vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2016-3-137-144vtio-680Research ArticleОбзор литературыLiterature ReviewsБИОМАРКЕРЫ ИММУННОЙ ТОЛЕРАНТНОСТИ ПРИ ТРАНСПЛАНТАЦИИ ПЕЧЕНИBIOMARKERS OF IMMUNE TOLERANCE IN LIVER TRANSPLANTATIONШевченкоО. П.ShevchenkoO. P.

Кафедра трансплантологии и искусственных органов

123182, Москва, ул. Щукинская, 1. Тел. (499) 190-38-77

Department of Transplantology and Artifi cial Organs

1, Shchukinskaya St., Moscow, 123182. Tel. (499) 190-38-77

transplant2009@mail.ruКурабековаР. М.KurabekovaR. M.ЦирульниковаО. М.TsiroulnikovaO. M.

Кафедра трансплантологии и искусственных органов

Department of Transplantology and Artifi cial Organs

ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России, Москва; ГБОУ ВПО «Первый МГМУ имени И.М. Сеченова», МоскваРоссияV.I. Shumakov Federal Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian Federation, Moscow; I.M. Sechenov Fist Moscow State Medical University, MoscowRussian FederationФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России, МоскваРоссияV.I. Shumakov Federal Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian Federation, MoscowRussian Federation201618112016183137144Copyright © Шевченко О.П., Курабекова Р.М., Цирульникова О.М., 20162016Шевченко О.П., Курабекова Р.М., Цирульникова О.М.Shevchenko O.P., Kurabekova R.M., Tsiroulnikova O.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/680

Обзор литературы посвящен анализу исследований биомаркеров, позволяющих прогнозировать формирование иммунной толерантности и идентифицировать пациентов, которым можно безопасно минимизировать иммуносупрессию после трансплантации печени. В обзоре проанализированы 46 источников литературы, большая часть которых опубликована в последние пять лет. В настоящее время бурно развиваются новые технологии, позволяющие понять молекулярные механизмы нормальных, патологических и фармакологических процессов, протекающих при трансплантации органов. Однако до настоящего времени нет биомаркеров, валидированных для определения состояния иммунной толерантности и индивидуального подбора иммуносупрессантов. Накопление данных по пациентам вкупе с совершенствованием биоинформатики может значительно ускорить процесс развития подходов для стратификации пациентов. 

This review of literature is dedicated to the analysis of the current studies of biomarkers, which could help predict immune tolerance development and identify the patients, who can safely minimize immunosuppression after liver transplantation. The review analyzed 46 sources of literature, more than half of those were published in the last fi ve years. Up to date advanced technologies are intensively developed, which help understand molecular mechanisms of normal, pathological and pharmacological processes involved in organ transplantations. However, there are no biomarkers yet validated for the identifi cation of immune tolerance development or individual prescription of immunosuppressants. Further data collection on patients along with the progress in bioinformatics could accelerate development of approaches for patient stratifi cation. 

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The authors declare that there are no conflicts of interest present.