vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2010-1-61-67vtio-292Research ArticleНовые технологииAdvanced technologyНОРМОТЕРМИЧЕСКАЯ ЭКСТРАКОРПОРАЛЬНАЯ ПЕРФУЗИЯ IN SITU КАК СПОСОБ ВОССТАНОВЛЕНИЯ ЖИЗНЕСПОСОБНОСТИ ПОЧЕК У ДОНОРОВ С ВНЕЗАПНОЙ НЕОБРАТИМОЙ ОСТАНОВКОЙ КРОВООБРАЩЕНИЯNORMOTHERMIC EXTRACORPORAL PERFUSION IN SITU AS A WAY OF RECOVERY KIDNEY TRANSPLANTS FROM DONORS WITH SUDDEN IRREVERSIBLE CARDIAC ARRESTБагненкоС. Ф.BagnenkoS. F.СкворцовА. Е.SkvortsovA. E.ПопцовВ. Н.PoptsovV. N.ЛогиновИ. В.LoginovI. V.АнаньевА. Н.AnanyevA. N.РезникО. Н.ReznikO. N.onreznik@yahoo.comМойсюкЯ. Г.MoysyukY. G.ГУ «Санкт-Петербургский научно-исследовательский институт им И.И. Джанелидзе», Санкт-ПетербургРоссияState Research Institute for Emergency named after I.I. Djanelidze, Saint-PetersburgRussian FederationState Research Institute for Emergency named after I.I. Djanelidze, Saint-PetersburgRussian FederationФГУ «Федеральный научный центр трансплантологии и искусственных органов им. академика В.И. Шумакова» Минздравсоцразвития РФ, МоскваРоссияAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowRussian Federation201005062014121ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ том XII No 1–20106167Copyright © Багненко С.Ф., Скворцов А.Е., Попцов В.Н., Логинов И.В., Ананьев А.Н., Резник О.Н., Мойсюк Я.Г., 20102010Багненко С.Ф., Скворцов А.Е., Попцов В.Н., Логинов И.В., Ананьев А.Н., Резник О.Н., Мойсюк Я.Г.Bagnenko S.F., Skvortsov A.E., Poptsov V.N., Loginov I.V., Ananyev A.N., Reznik O.N., Moysyuk Y.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/292

В статье приводится обоснование и описание нового метода получения донорских органов от доноров с внезапной необратимой остановкой кровообращения с помощью экстракорпоральной нормотермической перфузией in situ. Сделана попытка определить максимальное приемлемое время первичной тепловой ишемии при использовании такого перфузионного протокола для почек. Статья содержит описание ре- зультатов первых пересадок почек, полученных с помощью нового метода. Обосновываются изменения в практике работы донорской службы для увеличения числа эффективных доноров почек. 

The potential of donors after cardiac death is actual issue. The crucial point in uncontrolled donors after cardiac death is the warm ischemical time. Definition of the limit of warm ischemic time is was the one task of our work and other one is development of preservation protocol saving quality of kidneys. There were 6 uncontrolled donors with warm ischemic time from 45 up to 91 minutes in which was adapted extracorporal perfusion device for preservation and restoration of kidneys after ischemical damage. The main attention was paid to the elimination of leucocytes as the main damaging factor from modificated donor’s blood circulating in device. In 6 of such kidneys recipients from 12 were immediately graft function, and to the end of third month the average creatinine was 121,3 ± 28,9 mmol/l. Treatment of ischemically damaged kidneys by normothermic extracorporal perfusion with leucocytes depletion before procurement could consider as challenging protocol and demands further study. 

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The authors declare that there are no conflicts of interest present.