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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vtio</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник трансплантологии и искусственных органов</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Transplantology and Artificial Organs</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-1191</issn><publisher><publisher-name>Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15825/1995-1191-2009-2-67-74</article-id><article-id custom-type="elpub" pub-id-type="custom">vtio-235</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Обзор литературы</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Literature Reviews</subject></subj-group></article-categories><title-group><article-title>ТРАНСПЛАНТАЦИЯ КЛЕТОК КОСТНОГО МОЗГА И ПУПОВИННОЙ КРОВИ КАК СПОСОБ КОРРЕКЦИИ АУТОИММУННЫХ МЕХАНИЗМОВ РАЗВИТИЯ САХАРНОГО ДИАБЕТА I ТИПА</article-title><trans-title-group xml:lang="en"><trans-title>TRANSPLANTATION OF BONE MARROW CELLS AND UMBILICAL CORD BLOOD CELLS AS A WAY FOR CORRECTION OF AUTOIMMUNE MECHANISMS IN DEVELOPMENT OF DIABETES MELLITUS TYPE I</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Великий</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Velikiy</surname><given-names>D. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Закирьянов</surname><given-names>А. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Zakirianov</surname><given-names>A. R.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Поздняков</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Pozdnyakov</surname><given-names>O. M.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Онищенко</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Onischenko</surname><given-names>N. A.</given-names></name></name-alternatives><email xlink:type="simple">illak@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздравсоцразвития РФ, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГУ «НИИ общей патологии и патофизиологии РАМН», Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute of General Pathology and Pathophysiology RAMS, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2009</year></pub-date><pub-date pub-type="epub"><day>30</day><month>05</month><year>2014</year></pub-date><volume>11</volume><issue>2</issue><fpage>67</fpage><lpage>74</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Великий Д.А., Закирьянов А.Р., Поздняков О.М., Онищенко Н.А., 2009</copyright-statement><copyright-year>2009</copyright-year><copyright-holder xml:lang="ru">Великий Д.А., Закирьянов А.Р., Поздняков О.М., Онищенко Н.А.</copyright-holder><copyright-holder xml:lang="en">Velikiy D.A., Zakirianov A.R., Pozdnyakov O.M., Onischenko N.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.transpl.ru/vtio/article/view/235">https://journal.transpl.ru/vtio/article/view/235</self-uri><abstract><p>В обзоре представлена современная концепция развития аутоиммунного сахарного диабета. Рассмот- рена возможность коррекции иммунных нарушений и регенерации β-клеток путем трансплантации клеток костного мозга и пуповинной крови. </p></abstract><trans-abstract xml:lang="en"><p>In this review the modern conception of development of autoimmune diabetes mellitus was presented. Possibilities of immune disturbances correction and β-cells regeneration at transplantation of bone marrow and umbilical cord blood cells were considered. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>аутоиммунный сахарный диабет</kwd><kwd>клетки костного мозга</kwd><kwd>регенерация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>autoimmune diabetes mellitus</kwd><kwd>bone marrow cells</kwd><kwd>regeneration</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Аскаров М.Б., Онищенко Н.А., Макарова О.В. Восста- новление морфофункционального состояния орга- нов иммуногенеза и течение длительно незаживаю- щих аутоиммунных язв желудка при трансплантации культивированных клеток аутогенного костного моз- га // Клеточная трансплант. и тканевая инженерия. 2008. V. 3. P. 36–42.</mixed-citation><mixed-citation xml:lang="en">Аскаров М.Б., Онищенко Н.А., Макарова О.В. Восста- новление морфофункционального состояния орга- нов иммуногенеза и течение длительно незаживаю- щих аутоиммунных язв желудка при трансплантации культивированных клеток аутогенного костного моз- га // Клеточная трансплант. и тканевая инженерия. 2008. V. 3. P. 36–42.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Бабаева А.Г. Роль иммунной системы в дизрегуляции морфогенетических процессов // Дизрегуляционная патология; под ред. Г.Н. Крыжановского. М.: Меди- цина, 2002. С. 366–385.</mixed-citation><mixed-citation xml:lang="en">Бабаева А.Г. Роль иммунной системы в дизрегуляции морфогенетических процессов // Дизрегуляционная патология; под ред. Г.Н. Крыжановского. М.: Меди- цина, 2002. С. 366–385.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Галактионов В.Г. Эволюционная иммунология. М.: Академкнига, 2005. 408 с.</mixed-citation><mixed-citation xml:lang="en">Галактионов В.Г. Эволюционная иммунология. М.: Академкнига, 2005. 408 с.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Гольдберг Е.Д., Дыгай А.М., Жданов В.В. и др. Со- стояние пулов стволовых клеток при эксперимен- тальном сахарном диабете // Клеточные технологии в биологии и медицине. 2006. V. 3. P. 123–127.</mixed-citation><mixed-citation xml:lang="en">Гольдберг Е.Д., Дыгай А.М., Жданов В.В. и др. Со- стояние пулов стволовых клеток при эксперимен- тальном сахарном диабете // Клеточные технологии в биологии и медицине. 2006. V. 3. P. 123–127.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И.И., Балаболкин М.И., Клебанова Е.М., Кре- минская В.М., Чазова Т.Е. Сахарный диабет: пато- генез, классификация, диагностика и лечение. М., 2003. 171 с.</mixed-citation><mixed-citation xml:lang="en">Дедов И.И., Балаболкин М.И., Клебанова Е.М., Кре- минская В.М., Чазова Т.Е. Сахарный диабет: пато- генез, классификация, диагностика и лечение. М., 2003. 171 с.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Делягин В.М., Волков И.Э., Румянцев А.Г., Скурко- вич С.В. Иммунные и неиммунные нарушения при сахарном диабете типа 1 у детей // Вопросы гемато- логии / онкологии и иммунопатологии в педиатрии. 2004. V. 3 (2). P. 76–80.</mixed-citation><mixed-citation xml:lang="en">Делягин В.М., Волков И.Э., Румянцев А.Г., Скурко- вич С.В. Иммунные и неиммунные нарушения при сахарном диабете типа 1 у детей // Вопросы гемато- логии / онкологии и иммунопатологии в педиатрии. 2004. V. 3 (2). P. 76–80.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Закирьянов А.Р., Онищенко Н.А., Клименко Е.Д., Поз- дняков О.М. Регенерационная клеточная терапия са- харного диабета I типа и его осложнений // Вестник РАМН. 2008. V. 3. P. 42–51.</mixed-citation><mixed-citation xml:lang="en">Закирьянов А.Р., Онищенко Н.А., Клименко Е.Д., Поз- дняков О.М. Регенерационная клеточная терапия са- харного диабета I типа и его осложнений // Вестник РАМН. 2008. V. 3. P. 42–51.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Темнов А.А. Клеточная трансплантация при лече- нии хронической сердечной недостаточности: Дис. ... д-ра мед. наук. М., 2008.</mixed-citation><mixed-citation xml:lang="en">Темнов А.А. Клеточная трансплантация при лече- нии хронической сердечной недостаточности: Дис. ... д-ра мед. наук. М., 2008.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Abdi R., Fiorina P., Adra C.N., Atkinson M., Sayegh M.H. Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetes // Diabetes. 2008. V. 57. P1759–1767.</mixed-citation><mixed-citation xml:lang="en">Abdi R., Fiorina P., Adra C.N., Atkinson M., Sayegh M.H. Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetes // Diabetes. 2008. V. 57. P1759–1767.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Aggarwal S., Pittenger M.F. Human mesenchymal stem cells modulate allogenetic immune cell responses // Blood. 2005. V. 105. P. 1815–1822.</mixed-citation><mixed-citation xml:lang="en">Aggarwal S., Pittenger M.F. Human mesenchymal stem cells modulate allogenetic immune cell responses // Blood. 2005. V. 105. P. 1815–1822.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Alvarez-Dolado M. Cell fusion: biological perspectives and potential for regenerative medicine // Front Biosci. 2007. V. 12. P. 1–12.</mixed-citation><mixed-citation xml:lang="en">Alvarez-Dolado M. Cell fusion: biological perspectives and potential for regenerative medicine // Front Biosci. 2007. V. 12. P. 1–12.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Arthur A., Zannettino A., Gronthos S. The therapeutic applications of multipotential mesenchymal/stromal stem cells in skeletal tissue repair // J Cell Physiol. 2009. V. 218 (2). P. 237–245.</mixed-citation><mixed-citation xml:lang="en">Arthur A., Zannettino A., Gronthos S. The therapeutic applications of multipotential mesenchymal/stromal stem cells in skeletal tissue repair // J Cell Physiol. 2009. V. 218 (2). P. 237–245.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Banerjee M., Kumar A., Bhonde R.R. Reversal of ex- perimental diabetes by multiple bone marrow trans- plantation // Biochem. Biophys. Res. Commun. 2005. V. 328 (1). P. 318–325.</mixed-citation><mixed-citation xml:lang="en">Banerjee M., Kumar A., Bhonde R.R. Reversal of ex- perimental diabetes by multiple bone marrow trans- plantation // Biochem. Biophys. Res. Commun. 2005. V. 328 (1). P. 318–325.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Boumaza I., Srinivasan S., Witt W.T., Feghali-Bost- wick C., Dai Y., Garcia-Ocana A., Feili-Hariri M. Auto- logous bone marrow-derived rat mesenchymal stem cells promote PDX-1 and insulin expression in the islets, alter T-cell cytokine pattern and preserve regulatory T-cells in the periphery and induce sustained normoglycemia // J Autoimmun. 2008 Dec 3. [Epub ahead of print].</mixed-citation><mixed-citation xml:lang="en">Boumaza I., Srinivasan S., Witt W.T., Feghali-Bost- wick C., Dai Y., Garcia-Ocana A., Feili-Hariri M. Auto- logous bone marrow-derived rat mesenchymal stem cells promote PDX-1 and insulin expression in the islets, alter T-cell cytokine pattern and preserve regulatory T-cells in the periphery and induce sustained normoglycemia // J Autoimmun. 2008 Dec 3. [Epub ahead of print].</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Corcione A., Benvenuto F., Ferretti E. et al. Human mesenchymal stem cells modulate B-cell functions // Blood. 2006. V. 107. P. 367–372.</mixed-citation><mixed-citation xml:lang="en">Corcione A., Benvenuto F., Ferretti E. et al. Human mesenchymal stem cells modulate B-cell functions // Blood. 2006. V. 107. P. 367–372.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Dazzi F., van Laar J.M., Cope1 A., Tyndall A. Cell thera- py for autoimmune diseases. Arthritis Research &amp; Ther- apy. 2007. V. 9. P. 206.</mixed-citation><mixed-citation xml:lang="en">Dazzi F., van Laar J.M., Cope1 A., Tyndall A. Cell thera- py for autoimmune diseases. Arthritis Research &amp; Ther- apy. 2007. V. 9. P. 206.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">de Kleer I., Vastert B., Klein M., Teklenburg G. et al. Autologous stem cell transplantation for autoimmunity induces immunologic self-tolerance by reprogramming autoreactive T-cells and restoring the CD4+CD25+ immune regulatory network // Blood. 2006. V. 107. P. 1696–1702.</mixed-citation><mixed-citation xml:lang="en">de Kleer I., Vastert B., Klein M., Teklenburg G. et al. Autologous stem cell transplantation for autoimmunity induces immunologic self-tolerance by reprogramming autoreactive T-cells and restoring the CD4+CD25+ immune regulatory network // Blood. 2006. V. 107. P. 1696–1702.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Haller M.J., Viener H., Wasserfall C. et al. Autologous umbilical cord blood infusion for type 1 diabetes // Ex- perimental Hematology. 2008. V. 36. P. 710–715.</mixed-citation><mixed-citation xml:lang="en">Haller M.J., Viener H., Wasserfall C. et al. Autologous umbilical cord blood infusion for type 1 diabetes // Ex- perimental Hematology. 2008. V. 36. P. 710–715.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Hess D., Li L., Martin M. et al. Bone marrow-derived stem cells initiate pancreatic regeneration. Nat. Biotech- nol. 2003. V. 21 (7). P. 763–770.</mixed-citation><mixed-citation xml:lang="en">Hess D., Li L., Martin M. et al. Bone marrow-derived stem cells initiate pancreatic regeneration. Nat. Biotech- nol. 2003. V. 21 (7). P. 763–770.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Homo-Delarche F., Drexhage H.A. Immune cells, pan- creas development, regeneration and type 1 diabetes. Trends Immunol. 2004. V. 25 (5). P. 222–229.</mixed-citation><mixed-citation xml:lang="en">Homo-Delarche F., Drexhage H.A. Immune cells, pan- creas development, regeneration and type 1 diabetes. Trends Immunol. 2004. V. 25 (5). P. 222–229.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Izumida Y., Aoki T., Yasuda D. et al. Hepatocyte growth factor is constitutively produced by donor-derived bone marrow cells and promotes regeneration of pancreatic beta-cells // Biochem. Biophys. Res. Commun. 2005. V. 333 (1). P. 273–282.</mixed-citation><mixed-citation xml:lang="en">Izumida Y., Aoki T., Yasuda D. et al. Hepatocyte growth factor is constitutively produced by donor-derived bone marrow cells and promotes regeneration of pancreatic beta-cells // Biochem. Biophys. Res. Commun. 2005. V. 333 (1). P. 273–282.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Jahromi M.M., Eisenbarth G.S. Genetic determinants of type 1 diabetes across populations // Ann. N.Y. Acad. Sci. 2006. V. 1079. P. 289–299.</mixed-citation><mixed-citation xml:lang="en">Jahromi M.M., Eisenbarth G.S. Genetic determinants of type 1 diabetes across populations // Ann. N.Y. Acad. Sci. 2006. V. 1079. P. 289–299.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Kayali A.G., Van Gunt K., Campbell I., Stotland A., Krit- zik M., Liu G. et al. The stromal cell-derived factor-1al- pha/CXCR4 ligand-receptor axis is critical for progeni- tor survival and migration in the pancreas // J Cell Biol. 2003. V. 163. P. 859–869.</mixed-citation><mixed-citation xml:lang="en">Kayali A.G., Van Gunt K., Campbell I., Stotland A., Krit- zik M., Liu G. et al. The stromal cell-derived factor-1al- pha/CXCR4 ligand-receptor axis is critical for progeni- tor survival and migration in the pancreas // J Cell Biol. 2003. V. 163. P. 859–869.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Koblas T., Harman S.M., Saudek F. The application of umbilical cord blood cells in the treatment of diabetes mellitus // Rev Diabet Stud. 2005. V. 2. P. 228–234.</mixed-citation><mixed-citation xml:lang="en">Koblas T., Harman S.M., Saudek F. The application of umbilical cord blood cells in the treatment of diabetes mellitus // Rev Diabet Stud. 2005. V. 2. P. 228–234.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Lammert E., Cleaver O., Melton D. Induction of pan- creatic differentiation by signals from blood vessels // Science. 2001. V. 294 (5542). P. 564–567.</mixed-citation><mixed-citation xml:lang="en">Lammert E., Cleaver O., Melton D. Induction of pan- creatic differentiation by signals from blood vessels // Science. 2001. V. 294 (5542). P. 564–567.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Lee R.H., Seo M.J., Reger R.L. et al. Multipotent stro- mal cells from human marrow home to and promote re- pair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice // Proc. Natl. Acad. Sci. USA. 2006. V. 103 (46). P. 17438–17443.</mixed-citation><mixed-citation xml:lang="en">Lee R.H., Seo M.J., Reger R.L. et al. Multipotent stro- mal cells from human marrow home to and promote re- pair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice // Proc. Natl. Acad. Sci. USA. 2006. V. 103 (46). P. 17438–17443.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Lindley S., Dayan C.M., Bishop A., Roep B.O., Peak- man M., Tree T.I. Defective suppressor function in CD4+ CD25+ T-cells from patients with type 1 diabetes // Dia- betes. 2005. V. 54. P. 92–99.</mixed-citation><mixed-citation xml:lang="en">Lindley S., Dayan C.M., Bishop A., Roep B.O., Peak- man M., Tree T.I. Defective suppressor function in CD4+ CD25+ T-cells from patients with type 1 diabetes // Dia- betes. 2005. V. 54. P. 92–99.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Loomans C.J., de Koning E.J., Staal F.J. et al. Endothe- lial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabe- tes // Diabetes. 2004. V. 53 (1). P. 195–199.</mixed-citation><mixed-citation xml:lang="en">Loomans C.J., de Koning E.J., Staal F.J. et al. Endothe- lial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabe- tes // Diabetes. 2004. V. 53 (1). P. 195–199.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Lundsgaard D., Holm T.L., Hornum L., Markholst H. In vivo control of diabetogenic T-cells by regulatory CD4+CD25+ T-cells expressing Foxp3 // Diabetes. 2005. V. 54. P. 1040–1047.</mixed-citation><mixed-citation xml:lang="en">Lundsgaard D., Holm T.L., Hornum L., Markholst H. In vivo control of diabetogenic T-cells by regulatory CD4+CD25+ T-cells expressing Foxp3 // Diabetes. 2005. V. 54. P. 1040–1047.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Peng Y., Laouar Y., Li M.O., Green E.A., Flavell R.A. TGF-b regulates in vivo expansion of Foxp3-expressing CD4+ CD25+ regulatory T-cells responsible for protec- tion against diabetes // Proc. Natl. Acad. Sci. USA. 2004. V. 101. P. 4572–4577.</mixed-citation><mixed-citation xml:lang="en">Peng Y., Laouar Y., Li M.O., Green E.A., Flavell R.A. TGF-b regulates in vivo expansion of Foxp3-expressing CD4+ CD25+ regulatory T-cells responsible for protec- tion against diabetes // Proc. Natl. Acad. Sci. USA. 2004. V. 101. P. 4572–4577.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Rabinovitch A., Suarez-Pinzon W.L. Role of cytokines in the pathogenesis of autoimmune diabetes mellitus // Rev. Endocr. Metab. Disord. 2003. V. 4 (3). P. 291–299.</mixed-citation><mixed-citation xml:lang="en">Rabinovitch A., Suarez-Pinzon W.L. Role of cytokines in the pathogenesis of autoimmune diabetes mellitus // Rev. Endocr. Metab. Disord. 2003. V. 4 (3). P. 291–299.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Randolph D.A., Fathman C.G. CD4+CD25+ regulatory T-cells and their therapeutic potential // Annu Rev Med. 2006. V. 57. P. 381–402.</mixed-citation><mixed-citation xml:lang="en">Randolph D.A., Fathman C.G. CD4+CD25+ regulatory T-cells and their therapeutic potential // Annu Rev Med. 2006. V. 57. P. 381–402.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Ringden O., Uzunel M., Rasmusson I. et al. Mesen- chymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation. 2006. V. 81. P. 1390–1397.</mixed-citation><mixed-citation xml:lang="en">Ringden O., Uzunel M., Rasmusson I. et al. Mesen- chymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation. 2006. V. 81. P. 1390–1397.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Rosenzweig A. Cardiac cell therapy – mixed results from mixed cells // Engl J Med. 2006. V. 355. P. 1274– 1277.</mixed-citation><mixed-citation xml:lang="en">Rosenzweig A. Cardiac cell therapy – mixed results from mixed cells // Engl J Med. 2006. V. 355. P. 1274– 1277.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Sakaguchi S. Naturally arising CD4+ regulatory T-cells for immunologic self-tolerance and negative control of immune responses // Annu Rev Immunol. 2004. V. 22. P. 531–562.</mixed-citation><mixed-citation xml:lang="en">Sakaguchi S. Naturally arising CD4+ regulatory T-cells for immunologic self-tolerance and negative control of immune responses // Annu Rev Immunol. 2004. V. 22. P. 531–562.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Selmani Z., Naji A., Zidi I., Favier B., Gaiffe E. et al. Human leukocyte antigen-G5 secretion by human me- senchymal stem cells is required to suppress T-lymp- hocyte and natural killer function and to induce CD4+ CD25high Foxp3+ regulatory T-cells // Stem Cells. 2008. V. 26. P. 212–222.</mixed-citation><mixed-citation xml:lang="en">Selmani Z., Naji A., Zidi I., Favier B., Gaiffe E. et al. Human leukocyte antigen-G5 secretion by human me- senchymal stem cells is required to suppress T-lymp- hocyte and natural killer function and to induce CD4+ CD25high Foxp3+ regulatory T-cells // Stem Cells. 2008. V. 26. P. 212–222.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Sia C., Homo-Delarche F. Tolerance Induction and En- dogenous Regeneration of Pancreatic β-cells in Estab- lished Autoimmune Diabetes. Rev. Diabetic Stud. 2004. V. 1. P. 198–206.</mixed-citation><mixed-citation xml:lang="en">Sia C., Homo-Delarche F. Tolerance Induction and En- dogenous Regeneration of Pancreatic β-cells in Estab- lished Autoimmune Diabetes. Rev. Diabetic Stud. 2004. V. 1. P. 198–206.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Sotiropoulou P.A., Perez S.A., Gritzapis A.D., Baxeva- nis C.N., Papamichail M. Interactions between human mesenchymal stem cells and natural killer cells // Stem Cells. 2006. V. 24. P. 74–85.</mixed-citation><mixed-citation xml:lang="en">Sotiropoulou P.A., Perez S.A., Gritzapis A.D., Baxeva- nis C.N., Papamichail M. Interactions between human mesenchymal stem cells and natural killer cells // Stem Cells. 2006. V. 24. P. 74–85.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Tarbell K.V., Petit L., Zuo X., Toy P. et al. Dendritic cell- expanded, islet-specific CD4+ CD25+ CD62L+ regu- latory T-cells restore normoglycemia in diabetic NOD mice // J. Exp. Med. 2007. V. 204 (1). P. 191–201.</mixed-citation><mixed-citation xml:lang="en">Tarbell K.V., Petit L., Zuo X., Toy P. et al. Dendritic cell- expanded, islet-specific CD4+ CD25+ CD62L+ regu- latory T-cells restore normoglycemia in diabetic NOD mice // J. Exp. Med. 2007. V. 204 (1). P. 191–201.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Uccelli A., Pistoia V., Moretta L. Mesenchymal stem cells: a new strategy for immunosuppression? // Trends Immunol. 2007. V. 28. P. 219–226.</mixed-citation><mixed-citation xml:lang="en">Uccelli A., Pistoia V., Moretta L. Mesenchymal stem cells: a new strategy for immunosuppression? // Trends Immunol. 2007. V. 28. P. 219–226.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">van der Vliet H.J., Nieuwenhuis E.E. IPEX as a result of mutations in Foxp3 // Clin Dev Immunol. 2007. P. 89017.</mixed-citation><mixed-citation xml:lang="en">van der Vliet H.J., Nieuwenhuis E.E. IPEX as a result of mutations in Foxp3 // Clin Dev Immunol. 2007. P. 89017.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Vanikar A.V., Modi P.R., Patel R.D. et al. Hematopoi- etic stem cell transplantation in autoimmune diseases:the Ahmedabad experience // Transplant. Proc. 2007.</mixed-citation><mixed-citation xml:lang="en">Vanikar A.V., Modi P.R., Patel R.D. et al. Hematopoi- etic stem cell transplantation in autoimmune diseases:the Ahmedabad experience // Transplant. Proc. 2007.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">V. 39 (3). P. 703–708.</mixed-citation><mixed-citation xml:lang="en">V. 39 (3). P. 703–708.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Voltarelli J.C., Couri C.E., Stracieri A.B. et al. Autolo-</mixed-citation><mixed-citation xml:lang="en">Voltarelli J.C., Couri C.E., Stracieri A.B. et al. Autolo-</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">gous nonmyeloablative hematopoietic stem cell trans- plantation in newly diagnosed type 1 diabetes mellitus // JAMA. 2007. V. 297. P. 1568–1576.</mixed-citation><mixed-citation xml:lang="en">gous nonmyeloablative hematopoietic stem cell trans- plantation in newly diagnosed type 1 diabetes mellitus // JAMA. 2007. V. 297. P. 1568–1576.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">von Herrath M., Homann D. Islet regeneration needed for overcoming autoimmune destruction – considerati- ons on the pathogenesis of type 1 diabetes // Pediatr Di- abetes. 2004. V. 5 (Suppl. 2). P. 23–28.</mixed-citation><mixed-citation xml:lang="en">von Herrath M., Homann D. Islet regeneration needed for overcoming autoimmune destruction – considerati- ons on the pathogenesis of type 1 diabetes // Pediatr Di- abetes. 2004. V. 5 (Suppl. 2). P. 23–28.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Waldmann H., Chen T.C., Graca L., Adams E. et al. Re- gulatory T-cells in transplantation // Semin Immunol. 2006. V. 18. P. 111–119.</mixed-citation><mixed-citation xml:lang="en">Waldmann H., Chen T.C., Graca L., Adams E. et al. Re- gulatory T-cells in transplantation // Semin Immunol. 2006. V. 18. P. 111–119.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Wild S., Roglic G., Green A., Sicree R., King H. Global prevalence of diabetes // Diabetes Care. 2004. V. 27. P. 1047–1053.</mixed-citation><mixed-citation xml:lang="en">Wild S., Roglic G., Green A., Sicree R., King H. Global prevalence of diabetes // Diabetes Care. 2004. V. 27. P. 1047–1053.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Winter W.E., Harris N., Schatz D. Immunological markers in the diagnosis and prediction of autoimmu- ne type 1a diabetes // Clinical Diabetes. 2002. V. 20. P. 183–191.</mixed-citation><mixed-citation xml:lang="en">Winter W.E., Harris N., Schatz D. Immunological markers in the diagnosis and prediction of autoimmu- ne type 1a diabetes // Clinical Diabetes. 2002. V. 20. P. 183–191.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Yamazaki S., Bonito A.J., Spisek R., Dhodapkar M.V. et al. Dendritic cells are specialized accessory cells along with TGF-b for the differentiation of Foxp3+ CD4+ regula- tory T cells from peripheral Foxp3-precursors //Blood. 2007. V. 110. P. 4293–4302.</mixed-citation><mixed-citation xml:lang="en">Yamazaki S., Bonito A.J., Spisek R., Dhodapkar M.V. et al. Dendritic cells are specialized accessory cells along with TGF-b for the differentiation of Foxp3+ CD4+ regula- tory T cells from peripheral Foxp3-precursors //Blood. 2007. V. 110. P. 4293–4302.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Yoon J.W., Jun H.S. Autoimmune destruction of pancre- atic beta cells // Am. J. of Therapeutics. 2005. V. 12 (6). P. 580–591.</mixed-citation><mixed-citation xml:lang="en">Yoon J.W., Jun H.S. Autoimmune destruction of pancre- atic beta cells // Am. J. of Therapeutics. 2005. V. 12 (6). P. 580–591.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang W., Ge W., Li C., You S., Liao L. et al. Effects of mesenchymal stem cells on differentiation, matura- tion, and function of human monocyte-derived dendritic cells // Stem Cells Dev. 2004. V. 13. P. 263–271.</mixed-citation><mixed-citation xml:lang="en">Zhang W., Ge W., Li C., You S., Liao L. et al. Effects of mesenchymal stem cells on differentiation, matura- tion, and function of human monocyte-derived dendritic cells // Stem Cells Dev. 2004. V. 13. P. 263–271.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
