vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2010-1-100-110vtio-298Research ArticleОбзор литературыLiterature ReviewsОСТРОЕ ПОВРЕЖДЕНИЕ ПОЧЕК ПРИ КАРДИОХИРУРГИЧЕСКИХ ОПЕРАЦИЯХ С ИСКУССТВЕННЫМ КРОВООБРАЩЕНИЕМ И ТРАНСПЛАНТАЦИИ СЕРДЦАACUTE KIDNEY INJURY AFTER CARDIAC SURGERY WITH CARDIOPULMONARY BYPASS AND HEART TRANSPLANTATIONКопыловаЮ. В.KopylovaJ. V.julika.dr@gmail.comПозЯ. Л.PozY. L.СтроковА. Г.StrokovA. G.ПопцовВ. Н.PoptsovV. N.ВоронинаО. В.VoroninaO. V.УхренковС. Г.UhrenkovS. G.ФГУ «Федеральный научный центр трансплантологии и искусственных органов им. академика В.И. Шумакова» Минздравсоцразвития РФ, МоскваРоссияAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowRussian Federation201005062014121ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ том XII No 1–2010100110Copyright © Копылова Ю.В., Поз Я.Л., Строков А.Г., Попцов В.Н., Воронина О.В., Ухренков С.Г., 20102010Копылова Ю.В., Поз Я.Л., Строков А.Г., Попцов В.Н., Воронина О.В., Ухренков С.Г.Kopylova J.V., Poz Y.L., Strokov A.G., Poptsov V.N., Voronina O.V., Uhrenkov S.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/298

Острое повреждение почек (ОПП) развивается в среднем у 30% больных при операциях с искусственным кровообращением (ИК). При этом заместительная почечная терапия (ЗПТ) применяется, по разным данным, у 1–3,3% всех оперированных пациентов. В патогенезе ОПП при операциях с ИК имеют значение гемодинамические, воспалительные и нефротоксические факторы. Многочисленные клинические исследования позволили выявить предикторы развития ОПП в этой категории больных. Данных о риске и последствиях ОПП у пациентов при трансплантации сердца в литературе значительно меньше. В этих случаях помимо прочих факторов имеет значение и нефротоксическое действие иммуносупрессивных препаратов. 

The in-depth review is dedicated to the acute kidney injury (AKI) after cardiac surgery and heart transplan- tation (HT). The incidence of AKI is about 30% with requirement in renal replacement therapy in 1–3% of patients. Pathogenesis of AKI is multifactorial and includes haemodynamic, inflammatory, nephrotoxic factors. Predictors of AKI was revealed in multiple clinical studies. Data concerning AKI in patients after HT is limited. In these cases nephrotoxicity of immunosuppressive medicines has to be taken into account. 

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The authors declare that there are no conflicts of interest present.