vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2018-1-6-12vtio-849Research ArticleКлиническая трансплантологияClinical TransplantologyТРАНСПЛАНТАЦИЯ ПЕЧЕНИ ОТ ДОНОРОВ СТАРШЕ 60 ЛЕТLIVER TRANSPLANTATION FROM SEXAGENARIAN AND OLDERГотьеС. В.GautierS. V.КорниловМ. Н.KornilovМ. N.

Корнилов Максим Николаевич

123182, Москва, ул. Щукинская, д. 1

Kornilov Maksim Nikolaevich

1, Shchukinskaya st., Moscow, 123182

kornilov.transpl@gmail.comМилосердовИ. А.MiloserdovI. A.МининаМ. Г.MininaM. G.КругловД. Н.KruglovD. N.ЗубенкоС. И.ZubenkoS. I.ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России; ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский университет)РоссияV.I. Shumakov National Medical Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian Federation; I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovsky University)Russian FederationФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава РоссииРоссияV.I. Shumakov National Medical Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian FederationRussian FederationМосковский координационный центр органного донорства Департамента здравоохранения города МосквыРоссияMoscow coordinating centre of organ donation, Moscow Department of HealthRussian Federation201823042018201612Copyright © Готье С.В., Корнилов М.Н., Милосердов И.А., Минина М.Г., Круглов Д.Н., Зубенко С.И., 20182018Готье С.В., Корнилов М.Н., Милосердов И.А., Минина М.Г., Круглов Д.Н., Зубенко С.И.Gautier S.V., Kornilov М.N., Miloserdov I.A., Minina M.G., Kruglov D.N., Zubenko S.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/849

Дефицит донорских органов во всем мире способствует постепенному расширению донорских критериев для трансплантации.

Цель

Цель: провести анализ результатов трансплантации печени от доноров 60 лет и старше в сравнении с донорами более молодого возраста.

Материалы и методы

Материалы и методы: в исследование включено 390 трансплантаций печени: группа I – возраст донора 60 и более лет (n = 26); группа II – возраст донора менее 60 лет (n = 364), выполненных за период с 2010-го по ноябрь 2017 г. Доноры обеих групп стандартизованы по демографическим характеристикам, лабораторным показателям, а также объему инотропной поддержки.

Результаты

Результаты: статистически значимых различий тяжести ишемически-реперфузионного повреждения трансплантата, длительности пребывания в отделении реанимации, продолжительности пребывания в стационаре не выявлено.Также не выявлено различий в частоте развития билиарных или сосудистых осложнений. Сравнение 5-летней актуриальной выживаемости не показало достоверной разницы (группа I – 70%; группа II – 76%, р = 0,54).

Выводы

Выводы. По нашему опыту, использование трансплантатов печени от доноров старше 60 лет при условии минимизации факторов риска (холодовая ишемия, вторичная тепловая ишемия) не ухудшает результаты трансплантации печени в раннем и отдаленном сроке и может быть одним из путей увеличения числа трансплантаций печени от посмертного донора. Длительность наблюдения за реципиентами 8 лет.

Donor organs shortage leads to extending criteria for deceased liver donation in the whole world.

Aim

Aim: to compare results of deceased donor liver transplantation (DDLT) depending of donor age over 60 years old.

Materials and methods

Materials and methods: the study includes 390 DDLT from January 2010 to November 2017. All liver donors separated by age for two groups: I – 60 years and older (n = 26); II – younger than 60 years (n = 364). All donors were standardized by demographic, laboratory fi ndings and inotropic drug requirement.

 Results

 Results: no difference between both groups in severity of ischemia-reperfusion injury, ICU or in-hospital staying (median 2 and 7,5 days respectively) was found. There is also no difference between biliary or vascular complication rate. 5-year actuarial survival rate found no difference between both groups (I: 70%: II: 76%, p = 0,54).

Conclusion

Conclusion. Using grafts from donors older than 60 years don’t worsen early and late results of DDLT. Care should be taken to avoid other risk factors (cold ischemia time, warm ischemia time).

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The authors declare that there are no conflicts of interest present.