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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vtio</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник трансплантологии и искусственных органов</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Transplantology and Artificial Organs</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-1191</issn><publisher><publisher-name>Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15825/1995-1191-2018-1-32-38</article-id><article-id custom-type="elpub" pub-id-type="custom">vtio-852</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клиническая трансплантология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical Transplantology</subject></subj-group></article-categories><title-group><article-title>ДИНАМИКА ФИЗИЧЕСКОЙ РАБОТОСПОСОБНОСТИ И КАЧЕСТВА ЖИЗНИ У ПАЦИЕНТОВ ПОСЛЕ ТРАНСПЛАНТАЦИИ СЕРДЦА</article-title><trans-title-group xml:lang="en"><trans-title>DYNAMIC OF PHYSICAL CAPACITY AND QUALITY OF LIFE AFTER HEART TRANSPLANTATION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Симоненко</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Simonenko</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Симоненко Мария Андреевна</p><p>197341, Санкт-Петербург, ул. Аккуратова, д. 2</p></bio><bio xml:lang="en"><p>Dr. Maria Simonenko</p><p>197341, Akkuratova street, 2, Saint-Petersburg</p></bio><email xlink:type="simple">simonenko_ma@almazovcentre.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Березина</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Berezina</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Федотов</surname><given-names>П. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Fedotov</surname><given-names>P. A.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сазонова</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sazonova</surname><given-names>Y. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Первунина</surname><given-names>Т. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Pervunina</surname><given-names>T. M.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лелявина</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Lelyavina</surname><given-names>T. A.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ситникова</surname><given-names>М. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Sitnikova</surname><given-names>M. Y.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Николаев</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikolaev</surname><given-names>G. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гордеев</surname><given-names>М. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Gordeev</surname><given-names>M. L.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карпенко</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Karpenko</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России, Санкт-Петербург</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Almazov National Medical Research Centre</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>23</day><month>04</month><year>2018</year></pub-date><volume>20</volume><issue>1</issue><fpage>32</fpage><lpage>38</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Симоненко М.А., Березина А.В., Федотов П.А., Сазонова Ю.В., Первунина Т.М., Лелявина Т.А., Ситникова М.Ю., Николаев Г.В., Гордеев М.Л., Карпенко М.А., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Симоненко М.А., Березина А.В., Федотов П.А., Сазонова Ю.В., Первунина Т.М., Лелявина Т.А., Ситникова М.Ю., Николаев Г.В., Гордеев М.Л., Карпенко М.А.</copyright-holder><copyright-holder xml:lang="en">Simonenko M.A., Berezina A.V., Fedotov P.A., Sazonova Y.V., Pervunina T.M., Lelyavina T.A., Sitnikova M.Y., Nikolaev G.V., Gordeev M.L., Karpenko M.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.transpl.ru/vtio/article/view/852">https://journal.transpl.ru/vtio/article/view/852</self-uri><abstract><sec><title>Цель</title><p>Цель. Оценить уровень физической работоспособности (ФР) и качества жизни (КЖ) у реципиентов после трансплантации сердца (ТС) и выявить факторы, влияющие на динамику этих показателей.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. С января 2010-го по сентябрь 2016 г. было обследовано 76 реципиентов до и после ТС (средний возраст – 45,4 ± 1,6 года). Физическую активность (ФА) оценивали по результатам IPAQ-анкетирования (через 6 месяцев, 1 год после ТС). Уровень ФР определяли методом кардиореспираторного тестирования (Oxycon Pro, Germany) исходно, через 6 месяцев (n = 32) и 1 год (n = 31) после ТС; в эти же сроки оценивали КЖ (опросник SF-36).</p></sec><sec><title>Результаты</title><p>Результаты. Уровень ФР через 6 месяцев после ТС улучшился (VO2peak – 12,6 ± 0,5 и 17,3 ± 0,6 мл/мин/кг, p &lt; 0,001) по сравнению с результатами до ТС. Через 1 год после ТС у физически активных реципиентов (n = 21) уровень ФР был выше, чем у пациентов, продолжавших вести сидячий образ жизни (VO2peak – 18,7 ± 0,9 и 16,7 ± 0,4 мл/мин/кг, p &lt; 0,05). Через 6 месяцев 59,4% (n = 19) и 1 год после ТС 77,4% (n = 24) пациентов достигли нормальных значений VO2peak, характерных для данного пола и возраста (VO2peak ≥ 84% и/или 40–60% от VO2-АП), из них 20 реципиентов были физически активными. Различий в динамике ФР в зависимости от исходной тяжести хронической сердечной недостаточности, давности заболевания, длительности пребывания в листе ожидания ТС не было выявлено. Через 6 месяцев после ТС КЖ улучшилось в сфере физического благополучия (32,2 ± 1,1 и 48,2 ± 1,6, p &lt; 0,001), не изменилось в сфере психологического благополучия и оставалось стабильным через 1 год после ТС. При этом КЖ у физически активных пациентов было выше, чем у тех, кто вел сидячий образ жизни. Выявлены корреляционные связи между показателем физического благополучия и длительностью ФА (r = 0,4; p &lt; 0,05), VO2peak (r = 0,3; p &lt; 0,05), VO2-АП (r = 0,4; p &lt; 0,05), VE/VCO2 (r = –0,5; p &lt; 0,5).</p></sec><sec><title>Выводы</title><p>Выводы. Уровни физической работоспособности и качества жизни в сфере физического благополучия у больных после трансплантации сердца улучшились, результаты были лучше у физически активных пациентов. Факторами, влияющими на прирост физической работоспособности, были улучшение функционального состояния сердечно-сосудистой системы и физическая активность.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim: to estimate physical capacity and quality of life (QoL) and defi ne factors which impact on their dynamic in recipients after heart transplantation (HTx).</p></sec><sec><title>Materials and methods</title><p>Materials and methods. From January 2010 to September 2016 we performed 76 HTx (mean age – 45,4 ± 1,6 yrs). Physical activity (PA) was evaluated by IPAQ questionnaire, QoL – by SF-36 (6 months and 1 yr after HTx). Patients underwent cardiopulmonary exercise test (Oxycon Pro, Germany) before, 6 months (n = 32) and 1 yr (n = 31) after HTx.</p></sec><sec><title>Results</title><p>Results. In 6 months after HTx PC improved (VO2peak – 12,6 ± 0,5 and 17,3 ± 0,6 ml/min/kg, p &lt; 0,001). One yr after HTx physically active recipients (n = 21) showed better results (VO2peak – 18,7 ± 0,9 vs. 16,7 ± 0,4 ml/min/kg, p &lt; 0,05). Moreover, 6 months 59,4% (n = 19) and 1 yr after HTx 77,4% (n = 24) of all patients reached normal values, 20 of them were physically active. We did not fi nd any difference in results depending on heart failure severity, duration of illness and of time spent in HT waiting list. In 6 months after HTx physical health (PH) increased (32,2 ± 1,1 vs. 48,2 ± 1,6, p &lt; 0,001), on the other hand, results of mental health (MH) were the same and remained stable in 1 yr after HTx. In addition, QoL was higher in physically active patients than in sedentary lifestyle ones. There was correlations between PH and PA duration (r = 0,4; p &lt; 0,05), VO2peak (r = 0,3; p &lt; 0,05), VO2 at AT (r = 0,4; p &lt; 0,05) and VE/VCO2 (r = –0,5; p &lt; 0,05).</p></sec><sec><title>Conclusion</title><p>Conclusion. After heart transplantation physical capacity and physical health improved but physically active recipients showed better results. Factors affecting the increase in physical capacity were improvement in the functional state of the cardiovascular system and physical activity.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>трансплантация сердца</kwd><kwd>сердечная недостаточность</kwd><kwd>физическая активность</kwd><kwd>физическая работоспособность</kwd><kwd>кардиореспираторный тест (КРТ)</kwd><kwd>качество жизни</kwd></kwd-group><kwd-group xml:lang="en"><kwd>heart transplantation</kwd><kwd>heart failure</kwd><kwd>physical activity</kwd><kwd>physical capacity</kwd><kwd>cardiopulmonary exercise test (CPET)</kwd><kwd>quality of life (QoL)</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Клинические рекомендации. 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