vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2017-2-47-51vtio-751Research ArticleКлиническая трансплантологияClinical TransplantologyТрансплантация печени от посмертного донора 73 летLiver transplantation from 73-year-old cadaveric donorКорниловМ. Н.KornilovM. N.kornilov.transpl@gmail.comМининаМ. Г.MininaM. G.МилосердовИ. А.MiloserdovI. A.КругловД. Н.KruglovD. N.ЧайкинР. С.ChaikinR. S.МалаховА. Г.MalakhovA. G.ЗубенкоС. И.ZubenkoS. I.ГотьеС. В.GautierS. V.ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России;РоссияV.I. Shumakov Federal Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation;Russian FederationМосковский координационный центр органного донорстваРоссияMoscow Organ Donor Coordination CenterRussian FederationФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России; ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский университет)РоссияV.I. Shumakov Federal Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation; I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian FederationRussian Federation2017210620171924751Copyright © Корнилов М.Н., Минина М.Г., Милосердов И.А., Круглов Д.Н., Чайкин Р.С., Малахов А.Г., Зубенко С.И., Готье С.В., 20172017Корнилов М.Н., Минина М.Г., Милосердов И.А., Круглов Д.Н., Чайкин Р.С., Малахов А.Г., Зубенко С.И., Готье С.В.Kornilov M.N., Minina M.G., Miloserdov I.A., Kruglov D.N., Chaikin R.S., Malakhov A.G., Zubenko S.I., Gautier S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/751

Расширение критериев изъятия печени при трансплантации от доноров со смертью мозга представляет собой наиболее распространенную практику преодоления дефицита органов для трансплантации. В зависимости от принятых правил большинство центров трансплантации не считают возраст противопоказанием к донорству органов при прочих удовлетворительных параметрах, а правильный подбор пары «донор–реципиент» позволяет получить удовлетворительный результат. Приводится клиническое наблюдение трансплантации печени от донора 73 лет реципиенту с метастазами нейроэндокринной опухоли в печень. Функция трансплантата удовлетворительная в течение 3 месяцев на момент публикации. Положительный исход, обзор опыта большого количества центров трансплантации печени позволяют надеяться на дальнейшее расширение подобной практики.

Orthotopic liver transplantation is the only way to cure chronic liver failure and certain liver tumors. Deceased donor organs are the prevailing source in most transplantation centers. However, there is an organ shortage because of the increasing number of patients in need of transplantation. Using expanded criteria deceased donors is a routine way to overcome organ shortage. The majority of transplantation centers take older donors depending on the local rules. Successful liver transplantation from 73-year-old deceased donor. Recipient suffered from liver neuroendocrine tumor without signs of extrahepatic spread. Liver function is adequate during 90-day follow-up. Liver transplantation from older deceased donors has good outcome according to world experience. Careful donor-recipient selection is the key to success. The first positive trial in our center enlightens the way for further practice.

трансплантация печенидонор с расширенными критериямипожилые донорыliver transplantationexpanded donor criteriaolder donorsReferencesГотье СВ, Хомяков СМ. Донорство и трансплантация органов в Российской Федерации в 2015 году. VIII сообщение регистра Российского трансплантологического общества. Вестник трансплантологии и искусственных органов. 2016; 18 (2): 6–26. Gautier SV, Khomyakov SM. Organ donation and transplantation in Russian Federation in 2015. 8th report of National Register. Russian Journal of Transplantology and Artificial Organs. 2016; 18 (2): 6–26. [In Russ, English abstract]. doi: 10.15825/1995-1191-2016-2-6-26.Готье СВ, Хомяков СМ. Донорство и трансплантация органов в Российской Федерации в 2015 году. VIII сообщение регистра Российского трансплантологического общества. Вестник трансплантологии и искусственных органов. 2016; 18 (2): 6–26. Gautier SV, Khomyakov SM. Organ donation and transplantation in Russian Federation in 2015. 8th report of National Register. Russian Journal of Transplantology and Artificial Organs. 2016; 18 (2): 6–26. [In Russ, English abstract]. doi: 10.15825/1995-1191-2016-2-6-26.Lué A, Lorente S, Serrano MT, Solanas E et al. How important is donor age in liver transplantation? World J. Gastroenterol. 2016 Jun 7; 22 (21): 4966–4976.Lué A, Lorente S, Serrano MT, Solanas E et al. How important is donor age in liver transplantation? World J. Gastroenterol. 2016 Jun 7; 22 (21): 4966–4976.Готье СВ, Константинов БА, Цирульникова ОМ. Трансплантация печени. М.: МИА, 2008, 246. Gautier SV, Konstantinov BA, Tsirulnikova OM. Transplantatsiya pecheni. M.: MIA, 2008, 246.Готье СВ, Константинов БА, Цирульникова ОМ. Трансплантация печени. М.: МИА, 2008, 246. Gautier SV, Konstantinov BA, Tsirulnikova OM. Transplantatsiya pecheni. M.: MIA, 2008, 246.Busuttil RW, Klintmalm GB. Transplantation of the Liver. 3rd ed. Philadelphia: Elsevier Saunders, 2015.Busuttil RW, Klintmalm GB. Transplantation of the Liver. 3rd ed. Philadelphia: Elsevier Saunders, 2015.Starzl TE, Porter KA et al. Orthotopic liver transplantation in ninety-three patient. Syrg., Gyn. and Obst. 1976; 142: 487–505.Starzl TE, Porter KA et al. Orthotopic liver transplantation in ninety-three patient. Syrg., Gyn. and Obst. 1976; 142: 487–505.Anderson CD, Vachharajani N, Doyle M, Lowell JA, Wellen JR, Shenoy S et al. Advanced donor age alone does not affect patient or graft survival after liver transplantation. J. Am. Coll. Surg. 2008 Dec; 207 (6): 847–852.Anderson CD, Vachharajani N, Doyle M, Lowell JA, Wellen JR, Shenoy S et al. Advanced donor age alone does not affect patient or graft survival after liver transplantation. J. Am. Coll. Surg. 2008 Dec; 207 (6): 847–852.Franco CC, Martínez JM, Bellido CB, Artacho GS, Gó­ mez LM, Diez-Canedo JS et al. Results of liver transplants from donors aged 70 plus: analysis of Andalusian transplant register. Transplant. Proc. 2013; 45 (10): 3647–3649.Franco CC, Martínez JM, Bellido CB, Artacho GS, Gó­ mez LM, Diez-Canedo JS et al. Results of liver transplants from donors aged 70 plus: analysis of Andalusian transplant register. Transplant. Proc. 2013; 45 (10): 3647–3649.León Díaz FJ, Fernández Aguilar JL, Sánchez PB, Montiel CC, Aranda Narváez JM, Pérez Daga JA et al. Results of Liver Transplantation With Donors Older than 75 Years: A Case-Control Study. Transplant. Proc. 2016 Sep; 48 (7): 2499–2502.León Díaz FJ, Fernández Aguilar JL, Sánchez PB, Montiel CC, Aranda Narváez JM, Pérez Daga JA et al. Results of Liver Transplantation With Donors Older than 75 Years: A Case-Control Study. Transplant. Proc. 2016 Sep; 48 (7): 2499–2502.Rauchfuss F, Voigt R, Dittmar Y, Heise M, Settmacher U. Liver transplantation utilizing old donor organs: a German single-center experience. Transplant. Proc. 2010 Jan-Feb; 42 (1): 175–177.Rauchfuss F, Voigt R, Dittmar Y, Heise M, Settmacher U. Liver transplantation utilizing old donor organs: a German single-center experience. Transplant. Proc. 2010 Jan-Feb; 42 (1): 175–177.Borchert DH, Glanemann M, Mogl M, Langrehr J, Neuhaus P. Adult liver transplantation using liver grafts from donors over 70 years of age. Transplant. Proc. 2005 Mar; 37 (2): 1186–1187.Borchert DH, Glanemann M, Mogl M, Langrehr J, Neuhaus P. Adult liver transplantation using liver grafts from donors over 70 years of age. Transplant. Proc. 2005 Mar; 37 (2): 1186–1187.Grazi GL, Cescon M, Ravaioli M, Corti B, Pinna AD. Successful liver transplantation from a 95-year-old donor to a patient with MELD score 36 and delayed graft arterialization. Am. J. Transplant. 2008 Mar; 8 (3): 725–726.Grazi GL, Cescon M, Ravaioli M, Corti B, Pinna AD. Successful liver transplantation from a 95-year-old donor to a patient with MELD score 36 and delayed graft arterialization. Am. J. Transplant. 2008 Mar; 8 (3): 725–726.Romagnoli J, Urbani L, Catalano G, Costa A, Marciano E, Filipponi F et al. Liver transplantation using a 93-year-old donor. Transplant. Proc. 2001 Nov-Dec; 33 (7–8): 3797.Romagnoli J, Urbani L, Catalano G, Costa A, Marciano E, Filipponi F et al. Liver transplantation using a 93-year-old donor. Transplant. Proc. 2001 Nov-Dec; 33 (7–8): 3797.Grande L, Matus D, Rimola A, et al. Expanded liver donor age over 60 yeаs for hepatic transplantation. Clin. Transpl. 1998: 297–301.Grande L, Matus D, Rimola A, et al. Expanded liver donor age over 60 yeаs for hepatic transplantation. Clin. Transpl. 1998: 297–301.Boin IF, Ataide EC, Leonardi MI Stucchi R, Sevá-Pereira T, Pereira IW et al. Elderly donors for HCV(+) versus non-HCV recipients: patient survival following liver transplantation. Transplant. Proc. 2008 Apr; 40 (3): 792–796.Boin IF, Ataide EC, Leonardi MI Stucchi R, Sevá-Pereira T, Pereira IW et al. Elderly donors for HCV(+) versus non-HCV recipients: patient survival following liver transplantation. Transplant. Proc. 2008 Apr; 40 (3): 792–796.Kim DY, Cauduro SP, Bohorquez HE, Ishitani MB, Nyberg SL, Rosen CB. Routine use of livers from deceased donors older than 70: is it justified? Transplant. Int. 2005; 18: 73–77.Kim DY, Cauduro SP, Bohorquez HE, Ishitani MB, Nyberg SL, Rosen CB. Routine use of livers from deceased donors older than 70: is it justified? Transplant. Int. 2005; 18: 73–77.Serrano MT, Garcia-Gil A, Arenas J, Ber Y, Cortes L, Valiente C et al. Outcome of liver transplantation using donors older than 60 years of age. Clin. Transplant. 2010 Jul-Aug; 24 (4): 543–549.Serrano MT, Garcia-Gil A, Arenas J, Ber Y, Cortes L, Valiente C et al. Outcome of liver transplantation using donors older than 60 years of age. Clin. Transplant. 2010 Jul-Aug; 24 (4): 543–549.Lai Q, Melandro F, Levi Sandri GB, Mennini G, Corradini SG, Merli M et al. Use of elderly donors for liver transplantation: has the limit been reached? J. Gastrointestin. Liver Dis. 2011 Dec; 20 (4): 383–387.Lai Q, Melandro F, Levi Sandri GB, Mennini G, Corradini SG, Merli M et al. Use of elderly donors for liver transplantation: has the limit been reached? J. Gastrointestin. Liver Dis. 2011 Dec; 20 (4): 383–387.Kamo N, Kaido T, Hammad A, Ogawa K, Fujimoto Y, Uemura T et al. Impact of elderly donors for liver transplantation: A single-center experience. Liver Transpl. 2015 May; 21 (5): 591–598.Kamo N, Kaido T, Hammad A, Ogawa K, Fujimoto Y, Uemura T et al. Impact of elderly donors for liver transplantation: A single-center experience. Liver Transpl. 2015 May; 21 (5): 591–598.Audet M, Piardi T, Panaro F, Cag M, Ghislotti E, Habibeh H et al. Liver transplantation in recipients over 65 year old: a single center experience. Clin. Transplant. 2010 Jan-Feb; 24 (1): 84–90.Audet M, Piardi T, Panaro F, Cag M, Ghislotti E, Habibeh H et al. Liver transplantation in recipients over 65 year old: a single center experience. Clin. Transplant. 2010 Jan-Feb; 24 (1): 84–90.Dirican A, Soyer V, Koc S, Yagci MA, Sarici B, Onur A. Liver Transplantation With Livers From Octogenarians and a Nonagenarian. Transplant. Proc. 2015 Jun; 47 (5): 1323–1325.Dirican A, Soyer V, Koc S, Yagci MA, Sarici B, Onur A. Liver Transplantation With Livers From Octogenarians and a Nonagenarian. Transplant. Proc. 2015 Jun; 47 (5): 1323–1325.Ravaioli M, Grazi GL, Cescon M, Cucchetti A, Ercolani G, Fiorentino M et al. Liver transplantations with donors aged 60 years and above: the low liver damage strategy. Transpl. Int. 2009 Apr; 22 (4): 423–433.Ravaioli M, Grazi GL, Cescon M, Cucchetti A, Ercolani G, Fiorentino M et al. Liver transplantations with donors aged 60 years and above: the low liver damage strategy. Transpl. Int. 2009 Apr; 22 (4): 423–433.Carlos JR, Clemares-Lama M, Manrique-Municio A, García-Sesma A, Calvo-Pulido J, Moreno-González E. Long-Term Results Using Old Liver Grafts for Transplantation: Sexagenerian Versus Liver Donors Older than 70 Years.Carlos JR, Clemares-Lama M, Manrique-Municio A, García-Sesma A, Calvo-Pulido J, Moreno-González E. Long-Term Results Using Old Liver Grafts for Transplantation: Sexagenerian Versus Liver Donors Older than 70 Years.Alghamdi HM, Crawford MD, Gallagher JP, Mccaughan GW, Strasser SI, Verran DJ. Cadaveric liver transplant from older donors. Saudi Med. J. 2008 Apr; 29 (4): 533–538.Alghamdi HM, Crawford MD, Gallagher JP, Mccaughan GW, Strasser SI, Verran DJ. Cadaveric liver transplant from older donors. Saudi Med. J. 2008 Apr; 29 (4): 533–538.Borchert D, Glanemann M, Mogl M, Langrehr JM, Neuhaus P. Older liver graft transplantation, cholestasis and synthetic graft function. Transpl. Int. 2005; 18: 709–715.Borchert D, Glanemann M, Mogl M, Langrehr JM, Neuhaus P. Older liver graft transplantation, cholestasis and synthetic graft function. Transpl. Int. 2005; 18: 709–715.

The authors declare that there are no conflicts of interest present.