References

vtio

Вестник трансплантологии и искусственных органов

Russian Journal of Transplantology and Artificial Organs

1995-1191

Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation

10.15825/1995-1191-2014-1-65-75

vtio-67

Research Article

Обзор литературы

Literature Reviews

ОНЛАЙН-ГЕМОДИАФИЛЬТРАЦИЯ: КЛИНИЧЕСКИЕ РЕЗУЛЬТАТЫ И ЭКОНОМИЧЕСКАЯ ЭФФЕКТИВНОСТЬ

ONLINE HEMODIAFILTRATION: CLINICAL RESULTS AND ECONOMIC EVALUATION

Поз

Я. Л.

Poz

Y. L.

Строков

А. Г.

Strokov

A. G.

Копылова

Ю. В.

Kopylova

Y. V.

Отделение гемодиализа ФГБУ «Федеральный научный центр трансплантологии и искусственных органов им. академика В.И. Шумакова» Минздрава РФ, Москва, Российская ФедерацияHemodialysis division, «V.I. Shumakov Federal Research Center of Transplantology and Artificial organs», Ministry of Health of the Russian Federation, Moscow, Russian Federation

2014

14052014

161

ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ том XVI No 1–2014

6575

2014

Поз Я.Л., Строков А.Г., Копылова Ю.В.

Poz Y.L., Strokov A.G., Kopylova Y.V.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.transpl.ru/vtio/article/view/67

Вторая часть обзора посвящена правовым и финансовым аспектам онлайн-гемодиафильтрации, а также ее влиянию на непосредственные и отдаленные результаты лечения. Недавно завершенные рандомизи- рованные исследования подтвердили, что высокообъемная онлайн-гемодиафильтрация позволяет улуч- шить выживаемость пациентов. Эти данные должны переломить инерцию, препятствующую повсемес- тному внедрению онлайн-гемодиафильтрации в качестве основной методики в практику программного гемодиализа.

Second part of review summarizes legal and financial aspects of online hemodiafiltration and its influence on short-term and long-term treatment results. According to recently completed randomized clinical trials, high vo- lume online hemodiafiltration is able to improve patients' survival rate. The results mentioned in the review must overpower the inertia which obstructs a wide implementation of online hemodiafiltration into routine clinical practice.

онлайн-гемодиафильтрациярегулированиеклиническая эффективность

online hemodiafiltrationregulationoutcomes

References1

СПИСОК ЛИТЕРАТУРЫ / REFERENCES

Ledebo I. On-line preparation of solutions for dialysis: practical aspects versus safety and regulations. J. Am. Soc. Nephrol. 2002; 13: S78–S83.

Ledebo I., Blankestijn P.J. Haemodiafiltration – optimal efficiency and safety. NDT Plus. 2010; 3: 8–16.

Tattersall J.E., Ward R.A. Online haemodiafiltration: de- finition, dose quantification and safety revisited. Neph- rol. Dial. Transplant. 2013; 22: 542–550.

Del Vecchio M., Giordana G., Pedrini L., Marcelli D., Sisti N. Elements for economic evaluation on online He- modiafiltration (ol-HDF) versus standard Haemodialysis to treat patients with End-Stage Renal Disease (ESRD). IJPH. 2012; 9 (4) Suppl. 1: 1–50.

Kawanishi H., Yamashita A.C., Takemoto Y. Preface. Blood Purif. 2013; 35 Suppl. 1: 1.

Sichart J.M., Moeller S. Utilization of Hemodiafiltration as Treatment Modality in Renal Replacement Therapy for End-Stage Renal Disease Patients – A Global Pers- pective. On-line Hemodiafiltration: the journey and the vision. 2011; 175: 163–169.

ERA-EDTA Registry: ERA-EDTA Registry Annual Re- port 2010. Academic Medical Center, Department of Me- dical Informatics. Amsterdam, The Netherlands, 2012.

de Jager D.J., Grootendorst D.C., Jager K.J., van Dijk P.C., Tomas L.M., Ansell D., Collart F., Finne P., Heaf J.G., De Meester J., Wetzels J.F., Rosendaal F.R., Dekker F.W. Car- diovascular and Noncardiovascular Mortality Among Pa- tients Starting Dialysis. JAMA. 2009; 302 (16): 1782–1789.

Canaud B., Bragg-Gresham J.L., Marshall M.R., Desmeules S., Gillespie B.W., Depner T., Klassen P., Port F.K. Mortality risk for patients receiving hemodia- filtration versus hemodialysis: European results from the DOPPS. Kidney Int. 2006; (69): 2087–2093.

Grooteman M.P.C., van den Dorpel M.A., Bots M.L., Penne E.L., van der Weerd N.C., Mazairac A.H., den Hoedt C.H., van der Tweel I., Lévesque R., Nubé M.J., ter Wee P.M., Blankestijn P.J. CONTRAST Investiga- tors. Effect of Online Hemodiafiltration on All-Cause Mortality and Cardiovascular Outcomes. J. Am. Soc. Nephrol. 2012; 23: 1087–1096.

Ok E., Asci G., Toz H., Ok E.S., Kircelli F., Yilmaz M., Hur E., Demirci M.S., Demirci C., Duman S., Bas- ci A., Adam S.M., Isik I.O., Zengin M., Suleymanlar G., Yilmaz M.E., Ozkahya M. Turkish online haemodiafiltra- tion study. Mortality and cardiovascular events in online haemodiafiltration (OL-HDF) compared with high-flux dialysis: results from the Turkish OL-HDF Study. Neph- rol. Dial. Transplant. 2013; 28: 192–202.

Maduell F., Moreso F., Pons M., Ramos R., Mora- Macià J., Carreras J., Soler J., Torres F., Campis- tol J.M., Martinez-Castelao A. ESHOL Study Group. High-efficiency postdilution online hemodiafiltration reduces all-cause mortality in hemodialysis patients. J. Am. Soc. Nephrol. 2013; 24 (3): 487–497.

Locatelli F., Marcelli D., Conte F., Limido A., Malber- ti F., Spotti D. Comparison of mortality in ESRD patients on convective and diffusive extracorporeal treatments. Kidney Int. 1999, 55 (1): 286–293.

Panichi V., Rizza G.M., Paoletti S., Bigazzi R., Aloisi M., Barsotti G., Rindi P., Donati G., Antonelli A., Panicuc- ci E., Tripepi G., Tetta C., Palla R. RISCAVID Study Group. Chronic inflammation and mortality in haemo- dialysis: effect of different renal replacement thera- pies. Results from the RISCAVID study. Nephrol. Dial. Transplant. 2008; (23): 2337–2343.

Jirka T., Cesare S., Di Benedetto A., Perera Chang M., Ponce P., Richards N., Tetta C., Vaslaky L. Mortality risk for patients receiving hemodiafiltration versus hemodia- lysis. Kidney International. 2006; 70: 1524.

Vilar E., Fry A.C., Wellsted D., Tattersall J.E., Green- wood R.N., Farrington K. Long-Term outcomes in on- line hemodiafiltration and high-flux hemodialysis: a comparative analysis. Clin. J. Am. Soc. Nephrol. 2009; 4: 1944–1953.

Vinhas J., Vaz Á., Barreto C., Assunção J. Survival ad- vantage of patients on haemodiafiltration is independent of dialysis dose and patient characteristics: data from a single centre. Port. J. Nephrol. Hypert. 2007; 21 (4): 287–292.

Bosch J.P., Lew S.Q., Barlee V., Mishkin G.J., von Al- bertini B. Clinical use of high-efficiency hemodialysis treatments: long-term assessment. Hemodial. Int. 2006; 10 (1): 73–81.

Nangaku M., Eckardt K-U. Pathogenesis of renal ane- mia. Semin. Nephrol. 2006; 26: 261–268.

Tarng D.C., Huang T.P., Chen T.W., Yang W.C. Erythro- poietin hyporesponsiveness: from iron deficiency to iron overload. Kidney Int. Suppl. 1999; 69: 107–118.

Horl W.H. Is there a role for adjuvant therapy in patients being treated with erythropoietin? Nephrol. Dial. Trans- plant. 1999; 14: 50–60.

Bowry S.K., Gatti E. Impact of hemodialysis therapy on anemia of chronic kidney disease: the potential mecha- nisms. Blood Purif. 2011; 32: 210–219.

Vaslaki L., Major L., Berta K., Karatson A., Misz M., Pethoe F., Ladanyi E., Fodor B., Stein G., Pischetsrie- der M., Zima T., Wojke R., Gauly A., Passlick-Deetjen J. On-line haemodiafiltration versus haemodialysis: stable haematocrit with less erythropoietin and improvement of other relevant blood parameters. Blood Purif. 2006; 24 (2): 163–173.

Pedrini L.A., De Cristofaro V., Comelli M., Casino F.G., Prencipe M., Baroni A., Campolo G., Manzoni C., Colì L., Ruggiero P., Acquistapace I., Auriemma L. Long-term effects of high-efficiency on-line haemodia- filtration on uraemic toxicity. A multicentre prospective randomized study. Nephrol. Dial. Transplant. 2011; 26: 2617–2624.

Schiffl H. Prospective randomized cross-over long-term comparison of online haemodiafiltration and ultrapure high-flux haemodialysis. Eur. J. Med. Res. 2007; 12 (1): 26–33.

Bonforte G., Grillo P., Zerbi S., Surian M. Improvement of anemia in hemodialysis patients treated by hemodia-

filtration with high-volume on-line-prepared substitution

fluid. Blood Purif. 2002; 20 (4): 357–363.

Lin C.L., Huang C.C., Yu C.C., Wu C.H., Chang C.T., Hsu H.H., Hsu P.Y., Yang C.W. Improved iron utilization and reduced erythropoietin resistance by on-line hemo-

diafiltration. Blood Purif. 2002; 20: 349–356.

Maduell F., del Pozo C., Garcia H., Sanchez L., Hdez- Jaras J., Albero M.D., Calvo C., Torregrosa I., Navar- ro V. Change from conventional haemodiafiltration to on-line haemodiafiltration. Nephrol. Dial. Transplant.

; 14 (5): 1202–1207.

Almirall J., Valenzuela M.P. The safety of phosphate

binders. Expert Opin Drug Saf. 2006; 5 (5): 675–686.

Lopez-Hilker S., Dusso A.S., Rapp N.S., Martin K.J., Slatopolsky E. Phosphorus restriction reverses hyper- parathyroidism in uremia independent of changes in cal- cium and calcitriol. Am. J. Physiol. 1990; 259 (3 Pt 2):

F432–437.

Slatopolsky E., Delmez J.A. Pathogenesis of secondary

hyperparathyroidism. Am. J. Kidney Dis. 1994; 23 (2):

–236.

Qunibi W.Y. Consequences of hyperphosphatemia in pa-

tients with end-stage renal disease (ESRD). Kidney Int.

Suppl. 2004; 90: S8–S12.

Goodman W.G., Goldin J., Kuizon B.D., Yoon C.,

Gales B., Sider D., Wang Y., Chung J., Emerick A., Greaser L., Elashoff R.M., Salusky I.B. Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N. Engl. J. Med. 2000; 342 (20): 1478–1483.

Ganesh S.K., Stack A.G., Levin N.W., Hulbert-Shearon T., Port F.K. Association of elevated serum PO(4), Ca x PO(4) product, and parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients. J. Am. Soc. Nephrol. 2001; 12 (10): 2131–2138.

Block G.A., Klassen P.S., Lazarus J.M., Ofsthun N., Low- rie E.G., Chertow G.M. Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J. Am. Soc. Nephrol. 2004; 15 (8): 2208–2218.

Spalding E.M., Chamney P.W., Farrington K. Phosphate kinetics during hemodialysis: evidence for biphasic re- gulation. Kidney Int. 2002; 61: 655–657.

Pieratos A., Owendyk M., Francoeur R., Vas S., Raj D.S., Ecclestone A.M., Langos V., Uldall R. Nocturnal hemo- dialysis: three-year experience. J. Am. Soc. Nephrol. 1998; 9: 859–868.

Davenport A., Will E.J., Davison A.M. Effect of renal replacement therapy on patients with combined acute re- nal and fulminant hepatic failure. Kidney Int. 1993; 41: S245–S251.

Gura V., Davenport A., Beizai M., Ezon C., Ronco C. β2 Microglobulin and phosphate clearances using a wear- able artificial kidney: pilot study. Am. J. Kidney. Dis. 2009; 54: 104–111.

Davenport A., Gardner C., Delaney M. The effect of dia- lysis modality on phosphate control: haemodialysis com- pared to haemodiafiltration – the pan thames renal audit. Nephrol. Dial. Transplant. 2010; 25: 897–901.

Minutolo R., Bellizzi V., Cioffi M., Iodice C., Giannat- tasio P., Andreucci M., Terracciano V., Di Iorio B.R.,Conte G., De Nicola L. Postdialytic rebound of serum phosphorus: pathogenetic and clinical insights. J. Am. Soc. Nephrol. 2002; 13: 1046–1054.

Lornoy W., Because I., Billiouw J.M., Sierens L., Van Malderen P., D'Haenens P. On-line haemodiafiltration. Remarkable removal of beta2 microglobulin. Long-term clinical observations. Nephrol. Dial. Transplant. 2000, 15 (Suppl 1): 49–54.

Zehnder C., Gutzwiller J.P., Renggli K. Hemodiafiltra- tion – a new treatment option for hyperphosphatemia in he- modialysis patients. Clin. Nephrol. 1999. 52 (3): 152–159.

Penne E.L., van der Weerd N.C., van den Dorpel M.A., Grooteman M.P., Lévesque R., Nubé M.J., Bots M.L., Blankestijn P.J., ter Wee P.M. CONTRAST Investiga- tors. Short-term effects of online hemodiafiltration on phosphate control: a result from the randomized con- trolled Convective Transport Study (CONTRAST). Am. J. Kidney Dis. 2010; 55 (1): 77–87.

Movilli E., Camerini C., Gaggia P., Poiatti P., Pola A., Viola B.F., Zubani R., Jeannin G., Cancarini G. Effect of post-dilutional on-line haemodiafiltration on serum calcium, phosphate and parathyroid hormone concent- rations in uraemic patients. Nephrol. Dial. Transplant. 2011; 26: 4032–4037.

Oates T., Cross J., Davenport A. Cost comparison of on- line haemodiafiltration with high-flux haemodialysis. J. Nephrol. 2012; 25 (02): 192–197.

Bonforte G., Zerbi S., Pasi A., Rivera R., Surian M. Ef- fect of on-line hemodiafiltration on morbidity. Nephrol. Dial. Transplant. 2001; 16 (6): A183.

Donauer J., Schweiger C., Rumberger B., Krumme B., Böhler J. Reduction of hypotensive side effects during online-haemodiafiltration and low temperature haemodi- alysis. Nephrol. Dial. Transplant. 2003; 18: 1616–1622.

Locatelli F., Andrulli S., Di Filippo S., Redaelli B., Man- gano S., Navino C., Ariano R., Tagliaferri M., Fidelio T., Corti M., Civardi S., Tetta C. Effect of on-line conducti- vity plasma ultrafiltrate kinetic modeling on cardio- vascular stability of hemodialysis patients. Kidney Int. 1998; 53 (4): 1052–1060.

McIntyre C.W. Haemodialysis-induced myocardial stun- ning in chronic kidney disease – a new aspect of cardio- vascular disease. Blood Purif. 2010; 29 (2): 105–110.

Chang T.I., Paik J., Greene T., Desai M., Bech F., Cheung A.K., Chertow G.M. Intradialytic hypotension and vascular access thrombosis. J. Am. Soc. Nephrol. 2011; 22 (8): 1526–1533.

Burton J.O., Jefferies H.J., Selby N.M., McIntyre C.W. Hemodialysis-induced cardiac injury: determinants and associated outcomes. Clin. J. Am. Soc. Nephrol. 2009; 4 (5): 914–920.

Shoji T., Tsubakihara Y., Fujii M., Imai E. Hemodialysis- associated hypotension as an independent risk factor for two-year mortality in hemodialysis patients. Kidney Int. 2004; 66 (3): 1212–1220.

Movilli E., Camerini C., Zein H., D'Avolio G., Sandri- ni M., Strada A., Maiorca R. A prospective comparison of bicarbonate dialysis, hemodiafiltration, and acetate- free biofiltration in the elderly. Am. J. Kidney. Dis. 1996; 27 (4): 541–547.

Tiranathanagul K., Praditpornsilpa K., Katavetin P., Srisawat N., Townamchai N., Susantitaphong P., Tung- sanga K., Eiam-Ong S. On-line hemodiafiltration in Southeast Asia: a three-year prospective study of a single center. Ther. Apher. Dial. 2009; 13 (1): 56–62.

Mora-Bravo F.G., De-La-Cruz G., Rivera S., Ramí- rez A.M., Raimann J.G., Pérez-Grovas H. Association of intradialytic hypotension and convective volume in he- modiafiltration: results from a retrospective cohort study. BMC Nephrology. 2012, 13: 106.

Krieter D.H., Lemke H.D., Canaud B., Wanner C. Beta (2)-microglobulin removal by extracorporeal renal re- placement therapies. Biochim. Biophys. Acta. 2005; 1753 (1): 146–153.

Cheung A.K., Greene T., Leypoldt J.K., Yan G., Allon M., Delmez J., Levey A.S., Levin N.W., Rocco M.V., Schul- man G., Eknoyan G. HEMO Study Group. Association between serum 2-microglobulin level and infectious mortality in hemodialysis patients. Clin. J. Am. Soc. Nephrol. 2008; 3 (1): 69–77.

Okuno S., Ishimura E., Kohno K., Fujino-Katoh Y., Mae- no Y., Yamakawa T., Inaba M., Nishizawa Y. Serum be- ta2-microglobulin level is a significant predictor of mor- tality in maintenance haemodialysis patients. Nephrol. Dial. Transplant. 2009; 24 (2): 571–577.

Nakai S., Iseki K., Tabei K., Kubo K., Masakane I., Fushimi K., Kikuchi K., Shinzato T., Sanaka T., Akiba T. Outcomes of hemodiafiltration based on Japanese di- alysis patient registry. Am. J. Kidney Dis. 2001; 38 (4 Suppl. 1): S212–216.

Lin C.L., Yang C.W., Chiang C.C., Chang C.T., Hu- ang C.C. Long-term on-line hemodiafiltration reduces predialysis beta-2-microglobulin levels in chronic he- modialysis patients. Blood Purif. 2001; 19 (3): 301–307.

Teixeira Nunes F., de Campos G., Xavier de Paula S.M., Merhi V.A., Portero-McLellan K.C., da Motta D.G., de Oliveira M.R. Dialysis adequacy and nutritional status of hemodialysis patients. Hemodial. Int. 2008; 12 (1): 45–51.

Chazot C., Laurent G., Charra B., Blanc C., VoVan C., Jean G., Vanel T., Terrat J.C., Ruffet M. Malnutrition in long-term haemodialysis survivors. Nephrol. Dial. Transplant. 2001; 16 (1): 61–69.

Penne E.L. Online hemodiafiltration: treatment optimi- zation and effects on biochemical parameters. Universi- teit Utrecht: Amsterdam, 2009; 180.

Fischbach M., Terzic J., Menouer S., Dheu C., Seuge L., Zalosczic A. Daily online haemodiafiltration promotes catch-up growth in children on chronic dialysis. Nephrol. Dial. Transplant. 2010; 25: 867–873.

McBrien K.A., Manns B.J. Haemodiafiltration: not ef- fective or cost-effective compared with haemodialy- sis. Nephrol. Dial. Transplant. 2013; 28 (7): 1630– 1633.

Lebourg L., Amato S., Toledano D., Petitclerc T., Créput C. Online hemodiafiltration: is it really more expensive? Nephrologie & Therapeutique. 2013, 9 (4): 209–214 (English Abstract).

Mazairac A.H., Blankestijn P.J., Grooteman M.P., Pen- ne E.L., van der Weerd N.C., den Hoedt C.H., Buskens E.,van den Dorpel M.A., ter Wee P.M., Nubé M.J., Bots M.L., de Wit G.A. CONTRAST investigators. The cost-utility of haemodiafiltration versus haemodialysis in the Convecti- ve Transport Study. Nephrol. Dial. Transplant. 2013; 28 (7): 1865–1873.

Takura T., Kawanishi H., Minakuchi J., Nagake Y., Ta- kahashi S. Cost-effectiveness analysis of on-line hemo- diafiltration in Japan. Blood Purif. 2013; 35(suppl 1): 85–89.

Meert N., Eloot S., Waterloos M.-A., Van Landschoot M., Dhondt A., Glorieux G., Ledebo I., Vanholder R. Effec- tive removal of protein-bound uraemic solutes by diffe- rent convective strategies: a prospective trial. Nephrol. Dial. Transplant. 2009; 24: 562–570.

Blankestijn P.J. Haemodiafiltration: becoming the new standard? Nephrol. Dial. Transplant. 2013; 28: 1–2.

The authors declare that there are no conflicts of interest present.