vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2013-3-102-114vtio-437Research ArticleОбзор литературыLiterature ReviewsПРОФИЛАКТИКА И ЛЕЧЕНИЕ ИШЕМИЧЕСКИ-РЕПЕРФУЗИОННЫХ ПОВРЕЖДЕНИЙ ПРИ ТРАНСПЛАНТАЦИИ ПЕЧЕНИ – ВОЗМОЖНЫЙ ПУТЬ К РАСШИРЕНИЮ ДОНОРСКОГО ПУЛАPREVENTION AND TREATMENT OF ISCHEMIA-REPERFUSION INJURY IN LIVER TRANSPLANTATION-POSSIBLE WAY TO EXPAND THE DONOR POOLЦойД. Л.TsoyD. L.tsoy.transpl@gmail.comМойсюкЯ. Г.MoysyukY. G.Отделение трансплантации почки и печени (зав. – проф. Я.Г. Мойсюк ) ФГБУ «ФНЦ трансплантологии и искусственных органов им. акад. В.И. Шумакова» Минздрава России (директор – академик РАМН, проф. С.В. Готье), Москва, Российская ФедерацияРоссияAcademician V.I. Shumakov Federal research center of transplantology and artificial organs (Head – academician, prof. S.V. Gautier), Moscow, Russian FederationRussian FederationОтделение трансплантации почки и печени (зав. – проф. Я.Г. Мойсюк ) ФГБУ «ФНЦ трансплантологии и искусственных органов им. акад. В.И. Шумакова» Минздрава России (директор – академик РАМН, проф. С.В. Готье), Москва, Российская Федерация Кафедра трансплантологии и искусственных органов (зав. – академик РАМН, проф. С.В. Готье), ГБОУ ВПО «Первый МГМУ им. Сеченова» (ректор – член-корр. РАМН, проф. П.В. Глыбочко), Москва, Российская ФедерацияРоссияAcademician V.I. Shumakov Federal research center of transplantology and artificial organs (Head – academician, prof. S.V. Gautier), Moscow, Russian Federation I.M. Sechenov First Moscow State Medical University Department of transplantology and artificial organs (Rector – korresponding member of RAMSci, prof. P.V. Glybochko), Moscow, Russian FederationRussian Federation201324062014153ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ том XV No 3–2013102114Copyright © Цой Д.Л., Мойсюк Я.Г., 20132013Цой Д.Л., Мойсюк Я.Г.Tsoy D.L., Moysyuk Y.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/437

Дефицит донорских органов индуцирует поиск альтернативных путей увеличения донорского пула. Од- ним из таковых является расширение критериев маргинального донора. Применение трансплантатов печени от доноров данной группы сопряжено с высоким риском развития ранней дисфункции транс- плантата, в основе которого лежит ишемически-реперфузионное повреждение (ИРП) печени. В связи с этим в обзоре рассмотрены основные этапы патогенеза ИРП печени, а также современные методы его профилактики и лечения. 

The shortage of donor organs results in the search for alternative ways to increase the donor pool. One of these is the expansion of marginal donor criteria. The use of liver grafts from donors in this group is associated with a high risk of primary non-functioning graft which lies at the basis of ischemia-reperfusion injury of the liver. In this regard, in this review, we examined the main stages of the pathogenesis of liver disturbances as well as modern methods of prevention and treatment. 

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The authors declare that there are no conflicts of interest present.