vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2010-3-121-128vtio-336Research ArticleОбзор литературыLiterature ReviewsII. СИСТЕМА АУТОТОЛЕРАНТНОСТИ И ЕЕ ФУНКЦИОНИРОВАНИЕ ПРИ ТРАНСПЛАНТАЦИИ АЛЛОГЕННЫХ ОРГАНОВII. THE SYSTEM OF AUTOTOLERANCE AND ITS FUNCTIONING IN ALLOGENIC ORGAN TRANSPLANTATIONАртамоновС. Д.ArtamonovS. D.ОнищенкоН. А.OnishchenkoN. A.БашкинаЛ. В.BashkinaL. V.СусковаВ. С.SuskovaV. S.КрашенинниковМ. Е.KrasheninnikovM. E.НикольскаяА. О.Nikol’skayaA. O.ВеликийД. А.VelikiyD. A.ФГУ «Федеральный научный центр трансплантологии и искусственных органов им. академика В.И. Шумакова» Минздравсоцразвития РФ, МоскваРоссияAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowRussian Federation201005062014123ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ том XII No 3–2010121128Copyright © Артамонов С.Д., Онищенко Н.А., Башкина Л.В., Сускова В.С., Крашенинников М.Е., Никольская А.О., Великий Д.А., 20102010Артамонов С.Д., Онищенко Н.А., Башкина Л.В., Сускова В.С., Крашенинников М.Е., Никольская А.О., Великий Д.А.Artamonov S.D., Onishchenko N.A., Bashkina L.V., Suskova V.S., Krasheninnikov M.E., Nikol’skaya A.O., Velikiy D.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/336

Результаты анализа современного состояния проблемы формирования трансплантационной толерант- ности показывают, что индукция толерантности связана с использованием регуляторных возможностей клеток костного мозга донора. Гемопоэтические стволовые клетки костного мозга могут быть использо- ваны для создания центральной толерантности. Для создания активной периферической толерантности могут быть использованы малодифференцированные дендритные клетки мононуклеарной фракции кост- ного мозга, которые при сокультивировании способны участвовать в получении Т-регуляторных клеток памяти реципиента и в предотвращении острого и хронического отторжения трансплантата. 

It was ascertained, that induction of transplantation tolerance are bound with the using of regulatory possibilities of donor’s bone marrow cells. Hemopoietical bone marrow stem cells may be used to induct the central tole- rance into organism of recipient. For inducing of the active peripheral tolerance may be used small-differentiated dendrite cells of bone marrow, which are able to take part in receiving of T-regulatory memory cells, which are preventing both acute and chronic allograft rejection. 

центральная толерантностьпериферическая толерантностькостный мозгТ-регуляторные клеткитрансплантационная толерантность.central toleranceperipheral tolerancebone marrowT-regulatory cellstransplantation tolerance.ReferencesБыков В.Л. Цитология и общая гистология. СПб.: Со- тис, 2001.Быков В.Л. Цитология и общая гистология. СПб.: Со- тис, 2001.Зайчик А.Ш., Чурилов Л.П. Патофизиология. Т. 1: Общая патофизиология. СПб.: ЭЛБИ-СПб, 2002.Зайчик А.Ш., Чурилов Л.П. Патофизиология. Т. 1: Общая патофизиология. СПб.: ЭЛБИ-СПб, 2002.Зотиков Е.А., Бабаева А.Г., Порешина Л.П. Клеточный химеризм и химеризм клетки при трансплантации костного мозга. М.: Хризостом, 2003. 112 с.Зотиков Е.А., Бабаева А.Г., Порешина Л.П. Клеточный химеризм и химеризм клетки при трансплантации костного мозга. М.: Хризостом, 2003. 112 с.Рабсон А., Ройт А., Делвз П. Основы медицинской иммунологии. М.: Мир, 2006.Рабсон А., Ройт А., Делвз П. Основы медицинской иммунологии. М.: Мир, 2006.Ройт А., Бростофф Д., Мейл Д. Иммунология. 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The authors declare that there are no conflicts of interest present.