vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2011-3-15-19vtio-410Research ArticleТрансплантомикаTransplantomicsДИАГНОСТИКА ОСТРОГО ОТТОРЖЕНИЯ ПО ПУНКЦИОННЫМ БИОПТАТАМ АЛЛОТРАНСПЛАНТИРОВАННОЙ ПЕЧЕНИTHE DIAGNOSIS OF LIVER ALLOGRAFT ACUTE REJECTION IN LIVER BIOPSIESШкаловаЛ. В.ShkalovaL. V.МожейкоН. П.MogeikoN. P.ИльинскийИ. М.IljinskyI. M.iiljinsky@mail.ruМойсюкЯ. Г.MoysyukY. G.ЦирульниковаО. М.TsirulnikovaO. M.ГотьеС. В.GautierS. V.ФГУ «Приволжский окружной медицинский центр ФМБА России», Нижний НовгородРоссияFederal State Institution Volga Regional Medical Center of Federal Bio-Medical Agency, Nizhny NovgorodRussian FederationФГУ «ФНЦ трансплантологии и искусственных органов им. академика В.И. Шумакова» Минздравсоцразвития РФ, МоскваРоссияAcademician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, MoscowRussian FederationФГУ «ФНЦ трансплантологии и искусственных органов им. академика В.И. Шумакова» Минздравсоцразвития РФ, Москва Кафедра трансплантологии и искусственных органов I МГМУ имени И.М. Сеченова, МоскваРоссияAcademician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, Moscow Dept of Transplantology and artificials organs of Sechenov First Moscow Medical University, MoscowRussian Federation201118062014133ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ том XIII No 3–20111519Copyright © Шкалова Л.В., Можейко Н.П., Ильинский И.М., Мойсюк Я.Г., Цирульникова О.М., Готье С.В., 20112011Шкалова Л.В., Можейко Н.П., Ильинский И.М., Мойсюк Я.Г., Цирульникова О.М., Готье С.В.Shkalova L.V., Mogeiko N.P., Iljinsky I.M., Moysyuk Y.G., Tsirulnikova O.M., Gautier S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/410

Проведено гистологическое исследование 80 пункционных биоптатов аллотрансплантированной пе- чени, из которых в 34 подтвержден предполагаемый клинический диагноз острого отторжения. Гисто- логические изменения в биоптатах при различной степени острого отторжения оценивали по Banff- классификации 1995, 1997 гг. и сопоставляли с данными современной литературы. В статье обсуждается морфологическая значимость градации острого отторжения на раннее и позднее, анализируется изме- нение тактики лечения пациентов после постановки морфологического диагноза острого отторжения аллотрансплантированной печени. 

We performed histological examination of 80 liver allograft biopsies, the diagnosis of acute rejection was proved in 34 cases. Histological changes in liver biopsies in different grades of acute rejection were estimated according to Banff classification 1995, 1997 and were compared with current literature data. The article deals with the question of morphological value of grading acute rejection on early and late, also we analyze changes in treat- ment tactics after morphological verification of liver allograft acute rejection. 

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The authors declare that there are no conflicts of interest present.