References

vtio

Вестник трансплантологии и искусственных органов

Russian Journal of Transplantology and Artificial Organs

1995-1191

Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation

10.15825/1995-1191-2016-4-133-145

vtio-708

Research Article

Обзор литературы

Literature Reviews

ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ ТКАНЕИНЖЕНЕРНЫХ КОНСТРУКЦИЙ ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ В ЛЕЧЕНИИ САХАРНОГО ДИАБЕТА 1-го ТИПА

PROSPECTS OF APPLICATION OF TISSUE-ENGINEERED PANCREATIC CONSTRUCTS IN THE TREATMENT OF TYPE 1 DIABETES

Скалецкая

Г. Н.

Skaletskaya

G. N.

Москва, Российская Федерация

Moscow, Russian Federation

Скалецкий

Н. Н.

Skaletskiy

N. N.

Адрес: 123182, Москва, ул. Щукинская, д. 1. Тел.: (499) 190-42-66, (903) 790-95-39

Address: 1, Shchukinskaya St., Moscow, 123182, Russian Federation. Tel.: (499) 190-42-66, (903) 790-95-39

NSkaletsky@mail.ru

Севастьянов

В. И.

Sevastianov

V. I.

Москва, Российская Федерация

Moscow, Russian Federation

ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава РоссииРоссияV.I. Shumakov Federal Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian FederationRussian Federation

2016

28012017

184133145

2017

Скалецкая Г.Н., Скалецкий Н.Н., Севастьянов В.И.

Skaletskaya G.N., Skaletskiy N.N., Sevastianov V.I.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.transpl.ru/vtio/article/view/708

Наиболее эффективным методом лечения сахарного диабета 1-го типа по-прежнему является аллотранс-плантация островков поджелудочной железы, которая при сочетании благоприятных условий (достаточное количество выделенных островков, удачная комбинация иммуносупрессивных препаратов) способна достичь инсулиннезависимости реципиентов на протяжении нескольких лет. Однако постоянный дефицит донорских поджелудочных желез и ограниченность выживания островков в организме реципиента не позволяют увеличить количество таких трансплантаций и повысить их эффективность. В настоящем обзоре дан критический анализ работ российских и зарубежных авторов по созданию тканеинженерных конструкций поджелудочной железы, направленных на решение трех главных проблем трансплантации островков поджелудочной железы: 1) дефицит донорского материала; 2) необходимость проведения иммуносупрессивной терапии; 3) непродолжительность выживания и функциональной активности пересаженных островков.

Allotransplantation of pancreatic islets remains the most effective method of treatment of diabetes mellitus type 1 being capable under combination of favorable conditions (suffi cient number of isolated islets, effective combination of immunosuppressive drugs) to reach the recipients’ insulin independence for several years. However, the overwhelming shortage of donor pancreas and limited post-transplantation islet survival do not allow increasing the number of such transplants and their effectiveness. This review presents a critical analysis of the work done by Russian and foreign authors onto creation of tissue-engineered pancreatic constructs that may lead to the resolution of the three main pancreatic islet transplantation issues: 1) lack of donor material; 2) necessity of immunosuppressive therapy; 3) limited survival and functional activity of the islet.

сахарный диабет 1-го типатрансплантацияостровкиподжелудочная железатканеинженерные конструкции

diabetes mellitus type 1transplantationisletspancreastissue-engineered constructs

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The authors declare that there are no conflicts of interest present.