vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2017-4-124-129vtio-836Research ArticleОбзор литературыLiterature ReviewsВакцинация против вирусного гепатита B у детей при трансплантации печениVaccination against viral hepatitis b in pediatric liver transplant recipientsЖилкинИ. В.ZhilkinV. I.

Москва.

Moscow.

izhilkin@gmail.comЦирульниковаО. М.TsiroulnikovaO. M.

Москва.

Moscow.

ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России.РоссияV.I. Shumakov National Medical Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian Federation.Russian FederationКафедра трансплантологии и искусственных органов ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский университет); ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России.РоссияI.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation, Department of transplantology and artifi cial organs (Sechenovskiy University); V.I. Shumakov National Medical Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian Federation.Russian Federation201701022018194124129Copyright © Жилкин И.В., Цирульникова О.М., 20182018Жилкин И.В., Цирульникова О.М.Zhilkin V.I., Tsiroulnikova O.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/836

Надежная защита от гепатит-В-вирусной (HBV) инфекции и других управляемых инфекционных заболеваний у детей имеет существенное значение в связи с улучшениями показателей отдаленной выживаемости реципиентов и трансплантатов после трансплантации печени. В настоящее время имеются только ограниченные данные об иммуногенности вакцин у детей при трансплантации. Обзор литературы представляет информацию о текущем подходе к проведению вакцинации против HBV-инфекции, принятых графиках вакцинации, целевых показателях уровня специфических антител до и после трансплантации печени детям. Также представлена информация о различных типах вакцин для провилактики HBV-инфекции и эффективности вакцинации в различных трансплантационных центрах.

Durable protection from hepatitis B virus (HBV) and other vaccine-preventable diseases assumes great importance due to improved long-term patient and graft survival rates in pediatric liver transplantation (PLT). Vaccine immunogenicity data in transplanted children is limited. The review presents aspects of current approach for childhood HBV immunization schedule prior to transplant, duration of time since transplant for receive booster dose, target median HBsAb levels before and after PLT. The latest data about types of vaccine against HBV and vaccine effectiveness in PLT centers in the world are also presented.

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The authors declare that there are no conflicts of interest present.