vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2010-1-72-77vtio-294Research ArticleОбзор литературыLiterature ReviewsРОЛЬ НУКЛЕАРНОГО ФАКТОРА ТРАНСКРИПЦИИ NF-κB В РАЗВИТИИ ОТТОРЖЕНИЯ ТРАНСПЛАНТАТАROLE OF NUCLEAR FACTOR NF-κB IN ALLOGRAFT REJEKTIONКунцевичН. В.KuncevichN. V.transplant2009@mail.ruФГУ «Федеральный научный центр трансплантологии и искусственных органов им. академика В.И. Шумакова» Минздравсоцразвития РФ, МоскваРоссияAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowRussian Federation201005062014121ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ том XII No 1–20107277Copyright © Кунцевич Н.В., 20102010Кунцевич Н.В.Kuncevich N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/294

В обзоре представлена информация о роли нуклеарного фактора транскрипции NF-κB при отторжении пересаженного органа. Описаны структура и основные функции NF-κB. Представлены механизмы активации NF-κB при развитии отторжения пересаженного органа и его роль в следующих патологических процессах: активация эндотелиальных клеток, активация T-клеток реципиента, созревание дендритных клеток (антиген представляющих иммунных клеток). Рассмотрены возможные терапевтические подходы, направленные на изменение активности на NF-κB у трансплантологических больных и позволяющие продлить выживаемость пересаженного органа. 

Nuclear factor kappa B (NF-κB) is a rapid response transcription factor for genes whose products are critical for inflammation and immunity. In this review structure and general properties of NF-κB the role of transcription factor NF-κB in allograft rejection are presented. In this review considered the mechanism activation of NF-κB in allograft rejection and its role in following pathological processes: endothelial cells activation, recipient T-cells activation and maturation of dendritic cells (antigen – presenting immune cells). NF-κB – targeted therapeutics approaches, that might be effective in transplantation are presented. 

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The authors declare that there are no conflicts of interest present.