References

vtio

Вестник трансплантологии и искусственных органов

Russian Journal of Transplantology and Artificial Organs

1995-1191

Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation

10.15825/1995-1191-2010-1-86-93

vtio-296

Research Article

Обзор литературы

Literature Reviews

ВОЗМОЖНОСТИ ПРИМЕНЕНИЯ СТВОЛОВЫХ КЛЕТОК И КЛЕТОК-ПРЕДШЕСТВЕННИКОВ ДЛЯ СТИМУЛЯЦИИ РЕВАСКУЛЯРИЗАЦИИ И РЕГЕНЕРАЦИИ ОРГАНОВ

APPLICATION OF STEM CELLS AND PRECURSOR CELLS FOR STIMULATION OF ORGAN REVASCULARIZATION AND REGENERATION

Еремеева

М. В.

Eremeeva

M. V.

m_horoviz@hotmail.com

Научный центр сердечно-сосудистой хирургии им. А.Н. Бакулева РАМН, МоскваРоссияA.N. Bakulev Scientific Center of Cardiovascular Surgery, RAMS, MoscowRussian Federation

2010

05062014

121

ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ том XII No 1–2010

8693

2010

Еремеева М.В.

Eremeeva M.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.transpl.ru/vtio/article/view/296

Стимуляция ангиогенеза в ишемизированных тканях путем воздействия различными ангиогенными факторами долгое время остается в центре внимания ученых. Ключевую роль в процессе неоангиогенеза при ишемии играют эндотелиальные клетки-предшественники, богатейшим резервуаром которых является костный мозг. Однако в некоторых тканях или в снабжающих орган кровеносных сосудах содержатся резидентные эндотелиальные клетки-предшественники, которые также участвуют в неоангиогенезе. Теоретически экзогенное введение клеток-предшественников эндотелиоцитов может способствовать восстановлению кровоснабжения органа. В ряде экспериментальных протоколов в целях стимуляции регенерации миокарда были апробированы различные типы клеток. В результате исследований был получен универсальный результат в виде улучшения сократительной функции сердца в различной степени, но механизмы этого эффекта трансплантации различных типов клеток остаются малоизученными. В статье рассматриваются преимущества и недостатки применения эмбриональных, гематопоэтических и мезенхимальных стволовых клеток с целью стимуляции ангиогенеза и регенерации органов и тканей.

Different angiogenic factors induced angiogenesis stimulation in ischemic tissues stays in the focus of scientific research for long time. The key role in ischemic angiogenesis belongs to endothelial precursor cells, plenty of which are reserved in bone marrow. Resident endothelial precursor cells are also found in some tissues and in circulation. These cells are involved in neoangiogenesis as well. Theoretically, injection of exogeneous endothelial precusor cells might contribute to restoration of circulation in the ischemic organ. Various types of cells have been approved for regeneration stimulation in a number of experimental protocols. A various degree of improvement of myocardial contractive function has been obtained as a universal result of these investigations, though the mechanisms underlying observed effect remain evasive. The paper focuses on advantages and drawbacks of embryonic, hematopoetic and mesenhimal stem cells application for angiogenesis stimulation and organs and tissues regeneration.

неоангиогенезрегенерация миокардаэмбриональные стволовые клеткигематопоэтические стволовые клеткимезенхимальные стволовые клетки

neoangiogenesismyocardial regenerationembryonic stem cellshematopoetic stem cellsmesenhimal stem cell

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The authors declare that there are no conflicts of interest present.