vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2017-1-89-102vtio-738Research ArticleОбзор литературыLiterature ReviewsТрансплантация сердца от доноров старших возрастных группHeart transplantation from older donorsПопцовВ. Н.PoptsovV. N.

Адрес: 123182, Москва, ул. Щукинская, д. 1. Тел. (963) 644-96-39

Address: 1, Shchukinskaya st., Moscow, 123182, Russian Federation. Tel. (963) 644-96-39

poptsov_vit@mail.ruСпиринаЕ. А.SpirinaE. A.

Москва, Российская Федерация

Moscow, Russian Federation

КолосковаН. Н.KoloskovaN. N.

Москва, Российская Федерация

Moscow, Russian Federation

МасютинС. А.MasyutinS. A.

Москва, Российская Федерация

Moscow, Russian Federation

УхренковС. Г.UkhrenkovS. G.

Москва, Российская Федерация

Moscow, Russian Federation

ДогонашеваА. А.DogonashevaA. A.

Москва, Российская Федерация

Moscow, Russian Federation

ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава РоссииРоссияV.I. Shumakov Federal Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian FederationRussian Federation20171404201719189102Copyright © Попцов В.Н., Спирина Е.А., Колоскова Н.Н., Масютин С.А., Ухренков С.Г., Догонашева А.А., 20172017Попцов В.Н., Спирина Е.А., Колоскова Н.Н., Масютин С.А., Ухренков С.Г., Догонашева А.А.Poptsov V.N., Spirina E.A., Koloskova N.N., Masyutin S.A., Ukhrenkov S.G., Dogonasheva A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/738

В сложившейся ситуации дефицита донорских органов выполнение трансплантации сердца от так называемых возрастных доноров является одним из реальных путей повышения доступности и увеличения количества пересадок сердца, прежде всего у потенциальных реципиентов, нуждающихся в неотложном ее выполнении. При подготовке и выполнении трансплантации сердца от возрастных доноров необходимо учитывать повышенный риск развития ранней дисфункции сердечного трансплантата, наличия трансмиссивного атеросклероза коронарных артерий, развития и прогрессирования васкулопатии сердечного трансплантата, что может негативно сказаться на ранней и отдаленной выживаемости реципиентов. При правильном подборе пары «донор–реципиент», эффективном разрешении ранней дисфункции сердечного трансплантата, своевременном применении лечебных мер, направленных на профилактику васкулопатии сердечного трансплантата, а также на коррекцию трансмиссивного атеросклероза коронарных артерий, ранние и отдаленные результаты трансплантации сердца от возрастных доноров сопоставимы с результатами трансплантации от доноров со стандартными критериями.

In the current situation of the shortage of suitable donor organs, heart transplantation from older donors is one of the ways to increase the performance of more heart transplants, particularly, in patients with urgent need of transplantation. While planning a heart transplantation from older donor one should consider increased risk of early cardiac allograft dysfunction, preexisting coronary artery disease, accelerated transplant vasculopathy which may adversely affect early and long-term survival of recipients. Subject to careful selection of donor–recipient pairs, effective prevention and treatment of early cardiac allograft dysfunction, pre-existing atherosclerosis and transplant vasculopathy the early and long-term survival of heart transplant recipients from older donors is comparable to heart transplantation from young donors.

сердечная недостаточностьтрансплантация сердцаheart failureheart transplantationReferencesBrock MV, Salazar JD, Cameron DE et al. The changing profile of the cardiac donor. J. Heart Lung Transplant. 2001; 20: 1005–1009.Brock MV, Salazar JD, Cameron DE et al. The changing profile of the cardiac donor. J. Heart Lung Transplant. 2001; 20: 1005–1009.El Oakley RM, Yonan NA, Simpson BM et al. Extending criteria for cardiac allograft donors: a consensus study. J. Heart Lung Transpl. 1996; 15: 255–259.El Oakley RM, Yonan NA, Simpson BM et al. Extending criteria for cardiac allograft donors: a consensus study. J. Heart Lung Transpl. 1996; 15: 255–259.Katz JN, Waters SB, Hollis IB, Chang PP. Advanced therapies for end-stage heart failure. Current Cardiology Reviews. 2015; 11: 63–72.Katz JN, Waters SB, Hollis IB, Chang PP. Advanced therapies for end-stage heart failure. Current Cardiology Reviews. 2015; 11: 63–72.Colvin-Adams M, Smith JM, Heubner BM et al. OPTN/SRTR 2011 Annual Data Report: heart. Am. J. Transplant. 2013; 13 (suppl. 1): 119–148.Colvin-Adams M, Smith JM, Heubner BM et al. OPTN/SRTR 2011 Annual Data Report: heart. Am. J. Transplant. 2013; 13 (suppl. 1): 119–148.Young JB. Age before beauty: the use of «older» donor hearts for cardiac transplantation. J. Heart Lung Transplant. 1999; 18: 488–491.Young JB. Age before beauty: the use of «older» donor hearts for cardiac transplantation. J. Heart Lung Transplant. 1999; 18: 488–491.Wahler T, Wittwer T. Marginal donor grafts in heart transplantation: lessons learned from 25 years of experience. Transplant. Inernational. 2008; 21: 113–124.Wahler T, Wittwer T. Marginal donor grafts in heart transplantation: lessons learned from 25 years of experience. Transplant. Inernational. 2008; 21: 113–124.Roing E, Almenar L, Crespo-Leiro M et al. Heart transplantation using allografts from older donors: multicenter study results. J. Heart Lung Transplant. 2015; 34: 790–796.Roing E, Almenar L, Crespo-Leiro M et al. Heart transplantation using allografts from older donors: multicenter study results. J. Heart Lung Transplant. 2015; 34: 790–796.Drinkwater DC, Laks H, Blitz A et al. Outcomes of patients undergoing transplantation with older donor heart. J. Heart Lung Transplant. 1996; 15: 684–691.Drinkwater DC, Laks H, Blitz A et al. Outcomes of patients undergoing transplantation with older donor heart. J. Heart Lung Transplant. 1996; 15: 684–691.Mulvagh SL, Thornton B, Frazier OH et al. The older cardiac transplant donor. Relation to graft function and recipient survival longer than 6 years. Circulation. 1989; 189 (suppl. III): 126–132.Mulvagh SL, Thornton B, Frazier OH et al. The older cardiac transplant donor. Relation to graft function and recipient survival longer than 6 years. Circulation. 1989; 189 (suppl. III): 126–132.Pflugfelder PW, Singh NR, McKenzie FN et al. Extending cardiac allograft ischemic time and donor age: effect on survival and long-term cardiac function. J. Heart Lung Transplant. 1991; 10: 394–400.Pflugfelder PW, Singh NR, McKenzie FN et al. Extending cardiac allograft ischemic time and donor age: effect on survival and long-term cardiac function. J. Heart Lung Transplant. 1991; 10: 394–400.Menkis AH, Novics RJ, Kostuk WJ et al. Successful use of the «unacceptable» heart donor. J. Heart Lung Transplant. 1991; 10: 28–32.Menkis AH, Novics RJ, Kostuk WJ et al. Successful use of the «unacceptable» heart donor. J. Heart Lung Transplant. 1991; 10: 28–32.Zuckermann A, Kocher P, Simon P et al. Expanding the donor pool in cardiac transplantation by accepting donor heart >40 years. Transplant. Proc. 1997; 29: 179–180.Zuckermann A, Kocher P, Simon P et al. Expanding the donor pool in cardiac transplantation by accepting donor heart >40 years. Transplant. Proc. 1997; 29: 179–180.Mercer P, Sharples L, Edmunds J et al. Evaluating the door pool: impact of using hearts from donors over the age of 49 years. Transplant. Proc. 1997; 29: 3293–3296.Mercer P, Sharples L, Edmunds J et al. Evaluating the door pool: impact of using hearts from donors over the age of 49 years. Transplant. Proc. 1997; 29: 3293–3296.Loebe M, Potapov EV, Hummel M et al. Medium-term results of heart transplantation using older donor organs. J. Heart Lung Transplant. 2000; 19: 957–963.Loebe M, Potapov EV, Hummel M et al. Medium-term results of heart transplantation using older donor organs. J. Heart Lung Transplant. 2000; 19: 957–963.Blanche C, Kamlot A, Blanche DA et al. Heart transplantation with donors fifty years of age and older. J. Thorac. Cardiovasc. Surg. 2002; 123: 810–815.Blanche C, Kamlot A, Blanche DA et al. Heart transplantation with donors fifty years of age and older. J. Thorac. Cardiovasc. Surg. 2002; 123: 810–815.Potapov EV, Loebe M, Hubler M et al. Medium-term results of heart transplantation using donors over 63 years of age. Transplantation. 1999; 8: 1834–1838.Potapov EV, Loebe M, Hubler M et al. Medium-term results of heart transplantation using donors over 63 years of age. Transplantation. 1999; 8: 1834–1838.Gupta D, Piacentino V, Macha M et al. Effect of older donor age on risk for mortality after heart transplantation. Ann. Thorac. Surg. 2004; 78: 890–899.Gupta D, Piacentino V, Macha M et al. Effect of older donor age on risk for mortality after heart transplantation. Ann. Thorac. Surg. 2004; 78: 890–899.Bourge RC, Naftel DC, Costanzo-Nordin MR et al. Pretransplantation risk factors for death after heart transplantation: a multiinstitutional study. The Transplant Cardiologist Research Database Group. J. Heart Lung Transplant. 1993; 12: 549–562.Bourge RC, Naftel DC, Costanzo-Nordin MR et al. Pretransplantation risk factors for death after heart transplantation: a multiinstitutional study. The Transplant Cardiologist Research Database Group. J. Heart Lung Transplant. 1993; 12: 549–562.Ngiia AS, Hranjec T, Swenson BR et al. Donor age is associated with chronic allograft vasculopathy after adult heart transplantation: implications for donor allocation. Ann. Thorac. Surg. 2010; 90: 168–175.Ngiia AS, Hranjec T, Swenson BR et al. Donor age is associated with chronic allograft vasculopathy after adult heart transplantation: implications for donor allocation. Ann. Thorac. Surg. 2010; 90: 168–175.Stehlik J, Edwards LB, Kucheryavaya AY et al. The Registry of the International Society for Heart and Lung Transplantation: 29th Official Adult Heart Transplant Report – 2012. J. Heart Lung Transplant. 2012; 31: 1045–1095.Stehlik J, Edwards LB, Kucheryavaya AY et al. The Registry of the International Society for Heart and Lung Transplantation: 29th Official Adult Heart Transplant Report – 2012. J. Heart Lung Transplant. 2012; 31: 1045–1095.Prieto D, Correia P, Baptista M, Antunes MJ. Outcomes after heart transplantation from older donor age: expanding the donor pool. Eur. Cardiothorac. Surg. 2015; 47: 672–678.Prieto D, Correia P, Baptista M, Antunes MJ. Outcomes after heart transplantation from older donor age: expanding the donor pool. Eur. Cardiothorac. Surg. 2015; 47: 672–678.Reiss N, Leprince P, Bonnet N et al. Results after orthotopic heart transplantation accepting donor heart >50 years: experience at La Pitié-Salpêtrière, Paris. Transplant. Procced. 2007; 39: 549–553.Reiss N, Leprince P, Bonnet N et al. Results after orthotopic heart transplantation accepting donor heart >50 years: experience at La Pitié-Salpêtrière, Paris. Transplant. Procced. 2007; 39: 549–553.Ammirati E, Cipriani MG, Varrenti M et al. A prospective comparison of mid-term outcomes in patients treated with heart transplantation with advanced age donors versus left ventricular assist device implantation. Interact. Cardiovasc. Thorac. Surgery. 2016; 23: 584–592.Ammirati E, Cipriani MG, Varrenti M et al. A prospective comparison of mid-term outcomes in patients treated with heart transplantation with advanced age donors versus left ventricular assist device implantation. Interact. Cardiovasc. Thorac. Surgery. 2016; 23: 584–592.Patel J, Kobashigava JA. Cardiac transplantation: the alternate list and expansion of the donor pool. Curr. Opin. Cardiol. 2004; 19: 162–165.Patel J, Kobashigava JA. Cardiac transplantation: the alternate list and expansion of the donor pool. Curr. Opin. Cardiol. 2004; 19: 162–165.Chen JM, Russo MJ, Hammond KM et al. Alternate waiting list strategies for heart transplantation maximize donor organ utilization. Ann. Thorac. Surg. 2005; 80: 224–228.Chen JM, Russo MJ, Hammond KM et al. Alternate waiting list strategies for heart transplantation maximize donor organ utilization. Ann. Thorac. Surg. 2005; 80: 224–228.Korrmaz S, Bahre-Szabo S, Loganathan S et al. Marginal donor: can older hearts tolerate prolonged cold ischemia storage? Agin. Clin. Exp. Res. 2013; 25: 597–600.Korrmaz S, Bahre-Szabo S, Loganathan S et al. Marginal donor: can older hearts tolerate prolonged cold ischemia storage? Agin. Clin. Exp. Res. 2013; 25: 597–600.Wojtovich AP, Nadtochiy SM, Brookes PS et al. Ischemic preconditioning: the role of mitochondria and aging. Exp. Gerontol. 2012; 47: 1–7.Wojtovich AP, Nadtochiy SM, Brookes PS et al. Ischemic preconditioning: the role of mitochondria and aging. Exp. Gerontol. 2012; 47: 1–7.Kumarasinghe G, Hicks M, Villanueva J et al. Improved heart function from older donors using pharmacologic conditioning strategies. J. Heart Lung Transplant. 2016; 35: 636–646.Kumarasinghe G, Hicks M, Villanueva J et al. Improved heart function from older donors using pharmacologic conditioning strategies. J. Heart Lung Transplant. 2016; 35: 636–646.Chiari P, Piriou V, Hadour G et al. Preservation of ischemia and isoflurane-induced preconditioning after brain death in rabbit hearts. Am. J. Physiol. Heart Circ. Physiol. 2002; 283: H1769–H1774.Chiari P, Piriou V, Hadour G et al. Preservation of ischemia and isoflurane-induced preconditioning after brain death in rabbit hearts. Am. J. Physiol. Heart Circ. Physiol. 2002; 283: H1769–H1774.Hausenloy DJ, Yellon DM. Myocardial ischemia-reperfusion injury: a neglected therapeutic target. J. Clin. Invest. 2013; 24: 306–318.Hausenloy DJ, Yellon DM. Myocardial ischemia-reperfusion injury: a neglected therapeutic target. J. Clin. Invest. 2013; 24: 306–318.Jabbour A, Gao L, Kwan J et al. A recombinant human neurogulin-1-peptide improves preservation of the rodent heart after prolonged hypothermic storage. Transplantation. 2011; 91: 961–967.Jabbour A, Gao L, Kwan J et al. A recombinant human neurogulin-1-peptide improves preservation of the rodent heart after prolonged hypothermic storage. Transplantation. 2011; 91: 961–967.Watson AJ, Gao L, Sun L et al. Enhanced preservation of pig cardiac allografts by combining erythropoietin with glyceril trinitrate and zoniporide. Am. J. Transplant. 2013; 13: 1676–1687.Watson AJ, Gao L, Sun L et al. Enhanced preservation of pig cardiac allografts by combining erythropoietin with glyceril trinitrate and zoniporide. Am. J. Transplant. 2013; 13: 1676–1687.Ebrahim Z, Yellon DM, Baxter GF. Ischemic preconditioning is lost in aging hypertensive rat heart: independing effects of aging and longstanding hypertension. Exp. Gerontol. 2007; 42: 807–814.Ebrahim Z, Yellon DM, Baxter GF. Ischemic preconditioning is lost in aging hypertensive rat heart: independing effects of aging and longstanding hypertension. Exp. Gerontol. 2007; 42: 807–814.Schulman D, Latchman DS, Yellon DM. Effect of aging on the ability of preconditioning to protect rat heart from ischemia-reperfusion injury. Am. J. Physiol. Heart Circ. Physiol. 2001; 281: H1630–H1606.Schulman D, Latchman DS, Yellon DM. Effect of aging on the ability of preconditioning to protect rat heart from ischemia-reperfusion injury. Am. J. Physiol. Heart Circ. Physiol. 2001; 281: H1630–H1606.Fenton RA, Dickson EW, Dobson JG Jr. Inhibition of phosphatase activity enhances preconditioning and limits cell death in ischemia/reperfused aged rat heart. Life Sci. 2005; 77: 3375–3388.Fenton RA, Dickson EW, Dobson JG Jr. Inhibition of phosphatase activity enhances preconditioning and limits cell death in ischemia/reperfused aged rat heart. Life Sci. 2005; 77: 3375–3388.Boengler K, Schulz R, Heusch G et al. Loss of cardioprotection with ageing. Cardiovasc. Res. 2012; 110: 1109–1124.Boengler K, Schulz R, Heusch G et al. Loss of cardioprotection with ageing. Cardiovasc. Res. 2012; 110: 1109–1124.Russo MJ, Chen JM, Sorabella RA et al. The effect of ischemic time on survival after heart transplantation varies by donor age: an analysis of the United Network for Organ Sharing database. J. Thorac. Cardiovasc. Surg. 2007; 133: 554–559.Russo MJ, Chen JM, Sorabella RA et al. The effect of ischemic time on survival after heart transplantation varies by donor age: an analysis of the United Network for Organ Sharing database. J. Thorac. Cardiovasc. Surg. 2007; 133: 554–559.Marasco SF, Esmore DS, Negri J et al. Early institution of mechanical support improves outcomes in primary cardiac allograft failure. J. Heart Lung Transpl. 2005; 24: 2037–2042.Marasco SF, Esmore DS, Negri J et al. Early institution of mechanical support improves outcomes in primary cardiac allograft failure. J. Heart Lung Transpl. 2005; 24: 2037–2042.Billingham ME. Cardiac transplant atherosclerosis. Transplant. Proc. 1987; 4: 19–25.Billingham ME. Cardiac transplant atherosclerosis. Transplant. Proc. 1987; 4: 19–25.Pinney SP, Manchini D. Cardiac allograft vasculopathy: advences in understanding its pathophysiology, prevention, and treatment. Curr. Opin. Cardiol. 2004; 19: 170– 176.Pinney SP, Manchini D. Cardiac allograft vasculopathy: advences in understanding its pathophysiology, prevention, and treatment. Curr. Opin. Cardiol. 2004; 19: 170– 176.Gao HZ, Hunt SA, Alderman EL et al. Relation donor age and preexisting coronary artery disease on angiography and intracoronary ultrasound to latter development of accelerated allograft coronary artery disease. J. Am. Coll. Cardiol. 1997; 29: 623–629.Gao HZ, Hunt SA, Alderman EL et al. Relation donor age and preexisting coronary artery disease on angiography and intracoronary ultrasound to latter development of accelerated allograft coronary artery disease. J. Am. Coll. Cardiol. 1997; 29: 623–629.Lietz K, John R, Anzai H et al. Outcomes in cardiac transplant recipients using allograft from older donors versus mortality on the transplant waiting list; Implications for donor selection criteria. J. Am. Coll. Cardiol. 2004; 43: 1553–1561.Lietz K, John R, Anzai H et al. Outcomes in cardiac transplant recipients using allograft from older donors versus mortality on the transplant waiting list; Implications for donor selection criteria. J. Am. Coll. Cardiol. 2004; 43: 1553–1561.Grauhan O, Wesslau C, Hetzer R. Routine screening of donor hearts by coronary angiography is feasible. Transplant. Proc. 2006; 38: 666–667.Grauhan O, Wesslau C, Hetzer R. Routine screening of donor hearts by coronary angiography is feasible. Transplant. Proc. 2006; 38: 666–667.Estevez-Loureino R, Paniagua-Martin MJ, Calvino-Santos R et al. Prevalence of donor-transmitted coronary artery disease and its influence on heart transplant outcomes. Transplant. Proceed. 2010; 42: 2987–2991.Estevez-Loureino R, Paniagua-Martin MJ, Calvino-Santos R et al. Prevalence of donor-transmitted coronary artery disease and its influence on heart transplant outcomes. Transplant. Proceed. 2010; 42: 2987–2991.Laks H, Gates RN, Ardehali A et al. Orthotopic heart transplantation and concurrent coronary bypass. J. Heart Lung Transplant. 1993; 12: 810–815.Laks H, Gates RN, Ardehali A et al. Orthotopic heart transplantation and concurrent coronary bypass. J. Heart Lung Transplant. 1993; 12: 810–815.Abid Q, Parry G, Forty J et al. Concurrent coronary grafting of the donor heart with left internal mammary artery: 10-year experience. J. Heart Lung Transplant. 2002; 21: 812–814.Abid Q, Parry G, Forty J et al. Concurrent coronary grafting of the donor heart with left internal mammary artery: 10-year experience. J. Heart Lung Transplant. 2002; 21: 812–814.Rabago G, Martin-Trenor A, Lopez Coronaro JL et al. Coronary angioplasty and stenting following heart transplantation with older donor: Is this a rational approach? Eur. J. Cardiothorac. Surg. 1998; 13: 209–211.Rabago G, Martin-Trenor A, Lopez Coronaro JL et al. Coronary angioplasty and stenting following heart transplantation with older donor: Is this a rational approach? Eur. J. Cardiothorac. Surg. 1998; 13: 209–211.Schuler S, Matschke K, Loebe M et al. Coronary artery disease in patients with hearts from older donors: morphologic features and therapeutic implications. J. Heart Lung Transplant. 1993; 12: 100–108.Schuler S, Matschke K, Loebe M et al. Coronary artery disease in patients with hearts from older donors: morphologic features and therapeutic implications. J. Heart Lung Transplant. 1993; 12: 100–108.Tuzcu EM, Hobbs RE, Rincon G et al. Occult and frequent transmission of atherosclerotic coronary disease with cardiac transplantation. Insight from intravascular ultrasound. Circulation. 1995; 91: 1706–1713.Tuzcu EM, Hobbs RE, Rincon G et al. Occult and frequent transmission of atherosclerotic coronary disease with cardiac transplantation. Insight from intravascular ultrasound. Circulation. 1995; 91: 1706–1713.Pflugfelder PW, Singh NR, McKenzie FN et al. Extending cardiac allograft ischemic time and donor age: effect on survival and long-term cardiac function. J. Heart Lung Transplant. 1991; 10: 394–400.Pflugfelder PW, Singh NR, McKenzie FN et al. Extending cardiac allograft ischemic time and donor age: effect on survival and long-term cardiac function. J. Heart Lung Transplant. 1991; 10: 394–400.Mulvagh SL, Thornton B, Frazier OH et al. The older cardiac transplant donor: relation to graft function and recipient survival longer than 6 years. Circulation. 1989; 80 (suppl. III, pt 2): 126–132.Mulvagh SL, Thornton B, Frazier OH et al. The older cardiac transplant donor: relation to graft function and recipient survival longer than 6 years. Circulation. 1989; 80 (suppl. III, pt 2): 126–132.Kapadia SR, Nissen SE, Ziada KM et al. Development of transplantation vasculopathy and progression of donor-transmitted atherosclerosis. Comparison by serial intravascular ultrasound imaging. Circulation. 1998; 98: 2672–2678.Kapadia SR, Nissen SE, Ziada KM et al. Development of transplantation vasculopathy and progression of donor-transmitted atherosclerosis. Comparison by serial intravascular ultrasound imaging. Circulation. 1998; 98: 2672–2678.Botas J, Pinto FJ, Chenzbraun A et al. Influence of preexistent donor coronary artery disease on the progression of transplant vasculopathy. An intravascular ultrasound study. Circulation. 1995; 92: 1126–1132.Botas J, Pinto FJ, Chenzbraun A et al. Influence of preexistent donor coronary artery disease on the progression of transplant vasculopathy. An intravascular ultrasound study. Circulation. 1995; 92: 1126–1132.Marrelli D, Laks H, Bresson S et al. Results after transplantation using donor hearts with preexisting coronary artery disease. J. Thorac. Cardiovasc. Surg. 2003; 126: 821–825.Marrelli D, Laks H, Bresson S et al. Results after transplantation using donor hearts with preexisting coronary artery disease. J. Thorac. Cardiovasc. Surg. 2003; 126: 821–825.Grauhan O, Siniawski H, Dandel M et al. Coronary atherosclerosis of the donor heart – impact on early graft failure. Eur. J. Cardiothorac. Surg. 2007; 32: 634–638.Grauhan O, Siniawski H, Dandel M et al. Coronary atherosclerosis of the donor heart – impact on early graft failure. Eur. J. Cardiothorac. Surg. 2007; 32: 634–638.Kobashigawa JA, Tobis JM, Starling RC et al. Multicenter intravascular ultrasound validation study among heart transplant recipients: outcomes after five years. J. Am. Coll. Cardiol. 2005; 45: 1532–1537.Kobashigawa JA, Tobis JM, Starling RC et al. Multicenter intravascular ultrasound validation study among heart transplant recipients: outcomes after five years. J. Am. Coll. Cardiol. 2005; 45: 1532–1537.Ramzy D, Rao V, Brahm J et al. Cardiac allograft vasculopathy: a review. Can. J. Surg. 2005; 48: 319–327.Ramzy D, Rao V, Brahm J et al. Cardiac allograft vasculopathy: a review. Can. J. Surg. 2005; 48: 319–327.Lazaro SIJ, Bonet AL, Lopez MJ et al. Influence of traditional cardiovascular risk factors in the recipient on the development of cardiac allograft vasculopathy after heart transplantation. Transplant. Proc. 2008; 40: 3056–3057.Lazaro SIJ, Bonet AL, Lopez MJ et al. Influence of traditional cardiovascular risk factors in the recipient on the development of cardiac allograft vasculopathy after heart transplantation. Transplant. Proc. 2008; 40: 3056–3057.Taylor DO, Edwards LB, Aurora P et al. Registry of the International Society for Heart and Lung Transplantation: twenty-fifth official adult heart transplant report – 2008. J. Heart Lung Transplant. 2008; 27: 943–956.Taylor DO, Edwards LB, Aurora P et al. Registry of the International Society for Heart and Lung Transplantation: twenty-fifth official adult heart transplant report – 2008. J. Heart Lung Transplant. 2008; 27: 943–956.Costanzo MR, Naftel DC, Pritzker MR et al. Heart transplant coronary artery disease detected by coronary angiography: a multiinstitutional study of preoperative donor and recipient risk factors. Cardiac Transplant Research Database. J. Heart Lung Transplant. 1998; 17: 744–753.Costanzo MR, Naftel DC, Pritzker MR et al. Heart transplant coronary artery disease detected by coronary angiography: a multiinstitutional study of preoperative donor and recipient risk factors. Cardiac Transplant Research Database. J. Heart Lung Transplant. 1998; 17: 744–753.Blanche C, Kamlot A, Blanche D et al. Heart transplantation with donor fifty years of age and older. Cardiothorac. Transplant. 2002; 123: 810–815.Blanche C, Kamlot A, Blanche D et al. Heart transplantation with donor fifty years of age and older. Cardiothorac. Transplant. 2002; 123: 810–815.Bruschi G, Colombo T, Oliva F et al. Orthotopic heart transplantation with donor greater than or equal to 60 years of age: a single-centre experience. Eur. J. Cardiothorac. Surg. 2011; 40: 55–61.Bruschi G, Colombo T, Oliva F et al. Orthotopic heart transplantation with donor greater than or equal to 60 years of age: a single-centre experience. Eur. J. Cardiothorac. Surg. 2011; 40: 55–61.Fiorelli AI, Branco JN, Dinkhuysen JJ et al. Risk factor analysis of late survival after heart transplantation according to donor profile: a multi-institutional retrospective study of 512 transplants. Transplant. Proc. 2012; 44: 2469–2472.Fiorelli AI, Branco JN, Dinkhuysen JJ et al. Risk factor analysis of late survival after heart transplantation according to donor profile: a multi-institutional retrospective study of 512 transplants. Transplant. Proc. 2012; 44: 2469–2472.Weiss ES, Nwakfnna LU, Patel ND, Yuh DD. Outcomes in patients older than 60 years of age undergoing orthotopic heart transplantation: an analysis of the UNOS database. J. Heart Lung Transplant. 2008; 27: 184–191.Weiss ES, Nwakfnna LU, Patel ND, Yuh DD. Outcomes in patients older than 60 years of age undergoing orthotopic heart transplantation: an analysis of the UNOS database. J. Heart Lung Transplant. 2008; 27: 184–191.Kilic A, Weiss E, Yuh D, Shah A, Conte J. Factors associated with 5-year survival in older heart transplant recipients. Cardiothorac. Transplant. 2012; 143: 468–474.Kilic A, Weiss E, Yuh D, Shah A, Conte J. Factors associated with 5-year survival in older heart transplant recipients. Cardiothorac. Transplant. 2012; 143: 468–474.Meyer S, Modry D, Norris C et al. Pretransplant diabetes, not donor age, predicts long-term outcomes in cardiac transplantation. J. Card. Surg. 2006; 21: 117–124.Meyer S, Modry D, Norris C et al. Pretransplant diabetes, not donor age, predicts long-term outcomes in cardiac transplantation. J. Card. Surg. 2006; 21: 117–124.Lund HL, Edwards LB, Dipchand AI et al. The Registry of the International Society for Heart and Lung Transplantation: Thirty-third Adult Heart Transplantation Report – 2016; Focus Theme: Primary Diagnostic Indications for Transplant. J. Heart Lung Transplant. 2016; 35: 1149–1205.Lund HL, Edwards LB, Dipchand AI et al. The Registry of the International Society for Heart and Lung Transplantation: Thirty-third Adult Heart Transplantation Report – 2016; Focus Theme: Primary Diagnostic Indications for Transplant. J. Heart Lung Transplant. 2016; 35: 1149–1205.Patel CB, Cowger JA, Zuckermann AA. A contemporary review of mechanical circulatory support. J. Heart Lung Transplant. 2014; 33: 667–674.Patel CB, Cowger JA, Zuckermann AA. A contemporary review of mechanical circulatory support. J. Heart Lung Transplant. 2014; 33: 667–674.Quader MA, Luke GW, Kasirajan V. Heart transplantation outcomes in patients with continuous-flow left ventricular assist device-related complication. J. Heart Lung Transplant. 2015; 34: 75–81.Quader MA, Luke GW, Kasirajan V. Heart transplantation outcomes in patients with continuous-flow left ventricular assist device-related complication. J. Heart Lung Transplant. 2015; 34: 75–81.Ammirati E, Cipriani MG, Varrenti M et al. A prospective comparison of mid-term outcomes in patients treated with heart transplantation with advanced age donors versus left ventricular assist device implantation. Interact. Cardiovasc. Thorac. Surgery. 2016; 23: 584–592.Ammirati E, Cipriani MG, Varrenti M et al. A prospective comparison of mid-term outcomes in patients treated with heart transplantation with advanced age donors versus left ventricular assist device implantation. Interact. Cardiovasc. Thorac. Surgery. 2016; 23: 584–592.Singh TP, Milliren CE, Almond CS, Graham D. Survival benefit from transplantation in patients listed for heart transplantation in United States. J. Am. Coll. Cardiol. 2014; 63: 1169–1178.Singh TP, Milliren CE, Almond CS, Graham D. Survival benefit from transplantation in patients listed for heart transplantation in United States. J. Am. Coll. Cardiol. 2014; 63: 1169–1178.Kirklin J, Naftel D, Pagani F et al. Sixth INTERMACS annual report: a 10.000-patient. J. Heart Lung Transplant. 2014; 32: 555–564.Kirklin J, Naftel D, Pagani F et al. Sixth INTERMACS annual report: a 10.000-patient. J. Heart Lung Transplant. 2014; 32: 555–564.Mancini DM, Schulze PC. Heart transplant allocation. In desperate need of revision. J. Am. Coll. Cardiol. 2014; 63: 1179–1181.Mancini DM, Schulze PC. Heart transplant allocation. In desperate need of revision. J. Am. Coll. Cardiol. 2014; 63: 1179–1181.

The authors declare that there are no conflicts of interest present.