vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2017-2-52-60vtio-752Research ArticleКлиническая трансплантологияClinical TransplantologyПервый опыт успешного вынашивания беременности после симультанной трансплантации печени и почки с рено-портальной транспозициейThe first experience of successful pregnancy after simultaneous liver-kidney transplantation with reno-portal transpositionТкаченкоО. В.TkachenkoO. V.tkachenkoolgavladimirovna@gmail.comВильчукК. У.VilchukK. U.РуммоО. О.RummoO. O.КурловичИ. В.KurlovichI. V.ЩербаА. Е.ShcherbaA. E.НаумчикИ. В.NaumchikI. V.НагибовичС. Ю.NagibovichC. Yu.ПанкратоваО. А.PankratovaO. A.РимашевскийВ. В.RimashevskiV. V.БелугаМ. В.BelugaM. V.ФедорукД. А.FedorukD. A.ГУ «Республиканский научно-практический центр «Мать и дитя»БеларусьRepublican Scientific Practical Centre «Mother and Child»BelarusГУ «Республиканский научно-практический центр трансплантации органов и тканей», УЗ «9-я городская клиническая больница»БеларусьRepublican Scientific Practical Centre of Organ and Tissue Transplantation, Minsk 9 Municipal ClinicBelarus2017220620171925260Copyright © Ткаченко О.В., Вильчук К.У., Руммо О.О., Курлович И.В., Щерба А.Е., Наумчик И.В., Нагибович С.Ю., Панкратова О.А., Римашевский В.В., Белуга М.В., Федорук Д.А., 20172017Ткаченко О.В., Вильчук К.У., Руммо О.О., Курлович И.В., Щерба А.Е., Наумчик И.В., Нагибович С.Ю., Панкратова О.А., Римашевский В.В., Белуга М.В., Федорук Д.А.Tkachenko O.V., Vilchuk K.U., Rummo O.O., Kurlovich I.V., Shcherba A.E., Naumchik I.V., Nagibovich C.Y., Pankratova O.A., Rimashevski V.V., Beluga M.V., Fedoruk D.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/752

Статья посвящена вопросу ведения беременности и родоразрешения после симультанной трансплантации печени и почки (СТПП). Приведены общие исторические и статистические сведения, и представлен первый в мировой практике клинический случай благоприятного исхода беременности у пациентки после СТПП с рено-портальной транспозицией.

The article is dedicated to the problem of pregnancy management and delivery after simultaneous liver-kidney transplantation (SLKT). The article contains general historic and statistic information, and presents the first real world clinical case of favorable pregnancy outcome in patient after simultaneous liver-kidney transplantation with reno-portal transposition.

беременностьсимультанная трансплантация печени и почкирено-портальная транспозициякритический стеноз воротной венысплено-ренальный шунтаутосомно-рецессивная поликистозная болезньpregnancysimultaneous liver-kidney transplantationreno-portal transpositionportal vein critical stenosissplenorenal shuntpolycystic kidney and hepatic diseaseReferencesРуммо ОО. Инновационные перспективы развития службы органной трансплантации в Республике Беларусь. Инновационные технологии в медицине. 2016; 1 (1): 273–285. Rummo OO. Innovation perspectives of the organ transplantation in the Republic of Belarus. Innovacionnye tehnologii v medicine. 2016; 1 (1): 273–285. [In Russ, English abstract].Руммо ОО. Инновационные перспективы развития службы органной трансплантации в Республике Беларусь. Инновационные технологии в медицине. 2016; 1 (1): 273–285. Rummo OO. Innovation perspectives of the organ transplantation in the Republic of Belarus. Innovacionnye tehnologii v medicine. 2016; 1 (1): 273–285. [In Russ, English abstract].Готье СВ. Трансплантация печени в России: 25-летний опыт и современные возможности. Ма­териалы конгресса «Трансплантация и донор­ ство органов» 8–10 июня 2015 года, Москва. Gautier SV. Transplantaсya pecheni v Rossii: 25-letniy opyt i sovremennye vozmojnosti. Materialy kongressa «Transplantaсya i donorstvo organov», 8–10 iunya 2015 goda (electronic resource). Available at: http://journal.transpl.ru. doi: 10.15825/1995-1191-2015-2-93-95.Готье СВ. Трансплантация печени в России: 25-летний опыт и современные возможности. Ма­териалы конгресса «Трансплантация и донор­ ство органов» 8–10 июня 2015 года, Москва. Gautier SV. Transplantaсya pecheni v Rossii: 25-letniy opyt i sovremennye vozmojnosti. Materialy kongressa «Transplantaсya i donorstvo organov», 8–10 iunya 2015 goda (electronic resource). Available at: http://journal.transpl.ru. doi: 10.15825/1995-1191-2015-2-93-95.Мойсюк ЯГ. Cимультанная трансплантация печени и почки. Опыт ФНЦТИО им. ак. В.И. Шумакова, 11 марта 2016 года, Москва. Moysyuk YG. Simultannaya transplantaсya pecheni i pochki. Opyt FNCTIO im. ak. V.I. Shumakova. Paper presented at Title of conference, 11.03.2016, Moscow (electronic resource). Available at: http: // www.nephro.ru.Мойсюк ЯГ. Cимультанная трансплантация печени и почки. Опыт ФНЦТИО им. ак. В.И. Шумакова, 11 марта 2016 года, Москва. Moysyuk YG. Simultannaya transplantaсya pecheni i pochki. Opyt FNCTIO im. ak. V.I. Shumakova. Paper presented at Title of conference, 11.03.2016, Moscow (electronic resource). Available at: http: // www.nephro.ru.Bharadwaj S, Tandon P, Gohel TD. Current status of intestinal and multivisceral transplantation. Gastroenterol. Rep. (Oxf.). 2017; 26: 324–328. doi: 10.1093/gastro/gow045.Bharadwaj S, Tandon P, Gohel TD. Current status of intestinal and multivisceral transplantation. Gastroenterol. Rep. (Oxf.). 2017; 26: 324–328. doi: 10.1093/gastro/gow045.Lisa A, Coscia JM, Davison MJ, Moritz VT, Armenti G. Pregnancy After Liver Transplantation. [Show abstract] Chapter. 2017; 23: 57–58.Lisa A, Coscia JM, Davison MJ, Moritz VT, Armenti G. Pregnancy After Liver Transplantation. [Show abstract] Chapter. 2017; 23: 57–58.Doyle MB, Subramanian V, Vachharajani N. Results of simultaneous liver and kidney transplantation: a singlecenter review. J. Am. Coll. Surg. 2016; 223: 193–201.Doyle MB, Subramanian V, Vachharajani N. Results of simultaneous liver and kidney transplantation: a singlecenter review. J. Am. Coll. Surg. 2016; 223: 193–201.Lunsford KE, Bodzin AS, Markovic D. Avoiding futility in simultaneous liver-kidney transplantation: analysis of 331 consecutive patients listed for dual organ replacement. Ann. Surg. 2016; 10: 1097–1101.Lunsford KE, Bodzin AS, Markovic D. Avoiding futility in simultaneous liver-kidney transplantation: analysis of 331 consecutive patients listed for dual organ replacement. Ann. Surg. 2016; 10: 1097–1101.Jalanko H, Pakarinen M. Combined liver and kidney transplantation in children. Pediatr. Nephrol. 2014; 29 (5): 805–814.Jalanko H, Pakarinen M. Combined liver and kidney transplantation in children. Pediatr. Nephrol. 2014; 29 (5): 805–814.Paterno F, Girnita A, Brailey P. Successful Simultaneous Liver-Kidney Transplantation in the Presence of Multiple High-Titered Class I and II Antidonor HLA Antibodies. Transplant. Direct. 2016; 2 (12): 121–123.Paterno F, Girnita A, Brailey P. Successful Simultaneous Liver-Kidney Transplantation in the Presence of Multiple High-Titered Class I and II Antidonor HLA Antibodies. Transplant. Direct. 2016; 2 (12): 121–123.Cimsit B, Schilsky M, Moini M. Combined liver kidney transplantation: critical analysis of a single-center experience. Transplant. Proc. 2011; 43 (3): 901–904.Cimsit B, Schilsky M, Moini M. Combined liver kidney transplantation: critical analysis of a single-center experience. Transplant. Proc. 2011; 43 (3): 901–904.Rao S, Ghanta M, Moritz M, Constantinescu S. LongTerm Functional Recovery, Quality of Life, and Pregnancy After Solid Organ Transplantation. Med Clin North Am. 2016; 100 (3): 613–629.Rao S, Ghanta M, Moritz M, Constantinescu S. LongTerm Functional Recovery, Quality of Life, and Pregnancy After Solid Organ Transplantation. Med Clin North Am. 2016; 100 (3): 613–629.Belingheri M, Ghio L, Sala A, Menni F, Trespidi L, Ferraresso M. Combined liver-kidney transplantation in glycogen storage disease Ia: a case beyond the guidelines. Liver Transpl. 2007; 13 (5): 762–764.Belingheri M, Ghio L, Sala A, Menni F, Trespidi L, Ferraresso M. Combined liver-kidney transplantation in glycogen storage disease Ia: a case beyond the guidelines. Liver Transpl. 2007; 13 (5): 762–764.Lee PJ, Muiesan P, Heaton N. Successful pregnancy after combined renal-hepatic transplantation in glycogen storage disease type Ia. J. Inherit. Metab. Dis. 2004; 27: 537–538.Lee PJ, Muiesan P, Heaton N. Successful pregnancy after combined renal-hepatic transplantation in glycogen storage disease type Ia. J. Inherit. Metab. Dis. 2004; 27: 537–538.Pruvot FR, Noel C, Declerck N, Valat-Rigot AS, Roumilhac D, Hazzan M. Consecutive successful pregnancies in a combined liver and kidney transplant recipient with type 1 primary hyperoxaluria. Transplantation. 1997; 63 (4): 615–616.Pruvot FR, Noel C, Declerck N, Valat-Rigot AS, Roumilhac D, Hazzan M. Consecutive successful pregnancies in a combined liver and kidney transplant recipient with type 1 primary hyperoxaluria. Transplantation. 1997; 63 (4): 615–616.Skannal DG, Dungy-Poythress LJ, Miodovnik M, First MR. Pregnancy in a combined liver and kidney transplant recipient with type 1 primary hyperoxaluria. Obstet. Gynecol. 1995; 86 (4): 64–73.Skannal DG, Dungy-Poythress LJ, Miodovnik M, First MR. Pregnancy in a combined liver and kidney transplant recipient with type 1 primary hyperoxaluria. Obstet. Gynecol. 1995; 86 (4): 64–73.Raja K, Jacob M, Asthana SJ. Portal vein thrombosis in cirrhosis. Clin. Exp. Hepatol. 2014; 4 (4): 320–331. doi: 10.1016/j.jceh.2013.12.003.Raja K, Jacob M, Asthana SJ. Portal vein thrombosis in cirrhosis. Clin. Exp. Hepatol. 2014; 4 (4): 320–331. doi: 10.1016/j.jceh.2013.12.003.Akbulut S, Kayaalp C, Yilmaz M, Yilmaz S. Auxiliary reno-portal anastomosis in living donor liver transplantation: a technique for recipients with low portal inflow. Transpl. Int. 2012; 25 (6): 73–75. doi: 10.1111/j.1432-2277.2012.01471.x.Akbulut S, Kayaalp C, Yilmaz M, Yilmaz S. Auxiliary reno-portal anastomosis in living donor liver transplantation: a technique for recipients with low portal inflow. Transpl. Int. 2012; 25 (6): 73–75. doi: 10.1111/j.1432-2277.2012.01471.x.Lai Q, Spoletini G, Pinheiro RS, Melandro F, Guglielmo N, Lerut J. From portal to splanchnic venous thrombosis: What surgeons should bear in mind? World. J. Hepatol. 2014; 6 (8): 549–558. doi: 10.4254/wjh.v6.i8.549PMCID: PMC4163738.Lai Q, Spoletini G, Pinheiro RS, Melandro F, Guglielmo N, Lerut J. From portal to splanchnic venous thrombosis: What surgeons should bear in mind? World. J. Hepatol. 2014; 6 (8): 549–558. doi: 10.4254/wjh.v6.i8.549PMCID: PMC4163738.Moon DB, Lee SG, Ahn CS, Kim KH, Hwang S, Ha TY et al. Technical modification of reno-portal anastomosis in living donor liver transplantation for patients with obliterated portal vein and large spontaneous splenorenal shunts. Hepatogastroenterology. 2008; 55 (88): 2193–2199.Moon DB, Lee SG, Ahn CS, Kim KH, Hwang S, Ha TY et al. Technical modification of reno-portal anastomosis in living donor liver transplantation for patients with obliterated portal vein and large spontaneous splenorenal shunts. Hepatogastroenterology. 2008; 55 (88): 2193–2199.Azoulay D, Adam R, Castaing D, Muresan S, Essomba A, Vibert E. Liver transplantation with cavoportal or renoportal anastomosis: a solution in cases of diffuse portal thrombosis. Gastroenterol Clin Biol. 2002; 26 (4): 325–330 [In French, English abstract].Azoulay D, Adam R, Castaing D, Muresan S, Essomba A, Vibert E. Liver transplantation with cavoportal or renoportal anastomosis: a solution in cases of diffuse portal thrombosis. Gastroenterol Clin Biol. 2002; 26 (4): 325–330 [In French, English abstract].ESPN/ERA-EDTA Registry (electronic resource). Available at: http://www.espn-reg.org.ESPN/ERA-EDTA Registry (electronic resource). Available at: http://www.espn-reg.org.Chandar J, Garcia J, Jorge L, Tekin A. Transplantation in autosomal recessive polycystic kidney disease: liver and/or kidney? Pediatr. Nephrol. 2015; 30 (8): 1233–1242.Chandar J, Garcia J, Jorge L, Tekin A. Transplantation in autosomal recessive polycystic kidney disease: liver and/or kidney? Pediatr. Nephrol. 2015; 30 (8): 1233–1242.Luoto TT, Pakarinen MP, Jahnukainen T, Jalanko H. Liver disease in autosomal recessive polycystic kidney disease: clinical characteristics and management in relation to renal failure. J. Pediatr. Gastroenterol. Nutr. 2014; 59 (2): 190–196.Luoto TT, Pakarinen MP, Jahnukainen T, Jalanko H. Liver disease in autosomal recessive polycystic kidney disease: clinical characteristics and management in relation to renal failure. J. Pediatr. Gastroenterol. Nutr. 2014; 59 (2): 190–196.Halvorson CR., Bremmer MS, Jacobs SC. Polycystic kidney disease: inheritance, pathophysiology, prognosis and treatment. Intern. J. Nephrol. Renovascular Disease. 2010; 3: 69–83.Halvorson CR., Bremmer MS, Jacobs SC. Polycystic kidney disease: inheritance, pathophysiology, prognosis and treatment. Intern. J. Nephrol. Renovascular Disease. 2010; 3: 69–83.Bergman C, Senderek J, Ellenwindelen F. Clinical consequences of PKHD1 mutations in 164 patients with autosomal-recessive polycystic kidney disease (ARPKD). Kidney International. 2005; 67: 829–848.Bergman C, Senderek J, Ellenwindelen F. Clinical consequences of PKHD1 mutations in 164 patients with autosomal-recessive polycystic kidney disease (ARPKD). Kidney International. 2005; 67: 829–848.Sweeney WE, Avner ED. Polycystic Kidney Disease, Autosomal Recessive. SourceGeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle. 2016; 7: 1993–2017.Sweeney WE, Avner ED. Polycystic Kidney Disease, Autosomal Recessive. SourceGeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle. 2016; 7: 1993–2017.Jiang L, Fang P, Weemhoff JL. Evidence for a «Pathogenic Triumvirate» in Congenital Hepatic Fibrosis in Autosomal Recessive Polycystic Kidney Disease. Biomed. Res. Int. 2016; 49 (18): 798–805.Jiang L, Fang P, Weemhoff JL. Evidence for a «Pathogenic Triumvirate» in Congenital Hepatic Fibrosis in Autosomal Recessive Polycystic Kidney Disease. Biomed. Res. Int. 2016; 49 (18): 798–805.Zerres K, Rudnik-Schoneborn S, Deget F. Autosomal recessive polycystic kidney disease in 115 children: clinical presentation, course and influence of gender. Nephrolog. 1996; 85: 437–445.Zerres K, Rudnik-Schoneborn S, Deget F. Autosomal recessive polycystic kidney disease in 115 children: clinical presentation, course and influence of gender. Nephrolog. 1996; 85: 437–445.Guay-Woodford LM, Desmond RA. Autosomal Recessive Polycystic Kidney Disease: The Clinical Experience in North America. Pediatrics. 2003; 111: 1072–1079.Guay-Woodford LM, Desmond RA. Autosomal Recessive Polycystic Kidney Disease: The Clinical Experience in North America. Pediatrics. 2003; 111: 1072–1079.http://www.humgen.rwth-aachen.de.http://www.humgen.rwth-aachen.de.Turkbey B, Ocak I, Daryanani K. Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis (AR-PKD/CHF). Pediatr. Radiol. 2009; 39 (2): 100–111.Turkbey B, Ocak I, Daryanani K. Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis (AR-PKD/CHF). Pediatr. Radiol. 2009; 39 (2): 100–111.Ebner K, Feldkoetter M, Ariceta G, Bergmann C. Rationale, design and objectives of ARegPKD, a European ARPKD registry study. BMC Nephrol. 2015; 18: 16–22. doi:10.1186/s12882-015-0002z.Ebner K, Feldkoetter M, Ariceta G, Bergmann C. Rationale, design and objectives of ARegPKD, a European ARPKD registry study. BMC Nephrol. 2015; 18: 16–22. doi:10.1186/s12882-015-0002z.Tanriover B, MacConmara MP, Parekh J. Simultaneus liver-kidney translantation: importance of creatinine levels, dialysis, and organ quality in survival. Kidney Int. Rep. 2016; 1 (4): 221–229.Tanriover B, MacConmara MP, Parekh J. Simultaneus liver-kidney translantation: importance of creatinine levels, dialysis, and organ quality in survival. Kidney Int. Rep. 2016; 1 (4): 221–229.

The authors declare that there are no conflicts of interest present.