vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2018-1-127-137vtio-864Research ArticleОбзор литературыLiterature ReviewsПЕРСОНАЛИЗИРОВАННЫЙ ПОДХОД К ВЫБОРУ ИММУНОСУПРЕССИВНОЙ ТЕРАПИИ ПРИ ТРАНСПЛАНТАЦИИ СЕРДЦАTHE INDIVIDUAL TAILORING OF IMMUNOSUPPRESSIVE THERAPY AFTER HEART TRANSPLANTATIONКолосковаН. Н.KoloskovaN. N.

Колоскова Надежда Николаевна

123182, Москва, ул. Щукинская, д. 1

Koloskova Nadezhda Nikolaevna

1, Shchukinskaya st., Moscow, 123182

nkrasotka@mail.ruПопцовВ. Н.PoptsovV. N.ШевченкоА. О.ShevchenkoA. О.ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава РоссииРоссияV.I. Shumakov National Medical Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian FederationRussian FederationФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России; ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский университет)РоссияV.I. Shumakov National Medical Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian Federation; I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovsky University)Russian Federation201824042018201127137Copyright © Колоскова Н.Н., Попцов В.Н., Шевченко А.О., 20182018Колоскова Н.Н., Попцов В.Н., Шевченко А.О.Koloskova N.N., Poptsov V.N., Shevchenko A.О.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/864

На сегодняшний день трансплантация сердца остается «золотым стандартом» лечения терминальной стадии хронической сердечной недостаточности. Применение иммуносупрессивной терапии в послеоперационном периоде направлено на предотвращение развития острого отторжения трансплантата и является краеугольным камнем в ведении этих пациентов. Однако развитие побочных эффектов от приема иммуносупрессивных препаратов является причиной снижения качества и ограничения продолжительности жизни. Задача персонализации иммуносупрессивной терапии, с одной стороны, заключается в сохранении функции трансплантата, а с другой – в минимизации побочных эффектов, возникающих на фоне иммуносупрессии. Цель нашего обзора – провести анализ протоколов назначения иммуносупрессивной терапии у различных групп реципиентов после трансплантации сердца.

Heart transplantation is the «gold standard» of treatment severe heart failure. Immunosuppressive therapy aimed at the prevention of acute allograft rejection is the cornerstone of post-transplant management. In addition to its direct effects, immunosuppressive therapy is also involved in the generation of a number of post-transplant morbidities that limit the long-term outcome of heart transplant recipients. Given these data it appears that the individual tailoring of immunosuppressive therapy is of paramount importance in determining the outcome of heart transplantation. The goal of immunosuppressive therapy is to prevent rejection of the transplanted heart, while minimizing drug-related effects, such as infection, malignancy, diabetes, hypertension, and renal insuffi ciency. This review aimed is to analyze the protocols for the appointment of immunosuppressive therapy in various groups of recipients after heart transplantation.

трансплантация сердцаиммуносупрессивная терапиявыживаемость реципиентовлекарственное взаимодействиеheart transplantationimmunosuppressive therapycardiac recipient survivaldrug interaction.ReferencesГотье СВ. Иммуносупрессия при трансплантации солидных органов. М.–Тверь: Триада, 2011: 12–17.Gautier SV. Immunosupressiya pri transplantatsii solidnykh organov. M.–Tver’: Triada, 2011: 12–17.Zabriskie JB. Essential clinical immunology. Cambridge University Press. 2009; 331–336.Zabriskie JB. Essential clinical immunology. Cambridge University Press. 2009; 331–336.Zuckermann A, Schulz U, Deuse T, Ruhpawar A et al. Thymoglobulin induction in heart transplantation: patient selection and implications for maintenance immunosuppression. Transpl. Int. 2015 Mar; 28 (3): 259–269.Zuckermann A, Schulz U, Deuse T, Ruhpawar A et al. Thymoglobulin induction in heart transplantation: patient selection and implications for maintenance immunosuppression. Transpl. Int. 2015 Mar; 28 (3): 259–269.Schweiger М. 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The authors declare that there are no conflicts of interest present.