vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2017-2-126-132vtio-760Research ArticleОбзор литературыLiterature ReviewsМикроРНК у реципиентов сердечного трансплантатаMicroRNAs in heart transplant recipientsВеликийД. А.VelikiyD. A.dim_vel@mail.ruГичкунО. Е.GichkunO. E.ШевченкоО. П.ShevchenkoO. P.ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава РоссииРоссияV.I. Shumakov Federal Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian FederationRussian FederationФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России; ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский университет)РоссияV.I. Shumakov Federal Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation; I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian FederationRussian Federation201723062017192126132Copyright © Великий Д.А., Гичкун О.Е., Шевченко О.П., 20172017Великий Д.А., Гичкун О.Е., Шевченко О.П.Velikiy D.A., Gichkun O.E., Shevchenko O.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/760

Представлен анализ данных, посвященных прогностической роли микроРНК при отторжении трансплантированного сердца. МикроРНК представляют собой класс малых некодирующих РНК, регулирующих экспрессию генов и влияющих на различные клеточные функции. Отмечены изменения их профилей при различных патологических процессах и отторжении солидных органов. Предположительно измерение уровней микроРНК при трансплантации сердца может иметь диагностическое и прогностическое значение при оценке риска развития отторжения и возможности минимизации иммуносупрессивной терапии. В настоящее время клинических данных о роли этих биомаркеров при трансплантации сердца накоплено недостаточно, и необходимы дальнейшие исследования связи уровней микроРНК с различными клиническими и лабораторными показателями у реципиентов сердца.

This review summarizes the current literature dedicated to the analysis of prognostic role of microRNAs in rejection of the transplanted heart. MicroRNAs are a class of small non-coding RNAs that regulate gene expression and affect various cellular functions. Variations of their profiles are noted at various pathological processes and rejection of solid organs. Presumably, measuring the level of microRNAs in heart transplant may have diagnostic and prognostic value in the assessment of risk of rejection and possibility of minimizing immunosuppressive therapy. Currently, accumulated clinical data on the role of the given biomarkers in heart transplantation are not enough, and further research on the relation of microRNAs levels and different clinical and laboratory parameters in heart recipients is necessary.

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The authors declare that there are no conflicts of interest present.