vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2017-3-93-103vtio-785Research ArticleОбзор литературыLiterature ReviewsМеханическая поддержка кровообращения в лечении детей с терминальной сердечной недостаточностьюMechanical circulation support of the treatment for children with end-stage chronic heart failureГотьеС. В.GautierS. V.

Кафедра трансплантологии и искусственных органов

ИткинГ. П.ItkinG. P.

кафедра физики живых систем

Адрес: 123182, Москва, ул. Щукинская, д. 1. Тел. (499) 190-60-34

Department of physics of living systems

Address: 1, Shchukinskaya st., Moscow, 123182, Russian Federation. Tel. (499) 190-60-34

georgeitkin@mail.ruДмитриеваО. Ю.DmitrievaO. Yu.КозловВ. А.KozlovV. A.

кафедра физики живых систем

Department of physics of living systems

ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский университет)РоссияV.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian FederationRussian FederationФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России Московский физико-технический институт (государственный университет)РоссияV.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation Moscow Institute of Physics and Technology (State University)Russian FederationФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава РоссииРоссияV.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian FederationRussian FederationФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России Московский физико-технический институт (государственный университет)РоссияV.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian FederationRussian Federation20171709201719393103Copyright © Готье С.В., Иткин Г.П., Дмитриева О.Ю., Козлов В.А., 20172017Готье С.В., Иткин Г.П., Дмитриева О.Ю., Козлов В.А.Gautier S.V., Itkin G.P., Dmitrieva O.Y., Kozlov V.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/785

Механическая поддержка кровообращения за последние десятилетия стала одним из наиболее эффективных средств лечения больных с терминальной сердечной недостаточностью. К сожалению, в педиатрии данный метод в основном используется для кратковременного подключения, и к нему относятся прежде всего экстракорпоральная мембранная оксигенация и левожелудочковый обход с помощью экстракорпорального подключения центробежных насосов. При этом применение данных методов у детей позволило значительно уменьшить смертность в листе ожидания на трансплантацию сердца. На сегодняшний день практически единственным методом длительной механической поддержки кровообращения у новорожденных и детей младшего возраста является система паракорпорального подключения искусственных желудочков EXCOR, применение которых связано с большими проблемами тромбоосложнений. Имеется относительно небольшой клинический опыт использования полностью имплантируемых систем, разработанных для взрослых, у детей старшего возраста. Поэтому, как показано в настоящем обзоре, задача создания систем длительной поддержки кровообращения для новорожденных и детей младшего возраста на основе имплантируемых насосов является актуальной.

Over the last decades mechanical circulation support has become one of the most effective treatment methods for patients with terminal heart failure. Unfortunately, in pediatrics this method is generally used on a short-term basis and includes, first of all, extracorporeal membranous oxygenation and left ventricular bypass by means of the extracorporeal centrifugal pumps. Nevertheless, using of these methods in children allowed considerably reducing mortality on the waiting list for heart transplant. Today, practically the only method of long term mechanical circulatory support in newborns and children at an early age being used is the system of paracorporeal artificial ventricles EXCOR, the usage of which results in larger problems of thrombosis. There is little clinical experience in using of the fully implanted systems developed for adults in older children. Therefore, as shown in the present review, the problem of creating long term circulatory support systems for newborns and younger children on the basis of the implanted pumps continues to be relevant.

трансплантация сердцалист ожиданияврожденные пороки сердцакардиомиопатияпедиатрическая механическая поддержка кровообращенияэкстракорпоральная мембранная оксигенациялевожелудочковый обходбивентрикулярный обходнасосы пульсирующего потоканасосы непульсирующего потокаheart transplantationwaiting listcongenital heart diseasescardiomyopathypediatric mechanical circulatory supportextracorporeal membrane oxygenationleft ventricular bypassbiventricular bypasspulsatile flow pumpsnonpulsatile flow pumpsReferencesChristianson A, Howson CP, Modell B. March of Dimes Global Report on Birth Defects: The Hidden Toll of Dying and Disabled Children. March of Dimes Birth Defects Foundation; 2006.Christianson A, Howson CP, Modell B. March of Dimes Global Report on Birth Defects: The Hidden Toll of Dying and Disabled Children. March of Dimes Birth Defects Foundation; 2006.Boucek MM, Aurora P, Edwards LB, Taylor DO, Trulock EP, Christie J et al. 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The authors declare that there are no conflicts of interest present.