vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2010-4-86-92vtio-349Research ArticleОбзор литературыLiterature ReviewsМОБИЛИЗАЦИЯ ГЕМОПОЭТИЧЕСКИХ СТВОЛОВЫХ КЛЕТОК ПРИ ТРАНСПЛАНТАЦИИ И РЕЗЕКЦИИ ПЕЧЕНИMOBILIZATION OF STEM CELLS AFTER LIVER TRANSPLANTATION AND RESECTIONКурабековаР. М.KurabekovaR. M.kourabr@yandex.ruЦирульниковаО. М.TsirulnikovaO. M.ШевченкоО. П.ShevchenkoO. P.ФГУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздравсоцразвития РФ, МоскваРоссияAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial OrgansRussian Federation201009062014124ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ том XII No 4–20108692Copyright © Курабекова Р.М., Цирульникова О.М., Шевченко О.П., 20102010Курабекова Р.М., Цирульникова О.М., Шевченко О.П.Kurabekova R.M., Tsirulnikova O.M., Shevchenko O.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/349

Обзор посвящен анализу литературы по мобилизации CD34/CD45-позитивных клеток костного мозга в периферическую кровь после повреждения печени. В статье обсуждаются данные работ по изучению механизма мобилизации стволовых клеток костного мозга в периферическую кровь, роль этих клеток в восстановлении поврежденной печени, а также результаты клинических исследований эффекта мобили- зации гемопоэтических стволовых клеток у пациентов после трансплантации и резекции печени. В по- следние годы публикуются данные, свидетельствующие о возможности участия стволовых клеток кост- ного мозга в восстановлении ткани и функций печени после ее повреждения. Одним из доказательств та- кого предположения является эффект мобилизации клеток костного мозга в периферическую кровь по- сле повреждения печени, который наблюдали как на экспериментальных моделях, так и в клинических исследованиях. Однако до настоящего времени на этот счет нет единого мнения, так как в ряде исследо- ваний не удавалось обнаружить мобилизацию стволовых клеток костного мозга в периферическую кровь после трансплантации или резекции печени у пациентов. В обзоре суммированы последние публикации по данному спорному вопросу. 

The review article analyses the published literature for mobilization of CD34/CD45 positive bone marrow cells into peripheral blood after liver injury. Recent investigations of mechanism of bone marrow stem cells mobiliza- tion into peripheral blood, role of the stem cells in recovery of injured liver and clinical studies of hematopoietic stem cells mobilization after liver transplantation and resection are discussed in the review. Recently some stu- dies have demonstrated that bone marrow stem cells can participate in recovery of liver tissue and functions after its injury. Mobilization of bone marrow stem cells into peripheral blood after liver injury is one of the possible evidence of such participation. The mobilization of bone marrow stem cells was shown in experimental models and in clinical investigations. However the issue is still controversial as there are publications which failed to find mobilization of bone marrow stem cells into peripheral blood after liver transplantation or resection in pa- tients. In this review we investigate and summarize recent research of the topic. 

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The authors declare that there are no conflicts of interest present.