vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2015-2-64-69vtio-551Research ArticleОбзор литературыLiterature ReviewsФАКТОРЫ РИСКА И НОЗОКОМИАЛЬНЫЕ ИНФЕКЦИИ, ВЫЗЫВАЕМЫЕ ЭНТЕРОКОККАМИRISK FACTORS AND NOSOCOMIAL INFECTIONS CAUSED BY ENTEROCOCCIГабриэлянН. И.GabrielyanN. I.

Для корреспонденции: Габриэлян Нина Индзаровна. Адрес: 123182, г. Москва, ул. Щукинская, д. 1. Teл. (499) 748-53-09. E-mail: labgso@mail.ru.

labgso@mail.ruГорскаяЕ. М.GorskayaE. M.labgso@mail.ruЦирульниковаО. М.TsiroulnikovaO. M.labgso@mail.ruФедеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова, МоскваРоссияV.I. Shumakov Federal Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation, MoscowRussian Federation2015270520151726469Copyright © Габриэлян Н.И., Горская Е.М., Цирульникова О.М., 20152015Габриэлян Н.И., Горская Е.М., Цирульникова О.М.Gabrielyan N.I., Gorskaya E.M., Tsiroulnikova O.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/551

Цель: анализ нозокомиальных инфекций и факторов риска, вызываемых энтерококками. Представлен обзор данных зарубежной и отечественной литературы по биологии, факторам вирулентности энтерококков – ведущих возбудителей нозокомиальных инфекций. Приводятся сведения о факторах риска и послеоперационных инфекционных осложнениях, возбудителями которых являются энтерококки, в хирургических клиниках и клиниках по трансплантации органов. Подчеркивается нарастание антибиотикорезистентности энтерококков и связь между показателями летальности и частотой распространения антибиотикорезистентных штаммов.

энтерококкинозокомиальные инфекцииантибиотикорезистентностьтрансплантация органовenterococcinosocomial infectionsantibiotic resistanceorgans transplantationReferencesСПИСОК ЛИТЕРАТУРЫ / REFERENCESСПИСОК ЛИТЕРАТУРЫ / REFERENCESFisher K, Phillips C. The ecology, epidemiology and virulence of Enterococcus. Microbiology. 2009; 155 (6): 1749–1757.Fisher K, Phillips C. The ecology, epidemiology and virulence of Enterococcus. Microbiology. 2009; 155 (6): 1749–1757.Внутрибольничные инфекции / Под ред. Р.П. Венцеля. М.: Медицина, 2004. Vnutribol'nichnye infekcii / Pod red. R.P. Vencelja. M.: Medicina, 2004.Внутрибольничные инфекции / Под ред. Р.П. Венцеля. М.: Медицина, 2004. Vnutribol'nichnye infekcii / Pod red. R.P. Vencelja. M.: Medicina, 2004.Габриэлян НИ, Горская ЕМ, Арефьева ЛИ, Семеновский МЛ, Спирина ТС, Ромашкина ЛЮ, Саид ТФ. Микрофлора резецированных клапанов пациентов с инфекционным эндокардитом. Анналы хирургии. 2012; 3: 22–25. Gabrijeljan NI, Gorskaja EM, Aref'eva LI, Semenovskij ML, Spirina TS, Romashkina LJu, Said TF. Mikroflora rezecirovannyh klapanov pacientov s infekcionnym jendokarditom. Annaly hirurgii. 2012; 3: 22–25.Габриэлян НИ, Горская ЕМ, Арефьева ЛИ, Семеновский МЛ, Спирина ТС, Ромашкина ЛЮ, Саид ТФ. Микрофлора резецированных клапанов пациентов с инфекционным эндокардитом. Анналы хирургии. 2012; 3: 22–25. Gabrijeljan NI, Gorskaja EM, Aref'eva LI, Semenovskij ML, Spirina TS, Romashkina LJu, Said TF. Mikroflora rezecirovannyh klapanov pacientov s infekcionnym jendokarditom. Annaly hirurgii. 2012; 3: 22–25.Vincept JL, Rello J, Marshall J, Silva E et al. International study of the prevalence and outcomes of infection in intensive care units. JAMA. 2009; 302 (21): 2323–2329.Vincept JL, Rello J, Marshall J, Silva E et al. International study of the prevalence and outcomes of infection in intensive care units. JAMA. 2009; 302 (21): 2323–2329.Dan M, Poch F, Leibson L, Smetana S et al. Rectal colonization with vancomycin-resistant enterococci among high-risk patients in an Israeli hospital. J. Hosp. Infect. 1999; 43 (3): 231–238.Dan M, Poch F, Leibson L, Smetana S et al. Rectal colonization with vancomycin-resistant enterococci among high-risk patients in an Israeli hospital. J. Hosp. Infect. 1999; 43 (3): 231–238.Ostrowsky BE, Venkataraman L, D'Agata EM, Gold HS et al. Vancomycin-resistant enterococci in intensive care units: high frequency of stool carriage during a non-outbreak period. Arch. Intern. Med. 1999; 159 (13): 1467–1472.Ostrowsky BE, Venkataraman L, D'Agata EM, Gold HS et al. Vancomycin-resistant enterococci in intensive care units: high frequency of stool carriage during a non-outbreak period. Arch. Intern. Med. 1999; 159 (13): 1467–1472.Bonten MJ, Slaughter S, Hayden MK, Nathan C et al. External sources of vancomycin-resistant enterococci for intensive care units. Crit. Care Med. 1998; 26 (12): 2001–2004.Bonten MJ, Slaughter S, Hayden MK, Nathan C et al. External sources of vancomycin-resistant enterococci for intensive care units. Crit. Care Med. 1998; 26 (12): 2001–2004.Marothi YA, Agnihotri H, Dubey D. Enterococcal resistance – an overview. Indian J. Med. Microbiol. 2005; 23 (4): 214–219.Marothi YA, Agnihotri H, Dubey D. Enterococcal resistance – an overview. Indian J. Med. Microbiol. 2005; 23 (4): 214–219.Donabedian SM, Thal LA, Hershberger E, Perri MB et al. Molecular characterization of gentamicin-resistant enterococci in the United States evidence of spread from animals to humans through food. J. Clin. Microbiol. 2003; 41 (3): 1109–1113.Donabedian SM, Thal LA, Hershberger E, Perri MB et al. Molecular characterization of gentamicin-resistant enterococci in the United States evidence of spread from animals to humans through food. J. Clin. Microbiol. 2003; 41 (3): 1109–1113.Perichon B, Courvalin P. VanA-type vancomycin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 2009; 53 (11): 4580–4587.Perichon B, Courvalin P. VanA-type vancomycin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 2009; 53 (11): 4580–4587.Coburn PS, Baghdayan AS, Craig N, Burroughs A et al. A novel conjugative plasmid from Enterococcus faecalis F99 enhances resistance to ultraviolet radiation. Plasmid. 2010; 64 (1); 18–25.Coburn PS, Baghdayan AS, Craig N, Burroughs A et al. A novel conjugative plasmid from Enterococcus faecalis F99 enhances resistance to ultraviolet radiation. Plasmid. 2010; 64 (1); 18–25.Drees M, Snydman DR, Schmid CH, Barefoot L et al. Prior environmental contamination increases the risk of acquisition of vancomycin-resistant enterococci. Clin. Infect Dis. 2008; 46 (5): 678–685.Drees M, Snydman DR, Schmid CH, Barefoot L et al. Prior environmental contamination increases the risk of acquisition of vancomycin-resistant enterococci. Clin. Infect Dis. 2008; 46 (5): 678–685.Manson JM, Hancock LE, Gilmore MS. Mechanism of chromosal transfer of Enterococcus faecalis pathogenicity island, capsule, antimicrobial resistance, and other traits. Proc. Nat. Acad. Sci USA. 2010; 107 (27): 12 269–12 274.Manson JM, Hancock LE, Gilmore MS. Mechanism of chromosal transfer of Enterococcus faecalis pathogenicity island, capsule, antimicrobial resistance, and other traits. Proc. Nat. Acad. Sci USA. 2010; 107 (27): 12 269–12 274.Pillar CM, Gilmore MS. Enterococcal virulence-pathogenicity island of E. faecalis. Front. Biosci. 2004, 9: 2335–2346.Pillar CM, Gilmore MS. Enterococcal virulence-pathogenicity island of E. faecalis. Front. Biosci. 2004, 9: 2335–2346.Бондаренко ВМ. «Острова» патогенности бактерий. Журн. микробиол. 2001; 4: 67–74. Bondarenko VM. «Ostrova» patogennosti bakterij. Zhurn. mikrobiol. 2001; 4: 67–74.Бондаренко ВМ. «Острова» патогенности бактерий. Журн. микробиол. 2001; 4: 67–74. Bondarenko VM. «Ostrova» patogennosti bakterij. Zhurn. mikrobiol. 2001; 4: 67–74.Гармашева ИЛ, Коваленко НК. Биологическая активность и безопасность энтерококков. Микробиол. журн. 2011: 73 (4); 77–84. Garmasheva IL, Kovalenko NK. Biologicheskaja aktivnost' i bezopasnost' jenterokokkov. Mikrobiol. zhurn. 2011: 73 (4); 77–84.Гармашева ИЛ, Коваленко НК. Биологическая активность и безопасность энтерококков. Микробиол. журн. 2011: 73 (4); 77–84. Garmasheva IL, Kovalenko NK. Biologicheskaja aktivnost' i bezopasnost' jenterokokkov. Mikrobiol. zhurn. 2011: 73 (4); 77–84.Shiono A, Ike Y. Isolation of Enterococcus faecalis clinical isolates that efficiently adhere to human bladder carcinoma T24 cells and inhibition of adhesion by fibronectin and trypsin treatment. Infect. Immun. 1999; 67 (4); 1585–1592.Shiono A, Ike Y. Isolation of Enterococcus faecalis clinical isolates that efficiently adhere to human bladder carcinoma T24 cells and inhibition of adhesion by fibronectin and trypsin treatment. Infect. Immun. 1999; 67 (4); 1585–1592.Hendrix CW, Hammond JM, Swoboda SM, Merz WG et al. Surveillance strategies and impact of vancomycinresistant enterococcal colonization and infection in critically ill patients. Ann. Surg. 2001; 233 (2): 259–265.Hendrix CW, Hammond JM, Swoboda SM, Merz WG et al. Surveillance strategies and impact of vancomycinresistant enterococcal colonization and infection in critically ill patients. Ann. Surg. 2001; 233 (2): 259–265.Warren DK, Kollef MH, Seiler SM, Fridkin SK et al. The epidemiology of vancomycin-resistant Enterococcus colonization in a medical intensive care unit. Infect. Control Hosp. Epidemiol. 2003; 24 (4): 257–263.Warren DK, Kollef MH, Seiler SM, Fridkin SK et al. The epidemiology of vancomycin-resistant Enterococcus colonization in a medical intensive care unit. Infect. Control Hosp. Epidemiol. 2003; 24 (4): 257–263.Hidron Al, Edwards JR, Patel J, Horan TC et al. NHSH annual update antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006–2007. Infect. Control. Hosp. Epidemiol. 2008; 29 (11): 996–1011.Hidron Al, Edwards JR, Patel J, Horan TC et al. NHSH annual update antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006–2007. Infect. Control. Hosp. Epidemiol. 2008; 29 (11): 996–1011.Warren DK, Kollef MH, Seiler SM, Fridkin SK et al. The epidemiology of vancomycin-resistant Enterococcus colonization in a medical intensive care unit. Infect. Control. Hosp. Epidemiol. 2003; 24 (4): 257–263.Warren DK, Kollef MH, Seiler SM, Fridkin SK et al. The epidemiology of vancomycin-resistant Enterococcus colonization in a medical intensive care unit. Infect. Control. Hosp. Epidemiol. 2003; 24 (4): 257–263.Ruiz-Garbajosa P, de Regt M, Bonten M, Baquero F et al. High-density fecal Enterococcus faecium colonization in hospitalized patients is associated with the presence of polyclonal subcluster CC17. Eur. J. Clin. Microbiol. Infect. Dis. 2012; 31 (4): 519–522.Ruiz-Garbajosa P, de Regt M, Bonten M, Baquero F et al. High-density fecal Enterococcus faecium colonization in hospitalized patients is associated with the presence of polyclonal subcluster CC17. Eur. J. Clin. Microbiol. Infect. Dis. 2012; 31 (4): 519–522.Ott E, Saathoff S, Graf K, Schwab F, Chaberny IF. The prevalence of nosocomial and community acquired infections in a university hospital: an observational study. Dtsch Arztebl Int. 2013; 110 (31–32): 533–540.Ott E, Saathoff S, Graf K, Schwab F, Chaberny IF. The prevalence of nosocomial and community acquired infections in a university hospital: an observational study. Dtsch Arztebl Int. 2013; 110 (31–32): 533–540.Kafil HS, Asgharzadeh M. Vancomycin-resistant Enterococcus faecium and Enterococcus faecalis isolated from education hospital of Iran.Kafil HS, Asgharzadeh M. Vancomycin-resistant Enterococcus faecium and Enterococcus faecalis isolated from education hospital of Iran.Sidler JA, Battegay M, Tschudin-Sutter S, Widmer AF et al. Enterococci, Clostridium difficile and ESBL-producing bacteria: epidemiology, clinical impact and prevention in ICU patients. Swiss Med Wkly. 2014; 144: 9–39.Sidler JA, Battegay M, Tschudin-Sutter S, Widmer AF et al. Enterococci, Clostridium difficile and ESBL-producing bacteria: epidemiology, clinical impact and prevention in ICU patients. Swiss Med Wkly. 2014; 144: 9–39.Batistao DW, Gontijo-Filho PP, Conceicao N, Oliveira AG et al. Risk factors for vancomycin-resistant enterococci colonization in critically ill patients. Mem. Ins. Oswaldo Cruz. 2012; 107 (1): 57–63.Batistao DW, Gontijo-Filho PP, Conceicao N, Oliveira AG et al. Risk factors for vancomycin-resistant enterococci colonization in critically ill patients. Mem. Ins. Oswaldo Cruz. 2012; 107 (1): 57–63.Fagan RP, Edwards JR, Park BJ, Fridkin SK, Magill SS. Incidence trends in pathogen-specific central line-associated bloodstream infections in US intensive care units, 1990–2010. Infect. Control Hosp. Epidemiol. 2013; 34 (9): 893–899.Fagan RP, Edwards JR, Park BJ, Fridkin SK, Magill SS. Incidence trends in pathogen-specific central line-associated bloodstream infections in US intensive care units, 1990–2010. Infect. Control Hosp. Epidemiol. 2013; 34 (9): 893–899.Gotthardt DN, Weiss KH, Rupp C, Bode K et al. Bacteriobilia and fungibilia are associated with outcome in patients with endoscopic treatment of biliary complications after liver transplantationndoscopy. 2013: 45 (11): 890–896.Gotthardt DN, Weiss KH, Rupp C, Bode K et al. Bacteriobilia and fungibilia are associated with outcome in patients with endoscopic treatment of biliary complications after liver transplantationndoscopy. 2013: 45 (11): 890–896.Ziakas PD, Thapa R, Rice LB, Mylonakis E. Trends and significance of VRE colonization in the ICU: A metaanalysis of published studies. PloS One. 2013; 8 (9): e75658.Ziakas PD, Thapa R, Rice LB, Mylonakis E. Trends and significance of VRE colonization in the ICU: A metaanalysis of published studies. PloS One. 2013; 8 (9): e75658.Kierzkowska M, Majewska A, Dobrzaniecka K, SawickaGrzelak A et al. Blood infections in patients treated at transplantation wards of a clinical hospital in Warsaw. Transplant. Proc. 2014; 46 (8): 2589–2591.Kierzkowska M, Majewska A, Dobrzaniecka K, SawickaGrzelak A et al. Blood infections in patients treated at transplantation wards of a clinical hospital in Warsaw. Transplant. Proc. 2014; 46 (8): 2589–2591.Primeggia J, Matsumoto CS, Fishbein TM, Karacki PS et al. Infection among adult small bowel and multivisceral transplant recipients in the 30-day postoperative period. Transpl. Infect. Dis. 2013; 15 (5): 441–448.Primeggia J, Matsumoto CS, Fishbein TM, Karacki PS et al. Infection among adult small bowel and multivisceral transplant recipients in the 30-day postoperative period. Transpl. Infect. Dis. 2013; 15 (5): 441–448.Vydra J, Shanley RM, George I, Ustun C et al. Enterococcal bacteremia is associated with increased risk of mortality in recipients of allogeneic hematopoietic stem cell transplantation. Clin. Infect. Dis. 2012; 55 (6): 764–770.Vydra J, Shanley RM, George I, Ustun C et al. Enterococcal bacteremia is associated with increased risk of mortality in recipients of allogeneic hematopoietic stem cell transplantation. Clin. Infect. Dis. 2012; 55 (6): 764–770.Габриэлян НИ, Горская ЕМ, Спирина ТС, Преображенская ТБ. Энтерококки как возбудители послеоперационных инфекционных осложнений. Журн. микробиол. 2007; 4: 50–53. Gabrijeljan NI, Gorskaja EM, Spirina TS, Preobrazhenskaja TB. Jenterokokki kak vozbuditeli posleoperacionnyh infekcionnyh oslozhnenij. Zhurn. mikrobiol. 2007; 4: 50–53.Габриэлян НИ, Горская ЕМ, Спирина ТС, Преображенская ТБ. Энтерококки как возбудители послеоперационных инфекционных осложнений. Журн. микробиол. 2007; 4: 50–53. Gabrijeljan NI, Gorskaja EM, Spirina TS, Preobrazhenskaja TB. Jenterokokki kak vozbuditeli posleoperacionnyh infekcionnyh oslozhnenij. Zhurn. mikrobiol. 2007; 4: 50–53.

The authors declare that there are no conflicts of interest present.