vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2011-1-108-114vtio-367Research ArticleОбзор литературыLiterature ReviewsИНФЕКЦИИ У ПОТЕНЦИАЛЬНЫХ ДОНОРОВ ОРГАНОВ: ВСЕГДА ЛИ ЭТО ПРОТИВОПОКАЗАНИЕ К ДОНОРСТВУ?INFECTIONS IN THE POOL OF POTENTIAL ORGAN DONORS: IS IT ALWAYS CONTRAINDICATION TO DONATION?МининаМ. Г.MininaM. G.minmar50@yahoo.comМосковский координационный центр органного донорства Департамента здравоохранения города МосквыРоссияMoscow coordinating centre of organ donation Moscow Department of HealthRussian Federation201109062014131ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ том XIII No 1–2011108114Copyright © Минина М.Г., 20112011Минина М.Г.Minina M.G.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/367

Проблема наличия тех или иных трансмиссивных инфекций у потенциальных доноров органов ощуща- ется в России с каждым годом все острее. Это связано как с увеличением общего количества доноров, так и с использованием современных методов скрининговой диагностики возбудителей ВИЧ, инфекционных вирусных гепатитов, сифилиса. Основной вопрос, который необходимо решить специалистам: одинакова ли угроза, которую несет каждый из возбудителей инфекции для реципиента донорского органа. В статье рассматриваются современные данные по инфекциям у потенциальных доноров органов, основанные на анализе доступной отечественной и зарубежной литературы. 

The presence of certain infection in potential organ donors is significant problem for Russian Transplantology. The increase in detection of donor’s infections could be due to increase in general donor’s pool and also to utili- zation of modern diagnostic screening. We should strictly define which infections carry a real threat to recipients and which are not. In the present paper we did the literature review which we believe will help us to solve the problem. 

донорство органовинфекции у доноров органовлабораторная диагностикаorgan donationinfections on organ donorslaboratory diagnosticReferencesEastlund T. Infectious disease transmission through cell, tissue, and organ transplantation:Reducing the risk through donor selection. Cell Transplant. 1995. Vol. 4. P. 455–477.Eastlund T. Infectious disease transmission through cell, tissue, and organ transplantation:Reducing the risk through donor selection. Cell Transplant. 1995. Vol. 4. P. 455–477.Schaffner A. Pretransplant evaluation for infections in donors and recipients of solid organs. Clin. Infect. Dis. 2001. Vol. 33. P. 9–14.Schaffner A. Pretransplant evaluation for infections in donors and recipients of solid organs. Clin. Infect. Dis. 2001. Vol. 33. P. 9–14.Terrault N.A., Wright T.L. Viral hepatitis A through G. Sleisenger and Fordtran: Gastrointestinal and liver di- sease. W.B. Saunders. 1998.Terrault N.A., Wright T.L. Viral hepatitis A through G. Sleisenger and Fordtran: Gastrointestinal and liver di- sease. W.B. Saunders. 1998.Lutwick L.I., Sywassink J.M., Corry R.J., Shorey J.W. The transmission of hepatitis B by renal transplantation. Clin. Nephrol. 1983. Vol. 19. P. 317–319.Lutwick L.I., Sywassink J.M., Corry R.J., Shorey J.W. The transmission of hepatitis B by renal transplantation. Clin. Nephrol. 1983. Vol. 19. P. 317–319.Wolf J.L., Perkins H.A., Schreeder M.T., Vincenti F. The transplanted kidney as a source of hepatitis B infection. Ann Intern Med. 1979. Vol. 91. P. 412–413.Wolf J.L., Perkins H.A., Schreeder M.T., Vincenti F. The transplanted kidney as a source of hepatitis B infection. Ann Intern Med. 1979. Vol. 91. P. 412–413.Gonzalez-Peralta R.P., Andres J.M. Tung F.Y., Fang J.W. et al. Transplantation of a hepatitis B surface antigen- positive donor liver into a hepatitis B virus-negative re- cipient. Transplantation. 1994. Vol. 58. P. 114–116.Gonzalez-Peralta R.P., Andres J.M. Tung F.Y., Fang J.W. et al. Transplantation of a hepatitis B surface antigen- positive donor liver into a hepatitis B virus-negative re- cipient. Transplantation. 1994. Vol. 58. P. 114–116.Chan P.C., Lok A.S., Cheng I.K., Chan M.K. The impact of donor and recipient hepatitis B surface antigen status on liver disease and survival in renal transplant recipi- ents. Transplantation. 1992. Vol. 53. P. 128–131.Chan P.C., Lok A.S., Cheng I.K., Chan M.K. The impact of donor and recipient hepatitis B surface antigen status on liver disease and survival in renal transplant recipi- ents. Transplantation. 1992. Vol. 53. P. 128–131.Liang T.J., Baruch Y., Ben-Porath, Enat R., Basan L., Brown N.V. et al. Hepatitis B virus infection in patientsLiang T.J., Baruch Y., Ben-Porath, Enat R., Basan L., Brown N.V. et al. Hepatitis B virus infection in patientswith idiopathic liver disease. Hepatology. 1991. Vol. 13.with idiopathic liver disease. Hepatology. 1991. Vol. 13.P. 1044–1051.P. 1044–1051.Liang T.J., Bodenheimer H.C. Jr, Yankee R. et al. Pre-Liang T.J., Bodenheimer H.C. Jr, Yankee R. et al. Pre-sence of hepatitis B and C viral genomes in US blood donors as detected by polymerase chain reaction amplifi- cation // J. Med. Virol. 1994. Vol. 42. P. 151–157.sence of hepatitis B and C viral genomes in US blood donors as detected by polymerase chain reaction amplifi- cation // J. Med. Virol. 1994. Vol. 42. P. 151–157.Dodson S.F., Issa S., Araya V. et al. Infectivity of hepatic allografts with antibodies to hepatitis B virus. Transplan- tation. 1997. Vol. 64. P.1582–1584.Dodson S.F., Issa S., Araya V. et al. Infectivity of hepatic allografts with antibodies to hepatitis B virus. Transplan- tation. 1997. Vol. 64. P.1582–1584.Dickson R.C., Everhart J.E., Lake J.R. et al. Transmissi- on of hepatitis B by transplantation of livers from donors positive for antibody to hepatitis B core antigen. Gastro- enterology. 1997. Vol. 113. P. 1668–1674.Dickson R.C., Everhart J.E., Lake J.R. et al. Transmissi- on of hepatitis B by transplantation of livers from donors positive for antibody to hepatitis B core antigen. Gastro- enterology. 1997. Vol. 113. P. 1668–1674.Wachs M.E., Amend W.J., Ascher N.L. et al. The risk of transmission of hepatitis B from HbsAg (–), HbcAb (+), HBIgM (–) organ donors. Transplantation. 1995. Vol. 59. P. 230–234.Wachs M.E., Amend W.J., Ascher N.L. et al. The risk of transmission of hepatitis B from HbsAg (–), HbcAb (+), HBIgM (–) organ donors. Transplantation. 1995. Vol. 59. P. 230–234.Kadian M., Hawkins K., Schwartz H., Miller C. Use of hepatitis B core antibody-positive multi-organ donors // J. Transplant. Coord. 1994. Vol. 4. P. 57.Kadian M., Hawkins K., Schwartz H., Miller C. Use of hepatitis B core antibody-positive multi-organ donors // J. Transplant. Coord. 1994. Vol. 4. P. 57.DouglasD.D.,RakelaJ.,WrightT.L.,KromR.A.,Wiesner R.H. The clinical course of transplantation-associated de novo hepatitis B infection in the liver transplant recipient. Liver Transplant. Surg. 1997. Vol. 3. P. 105–111.DouglasD.D.,RakelaJ.,WrightT.L.,KromR.A.,Wiesner R.H. The clinical course of transplantation-associated de novo hepatitis B infection in the liver transplant recipient. Liver Transplant. Surg. 1997. Vol. 3. P. 105–111.Alter M.J. Epidemiology of hepatitis C. Hepatology. 1997. Vol. 26. P. 62–65.Alter M.J. Epidemiology of hepatitis C. Hepatology. 1997. Vol. 26. P. 62–65.Pereira B.J., Wright T.L., Schmid C.H., Bryan C.F. et al. Screening and confirmatory testing of cadaver organ donors for hepatitis C virus infection. Kidney Int. 1994. Vol. 46. P. 886–892.Pereira B.J., Wright T.L., Schmid C.H., Bryan C.F. et al. Screening and confirmatory testing of cadaver organ donors for hepatitis C virus infection. Kidney Int. 1994. Vol. 46. P. 886–892.Farci P., Alter H.J., Govindarajan S. et al. Lack of pro- tective immunity against reinfection with hepatitis C vi- rus. Science. 1992. Vol. 258. P. 135–140.Farci P., Alter H.J., Govindarajan S. et al. Lack of pro- tective immunity against reinfection with hepatitis C vi- rus. Science. 1992. Vol. 258. P. 135–140.Mulligan D.C., Goldstein R.M., Crippin J.S. et al. Use of anti-hepatitis C virus seropositiveorgans in liver trans- plantation. Transplant. Proc. 1995. Vol. 27. P. 1204– 1205.Mulligan D.C., Goldstein R.M., Crippin J.S. et al. Use of anti-hepatitis C virus seropositiveorgans in liver trans- plantation. Transplant. Proc. 1995. Vol. 27. P. 1204– 1205.GhobrialR.M.,SteadmanR.,GornbeinJ.etal.A10-year experience of liver transplantation for hepatitis C. Ann. Surg. 2001. Vol. 234. P. 384–393.GhobrialR.M.,SteadmanR.,GornbeinJ.etal.A10-year experience of liver transplantation for hepatitis C. Ann. Surg. 2001. Vol. 234. P. 384–393.Velidedeoglu E., Desai N.M., Campos L., Olthoff K.M. et al. The outcome of liver grafts procured from hepa- titis C-positive donors. Transplantation. 2002. Vol. 73. P. 582–587.Velidedeoglu E., Desai N.M., Campos L., Olthoff K.M. et al. The outcome of liver grafts procured from hepa- titis C-positive donors. Transplantation. 2002. Vol. 73. P. 582–587.Laskus T., Wang L.F., Rakela J. et al. Dynamic behavior of hepatitis C virus in chronically infected patients re- ceiving liver graft from infected donors. Virology. 1996. Vol. 220. P. 171–176.Laskus T., Wang L.F., Rakela J. et al. Dynamic behavior of hepatitis C virus in chronically infected patients re- ceiving liver graft from infected donors. Virology. 1996. Vol. 220. P. 171–176.Gibel L.J., Sterling W., Hoy W. et al. Is serological evi- dence of infection with syphilis a contraindication to kid- ney donation? // J. Urol. 1987. Vol. 138. P. 1226–1227.Gibel L.J., Sterling W., Hoy W. et al. Is serological evi- dence of infection with syphilis a contraindication to kid- ney donation? // J. Urol. 1987. Vol. 138. P. 1226–1227.Caballero F., Domingo P., Rabella N., Lopez-Navidad A. Successful transplantation of organs retrieved from a donor with syphilis. Transplantation. 1998. Vol. 65. P. 598–599.Caballero F., Domingo P., Rabella N., Lopez-Navidad A. Successful transplantation of organs retrieved from a donor with syphilis. Transplantation. 1998. Vol. 65. P. 598–599.Ko W.J., Chu S.H., Lee Y.H. et al. Successful preven- tion of syphilis transmission from a multiple organ do- nor with serological evidence syphilis. Transplant. Proc. 1998. Vol. 30. P. 3667–3668.Ko W.J., Chu S.H., Lee Y.H. et al. Successful preven- tion of syphilis transmission from a multiple organ do- nor with serological evidence syphilis. Transplant. Proc. 1998. Vol. 30. P. 3667–3668.

The authors declare that there are no conflicts of interest present.