vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2016-1-83-90vtio-623Research ArticleОбзор литературыLiterature ReviewsПРОБЛЕМЫ ОБЕСПЕЧЕНИЯ ИНФЕКЦИОННОЙ БЕЗОПАСНОСТИ ОРГАННОГО И ТКАНЕВОГО ДОНОРСТВА ПРИ ЛАБОРАТОРНОЙ ДИАГНОСТИКЕ ГЕМОКОНТАКТНЫХ ВИРУСНЫХ ИНФЕКЦИЙTHE PROBLEMS OF PROVIDING INFECTIOUS DISEASE SAFETY FOR ORGAN AND TISSUE DONATION BY SCREENING BLOOD-BORNE VIRAL INFECTIONSХубутияМ. Ш.KhubutiyaM. Sh.

129090, Москва, Б. Сухаревская пл., д. 3

Moscow

solonin@yahoo.comСолонинС. А.SoloninS. A.

129090, Москва, Б. Сухаревская пл., д. 3

3, Bol. Sukharevskaya sq., Moscow, 129090

solonin@yahoo.comГодковМ. А.GodkovM. A.

Москва

Moscow

ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского»РоссияN.V. Sklifosovsky Clinical and Research Institute for Emergency MedicineRussian Federation2016160420161818390Copyright © Хубутия М.Ш., Солонин С.А., Годков М.А., 20162016Хубутия М.Ш., Солонин С.А., Годков М.А.Khubutiya M.S., Solonin S.A., Godkov M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/623

Представлены данные о распространенности, клинической значимости и методах лабораторной диагностики скрытых форм гемоконтактных вирусных инфекций (ГВИ). Рассмотрены причины возникновения таких форм инфекции и их значимость для клинической трансплантологии. Проанализирован существующий алгоритм лабораторного обследования потенциального донора органов на ГВИ в РФ. Показано, что действующий алгоритм скрининга доноров на ГВИ не позволяет выявлять скрытые формы инфекции.

It provided data on the prevalence, clinical signifi cance and methods of laboratory diagnostics for occult forms of blood-borne viral infections (BBVIs). It considered causes of such forms of infection and their signifi cance for clinical transplantation. We analyzed the existing algorithm of laboratory screening of a potential organ donor for BBVIs in Russia. It is shown that the current screening algorithm doesn’t allow detecting hidden forms of BBVIs.

скрытая HBV-инфекцияскрытая HCV-инфекцияпотенциальный донор органовтрансплантацияoccult HBV infectionoccult HCV infectionpotential organ donortransplantationReferencesХубутия МШ, ред. Трансплантация органов и тканей в многопрофильном научном центре. М.: АирАрт, 2011; 424. Hubutiya MSh, red. Organ and tissue transplantation in a multifi eld scientifi c center. M.: AirArt, 2011; 424.Хубутия МШ, ред. Трансплантация органов и тканей в многопрофильном научном центре. М.: АирАрт, 2011; 424. Hubutiya MSh, red. Organ and tissue transplantation in a multifi eld scientifi c center. M.: AirArt, 2011; 424.http://www.who.int [Internet]. WHO Media centre. HIV/AIDS; [updated 2014 November; cited 2015 Apr 10]. Available from: http://www.who.int/mediacentre/factsheets/fs360/en/.http://www.who.int [Internet]. WHO Media centre. HIV/AIDS; [updated 2014 November; cited 2015 Apr 10]. Available from: http://www.who.int/mediacentre/factsheets/fs360/en/.http://www.who.int [Internet]. WHO Media centre. Hepatitis B; [updated 2014 Jul; cited 2015 Apr 10]. Available from: http://www.who.int/mediacentre/factsheets/fs204/en/.http://www.who.int [Internet]. WHO Media centre. Hepatitis B; [updated 2014 Jul; cited 2015 Apr 10]. Available from: http://www.who.int/mediacentre/factsheets/fs204/en/.http://www.who.int [Internet]. WHO Media centre. Hepatitis C; [updated 2014 Apr; cited 2015 Apr 10]. Available from: http://www.who.int/mediacentre/factsheets/fs164/en/.http://www.who.int [Internet]. WHO Media centre. Hepatitis C; [updated 2014 Apr; cited 2015 Apr 10]. Available from: http://www.who.int/mediacentre/factsheets/fs164/en/.Ющук НД, Климова ЕА, Знойко ОО, Кареткина ГН, Максимов СЛ, Маев ИВ. Вирусные гепатиты: клиника, диагностика, лечение. М.: ГЭОТАР-Медиа, 2014; 151. Yushchuk ND, Klimova EA, Znoyko OO, Karetkina GN, Maksimov SL, Maev IV. Viral hepatitis: clinical features, diagnosis, treatment. M.: GEOTAR-Media, 2014; 151.Ющук НД, Климова ЕА, Знойко ОО, Кареткина ГН, Максимов СЛ, Маев ИВ. Вирусные гепатиты: клиника, диагностика, лечение. М.: ГЭОТАР-Медиа, 2014; 151. Yushchuk ND, Klimova EA, Znoyko OO, Karetkina GN, Maksimov SL, Maev IV. Viral hepatitis: clinical features, diagnosis, treatment. M.: GEOTAR-Media, 2014; 151.О состоянии санитарно-эпидемиологического благополучия населения в Российской Федерации в 2013 г. Гос. доклад. М.: Федеральная служба по надзору в сфере защиты прав потребителей и благополучия человека, 2014; 191. http://rospotrebnadzor.ru/upload/iblock/3b8/gd_2013_dlya-sayta.pdf. http://www.rospotrebnadzor.ru/[Internet]. About the state of sanitary and epidemiological welfare of the population in the Russian Federation in 2013: state report. Moscow: Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 2014; 191. [updated 2014; cited 2015 Apr 10] Available from: http://rospotrebnadzor.ru/upload/iblock/3b8/gd_2013_dlya-sayta.pdf.О состоянии санитарно-эпидемиологического благополучия населения в Российской Федерации в 2013 г. Гос. доклад. М.: Федеральная служба по надзору в сфере защиты прав потребителей и благополучия человека, 2014; 191. http://rospotrebnadzor.ru/upload/iblock/3b8/gd_2013_dlya-sayta.pdf. http://www.rospotrebnadzor.ru/[Internet]. About the state of sanitary and epidemiological welfare of the population in the Russian Federation in 2013: state report. Moscow: Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 2014; 191. [updated 2014; cited 2015 Apr 10] Available from: http://rospotrebnadzor.ru/upload/iblock/3b8/gd_2013_dlya-sayta.pdf.Ison MG, Llata E, Conover CS, Friedewald JJ, Gerber SI, Grigoryan A et al. HIV-HCV Transplantation Transmission Investigation Team. Transmission of human immunodefi ciency virus and hepatitis C virus from an organ donor to four transplant recipients. Am J Transplant. 2011; 11 (6): 1218–1225. doi: 10.1111/j.1600-6143.2011.03597.x. PMID: 21645254Ison MG, Llata E, Conover CS, Friedewald JJ, Gerber SI, Grigoryan A et al. HIV-HCV Transplantation Transmission Investigation Team. Transmission of human immunodefi ciency virus and hepatitis C virus from an organ donor to four transplant recipients. Am J Transplant. 2011; 11 (6): 1218–1225. doi: 10.1111/j.1600-6143.2011.03597.x. PMID: 21645254Katchaki JN, Siem TH, Brouwer R. Serological evidence of presence of HBsAg undetectable by conventional radioimmunoassay in anti-HBc positive blood donor. J Clin Pathol. 1978; 31 (9): 837–839. PMID: 711912.Katchaki JN, Siem TH, Brouwer R. Serological evidence of presence of HBsAg undetectable by conventional radioimmunoassay in anti-HBc positive blood donor. J Clin Pathol. 1978; 31 (9): 837–839. PMID: 711912.Raimondo G, Allain JP, Brunetto MR, Buendia MA, Chen DS, Colombo M et al. Statements from the Taormina expert meeting on occult hepatitis B virus infection. J Hepatol. 2008; 49 (4): 652–657. doi: 10.1016/j.jhep.2008.07.014. PMID: 18715666.Raimondo G, Allain JP, Brunetto MR, Buendia MA, Chen DS, Colombo M et al. Statements from the Taormina expert meeting on occult hepatitis B virus infection. J Hepatol. 2008; 49 (4): 652–657. doi: 10.1016/j.jhep.2008.07.014. PMID: 18715666.Hollinger FB, Sood G. Occult hepatitis B virus infection: a covert operation. J Viral Hepat. 2010 Jan; 17 (1): 1–15. doi: 10.1111/j.1365-2893.2009.01245.x. PMID: 20002296.Hollinger FB, Sood G. Occult hepatitis B virus infection: a covert operation. J Viral Hepat. 2010 Jan; 17 (1): 1–15. doi: 10.1111/j.1365-2893.2009.01245.x. PMID: 20002296.Toyoda H, Hayashi K, Murakami Y, Honda T, Katano Y, Nakano I et al. Prevalence and clinical implications of occult hepatitis B viral infection in hemophilia patients in Japan. J. Med. Virol. 2004; 73: 195–199. PMID: 15122792.Toyoda H, Hayashi K, Murakami Y, Honda T, Katano Y, Nakano I et al. Prevalence and clinical implications of occult hepatitis B viral infection in hemophilia patients in Japan. J. Med. Virol. 2004; 73: 195–199. PMID: 15122792.Hollinger FB. Hepatitis B virus infection and transfusion medicine: science and the occult. Transfusion. 2008; 48 (5): 1001–1026. doi: 10.1111/j.1537-2995.2008.01701.x. PMID: 18454738.Hollinger FB. Hepatitis B virus infection and transfusion medicine: science and the occult. Transfusion. 2008; 48 (5): 1001–1026. doi: 10.1111/j.1537-2995.2008.01701.x. PMID: 18454738.Gutiérrez-García ML, Fernandez-Rodriguez CM, LledoNavarro JL, Buhigas-Garcia I. Prevalence of occult hepatitis B virus infection. World J Gastroenterol. 2011; 17 (12): 1538–1542. doi: 10.3748/wjg.v17.i12.1538. PMID: 21472117.Gutiérrez-García ML, Fernandez-Rodriguez CM, LledoNavarro JL, Buhigas-Garcia I. Prevalence of occult hepatitis B virus infection. World J Gastroenterol. 2011; 17 (12): 1538–1542. doi: 10.3748/wjg.v17.i12.1538. PMID: 21472117.Wang H, Fang M, Gu X, Ji Q, Li D, Cheng SQ et al. The intracellular HBV DNAs as novel and sensitive biomarkers for the clinical diagnosis of occult HBV infection in HBeAg negative hepatocellular carcinoma in China. PLoS One. 2014; 9 (9): e107162. doi: 10.1371/journal.pone.0107162. PMID: 25229710.Wang H, Fang M, Gu X, Ji Q, Li D, Cheng SQ et al. The intracellular HBV DNAs as novel and sensitive biomarkers for the clinical diagnosis of occult HBV infection in HBeAg negative hepatocellular carcinoma in China. PLoS One. 2014; 9 (9): e107162. doi: 10.1371/journal.pone.0107162. PMID: 25229710.Hollinger FB. Hepatitis B virus genetic diversity and its impact on diagnostic assays. J Viral Hepat. 2007; 14 (Suppl. 1): 11–15. PMID: 17958637.Hollinger FB. Hepatitis B virus genetic diversity and its impact on diagnostic assays. J Viral Hepat. 2007; 14 (Suppl. 1): 11–15. PMID: 17958637.Yotsuyanagi H, Yasuda K, Moriya K, Shintani Y, Fujie H, Tsutsumi T et al. Frequent presence of HBV in the sera of HBsAg-negative, anti-HBc-positive blood donors. Transfusion. 2001; 41 (9): 1093–1099. PMID: 11552064.Yotsuyanagi H, Yasuda K, Moriya K, Shintani Y, Fujie H, Tsutsumi T et al. Frequent presence of HBV in the sera of HBsAg-negative, anti-HBc-positive blood donors. Transfusion. 2001; 41 (9): 1093–1099. PMID: 11552064.Farci P, Niro GA. Clinical features of hepatitis D. Semin Liver Dis. 2012; 32 (3): 228–236. doi: 10.1055/s-0032-1323628. PMID: 22932971.Farci P, Niro GA. Clinical features of hepatitis D. Semin Liver Dis. 2012; 32 (3): 228–236. doi: 10.1055/s-0032-1323628. PMID: 22932971.Allain JP, Cox L. Challenges in hepatitis B detection among blood donors. Curr. Opin. Hematol. 2011; 18: 461–466. doi: 10.1097/MOH.0b013e32834bac10.Allain JP, Cox L. Challenges in hepatitis B detection among blood donors. Curr. Opin. Hematol. 2011; 18: 461–466. doi: 10.1097/MOH.0b013e32834bac10.Gerlich W.H., Brener C., Saniewski M, Schüttler CG, Wend UC, Willems WR et al. Occult hepatitis B virus infection: detection and signifi cance. Dig Dis. 2010; 28 (1): 116–125. doi: 10.1159/000282074. PMID: 21912252.Gerlich W.H., Brener C., Saniewski M, Schüttler CG, Wend UC, Willems WR et al. Occult hepatitis B virus infection: detection and signifi cance. Dig Dis. 2010; 28 (1): 116–125. doi: 10.1159/000282074. PMID: 21912252.Михайлов МИ, Кюрегян КК. Молекулярно-биологические основы контроля вирусных гепатитов. М.: Икар, 2013; 336. Mikhailov MI, Kyuregyan KK. Molecular and biological basis of control for viral hepatitis. M.: Ikar, 2013; 336.Михайлов МИ, Кюрегян КК. Молекулярно-биологические основы контроля вирусных гепатитов. М.: Икар, 2013; 336. Mikhailov MI, Kyuregyan KK. Molecular and biological basis of control for viral hepatitis. M.: Ikar, 2013; 336.Sticchi L, Caligiuri P, Cacciani R, Alicino C, Bruzzone B. Epidemiology of HBV S-gene mutants in the Liguria Region, Italy: Implications for surveillance and detection of new escape variants. Hum Vaccin Immunother. 2013; 9 (3): 568–571. PMID: 23296324Sticchi L, Caligiuri P, Cacciani R, Alicino C, Bruzzone B. Epidemiology of HBV S-gene mutants in the Liguria Region, Italy: Implications for surveillance and detection of new escape variants. Hum Vaccin Immunother. 2013; 9 (3): 568–571. PMID: 23296324Баженов АИ, Коноплева МВ, Фельдшерова АА, Эльгорт ДА, Хац ЮС, Лапина НЕ и др. Оценка чувствительности коммерческих тест-систем для иммунодетекции HBsAg по их способности выявлять HBsAg-мутанты вируса гепатита В. Журнал микробиологии, эпидемиологии и иммунобиологии. 2008; 3: 48–52. Bazhenov AI, Konopleva MV, Fel'dsherova AA, El'gort DA, Khats IuS, Lapina NE et al. Assessment of sensitivity of commercial test-systems for HBsAg immunodetection according to their ability to detect HBsAgmutants of hepatitis B virus. Zh Mikrobiol Epidemiol Immunobiol. 2008; 3: 48–53. [In Russ, English abstract]. PMID: 18597996.Баженов АИ, Коноплева МВ, Фельдшерова АА, Эльгорт ДА, Хац ЮС, Лапина НЕ и др. Оценка чувствительности коммерческих тест-систем для иммунодетекции HBsAg по их способности выявлять HBsAg-мутанты вируса гепатита В. Журнал микробиологии, эпидемиологии и иммунобиологии. 2008; 3: 48–52. Bazhenov AI, Konopleva MV, Fel'dsherova AA, El'gort DA, Khats IuS, Lapina NE et al. Assessment of sensitivity of commercial test-systems for HBsAg immunodetection according to their ability to detect HBsAgmutants of hepatitis B virus. Zh Mikrobiol Epidemiol Immunobiol. 2008; 3: 48–53. [In Russ, English abstract]. PMID: 18597996.Чирский ВС. Биопсийная диагностика неопухолевых заболеваний печени. СПб.: СПб МАПО, 2009. 80. Chirskiy VS. Biopsy diagnostics of nonneoplastic diseases of the liver. SPb.: SPb MAPO, 2009. 80.Чирский ВС. Биопсийная диагностика неопухолевых заболеваний печени. СПб.: СПб МАПО, 2009. 80. Chirskiy VS. Biopsy diagnostics of nonneoplastic diseases of the liver. SPb.: SPb MAPO, 2009. 80.Kwak MS, Kim YJ. Occult hepatitis B virus infection. World J Hepatol. 2014; 6 (12): 860–869. doi: 10.4254/wjh.v6.i12.860. PMID: 25544873.Kwak MS, Kim YJ. Occult hepatitis B virus infection. World J Hepatol. 2014; 6 (12): 860–869. doi: 10.4254/wjh.v6.i12.860. PMID: 25544873.Cholongitas E, Papatheodoridis GV, Burroughs AK. Liver grafts from anti-hepatitis B core positive donors: a systematic review. J Hepatol. 2010; 52 (2): 272–279. doi: 10.1016/j.jhep.2009.11.009. PMID: 20034693.Cholongitas E, Papatheodoridis GV, Burroughs AK. Liver grafts from anti-hepatitis B core positive donors: a systematic review. J Hepatol. 2010; 52 (2): 272–279. doi: 10.1016/j.jhep.2009.11.009. PMID: 20034693.Cheung CK, Lo CM, Man K, Lau GK. Occult hepatitis B virus infection of donor and recipient origin after liver transplantation despite nucleoside analogue prophylaxis. Liver Transpl. 2010; 16 (11): 1314–1323. doi: 10.1002/lt.22169. PMID: 21031547.Cheung CK, Lo CM, Man K, Lau GK. Occult hepatitis B virus infection of donor and recipient origin after liver transplantation despite nucleoside analogue prophylaxis. Liver Transpl. 2010; 16 (11): 1314–1323. doi: 10.1002/lt.22169. PMID: 21031547.Seetharam A, Perrillo R, Gish R. Immunosuppression in Patients with Chronic Hepatitis B. Curr Hepatol Rep. 2014; 13: 235–244. PMID: 25101233.Seetharam A, Perrillo R, Gish R. Immunosuppression in Patients with Chronic Hepatitis B. Curr Hepatol Rep. 2014; 13: 235–244. PMID: 25101233.Huang X, Hollinger FB. Occult hepatitis B virus infection and hepatocellular carcinoma: a systematic review. J Viral Hepat. 2014; 21 (3): 153–162. doi: 10.1111/jvh.12222. PMID: 24438677.Huang X, Hollinger FB. Occult hepatitis B virus infection and hepatocellular carcinoma: a systematic review. J Viral Hepat. 2014; 21 (3): 153–162. doi: 10.1111/jvh.12222. PMID: 24438677.Schubert A, Michel D, Mertens T. Late HBsAg seroreversion of mutated hepatitis B virus after bone marrow transplantation. BMC Infect Dis. 2013; 13: 223. doi: 10.1186/1471-2334-13-223. PMID: 23679074.Schubert A, Michel D, Mertens T. Late HBsAg seroreversion of mutated hepatitis B virus after bone marrow transplantation. BMC Infect Dis. 2013; 13: 223. doi: 10.1186/1471-2334-13-223. PMID: 23679074.Tsai MC, Chen YT, Chien YS, Chen TC, Hu TH. Hepatitis B virus infection and renal transplantation. World J Gastroenterol. 2010; 16 (31): 3878–3887. PMID: 20712048.Tsai MC, Chen YT, Chien YS, Chen TC, Hu TH. Hepatitis B virus infection and renal transplantation. World J Gastroenterol. 2010; 16 (31): 3878–3887. PMID: 20712048.Chamorro C, Aparicio M. Infl uence of HBcAb positivity in the organ donor in heart transplantation. Med Intensiva. 2012; 36 (8): 563–570. doi: 10.1016/j.medin.2012.01.011. PMID: 22440791.Chamorro C, Aparicio M. Infl uence of HBcAb positivity in the organ donor in heart transplantation. Med Intensiva. 2012; 36 (8): 563–570. doi: 10.1016/j.medin.2012.01.011. PMID: 22440791.Castillo I, Pardo M, Bartolomé J, Ortiz-Movilla N, Rodríguez-Iñigo E, de Lucas S et al. Occult hepatitis C virus infection in patients in whom the etiology of persistently abnormal results of liver-function tests is unknown. J Infect Dis. 2004; 189 (1): 7–14. PMID: 14702147.Castillo I, Pardo M, Bartolomé J, Ortiz-Movilla N, Rodríguez-Iñigo E, de Lucas S et al. Occult hepatitis C virus infection in patients in whom the etiology of persistently abnormal results of liver-function tests is unknown. J Infect Dis. 2004; 189 (1): 7–14. PMID: 14702147.Quiroga JA, Llorente S, Castillo I, Rodríguez-Iñigo E, Pardo M, Carreño V. Cellular immune responses associated with occult hepatitis C virus infection of the liver. J Virol. 2006; 80 (22): 10972–10979. PMID: 17071928.Quiroga JA, Llorente S, Castillo I, Rodríguez-Iñigo E, Pardo M, Carreño V. Cellular immune responses associated with occult hepatitis C virus infection of the liver. J Virol. 2006; 80 (22): 10972–10979. PMID: 17071928.Pham TNQ, Coffi n CS, Michalak T. Occult hepatitis C virus infection: what does it mean? Liver International. 2010; 30 (4): 502–511. doi: 10.1111/j.1478-231.2009.02193.x. PMID: 20070513.Pham TNQ, Coffi n CS, Michalak T. Occult hepatitis C virus infection: what does it mean? Liver International. 2010; 30 (4): 502–511. doi: 10.1111/j.1478-231.2009.02193.x. PMID: 20070513.Barril G, Castillo I, Arenas MD, Espinosa M, GarciaValdecasas J, Garcia-Fernández N et al. Occult hepatitis C virus infection among hemodialysis patients. J Am Soc Nephrol. 2008; 19 (12): 2288–2292. doi: 10.1681/ASN.2008030293. PMID: 18684893.Barril G, Castillo I, Arenas MD, Espinosa M, GarciaValdecasas J, Garcia-Fernández N et al. Occult hepatitis C virus infection among hemodialysis patients. J Am Soc Nephrol. 2008; 19 (12): 2288–2292. doi: 10.1681/ASN.2008030293. PMID: 18684893.Castillo I, Bartolomé J, Quiroga JA, Barril G, Carreño V. Hepatitis C virus infection in the family setting of patients with occult hepatitis C. J Med Virol. 2009; 81 (7): 1198–1203. doi: 10.1002/jmv.21483. PMID: 19475603.Castillo I, Bartolomé J, Quiroga JA, Barril G, Carreño V. Hepatitis C virus infection in the family setting of patients with occult hepatitis C. J Med Virol. 2009; 81 (7): 1198–1203. doi: 10.1002/jmv.21483. PMID: 19475603.De Marco L, Gillio-Tos A, Fiano V, Ronco G, Krogh V, Palli D et al. Occult HCV infection: an unexpected finding in a population unselected for hepatic disease. PLoS One. 2009; 4 (12): e8128. doi: 10.1371/journal. pone.0008128. PMID: 19956542.De Marco L, Gillio-Tos A, Fiano V, Ronco G, Krogh V, Palli D et al. Occult HCV infection: an unexpected finding in a population unselected for hepatic disease. PLoS One. 2009; 4 (12): e8128. doi: 10.1371/journal. pone.0008128. PMID: 19956542.Ison MG, Llata E, Conover CS, Friedewald JJ, Gerber SI, Grigoryan A et al. Transmission of human immunodeficiency virus and hepatitis C virus from an organ donor to four transplant recipients. Am J Transplant. 2011; 11 (6): 1218–12125. doi: 10.1111/j.1600-6143.2011.03597.x. PMID: 21645254.Ison MG, Llata E, Conover CS, Friedewald JJ, Gerber SI, Grigoryan A et al. Transmission of human immunodeficiency virus and hepatitis C virus from an organ donor to four transplant recipients. Am J Transplant. 2011; 11 (6): 1218–12125. doi: 10.1111/j.1600-6143.2011.03597.x. PMID: 21645254.Centers for Disease Control and Prevention (CDC). Transmission of hepatitis C virus through transplanted organs and tissue – Kentucky and Massachusetts, 2011. MMWR Morb Mortal Wkly Rep. 2011; 60 (50): 1697–700. Erratum in: MMWR Morb Mortal Wkly Rep. 2012; 61: 80. PMID: 22189891.Centers for Disease Control and Prevention (CDC). Transmission of hepatitis C virus through transplanted organs and tissue – Kentucky and Massachusetts, 2011. MMWR Morb Mortal Wkly Rep. 2011; 60 (50): 1697–700. Erratum in: MMWR Morb Mortal Wkly Rep. 2012; 61: 80. PMID: 22189891.Мазус АИ, Каминский ГД, Зимина ВН, Бессараб ТП, Пронин АЮ, Цыганова ЕВ и др. Национальные клинические рекомендации по диагностике и лечению ВИЧ-инфекции у взрослых. 2-е изд. М., 2014; 75. Mazus AI, Kaminskiy GD, Zimina VN, Bessarab TP, Pro nin AJu, Tsyganova EV et al. National clinical guidelines for the diagnosis and treatment of HIV infection in adults. Second edition. M., 2014; 75.Мазус АИ, Каминский ГД, Зимина ВН, Бессараб ТП, Пронин АЮ, Цыганова ЕВ и др. Национальные клинические рекомендации по диагностике и лечению ВИЧ-инфекции у взрослых. 2-е изд. М., 2014; 75. Mazus AI, Kaminskiy GD, Zimina VN, Bessarab TP, Pro nin AJu, Tsyganova EV et al. National clinical guidelines for the diagnosis and treatment of HIV infection in adults. Second edition. M., 2014; 75.Borchi B, Ambu S, Bresci S, Zanazzi M, Salvadori M, Leoncini F. Case report: HIV infection from a kidney transplant. Transplant Proc. 2010; 42 (6): 2267–2269. doi: 10.1016/j.transproceed.2010.05.026. PMID: 20692460.Borchi B, Ambu S, Bresci S, Zanazzi M, Salvadori M, Leoncini F. Case report: HIV infection from a kidney transplant. Transplant Proc. 2010; 42 (6): 2267–2269. doi: 10.1016/j.transproceed.2010.05.026. PMID: 20692460.Mukhopadhyay P, Kumar V, Rathi M, Kohli HS, Jha V, Sakhuja V. Transmission of human immunodefi ciency virus infection by renal transplantation. Indian J Nephrol. 2012; 22 (2): 133–135. doi: 10.4103/0971-4065.97135. PMID: 22787317.Mukhopadhyay P, Kumar V, Rathi M, Kohli HS, Jha V, Sakhuja V. Transmission of human immunodefi ciency virus infection by renal transplantation. Indian J Nephrol. 2012; 22 (2): 133–135. doi: 10.4103/0971-4065.97135. PMID: 22787317.Schmidt M, Korn K, Nübling CM, Chudy M, Kress J, Horst HA et al. First transmission of human immunodeficiency virus Type 1 by a cellular blood product after mandatory nucleic acid screening in Germany. Transfusion. 2009; 49 (9): 1836–1844. doi: 10.1111/j.1537-2995.2009.02203.x. PMID: 19453990.Schmidt M, Korn K, Nübling CM, Chudy M, Kress J, Horst HA et al. First transmission of human immunodeficiency virus Type 1 by a cellular blood product after mandatory nucleic acid screening in Germany. Transfusion. 2009; 49 (9): 1836–1844. doi: 10.1111/j.1537-2995.2009.02203.x. PMID: 19453990.Щербук ЮА, Багненко СФ, Гриненко ОА, Полушин ЮС, Логинов ИВ, Бутина ЛВ и др. Дефицит донорских органов: причины, проблемы, пути решения. Вестник анестезиологии и реаниматологии. 2011; 2: 31–42. Shcherbuk YuA, Bagnenko SF, Grinenko OA, Polushin YuS, Loginov IV, Butina LV et al. Shortage of donor organs: reasons, problems, ways of solution. Vestnik anesteziologii i reanimatologii. 2011; 2: 31–42. [In Russ, English abstract].Щербук ЮА, Багненко СФ, Гриненко ОА, Полушин ЮС, Логинов ИВ, Бутина ЛВ и др. Дефицит донорских органов: причины, проблемы, пути решения. Вестник анестезиологии и реаниматологии. 2011; 2: 31–42. Shcherbuk YuA, Bagnenko SF, Grinenko OA, Polushin YuS, Loginov IV, Butina LV et al. Shortage of donor organs: reasons, problems, ways of solution. Vestnik anesteziologii i reanimatologii. 2011; 2: 31–42. [In Russ, English abstract].Хубутия МШ, Солонин СА, Годков МА, Баженов АИ, Кобзева ЕН, Смирнова ЮВ и др. Эпидемиологические и медико-социальные особенности распространения гемоконтактных вирусных инфекций у потенциальных доноров органов и доноров крови. Вестник службы крови России. 2014; 1: 17–24. Khubutiya MSh, Solonin SA, Godkov MA, Bazhenov AI, Kobzeva EN, Smirnova YuV et al. Epidemiological and medical-social features of the spread of bloodborne infectious diseases among potential organ donors and blood donors. Vestnik sluzhby krovi Rossii. 2014; 1: 17–24. [In Russ, English abstract].Хубутия МШ, Солонин СА, Годков МА, Баженов АИ, Кобзева ЕН, Смирнова ЮВ и др. Эпидемиологические и медико-социальные особенности распространения гемоконтактных вирусных инфекций у потенциальных доноров органов и доноров крови. Вестник службы крови России. 2014; 1: 17–24. Khubutiya MSh, Solonin SA, Godkov MA, Bazhenov AI, Kobzeva EN, Smirnova YuV et al. Epidemiological and medical-social features of the spread of bloodborne infectious diseases among potential organ donors and blood donors. Vestnik sluzhby krovi Rossii. 2014; 1: 17–24. [In Russ, English abstract].Решетников АВ. Социология медицины: руководство. М.: ГЭОТАР-Медиа, 2010. 863. Reshetnikov AV. Sociology of Medicine: guide. Moscow: GEOTAR-Media, 2010. 863.Решетников АВ. Социология медицины: руководство. М.: ГЭОТАР-Медиа, 2010. 863. Reshetnikov AV. Sociology of Medicine: guide. Moscow: GEOTAR-Media, 2010. 863.Даниелян ШН, Годков МА, Абакумов ММ, Зубарева ОВ, Саприн АА. Медико-социальная характеристика пострадавших с гнойными осложнениями после закрытой травмы груди. Хирургия. 2013; 5: 19–25. Danielian ShN, Godkov MA, Abakumov MM, Zubareva OV, Saprin AA. Medical and social characteristics of patients with septic complications of the closed thoracic injury. Khirurgiia (Mosk). 2013; 5: 19–25. [In Russ, English abstract]. PMID: 23715417.Даниелян ШН, Годков МА, Абакумов ММ, Зубарева ОВ, Саприн АА. Медико-социальная характеристика пострадавших с гнойными осложнениями после закрытой травмы груди. Хирургия. 2013; 5: 19–25. Danielian ShN, Godkov MA, Abakumov MM, Zubareva OV, Saprin AA. Medical and social characteristics of patients with septic complications of the closed thoracic injury. Khirurgiia (Mosk). 2013; 5: 19–25. [In Russ, English abstract]. PMID: 23715417.Смертность населения Москвы от причин, связанных с употреблением алкоголя, за январь–декабрь 2013 года http://77.rospotrebnadzor.ru/index.php/san-epid/40-2009-08-20-06-08-14/1909-san-epid. http://77.rospotrebnadzor.ru [Internet]. Mortality among Moscow’s citizens from causes related to alcohol consumption in January–December 2013. [updated 2013 Mar; cited 2015 Apr 10]. Available from: http://77.rospotrebnadzor.ru/index.php/san-epid/40-2009-08-20-06-08-14/1909-san-epid.Смертность населения Москвы от причин, связанных с употреблением алкоголя, за январь–декабрь 2013 года http://77.rospotrebnadzor.ru/index.php/san-epid/40-2009-08-20-06-08-14/1909-san-epid. http://77.rospotrebnadzor.ru [Internet]. Mortality among Moscow’s citizens from causes related to alcohol consumption in January–December 2013. [updated 2013 Mar; cited 2015 Apr 10]. Available from: http://77.rospotrebnadzor.ru/index.php/san-epid/40-2009-08-20-06-08-14/1909-san-epid.Минина МГ. О некоторых аспектах организации органного донорства. Вестник трансплантологии и искусственных органов. 2010; 3: 81–88. Minina MG. To some organizational aspects of organ donation. Vestnik transplantologii i iskusstvennyh organov = Russian journal of transplantology and artifi cial organs. 2010; 3: 81–88. [In Russ, English abstract]. doi: 10.15825/1995-1191-2010-3.Минина МГ. О некоторых аспектах организации органного донорства. Вестник трансплантологии и искусственных органов. 2010; 3: 81–88. Minina MG. To some organizational aspects of organ donation. Vestnik transplantologii i iskusstvennyh organov = Russian journal of transplantology and artifi cial organs. 2010; 3: 81–88. [In Russ, English abstract]. doi: 10.15825/1995-1191-2010-3.Shafer TJ, Schkade D, Schkade L, Geier SS, Orlowski JP, Klintmalm G. Zero risk tolerance costs lives: loss of transplantable organs due to human immunodefi ciency virus nucleic acid testing of potential donors. Prog. Transplant. 2011; 21 (3): 236–247. PMID: 21977885.Shafer TJ, Schkade D, Schkade L, Geier SS, Orlowski JP, Klintmalm G. Zero risk tolerance costs lives: loss of transplantable organs due to human immunodefi ciency virus nucleic acid testing of potential donors. Prog. Transplant. 2011; 21 (3): 236–247. PMID: 21977885.Борт ГС, Иванов ИН, Савельев ВИ, Резник АГ, Рыков ЮА, Афиногенова АГ и др. Диагностика маркеров инфекционных заболеваний в перикардиальной жидкости и крови трупов доноров при заготовке тканей для трансплантации в травматологии и ортопедии. Травматология и ортопедия России. 2008; 2: 72–76. Bort GS, Ivanov IN, Savelev VI, Reznik AG, Rykov YuA, Afinogenova AG et al. The diagnostics of the markers of infectious diseases in the pericardial fl uid and blood of cadavers, donors at the purveyance of tissues for transplantation in traumatology and orthopedics. Traumatology and orthopedics of Russia. 2008; 2: 72–76. [In Russ, English abstract].Борт ГС, Иванов ИН, Савельев ВИ, Резник АГ, Рыков ЮА, Афиногенова АГ и др. Диагностика маркеров инфекционных заболеваний в перикардиальной жидкости и крови трупов доноров при заготовке тканей для трансплантации в травматологии и ортопедии. Травматология и ортопедия России. 2008; 2: 72–76. Bort GS, Ivanov IN, Savelev VI, Reznik AG, Rykov YuA, Afinogenova AG et al. The diagnostics of the markers of infectious diseases in the pericardial fl uid and blood of cadavers, donors at the purveyance of tissues for transplantation in traumatology and orthopedics. Traumatology and orthopedics of Russia. 2008; 2: 72–76. [In Russ, English abstract].Edler C, Wulff B, Schröder AS, Wilkemeyer I, Polywka S, Meyer T et al. A prospective time-course study on serological testing for human immunodefi ciency virus, hepatitis B virus and hepatitis C virus with blood samples taken up to 48 h after death. J. Med. Microbiol. 2011; 60 (Pt7): 920–926. doi: 10.1099/jmm.0.027763-0. PMID: 21436373.Edler C, Wulff B, Schröder AS, Wilkemeyer I, Polywka S, Meyer T et al. A prospective time-course study on serological testing for human immunodefi ciency virus, hepatitis B virus and hepatitis C virus with blood samples taken up to 48 h after death. J. Med. Microbiol. 2011; 60 (Pt7): 920–926. doi: 10.1099/jmm.0.027763-0. PMID: 21436373.Theodoropoulos N, Ison MG, Jaramillo A. Screening deceased organ donors for infectious diseases: optimization of testing. ASHI Quarterly. 10/2012; 36 (3): 18–26.Theodoropoulos N, Ison MG, Jaramillo A. Screening deceased organ donors for infectious diseases: optimization of testing. ASHI Quarterly. 10/2012; 36 (3): 18–26.Humar A, Morris M, Blumberg E, Freeman R, Preiksaitis J, Kiberd B et al. Nucleic acid testing (NAT) of organ donors: is the ‘best’ test the right test? A consensus conference report. Am. J. Transplant. 2010; 10 (4): 889–899. doi: 10.1111/j.1600-6143.2009.02992.x. PMID: 20121734.Humar A, Morris M, Blumberg E, Freeman R, Preiksaitis J, Kiberd B et al. Nucleic acid testing (NAT) of organ donors: is the ‘best’ test the right test? A consensus conference report. Am. J. Transplant. 2010; 10 (4): 889–899. doi: 10.1111/j.1600-6143.2009.02992.x. PMID: 20121734.

The authors declare that there are no conflicts of interest present.