vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2011-4-60-65vtio-395Research ArticleТрансплантомикаTransplantomicsАЛЛОТРАНСПЛАНТАЦИЯ МАКРОИНКАПСУЛИРОВАННЫХ ПАРАТИРЕОЦИТОВ В ЛЕЧЕНИИ ПОСЛЕОПЕРАЦИОННОГО ГИПОПАРАТИРЕОЗА: КЛИНИЧЕСКОЕ НАБЛЮДЕНИЕALLOTRANSPLANTATION OF MACROENCAPSULATED PARATHYROID CELLS IN SEVERE POSTSURGICAL HYPOPARATHYROIDISM: A CASE REPORTХрыщановичВ. Я.KhryshchanovichV. Ja.ТретьякС. И.TretyakS. I.ХарламоваА. Н.KharlamovaA. N.МохортТ. В.MochortT. V.БогомазоваЕ. В.BogomazovaE. V.КузьменковаЕ. И.KuzmenkovaE. I.КондратовичВ. А.KondratovichV. A.ПисаренкоА. М.PisarenkoA. M.РомановичА. В.RomanovichA. V.УО «Белорусский государственный медицинский университет»РоссияBelarusian State Medical UniversityRussian FederationГУ «Республиканский центр медицинской реабилитации и бальнеолечения»РоссияRepublic rehabilitation and balneotherapy centreRussian FederationУЗ «Минский городской клинический онкологический диспансер»РоссияMinsk clinical oncological hospitalRussian FederationУЗ «4-я городская клиническая больница г. Минска», Республика БеларусьРоссия4th Minsk clinical hospitalRussian Federation201116062014134ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ том XIII No 4–20116065Copyright © Хрыщанович В.Я., Третьяк С.И., Харламова А.Н., Мохорт Т.В., Богомазова Е.В., Кузьменкова Е.И., Кондратович В.А., Писаренко А.М., Романович А.В., 20112011Хрыщанович В.Я., Третьяк С.И., Харламова А.Н., Мохорт Т.В., Богомазова Е.В., Кузьменкова Е.И., Кондратович В.А., Писаренко А.М., Романович А.В.Khryshchanovich V.J., Tretyak S.I., Kharlamova A.N., Mochort T.V., Bogomazova E.V., Kuzmenkova E.I., Kondratovich V.A., Pisarenko A.M., Romanovich A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/395

ллотрансплантация макроинкапсулированных клеток паращитовидной железы является длительной те- рапевтической альтернативой в лечении тяжелых форм послеоперационного гипопаратиреоза. Подобная технология позволяет восполнить гормонодефицит путем имплантации клеток или ткани паращитовид- ной железы без применения иммуносупрессии. В настоящем сообщении приводятся сведения о возмож- ности эффективного функционирования паратиреоидного аллотрансплантата у пациентки с тяжелым ги- попаратиреозом, длительное время получавшей парентеральную заместительную терапию препаратами кальция. Макрокапсула, содержащая ~100 000 паратиреоцитов, была сконструирована из микропористой мембраны поливинилидиндифторида (ПВДФ) и имплантирована в глубокую бедренную артерию. Функ- циональная активность трансплантата, прослеженная на протяжении 3 месяцев, позволила исключить парентеральное введение препаратов кальция и компенсировать течение заболевания. 

The last therapeutic alternative in severe postsurgical hypoparathyroidism is allotransplantation of macroen- capsulated parathyroid cells. With this technique, it is possible to implant cells or tissue of parathyroid origin to replace them in such patients, without immusupression. We report an allotransplant of parathyroid cells in a patient with continous endovenous requirement of calcium to survive. The macroencapsulation was carried out with a polyvinylidine difluoride (PVDF). We implant ~100 000 parathyroid cells in the deep femoral artery. In this article, we show functionality of the graft for at least 3 months without requirement of endovenous calcium. We report this procedure as a therapeutical alternative in severe hypoparathyroidism. 

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The authors declare that there are no conflicts of interest present.