vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2010-3-52-61vtio-326Research ArticleТрансплантомикаTransplantomicsБИОХИМИЧЕСКИЕ МАРКЕРЫ РЕМОДЕЛИРОВАНИЯ КОСТНОЙ ТКАНИ – ПРЕДИКТОРЫ ДИНАМИКИ КОСТНЫХ ПОТЕРЬ ПОСЛЕ ПЕРЕСАДКИ ПЕЧЕНИBIOCHEMICAL BONE MARKERS AS PREDICTORS OF BONE LOSSES FOLLOWING LIVER TRANSPLANTATIONБузулинаВ. П.BuzulinaV. P.ПронченкоИ. А.PronchenkoI. A.ЕрмаковаИ. П.YermakovaI. P.lab_transpl_nii@mail.ruЯрошенкоЕ. Б.YaroshenkoE. B.КорниловМ. Н.KornilovM. N.ШмеркоН. П.ShmerkoN. P.ФГУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздравсоцразвития РФ, г. МоскваРоссияAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoskowRussian Federation201005062014123ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ том XII No 3–20105261Copyright © Бузулина В.П., Пронченко И.А., Ермакова И.П., Ярошенко Е.Б., Корнилов М.Н., Шмерко Н.П., 20102010Бузулина В.П., Пронченко И.А., Ермакова И.П., Ярошенко Е.Б., Корнилов М.Н., Шмерко Н.П.Buzulina V.P., Pronchenko I.A., Yermakova I.P., Yaroshenko E.B., Kornilov M.N., Shmerko N.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/326

Обследовано 24 реципиента (9 женщин и 5 мужчин) в возрасте 18–57 лет через 1–2 и в динамике че- рез 4–18 месяцев после ортотопической трансплантации печени (ОТП). При повторном исследовании минеральная плотность костной ткани (МПК) у 13 реципиентов возросла в среднем на 14 ± 10,5% и у 11 снизилась на 2,51 ± 2,56%. Увеличение МПК ассоциировалось с нормализацией костного обмена, проявляющейся соответствием степени увеличения маркера формирования остеокальцина и степени по- вышения маркера резорбции β-кросслапов. Снижение МПК ассоциировалось с ухудшением функции трансплантата, иммуносупрессией глюкокортикоидами, подавлением процесса формирования кости и увеличением процесса костной резорбции. 

24 recipients after ortotopic liver transplantation (9 women and 5 men) 18–57 years aged were studied in 1–2 and then through 4–18 months following operation. Bone mineral density (BMD) in repeated estimation in 13 recipients was elevated on 14 ± 10,5% and in 11 recipients was decreased on 2,5 ± 2,56%. BMD elevation was associated with bone remodelling normalization. BMD lowering followed transplant dysfunction, glucocorticoid therapy, bone resorption increasing and bone formation suppression. 

ртотопическая трансплантация печениминеральная плотность костной тканикостный обменбиохимические маркеры костного обмена.orthotopic liver transplantationbone mineral densitybone turnoverbiochemical bone markers.ReferencesAtamaz F., Hepculer S., Akuildiz M., Karasu Z. Effects of alendronate on bone mineral density and bone metabolic markers in patients with liver transplantation // Osteopo- ros. Int. 2006. Vol. 17. P. 942–949.Atamaz F., Hepculer S., Akuildiz M., Karasu Z. Effects of alendronate on bone mineral density and bone metabolic markers in patients with liver transplantation // Osteopo- ros. Int. 2006. Vol. 17. P. 942–949.Bjoro K., Brandsaeter B., Wiencke K. et al. Secondary osteoporosis in liver transplant recipients: a longitudinal study in patients with and without cholestatic liver dis- ease // Scand. J. Gastroenterol. 2003. Vol. 38. P. 320– 327.Bjoro K., Brandsaeter B., Wiencke K. et al. Secondary osteoporosis in liver transplant recipients: a longitudinal study in patients with and without cholestatic liver dis- ease // Scand. J. Gastroenterol. 2003. Vol. 38. P. 320– 327.Collier J. Bone disorders in chronic liver disease // Hepa- tology. 2007. Vol. 46. P. 1271–1278.Collier J. Bone disorders in chronic liver disease // Hepa- tology. 2007. Vol. 46. P. 1271–1278.Crawford B.A.L., Kam C., Donaghy A.J., McCaug- han G.W. The heterogeneity of bone disease in cirrhosis: a multivariate analysis // Osteoporos. Int. 2003. Vol. 14. P. 987–994.Crawford B.A.L., Kam C., Donaghy A.J., McCaug- han G.W. The heterogeneity of bone disease in cirrhosis: a multivariate analysis // Osteoporos. Int. 2003. Vol. 14. P. 987–994.Crawford B.A.L., Kam C., Pavlovic J., Byth K. et al. Zoledronic acid prevents bone loss after liver transplan- tation //Ann. Intern. Med. 2006. Vol. 144. P. 239–248.Crawford B.A.L., Kam C., Pavlovic J., Byth K. et al. Zoledronic acid prevents bone loss after liver transplan- tation //Ann. Intern. Med. 2006. Vol. 144. P. 239–248.Compston J.E. Osteoporosis after liver transplantation // Liver. Transpl. 2003. Vol. 9. P. 321–330.Compston J.E. Osteoporosis after liver transplantation // Liver. Transpl. 2003. Vol. 9. P. 321–330.Crosbie O.M., Freaney R., McKenna M.J., Curry M.P., Hegarty J.E. Bone density, vitamin D status, and disor- dered bone remodeling in end-stage chronic liver disease // Calcif. Tissue. Intern. 1999. Vol. 64. P. 295–300.Crosbie O.M., Freaney R., McKenna M.J., Curry M.P., Hegarty J.E. Bone density, vitamin D status, and disor- dered bone remodeling in end-stage chronic liver disease // Calcif. Tissue. Intern. 1999. Vol. 64. P. 295–300.Floreani A., Mega A., Tizian L., Burra P. et al. Bone me- tabolism and gonad function in male patients undergoing liver transplantation: a two-year longitudinal study // Os- teoporos. Int. 2001. Vol. 12. P. 749–754.Floreani A., Mega A., Tizian L., Burra P. et al. Bone me- tabolism and gonad function in male patients undergoing liver transplantation: a two-year longitudinal study // Os- teoporos. Int. 2001. Vol. 12. P. 749–754.Giannini S., Nobile M., Ciuffreda M., Iemmolo R.M. et al. Long-term persistence of low bone density in orthotopic liver transplantation // Osteoporos Int. 2000. Vol. 11. P. 417–424.Giannini S., Nobile M., Ciuffreda M., Iemmolo R.M. et al. Long-term persistence of low bone density in orthotopic liver transplantation // Osteoporos Int. 2000. Vol. 11. P. 417–424.Guichelaar M.M.J., Malinchoc M., Sibonga J. et al. Immunosuppression and other posttransplant effects of bone metabolism // Liver. Transpl. 2004. Vol. 10. P. 638– 647.Guichelaar M.M.J., Malinchoc M., Sibonga J. et al. Immunosuppression and other posttransplant effects of bone metabolism // Liver. Transpl. 2004. Vol. 10. P. 638– 647.Guichelaar M.M.J., Kendall R., Malinchoc M., Hay J.E. et al. Bone mineral density before and after OLT: long- term follow-up and predictive factors // Liver Transplan- tation. 2006. Vol. 12. P. 1390–1402.Guichelaar M.M.J., Kendall R., Malinchoc M., Hay J.E. et al. Bone mineral density before and after OLT: long- term follow-up and predictive factors // Liver Transplan- tation. 2006. Vol. 12. P. 1390–1402.Hamburg S.M., Piers D.A., van den Berg A.P. et al. Bone mineral density in long term after liver transplantation // Osteoporos. Int. 2000. Vol. 11. P. 600–606.Hamburg S.M., Piers D.A., van den Berg A.P. et al. Bone mineral density in long term after liver transplantation // Osteoporos. Int. 2000. Vol. 11. P. 600–606.de Kroon L., Drent G., van den Berg A.P., Haagsma E.B. Current health status of patients who have survived forde Kroon L., Drent G., van den Berg A.P., Haagsma E.B. Current health status of patients who have survived formore 15 years after liver transplantation // The Nitherlands Journal of Medicine. 2007. Vol. 65. P. 252–258.more 15 years after liver transplantation // The Nitherlands Journal of Medicine. 2007. Vol. 65. P. 252–258.McDonald J.A., Dunstan C.R., Dilworth P., Sherbon K. et al. Bone loss after liver transplantation // Hepatology.McDonald J.A., Dunstan C.R., Dilworth P., Sherbon K. et al. Bone loss after liver transplantation // Hepatology.Vol. 14. P. 50–55.Vol. 14. P. 50–55.Monegal A., Navasa M., Guanabens N., Peris P. et al. Bone disease after liver transplantation: a long-term pro- spective study of bone mass changes, hormonal disorders and histomorphometric characteristics // Osteoporos. Int. 2001. Vol. 12. P. 484–492.Monegal A., Navasa M., Guanabens N., Peris P. et al. Bone disease after liver transplantation: a long-term pro- spective study of bone mass changes, hormonal disorders and histomorphometric characteristics // Osteoporos. Int. 2001. Vol. 12. P. 484–492.Monegal A., Navasa M., Guanabens N., Peris P. et al. Bone mass and mineral metabolism in liver transplant patients treated with FK506 or cyclosporine A // Calcif. Tissue. Int. 2001. Vol. 68. P. 83–86.Monegal A., Navasa M., Guanabens N., Peris P. et al. Bone mass and mineral metabolism in liver transplant patients treated with FK506 or cyclosporine A // Calcif. Tissue. Int. 2001. Vol. 68. P. 83–86.Mounach A., Ouzzif Z., Wariaghli G., Achemlal L. et al. Primary biliary cirrhosis and osteoporosis: a case-control study // J. Bone. Miner. Metab. 2008. Vol. 26. P. 379–384.Mounach A., Ouzzif Z., Wariaghli G., Achemlal L. et al. Primary biliary cirrhosis and osteoporosis: a case-control study // J. Bone. Miner. Metab. 2008. Vol. 26. P. 379–384.Vedi S., Greer S., Skingle S.J., Garrahan N.J. et al. Mechanism of bone loss after liver transplantation: a his- tomorphometric analysis // J. Bone. Miner. Res. 1999. Vol. 14. P. 281–287.Vedi S., Greer S., Skingle S.J., Garrahan N.J. et al. Mechanism of bone loss after liver transplantation: a his- tomorphometric analysis // J. Bone. Miner. Res. 1999. Vol. 14. P. 281–287.

The authors declare that there are no conflicts of interest present.