vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2016-1-78-82vtio-622Research ArticleОбзор литературыLiterature ReviewsСОЧЕТАННАЯ ТРАНСПЛАНТАЦИЯ СЕРДЦА И ПОЧКИCOMBINED HEART-KIDNEY TRANSPLANTATIONПопцовВ. Н.PoptsovV. N.

123182, Москва, ул. Щукинская, д. 1

1, Shchukinskaya st., Moscow, 123182

poptsov_vit@mail.ruФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава РоссииРоссияV.I. Shumakov Federal Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian FederationRussian Federation2016160420161817882Copyright © Попцов В.Н., 20162016Попцов В.Н.Poptsov V.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/622

Сочетанная трансплантация сердца и почки является одним из возможных направлений эффективного лечения больных c сочетанием терминальной застойной сердечной недостаточности (ЗСН) и почечной недостаточности. Выделяют одномоментную, комбинированную, или симультанную (simultaneous), трансплантацию сердце–почка (КТСП) от одного и того же донора, а также последовательные (staged) трансплантации сердца и почки от двух генетически различных доноров. ISHLT также отмечает рост числа ежегодно выполняемых КТСП – от 22 (1994 г.) до 97 (2012 г.). В статье приводится мировой опыт выполнения КТСП, обсуждаются показания к ее выполнению, в том числе у пациентов с диализ-независимой почечной недостаточностью. Отмечается, что особенностью КТСП по сравнению с изолированной ТС и аллотрансплантацией трупной почки является меньшая частота и выраженность отторжения как сердечного, так и почечного трансплантата, а также частота возникновения болезни коронарных артерий пересаженного сердца. Приводится собственный опыт двух последовательных трансплантаций сердца и почки. Обсуждаются показания для одномоментной (симультанной) и последовательной трансплантации сердца и почки.

Combined heart-kidney transplantation may be performed in carefully selected patients with end-stage heart disease and renal failure. There are two types of combined transplantation of heart and kidney: 1) simultaneous heart-kidney transplantation (SHKT) from the same donor; 2) staged transplantation of heart and kidneys from two genetically different donors. The ISHLT registry in 2014 reported an increase in the number of SHKT over the years: from 22 in 1994 to 97 in 2012. World experience demonstrated excellent results of SHKT. Recipients of SHKT had superior survival, lower rates of acute cardiac and renal rejection compared to heart recipients. This article discusses the indications for simultaneous or staged heart-kidney transplantation in patients with dialysis-independent or dialysis-dependent renal failure, results and posttransplant survival of SHKT recipients. The author describes his own experience of 2 staged combined heart-kidney transplantations.

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The authors declare that there are no conflicts of interest present.