vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2013-3-38-43vtio-428Research ArticleКлиническая трансплантологияClinical TransplantologyКОНЦЕНТРАЦИЯ НИТРИТА/НИТРАТА (NOx), МЕТГЕМОГЛОБИНА, ЛАКТАТА В КРОВИ И ИХ ВЗАИМОСВЯЗЬ У БОЛЬНЫХ ПОСЛЕ ТРАНСПЛАНТАЦИИ ЛЕГКИХ НА ФОНЕ ПРИМЕНЕНИЯ ИНГАЛЯЦИОННОГО ОКСИДА АЗОТАBLOOD CONCENTRATIONS OF NITRITE/NITRATE (NOx), METHEMOGLOBIN, LACTATE AND THEIR CORRELATION IN PATIENS AFTER LUNG TRANSPLANTATION DURING TREATMENT WITH INHALED NITRIC OXIDEХубутияМ. Ш.KhubutiyaM. Sh.АбакумовМ. М.AbakumovM. M.КлычниковаЕ. В.KlychnikovaE. V.ltazina@yandex.ruТарабринЕ. А.TarabrinE. A.ТазинаЕ. В.TazinaE. V.ГодковМ. А.GodkovM. A.РомановА. А.RomanovA. A.КуриловаО. А.KurilovaO. A.ПерваковаЭ. И.PervakovaE. I.ЦуроваД. Х.TsurovaD. Kh.ГБУЗ города Москвы «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения города Москвы» (директор – член-корреспондент РАМН, проф. Хубутия М.С.), Москва, Российская ФедерацияРоссияSklifosovsky Research Institute for Emergency Medicine Health Department of Moscow (director – corresponding-member of RAMSci, prof. Khubutiya M.S.), Moscow, Russian FederationRussian Federation201324062014153ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ том XV No 3–20133843Copyright © Хубутия М.Ш., Абакумов М.М., Клычникова Е.В., Тарабрин Е.А., Тазина Е.В., Годков М.А., Романов А.А., Курилова О.А., Первакова Э.И., Цурова Д.Х., 20132013Хубутия М.Ш., Абакумов М.М., Клычникова Е.В., Тарабрин Е.А., Тазина Е.В., Годков М.А., Романов А.А., Курилова О.А., Первакова Э.И., Цурова Д.Х.Khubutiya M.S., Abakumov M.M., Klychnikova E.V., Tarabrin E.A., Tazina E.V., Godkov M.A., Romanov A.A., Kurilova O.A., Pervakova E.I., Tsurova D.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/428

Цель. Изучение взаимосвязи иNO, уровня NOx, MetHb и лактата в крови больных после ТЛ. Материалы и методы. Продолжительность иNO-терапии составила от 2 до 4 суток, проанализированы данные ТЛ у 7 больных. Результаты. Обнаружено достоверное повышение уровня NOx и лактата с 1-х по 5-е сутки после операции, концентрация MetHb при этом оставалась в пределах нормы. У больных выявлены до- стоверные положительные корреляции: между иNO и концентрацией NOх, иNO и концентрацией MetHb, иNO и концентрацией лактата, концентрацией NOx и MetHb, концентрацией NOx и лактата, концентра- цией MetHb и лактата. Заключение. Полученные данные свидетельствуют о том, что при использовании иNO у больных с ТЛ необходимо контролировать как концентрацию вводимого иNO и MetHb в крови, так и уровень NOx в сыворотке крови. 

Aim. The purpose of the research was correlation analysis of iNO, blood levels of NOx, MetHb and lacta- te in patients after LT. Materials and methods. The duration of iNO therapy was ranged from 2 to 4 days, the data of LT were analyzed in 7 patients. Results. There was a significant increase of NOx and lac- tate levels from 1 to 5 days after operation while the concentration of MetHb remained within the normal range. We have found significant positive correlations in patients after LT: between iNO and NOx concen- tration, iNO and MetHb concentration, iNO and lactate concentration, the concentration of NOx and Me- tHb, the concentration of NOx and lactate, the concentration of MetHb and lactate. Conclusion. The ob- tained data indicate that during application of iNO in patients with LT it is necessary to control both the concentration of administered iNO, the concentration of MetHb in blood and the level of NOx in serum. 

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The authors declare that there are no conflicts of interest present.