Heart. Lung. Transplant. 2015 Aug; 34 (8): 999–1004. doi: 10.1016/j.healun.2014.09.012.</mixed-citation><mixed-citation xml:lang="en">Moazami N, Dembitsky WP, Adamson R, Steffen RJ, Soltesz EG, Starling RC, Fukamachi K. Does pulsatility matter in the era of continuous-fl ow blood pumps? J. Heart. Lung. Transplant. 2015 Aug; 34 (8): 999–1004. doi: 10.1016/j.healun.2014.09.012.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Soucy KG, Koenig SC, Giridharan GA, Sobieski MA, Slaughter MS. Rotary Pumps and Diminished Pulsatility: Do We Need a Pulse? ASAIO Journal. 2013; 59: 355–366.</mixed-citation><mixed-citation xml:lang="en">Soucy KG, Koenig SC, Giridharan GA, Sobieski MA, Slaughter MS. Rotary Pumps and Diminished Pulsatility: Do We Need a Pulse? ASAIO Journal. 2013; 59: 355–366.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Saeed O, Jermyn R, Kargoli F, Madan S, Mannem S, Gunda S et al. Blood pressure and adverse events during continuous fl ow left ventricular assist device support. Circ. Heart. Fail. 2015 May; 8 (3): 551–556. doi: 10.1161/CIRCHEARTFAILURE.114.002000.</mixed-citation><mixed-citation xml:lang="en">Saeed O, Jermyn R, Kargoli F, Madan S, Mannem S, Gunda S et al. Blood pressure and adverse events during continuous fl ow left ventricular assist device support. Circ. Heart. Fail. 2015 May; 8 (3): 551–556. doi: 10.1161/CIRCHEARTFAILURE.114.002000.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Vandenberghe S, Segers P, Antaki J, Meyns B, Verdonck VPR. Hemodynamic modes of ventricular assist with a rotary blood pump: continuous, pulsatile, and failure. ASAIO Journal. 2005; 51: 711–718. PMID:16340355.</mixed-citation><mixed-citation xml:lang="en">Vandenberghe S, Segers P, Antaki J, Meyns B, Verdonck VPR. Hemodynamic modes of ventricular assist with a rotary blood pump: continuous, pulsatile, and failure. ASAIO Journal. 2005; 51: 711–718. PMID:16340355.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Thalmann M, Schima H, Wieselthaler G, Wolner E. Physiology of continuous blood fl ow in recipients of rotary cardiac assist devices. J. Heart. Lung. Transplant. 2005 Mar; 24 (3): 237–245. PMID: 15737748 DOI: 10.1016/j.healun.2004.04.018.</mixed-citation><mixed-citation xml:lang="en">Thalmann M, Schima H, Wieselthaler G, Wolner E. Physiology of continuous blood fl ow in recipients of rotary cardiac assist devices. J. Heart. Lung. Transplant. 2005 Mar; 24 (3): 237–245. PMID: 15737748 DOI: 10.1016/j.healun.2004.04.018.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Baba A, Dobsák P, Saito I, Isoyama T, Takiura K, Abe Y et al. Microcirculation of the bulbar conjunctiva in the goat implanted with a total artifi cial heart: Effects of pulsatile and nonpulsatile fl ow. ASAIO J. 2004; 50: 321– 327. PMID: 14616529.</mixed-citation><mixed-citation xml:lang="en">Baba A, Dobsák P, Saito I, Isoyama T, Takiura K, Abe Y et al. Microcirculation of the bulbar conjunctiva in the goat implanted with a total artifi cial heart: Effects of pulsatile and nonpulsatile fl ow. ASAIO J. 2004; 50: 321– 327. PMID: 14616529.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Amir O, Radovancevic B, Delgado RM, Kar B, Radovancevic R, Henderson M et al. Peripheral vascular reactivity in patients with pulsatile vs axial fl ow left ventricular assist device support. Journal of Heart and Lung Transplantation. 2006; 25: 391–394. PMID: 16563966 DOI: 10.1016/j.healun.2005.11.439.</mixed-citation><mixed-citation xml:lang="en">Amir O, Radovancevic B, Delgado RM, Kar B, Radovancevic R, Henderson M et al. Peripheral vascular reactivity in patients with pulsatile vs axial fl ow left ventricular assist device support. Journal of Heart and Lung Transplantation. 2006; 25: 391–394. PMID: 16563966 DOI: 10.1016/j.healun.2005.11.439.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Ji B, Undar A. Comparison of perfusion modes on microcirculation during acute and chronic cardiac support: Is there a difference? Perfusion. 2007; 22: 115–119. PMID: 17708160.</mixed-citation><mixed-citation xml:lang="en">Ji B, Undar A. Comparison of perfusion modes on microcirculation during acute and chronic cardiac support: Is there a difference? Perfusion. 2007; 22: 115–119. PMID: 17708160.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Orime Y, Shiono M, Nakata K, Hata M, Sezai A, Yamada H et al. The role of pulsatility in end organ microcirculation after cardiogenic shock. ASAIO J. 1996; 42: M724–M729. PMID: 8944976.</mixed-citation><mixed-citation xml:lang="en">Orime Y, Shiono M, Nakata K, Hata M, Sezai A, Yamada H et al. The role of pulsatility in end organ microcirculation after cardiogenic shock. ASAIO J. 1996; 42: M724–M729. PMID: 8944976.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Dobsák P, Novakova M, Baba A, Vasku J, Isoyama T, Saito I et al. Infl uence of fl ow design on microcirculation in conditions of undulation pump-left ventricle assist device testing. Artif Organs. 2006; 30: 478–487. PMID: 16734600 DOI: 10.1111/j.1525-1594.2006.00244.x.</mixed-citation><mixed-citation xml:lang="en">Dobsák P, Novakova M, Baba A, Vasku J, Isoyama T, Saito I et al. Infl uence of fl ow design on microcirculation in conditions of undulation pump-left ventricle assist device testing. Artif Organs. 2006; 30: 478–487. PMID: 16734600 DOI: 10.1111/j.1525-1594.2006.00244.x.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Ji, Undar A. An evaluation of the benefi ts of pulsatile versus non-pulsatile perfusion during cardiopulmonary bypass procedures in pediatric and adult cardiac patients. ASAIO J. 2006; 52: 357–361. PMID: 16883112 DOI: 10.1097/01.mat.0000225266.80021.9b.</mixed-citation><mixed-citation xml:lang="en">Ji, Undar A. An evaluation of the benefi ts of pulsatile versus non-pulsatile perfusion during cardiopulmonary bypass procedures in pediatric and adult cardiac patients. ASAIO J. 2006; 52: 357–361. PMID: 16883112 DOI: 10.1097/01.mat.0000225266.80021.9b.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Letsou GV, Shah N, Gregoric ID, Myers HJ, Delgado R, Frazier OH. Gastrointestinal bleeding from arteriovenous malformations in patients supported by the Jarvik 2000 axial-fl ow left ventricular assist device. J. Heart. Lung. Transplant. 2005; 24: 105–109. PMID: 15653390 DOI: 10.1016/j.healun.2003.10.018.</mixed-citation><mixed-citation xml:lang="en">Letsou GV, Shah N, Gregoric ID, Myers HJ, Delgado R, Frazier OH. Gastrointestinal bleeding from arteriovenous malformations in patients supported by the Jarvik 2000 axial-fl ow left ventricular assist device. J. Heart. Lung. Transplant. 2005; 24: 105–109. PMID: 15653390 DOI: 10.1016/j.healun.2003.10.018.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Hayes HM, Dembo LG, Larbalestier R, O’Driscoll G. Management options to treat gastrointestinal bleeding in patients supported on rotary left ventricular assist devices: A single-center experience. Artif. Organs. 2010; 34: 703–706. doi: 10.1111/j.15251594.2010.01084.x.</mixed-citation><mixed-citation xml:lang="en">Hayes HM, Dembo LG, Larbalestier R, O’Driscoll G. Management options to treat gastrointestinal bleeding in patients supported on rotary left ventricular assist devices: A single-center experience. Artif. Organs. 2010; 34: 703–706. doi: 10.1111/j.15251594.2010.01084.x.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">John R, Kamdar F, Liao K, Colvin-Adams M, Boyle A, Joyce L. Improved survival and decreasing incidence of adverse events with the HeartMate II left ventricular assist device as bridge-to-transplant therapy. Ann. Thorac. Surg. 2008; 86: 1227–1234; discussion 1234. DOI: 10.1016/j.athoracsur.2008.06.030.</mixed-citation><mixed-citation xml:lang="en">John R, Kamdar F, Liao K, Colvin-Adams M, Boyle A, Joyce L. Improved survival and decreasing incidence of adverse events with the HeartMate II left ventricular assist device as bridge-to-transplant therapy. Ann. Thorac. Surg. 2008; 86: 1227–1234; discussion 1234. DOI: 10.1016/j.athoracsur.2008.06.030.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">John R. Current axial-fl ow devices –The HeartMate II and Jarvik 2000 left ventricular assist devices. Semin. Thorac. Cardiovasc. Surg. 2008; 20: 264–272. PMID: 18805167 DOI: 10.1016/j.athoracsur.2008.06.030.</mixed-citation><mixed-citation xml:lang="en">John R. Current axial-fl ow devices –The HeartMate II and Jarvik 2000 left ventricular assist devices. Semin. Thorac. Cardiovasc. Surg. 2008; 20: 264–272. PMID: 18805167 DOI: 10.1016/j.athoracsur.2008.06.030.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Demirozu ZT, Radovancevic R, Hochman LF, Gregoric ID, Letsou GV, Kar B et al. Arteriovenous malformation and gastrointestinal bleeding in patients with the HeartMate II left ventricular assist device. J. Heart. Lung. Transplant. 2011; 30: 849–853. DOI: 10.1016/j.healun.2011.03.008.</mixed-citation><mixed-citation xml:lang="en">Demirozu ZT, Radovancevic R, Hochman LF, Gregoric ID, Letsou GV, Kar B et al. Arteriovenous malformation and gastrointestinal bleeding in patients with the HeartMate II left ventricular assist device. J. Heart. Lung. Transplant. 2011; 30: 849–853. DOI: 10.1016/j.healun.2011.03.008.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Morgan JA, Paone G, Nemeh HW, Henry SE, Patel R, Vavra J et al. Gastrointestinal bleeding with the HeartMate II left ventricular assist device. J. Heart. Lung. Transplant. 2012; 31: 715–718. DOI: 10.1016/j.healun.2012.02.015.</mixed-citation><mixed-citation xml:lang="en">Morgan JA, Paone G, Nemeh HW, Henry SE, Patel R, Vavra J et al. Gastrointestinal bleeding with the HeartMate II left ventricular assist device. J. Heart. Lung. Transplant. 2012; 31: 715–718. DOI: 10.1016/j.healun.2012.02.015.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Crow S, John R, Boyle A, Shumway S, Liao K, ColvinAdams M et al. Gastrointestinal bleeding rates in recipients of non-pulsatile and pulsatile left ventricular assist devices. J Thorac. Cardiovasc. Surg. 2009; 137: 208. DOI: 10.1016/j.jtcvs.2008.07.032.</mixed-citation><mixed-citation xml:lang="en">Crow S, John R, Boyle A, Shumway S, Liao K, ColvinAdams M et al. Gastrointestinal bleeding rates in recipients of non-pulsatile and pulsatile left ventricular assist devices. J Thorac. Cardiovasc. Surg. 2009; 137: 208. DOI: 10.1016/j.jtcvs.2008.07.032.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Geisen U, Heilmann C, Beyersdorf F, Benk C, BerchtoldHerz M, Schlensak et al. Nonsurgical bleeding in patients with ventricular assist devices could be explained by acquired von Willebrand disease. Eur. J. Cardiothorac. Surg. 2008; 33: 679–684. DOI: 10.1016/j.ejcts.2007.12.047.</mixed-citation><mixed-citation xml:lang="en">Geisen U, Heilmann C, Beyersdorf F, Benk C, BerchtoldHerz M, Schlensak et al. Nonsurgical bleeding in patients with ventricular assist devices could be explained by acquired von Willebrand disease. Eur. J. Cardiothorac. Surg. 2008; 33: 679–684. DOI: 10.1016/j.ejcts.2007.12.047.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Klovaite J, Gustafsson F, Mortensen SA, Sander K, Nielsen LB. Severely impaired von Willebrand factor-dependent platelet aggregation in patients with a continuousfl ow left ventricular assist device (HeartMate II). J. Am. Coll. Cardiol. 2009; 53: 2162–2167. DOI: 10.1016/j.jacc.2009.02.048.</mixed-citation><mixed-citation xml:lang="en">Klovaite J, Gustafsson F, Mortensen SA, Sander K, Nielsen LB. Severely impaired von Willebrand factor-dependent platelet aggregation in patients with a continuousfl ow left ventricular assist device (HeartMate II). J. Am. Coll. Cardiol. 2009; 53: 2162–2167. DOI: 10.1016/j.jacc.2009.02.048.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Crow S, Chen D, Milano C, Thomas W, Joyce L, Piacentino V 3rd et al. Acquired von Willebrand syndrome in continuous-fl ow ventricular assist device recipients. Ann. Thorac. Surg. 2010; 90: 1263–1269; discussion 1269.20868825. DOI: 10.1016/j.athoracsur.2010.04.099.</mixed-citation><mixed-citation xml:lang="en">Crow S, Chen D, Milano C, Thomas W, Joyce L, Piacentino V 3rd et al. Acquired von Willebrand syndrome in continuous-fl ow ventricular assist device recipients. Ann. Thorac. Surg. 2010; 90: 1263–1269; discussion 1269.20868825. DOI: 10.1016/j.athoracsur.2010.04.099.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Crow S, Milano C, Joyce L, Chen D, Arepally G, Bowles D et al. Comparative analysis of von Willebrand factor profi les in pulsatile and continuous left ventricular assist device recipients. ASAIO J. 2010; 56: 441–445, 1396–1404, 200. doi: 10.1097/MAT.0b013e3181e5de0a.</mixed-citation><mixed-citation xml:lang="en">Crow S, Milano C, Joyce L, Chen D, Arepally G, Bowles D et al. Comparative analysis of von Willebrand factor profi les in pulsatile and continuous left ventricular assist device recipients. ASAIO J. 2010; 56: 441–445, 1396–1404, 200. doi: 10.1097/MAT.0b013e3181e5de0a.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Giridharan GA, Ewert DL, Pantalos GM, Gillars KJ, Litwak KN, Gray LA et al. Left ventricular and myocardial perfusion responses to volume unloading and after-load reduction in a computer simulation. ASAIO J. 2004; 50: 512–518, DOI: 10.1097/01.MAT.0000136513.21369.75.</mixed-citation><mixed-citation xml:lang="en">Giridharan GA, Ewert DL, Pantalos GM, Gillars KJ, Litwak KN, Gray LA et al. Left ventricular and myocardial perfusion responses to volume unloading and after-load reduction in a computer simulation. ASAIO J. 2004; 50: 512–518, DOI: 10.1097/01.MAT.0000136513.21369.75.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Klotz S, Deng MC, Stypmann J, Roetker J, Wilhelm MJ, Hammel D et al. Left ventricular pressure and volume unloading during pulsatile versus nonpulsatile left ventricular assist device support. Ann. Thorac. Surg. 2004; 77: 143–149; discussion 149. DOI: 10.1016/S00034975(03)01336-5.</mixed-citation><mixed-citation xml:lang="en">Klotz S, Deng MC, Stypmann J, Roetker J, Wilhelm MJ, Hammel D et al. Left ventricular pressure and volume unloading during pulsatile versus nonpulsatile left ventricular assist device support. Ann. Thorac. Surg. 2004; 77: 143–149; discussion 149. DOI: 10.1016/S00034975(03)01336-5.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Thohan V, Stetson SJ, Nagueh SF, Rivas-Gotz C, Koerner MM, Lafuente JA et al. Cellular and hemodynamics responses of failing myocardium to continuous fl ow mechanical circulatory support using the DeBakey-Noon left ventricular assist device: A comparative analysis with pulsatile-type devices. J. Heart. Lung. Transplant. 2005; 24: 566–575, 2005. DOI: 10.1016/j.healun.2004.02.017.</mixed-citation><mixed-citation xml:lang="en">Thohan V, Stetson SJ, Nagueh SF, Rivas-Gotz C, Koerner MM, Lafuente JA et al. Cellular and hemodynamics responses of failing myocardium to continuous fl ow mechanical circulatory support using the DeBakey-Noon left ventricular assist device: A comparative analysis with pulsatile-type devices. J. Heart. Lung. Transplant. 2005; 24: 566–575, 2005. DOI: 10.1016/j.healun.2004.02.017.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Krabatsch T, Schweiger M, Dandel M, Stepanenko A, Drews T, Potapov E et al. Is bridge to recovery more likely with pulsatile left ventricular assist devices than with nonpulsatile-flow systems? Ann. Thorac. Surg. 2011; 91: 1335–1340. DOI: 10.1016/j.athoracsur.2011.01.027.</mixed-citation><mixed-citation xml:lang="en">Krabatsch T, Schweiger M, Dandel M, Stepanenko A, Drews T, Potapov E et al. Is bridge to recovery more likely with pulsatile left ventricular assist devices than with nonpulsatile-flow systems? Ann. Thorac. Surg. 2011; 91: 1335–1340. DOI: 10.1016/j.athoracsur.2011.01.027.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Kato TS, Chokshi A, Singh P, Khawaja T, Cheema F, Akashi H et al. Effects of continuous-fl ow versus pulsatilefl ow left ventricular assist devices on myocardial unloading and remodeling. Circ. Heart. Fail. 2011; 14: 546–553. DOI: 10.1161/CIRCHEARTFAILURE. 111.962142.</mixed-citation><mixed-citation xml:lang="en">Kato TS, Chokshi A, Singh P, Khawaja T, Cheema F, Akashi H et al. Effects of continuous-fl ow versus pulsatilefl ow left ventricular assist devices on myocardial unloading and remodeling. Circ. Heart. Fail. 2011; 14: 546–553. DOI: 10.1161/CIRCHEARTFAILURE. 111.962142.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Koenig SC, Pantalos GM, Gillars KJ, Ewert DL, Litwak KN, Etoch SW. Hemodynamic and pressure-volume responses to continuous and pulsatile ventricular assist in an adult mock circulation. ASAO J. 2004; 50: 15–24. DOI: 10.1097/01.MAT.0000104816.50277.EB.</mixed-citation><mixed-citation xml:lang="en">Koenig SC, Pantalos GM, Gillars KJ, Ewert DL, Litwak KN, Etoch SW. Hemodynamic and pressure-volume responses to continuous and pulsatile ventricular assist in an adult mock circulation. ASAO J. 2004; 50: 15–24. DOI: 10.1097/01.MAT.0000104816.50277.EB.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">May-Newman K, Enriquez-Almaguer L, Posuwattanakul P, Dembitsky W. Biomechanics of the aortic valve in the continuous fl ow VAD-assisted heart. ASAIO J. 2001; 56: 301–308. DOI: 10.1097/MAT.0b013e3181e321da.</mixed-citation><mixed-citation xml:lang="en">May-Newman K, Enriquez-Almaguer L, Posuwattanakul P, Dembitsky W. Biomechanics of the aortic valve in the continuous fl ow VAD-assisted heart. ASAIO J. 2001; 56: 301–308. DOI: 10.1097/MAT.0b013e3181e321da.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Mudd JO, Cuda JD, Halushka M, Soderlund KA, Conte J, Russell SD. Fusion of aortic valve commissures in patients supported by a continuous axial fl ow left ventricular assist device. J. Heart. Lung. Transplant. 2008; 27: 1269–1274. DOI: 10.1016/j.healun.2008.05.029.</mixed-citation><mixed-citation xml:lang="en">Mudd JO, Cuda JD, Halushka M, Soderlund KA, Conte J, Russell SD. Fusion of aortic valve commissures in patients supported by a continuous axial fl ow left ventricular assist device. J. Heart. Lung. Transplant. 2008; 27: 1269–1274. DOI: 10.1016/j.healun.2008.05.029.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Rose AG, Park SJ, Bank AJ, Miller LW. Partial aortic valve fusion induced by left ventricular assist device. Ann. Thorac. Surg. 2000; 70: 1270–1274. PMID: 1081884.</mixed-citation><mixed-citation xml:lang="en">Rose AG, Park SJ, Bank AJ, Miller LW. Partial aortic valve fusion induced by left ventricular assist device. Ann. Thorac. Surg. 2000; 70: 1270–1274. PMID: 1081884.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Hatano M, Kinugawa K, Shiga T, Kato N, Endo M, Hisagi M et al. Less frequent opening of the aortic valve and a continuous fl ow pump are risk factors for postoperative onset of aortic insuffi ciency in patients with a left ventricular assist device. Circ. J. 2011; 75: 1147–1155. DOI: 10.1253/circj.CJ-10-1106.</mixed-citation><mixed-citation xml:lang="en">Hatano M, Kinugawa K, Shiga T, Kato N, Endo M, Hisagi M et al. Less frequent opening of the aortic valve and a continuous fl ow pump are risk factors for postoperative onset of aortic insuffi ciency in patients with a left ventricular assist device. Circ. J. 2011; 75: 1147–1155. DOI: 10.1253/circj.CJ-10-1106.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Pak SW, Uriel N, Takayama H, Cappleman S, Song R, Colombo PC et al. Prevalence of de novo aortic insuffi ciency during long-term support with left ventricular assist devices. J. Heart. Lung. Transplant. 2010; 29: 1172–1176. DOI: 10.1016/j.healun.2010.05.018.</mixed-citation><mixed-citation xml:lang="en">Pak SW, Uriel N, Takayama H, Cappleman S, Song R, Colombo PC et al. Prevalence of de novo aortic insuffi ciency during long-term support with left ventricular assist devices. J. Heart. Lung. Transplant. 2010; 29: 1172–1176. DOI: 10.1016/j.healun.2010.05.018.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Tuzun E, Gregoric ID, Conger JL, Golden K, Jarvik R, Frazier OH. The effect of intermittent low speed mode upon aortic valve opening in calves supported with a Jarvik 2000 axial fl ow device. ASAIO J. 2005 Mar-Apr; 51 (2): 139–143. PMID: 15839437.</mixed-citation><mixed-citation xml:lang="en">Tuzun E, Gregoric ID, Conger JL, Golden K, Jarvik R, Frazier OH. The effect of intermittent low speed mode upon aortic valve opening in calves supported with a Jarvik 2000 axial fl ow device. ASAIO J. 2005 Mar-Apr; 51 (2): 139–143. PMID: 15839437.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Tolpen SI, Janmaat J, Reider C, Kallel F, Farrar D, May-Newman K. Programmed Speed Reduction Enables Aortic Valve Opening and Increased Pulsatility in the LVAD-Assisted Heart. ASAIO J. 2015; 61 (5): 540–547. doi: 10.1097/MAT.0000000000000241.</mixed-citation><mixed-citation xml:lang="en">Tolpen SI, Janmaat J, Reider C, Kallel F, Farrar D, May-Newman K. Programmed Speed Reduction Enables Aortic Valve Opening and Increased Pulsatility in the LVAD-Assisted Heart. ASAIO J. 2015; 61 (5): 540–547. doi: 10.1097/MAT.0000000000000241.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Larose JA, Tamez D, Ashenuga M, Reyes C. Design concepts and principle of operation of the Heart Ware ventricular assist system. ASAIO J. 2010; 56: 285–289. DOI: 10.1097/MAT.0b013e3181dfbab5.</mixed-citation><mixed-citation xml:lang="en">Larose JA, Tamez D, Ashenuga M, Reyes C. Design concepts and principle of operation of the Heart Ware ventricular assist system. ASAIO J. 2010; 56: 285–289. DOI: 10.1097/MAT.0b013e3181dfbab5.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Wang S, Rider AR, Kunselman AR, Richardson JS, Dasse KA, Undar A. Effects of the pulsatile fl ow settings on pulsatile waveforms and hemodynamic energy in a pedivas centrifugal pump. ASAIO J. 2009; 55: 271–276. DOI: 10.1097/MAT.0b013e31819401f9.</mixed-citation><mixed-citation xml:lang="en">Wang S, Rider AR, Kunselman AR, Richardson JS, Dasse KA, Undar A. Effects of the pulsatile fl ow settings on pulsatile waveforms and hemodynamic energy in a pedivas centrifugal pump. ASAIO J. 2009; 55: 271–276. DOI: 10.1097/MAT.0b013e31819401f9.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Vollkron M, Schima H, Huber L, Benkowski R, Morello G, Wieselthaler G. Advanced suction detection for an axial fl ow pump. Artif. Organs. 2006 Sep; 30 (9): 665–670. PMID: 16934094 DOI: 10.1111/j.15251594.2006.00282.x.</mixed-citation><mixed-citation xml:lang="en">Vollkron M, Schima H, Huber L, Benkowski R, Morello G, Wieselthaler G. Advanced suction detection for an axial fl ow pump. Artif. Organs. 2006 Sep; 30 (9): 665–670. PMID: 16934094 DOI: 10.1111/j.15251594.2006.00282.x.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Yuhki AI, Hatoh E, Nogawa M, Miura M, Shimazaki Y, Takatani S. Detection of suction and regurgitation of the implantable centrifugal pump based on the motor current waveform analysis and its application to optimization of pump fl ow. Artif. Organs. 1999 Jun; 23 (6): 532–527. PMID: 10392280.</mixed-citation><mixed-citation xml:lang="en">Yuhki AI, Hatoh E, Nogawa M, Miura M, Shimazaki Y, Takatani S. Detection of suction and regurgitation of the implantable centrifugal pump based on the motor current waveform analysis and its application to optimization of pump fl ow. Artif. Organs. 1999 Jun; 23 (6): 532–527. PMID: 10392280.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Tchantchaleishvili V, Jessica GY, Luc JGY, Cohan CM, Phan K, Hübbert L et al. Clinical implications of physiological fl ow adjustment in continuous-fl ow left ventricular assist devices. ASAIO J. 2017 May/Jun; 63 (3): 241–250. doi: 10.1097/MAT.0000000000000477.</mixed-citation><mixed-citation xml:lang="en">Tchantchaleishvili V, Jessica GY, Luc JGY, Cohan CM, Phan K, Hübbert L et al. Clinical implications of physiological fl ow adjustment in continuous-fl ow left ventricular assist devices. ASAIO J. 2017 May/Jun; 63 (3): 241–250. doi: 10.1097/MAT.0000000000000477.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Ising MS, Sobieski MA, Slaughter MS, Koenig SC, Giridharan GA. Feasibility of Pump Speed Modulation for Restoring Vascular Pulsatility with Rotary Blood Pumps. ASAIO J. 2015 Sep-Oct; 61 (5): 526–532. doi: 10.1097/MAT.0000000000000262.</mixed-citation><mixed-citation xml:lang="en">Ising MS, Sobieski MA, Slaughter MS, Koenig SC, Giridharan GA. Feasibility of Pump Speed Modulation for Restoring Vascular Pulsatility with Rotary Blood Pumps. ASAIO J. 2015 Sep-Oct; 61 (5): 526–532. doi: 10.1097/MAT.0000000000000262.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Bartoli CR, Giridharan GA, Litwak KN, Sobieski M, Prabhu SD, Slaughter MS et al. Hemodynamic responses to continuous versus pulsatilemechanical unloading of the failing left ventricle. ASAIO J. 2010 Sep-Oct; 56 (5): 410–416. doi: 10.1097/ MAT.0b013e3181e7bf3c.</mixed-citation><mixed-citation xml:lang="en">Bartoli CR, Giridharan GA, Litwak KN, Sobieski M, Prabhu SD, Slaughter MS et al. Hemodynamic responses to continuous versus pulsatilemechanical unloading of the failing left ventricle. ASAIO J. 2010 Sep-Oct; 56 (5): 410–416. doi: 10.1097/ MAT.0b013e3181e7bf3c.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Undar A. Myths and truths of pulsatile and nonpulsatile perfusion during acute and chronic cardiac support. Artif. Organs. 2004; 28 (5): 439–443. DOI: 10.1111/j.15251594.2004.00086.x.</mixed-citation><mixed-citation xml:lang="en">Undar A. Myths and truths of pulsatile and nonpulsatile perfusion during acute and chronic cardiac support. Artif. Organs. 2004; 28 (5): 439–443. DOI: 10.1111/j.15251594.2004.00086.x.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Kleinheyer M, Timms DL, Tansley GD, Nestler F, Greatrex NA, Frazier OH et al. Rapid Speed Modulation of a Rotary Total Artifi cial Heart Impeller. Artif. Organs. 2016; 40 (9): 824–833. doi: 10.1111/aor.12827.</mixed-citation><mixed-citation xml:lang="en">Kleinheyer M, Timms DL, Tansley GD, Nestler F, Greatrex NA, Frazier OH et al. Rapid Speed Modulation of a Rotary Total Artifi cial Heart Impeller. Artif. Organs. 2016; 40 (9): 824–833. doi: 10.1111/aor.12827.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Pirbodaghi T. Mathematical Modeling of Rotary Blood Pumps in a Pulsatile in vitro Flow Environment. Artif. Organs. 2017; 41 (8): 710–716. doi: 10.1111/aor.12860.</mixed-citation><mixed-citation xml:lang="en">Pirbodaghi T. Mathematical Modeling of Rotary Blood Pumps in a Pulsatile in vitro Flow Environment. Artif. Organs. 2017; 41 (8): 710–716. doi: 10.1111/aor.12860.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Bozkurt SI, van de Vosse FN, Rutten MC. Improving arterial pulsatility by feedback control of a continuous fl ow left ventricular assist device via in silico modeling. Int. J. Artif. Organs. 2014; 37 (10): 773–785. doi: 10.5301/ijao.5000328.</mixed-citation><mixed-citation xml:lang="en">Bozkurt SI, van de Vosse FN, Rutten MC. Improving arterial pulsatility by feedback control of a continuous fl ow left ventricular assist device via in silico modeling. Int. J. Artif. Organs. 2014; 37 (10): 773–785. doi: 10.5301/ijao.5000328.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Huang FI, Ruan X, Fu X. Pulse-pressure-enhancing controller for better physiologic perfusion of rotary blood pumps based on speed modulation. ASAIO J. 2014; 60 (3): 269–279. doi: 10.1097/MAT.0000000000000059.</mixed-citation><mixed-citation xml:lang="en">Huang FI, Ruan X, Fu X. Pulse-pressure-enhancing controller for better physiologic perfusion of rotary blood pumps based on speed modulation. ASAIO J. 2014; 60 (3): 269–279. doi: 10.1097/MAT.0000000000000059.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Bozkurt S. van de Vosse FN, Rutten MCM. Enhancement of Arterial Pressure Pulsatility by Left Ventricular Assist Device Flow Rate in Mock Circulatory System. J. Med. Biol. Eng. 2016; 36: 308–315. DOI 10.1007/s40846016-014060.</mixed-citation><mixed-citation xml:lang="en">Bozkurt S. van de Vosse FN, Rutten MCM. Enhancement of Arterial Pressure Pulsatility by Left Ventricular Assist Device Flow Rate in Mock Circulatory System. J. Med. Biol. Eng. 2016; 36: 308–315. DOI 10.1007/s40846016-014060.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Jahren SE, Ochsner G, Shu F, Amacher R, Antaki JF, Vandenberghe S. Analysis of pressure head-fl ow loops of pulsatile rotodynamic blood pumps. Artif. Organs. 2014; 38 (4): 316–326. doi: 10.1111/aor.12139.</mixed-citation><mixed-citation xml:lang="en">Jahren SE, Ochsner G, Shu F, Amacher R, Antaki JF, Vandenberghe S. Analysis of pressure head-fl ow loops of pulsatile rotodynamic blood pumps. Artif. Organs. 2014; 38 (4): 316–326. doi: 10.1111/aor.12139.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Garcia MAZV, Enriquez LA, Dembitsky W, May-Newman K. The Effect of Aortic Valve Incompetence on the Hemodynamics of a Continuous Flow Ventricular Assist Device in a Mock Circulation. SAIO Journal. 2008; 54: 237–244. DOI: 10.1097/MAT.0b013e31816a309b.</mixed-citation><mixed-citation xml:lang="en">Garcia MAZV, Enriquez LA, Dembitsky W, May-Newman K. The Effect of Aortic Valve Incompetence on the Hemodynamics of a Continuous Flow Ventricular Assist Device in a Mock Circulation. SAIO Journal. 2008; 54: 237–244. DOI: 10.1097/MAT.0b013e31816a309b.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Sumikura H, Homma A, Ohnuma K, Taenaka Y, Takewa Y, Mukaibayashi H et al. Development and evaluation of endurance test system for ventricular assist devices. J. Artif. Organs. 2013; 16: 138–148. DOI 10.1007/s10047-013-0687-3.</mixed-citation><mixed-citation xml:lang="en">Sumikura H, Homma A, Ohnuma K, Taenaka Y, Takewa Y, Mukaibayashi H et al. Development and evaluation of endurance test system for ventricular assist devices. J. Artif. Organs. 2013; 16: 138–148. DOI 10.1007/s10047-013-0687-3.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Soucy KG, Bartoli CR, Phillips D, Giridharan GA, Sobieski MA, Wead WB et al. Continuous-Flow Left Ventricular Assist Device Support Improves Myocardial Supply: Demand in Chronic Heart Failure. Ann. Biomed. Eng. 2017; 45 (6): 1475–1486. doi: 10.1007/s10439017-1804-x.</mixed-citation><mixed-citation xml:lang="en">Soucy KG, Bartoli CR, Phillips D, Giridharan GA, Sobieski MA, Wead WB et al. Continuous-Flow Left Ventricular Assist Device Support Improves Myocardial Supply: Demand in Chronic Heart Failure. Ann. Biomed. Eng. 2017; 45 (6): 1475–1486. doi: 10.1007/s10439017-1804-x.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Arakawa M, Nishimura T, Takewa Y, Umeki A, Ando M, Adachi H. et al. Alternation of left ventricular load by a continuous-fl ow left ventricular assist device with a native heart load control system in a chronic heart failure model. J. Thorac. Cardiovasc. Surg. 2014; 148 (2): 698–704. doi: 10.1016/j.jtcvs.2013.12.049.</mixed-citation><mixed-citation xml:lang="en">Arakawa M, Nishimura T, Takewa Y, Umeki A, Ando M, Adachi H. et al. Alternation of left ventricular load by a continuous-fl ow left ventricular assist device with a native heart load control system in a chronic heart failure model. J. Thorac. Cardiovasc. Surg. 2014; 148 (2): 698–704. doi: 10.1016/j.jtcvs.2013.12.049.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Karantonis DM, Lovell NH, Ayre PJ, Mason DG, Cloherty SL. Identifi cation and classifi cation of physiologically signifi cant pumping states in an implantable rotary blood pump. Artif. Organs. 2006; 30 (9): 671–679. DOI: 10.1111/j.1525-1594.2006.00283.x.</mixed-citation><mixed-citation xml:lang="en">Karantonis DM, Lovell NH, Ayre PJ, Mason DG, Cloherty SL. Identifi cation and classifi cation of physiologically signifi cant pumping states in an implantable rotary blood pump. Artif. Organs. 2006; 30 (9): 671–679. DOI: 10.1111/j.1525-1594.2006.00283.x.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Pirbodaghi Т, Cotter С, Bourque К. Power Consumption of Rotary Blood Pumps: Pulsatile Versus ConstantSpeed Mode. Artifi cial. Organs. 2014; 38 (12): 1024– 1028. doi:10.1111/aor.12323.</mixed-citation><mixed-citation xml:lang="en">Pirbodaghi Т, Cotter С, Bourque К. Power Consumption of Rotary Blood Pumps: Pulsatile Versus ConstantSpeed Mode. Artifi cial. Organs. 2014; 38 (12): 1024– 1028. doi:10.1111/aor.12323.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Kishimoto S, Date K, Arakawa M, Takewa Y, Nishimura T, Tsukiya T et al. Infl uence of a novelelectrocardiogramsynchronized rotational-speed-change system of an implantable continuous-fl ow left ventricular assist device (EVAHEART) on hemolytic performance. J. Artif. Organs. 2014; 17 (4): 373–377. doi: 10.1007/s10047014-0787-8.</mixed-citation><mixed-citation xml:lang="en">Kishimoto S, Date K, Arakawa M, Takewa Y, Nishimura T, Tsukiya T et al. Infl uence of a novelelectrocardiogramsynchronized rotational-speed-change system of an implantable continuous-fl ow left ventricular assist device (EVAHEART) on hemolytic performance. J. Artif. Organs. 2014; 17 (4): 373–377. doi: 10.1007/s10047014-0787-8.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
