vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2011-1-36-42vtio-356Research ArticleКлиническая трансплантологияClinical TransplantologyПАТОМОРФОЛОГИЯ НУЛЕВЫХ БИОПТАТОВ ДОНОРСКИХ ПОЧЕКPATHOMORPHOLOGY OF ZERO BIOPSIES OF DONOR KIDNEYSАрефьевМ. Л.ArefjevM. L.МининаМ. Г.MininaM. G.МожейкоН. П.MogeikoN. P.ИльинскийИ. М.IljinskyI. M.iiljinsky@mail.ruФГУ «Федеральный научный центр трансплантологии и искусственных органов им. академика В.И. Шумакова» Минздравсоцразвития РФ, МоскваРоссияAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowRussian FederationМосковский координационный центр органного донорства Департамента здравоохранения города Москвы, Москва Кафедра трансплантологии и искусственных органов I МГМУ имени И.М. Сеченова, МоскваРоссияMoscow coordinating centre of organ donation, Moscow Dept of Transplantology and artificials organs of Sechenov Moscow Medical Academy, MoscowRussian FederationФГУ «Федеральный научный центр трансплантологии и искусственных органов им. академика В.И. Шумакова» Минздравсоцразвития РФ, Москва Кафедра трансплантологии и искусственных органов I МГМУ имени И.М. Сеченова, МоскваРоссияAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow Dept of Transplantology and artificials organs of Sechenov Moscow Medical Academy, MoscowRussian Federation201109062014131ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ том XIII No 1–20113642Copyright © Арефьев М.Л., Минина М.Г., Можейко Н.П., Ильинский И.М., 20112011Арефьев М.Л., Минина М.Г., Можейко Н.П., Ильинский И.М.Arefjev M.L., Minina M.G., Mogeiko N.P., Iljinsky I.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/356

Использование для трансплантации почек доноров с расширенными критериями повышает риск отсро- ченной функции трансплантатов и первично-нефункционирующих трансплантатов. Поэтому наблюда- ется повышенный интерес к исследованию нулевых биоптатов донорских почек во многих трансплан- тологических центрах. Исследовано 65 нулевых биоптатов почек трупных доноров в возрасте от 19 до 71 года. У доноров пожилого возраста, страдавших артериальной гипертензией и умерших от геморраги- ческого инсульта или острого нарушения кровообращения, нефросклероз более выражен, чем у молодых доноров, погибших от черепно-мозговых травм. Однако в общем пуле доноров количество склерози- рованных клубочков в среднем составило 12,04 ± 2,65%. Вместе с тем были биоптаты, в которых коли- чество склерозированных клубочков достигало 50%. Тяжелая степень артериосклероза отсутствовала в исследованном материале. Нулевые биопсии следует выполнять по протоколу для выявления почек со значительной степенью гломерулосклероза (более 20%), что является основанием для отказа использова- ния их для трансплантации. 

There is well known fact that kidney transplants from Extended Criteria Donors may increase risk of De- layed Graft Function and Primary Non-Function of transplants. We have collected and tested 65 «zero» kidney biopsies from cadaver donors aged from 19 to 71 years old. In the pool of elderly donors who died from cerebrovascular accident the frequency of nephrosclerosis presentation was higher than in donors of yonger age who died from craniocephalic trauma. Nevertheless in the general donor pool the number of sclerosed glomeruli was no more than 12%. We did not meet at all in the whole volume of material any bi- opsy with the severe degree of arteriosclerosis. The «zero» biopsies of cadaver kidneys is quite usable and unexpensive tool to measure the degree of nephrosclerosis in order to exclude kidneys which are not fitable for transplantation. 

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The authors declare that there are no conflicts of interest present.